RU2018118993A - Терапевтическая антигенсвязывающая молекула, содержащая fcrn-связывающий домен, которая обеспечивает клиренс антигенов - Google Patents
Терапевтическая антигенсвязывающая молекула, содержащая fcrn-связывающий домен, которая обеспечивает клиренс антигенов Download PDFInfo
- Publication number
- RU2018118993A RU2018118993A RU2018118993A RU2018118993A RU2018118993A RU 2018118993 A RU2018118993 A RU 2018118993A RU 2018118993 A RU2018118993 A RU 2018118993A RU 2018118993 A RU2018118993 A RU 2018118993A RU 2018118993 A RU2018118993 A RU 2018118993A
- Authority
- RU
- Russia
- Prior art keywords
- binding domain
- amino acid
- fcrn
- antigen
- neutral
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000027455 binding Effects 0.000 claims 112
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 58
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 58
- 150000001413 amino acids Chemical class 0.000 claims 50
- 239000000427 antigen Substances 0.000 claims 46
- 108091007433 antigens Proteins 0.000 claims 46
- 102000036639 antigens Human genes 0.000 claims 46
- 235000001014 amino acid Nutrition 0.000 claims 34
- 238000000034 method Methods 0.000 claims 32
- 230000007935 neutral effect Effects 0.000 claims 23
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 11
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 11
- 235000013922 glutamic acid Nutrition 0.000 claims 11
- 239000004220 glutamic acid Substances 0.000 claims 11
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 10
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 10
- 235000003704 aspartic acid Nutrition 0.000 claims 10
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 10
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 10
- 235000004554 glutamine Nutrition 0.000 claims 10
- 230000002378 acidificating effect Effects 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 3
- 229910001424 calcium ion Inorganic materials 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011218736 | 2011-09-30 | ||
| JP2011-218736 | 2011-09-30 | ||
| JPPCT/JP2012/058603 | 2012-03-30 | ||
| PCT/JP2012/058603 WO2012133782A1 (ja) | 2011-03-30 | 2012-03-30 | 抗原結合分子の血漿中滞留性と免疫原性を改変する方法 |
| JP2012123782 | 2012-05-30 | ||
| JP2012123781 | 2012-05-30 | ||
| JP2012-123781 | 2012-05-30 | ||
| JP2012123773 | 2012-05-30 | ||
| JP1212-123782 | 2012-05-30 | ||
| JP2012-123773 | 2012-05-30 | ||
| JP2012-139211 | 2012-06-20 | ||
| JP2012139211 | 2012-06-20 | ||
| JP2012177311 | 2012-08-09 | ||
| JP2012-177311 | 2012-08-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117500/10A Division RU2014117500A (ru) | 2011-09-30 | 2012-09-28 | ТЕРАПЕВТИЧЕСКАЯ АНТИГЕНСВЯЗЫВАЮЩАЯ МОЛЕКУЛА, СОДЕРЖАЩАЯ FcRn-СВЯЗЫВАЮЩИЙ ДОМЕН, КОТОРАЯ ОБЕСПЕЧИВАЕТ КЛИРЕНС АНТИГЕНОВ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018118993A true RU2018118993A (ru) | 2018-11-07 |
| RU2018118993A3 RU2018118993A3 (enExample) | 2019-04-25 |
Family
ID=47996560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018118993A RU2018118993A (ru) | 2011-09-30 | 2012-09-28 | Терапевтическая антигенсвязывающая молекула, содержащая fcrn-связывающий домен, которая обеспечивает клиренс антигенов |
| RU2014117500/10A RU2014117500A (ru) | 2011-09-30 | 2012-09-28 | ТЕРАПЕВТИЧЕСКАЯ АНТИГЕНСВЯЗЫВАЮЩАЯ МОЛЕКУЛА, СОДЕРЖАЩАЯ FcRn-СВЯЗЫВАЮЩИЙ ДОМЕН, КОТОРАЯ ОБЕСПЕЧИВАЕТ КЛИРЕНС АНТИГЕНОВ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117500/10A RU2014117500A (ru) | 2011-09-30 | 2012-09-28 | ТЕРАПЕВТИЧЕСКАЯ АНТИГЕНСВЯЗЫВАЮЩАЯ МОЛЕКУЛА, СОДЕРЖАЩАЯ FcRn-СВЯЗЫВАЮЩИЙ ДОМЕН, КОТОРАЯ ОБЕСПЕЧИВАЕТ КЛИРЕНС АНТИГЕНОВ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10253100B2 (enExample) |
| EP (3) | EP3549956A3 (enExample) |
| JP (5) | JP6204350B2 (enExample) |
| KR (1) | KR20140069332A (enExample) |
| CN (2) | CN108948197A (enExample) |
| AU (2) | AU2012313670B2 (enExample) |
| BR (1) | BR112014007290A2 (enExample) |
| CA (1) | CA2850035A1 (enExample) |
| HK (1) | HK1257946A1 (enExample) |
| MX (1) | MX2014003891A (enExample) |
| RU (2) | RU2018118993A (enExample) |
| SG (2) | SG10201808187TA (enExample) |
| TW (3) | TW201817744A (enExample) |
| WO (1) | WO2013046704A2 (enExample) |
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| WO2013002362A1 (ja) | 2011-06-30 | 2013-01-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| TW201817744A (zh) * | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
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| EP3041863A4 (en) * | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
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| RS62749B1 (sr) * | 2014-12-19 | 2022-01-31 | Chugai Pharmaceutical Co Ltd | Anti-c5 antitela i načini njihove upotrebe |
| CA2974547A1 (en) * | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses thereof |
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