EA201491571A1 - МОДИФИЦИРОВАННЫЕ БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА IgG4 С АСИММЕТРИЧНОЙ ПОСЛЕДОВАТЕЛЬНОСТЬЮ - Google Patents

МОДИФИЦИРОВАННЫЕ БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА IgG4 С АСИММЕТРИЧНОЙ ПОСЛЕДОВАТЕЛЬНОСТЬЮ

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Publication number
EA201491571A1
EA201491571A1 EA201491571A EA201491571A EA201491571A1 EA 201491571 A1 EA201491571 A1 EA 201491571A1 EA 201491571 A EA201491571 A EA 201491571A EA 201491571 A EA201491571 A EA 201491571A EA 201491571 A1 EA201491571 A1 EA 201491571A1
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heavy chain
region
fragment
domain
replaced
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EA201491571A
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EA033720B1 (ru
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Дэвид Пол Хамфриз
Ширли Джейн Питерс
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Юсб Фарма С.А.
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Publication of EA201491571A1 publication Critical patent/EA201491571A1/ru
Publication of EA033720B1 publication Critical patent/EA033720B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Настоящее изобретение относится к асимметричному смешанному антителу, содержащему две тяжелые цепи или фрагмент тяжелой цепи, каждый из которых содержит по меньшей мере вариабельную область, шарнирную область и C1-домен, где первая тяжелая цепь или ее фрагмент принадлежит классу IgG4 и имеет: a) цистеин межцепочечной связи в положении 127 при нумерации по системе нумерации Kabat в домене C1 заменен на другую аминокислоту; b) необязательно, одна или несколько из аминокислот, расположенных в верхней шарнирной области, заменены цистеином; и где вторая тяжелая цепь или ее фрагмент отличается тем, что часть или вся цепь отличается по аминокислотной последовательности от указанной первой тяжелой цепи, по меньшей мере, в области вне вариабельной области (например, в константной области); к составам, содержащим их, терапевтическому средству, в котором используются оба из указанных выше, и к способам получения антител и состава.
EA201491571A 2012-02-22 2013-02-22 МОДИФИЦИРОВАННЫЕ БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА IgG4 С АСИММЕТРИЧНОЙ ПОСЛЕДОВАТЕЛЬНОСТЬЮ EA033720B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1203071.4A GB201203071D0 (en) 2012-02-22 2012-02-22 Biological products
PCT/EP2013/053615 WO2013124451A1 (en) 2012-02-22 2013-02-22 Sequence symmetric modified igg4 bispecific antibodies

Publications (2)

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EA201491571A1 true EA201491571A1 (ru) 2015-02-27
EA033720B1 EA033720B1 (ru) 2019-11-20

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EA201491571A EA033720B1 (ru) 2012-02-22 2013-02-22 МОДИФИЦИРОВАННЫЕ БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА IgG4 С АСИММЕТРИЧНОЙ ПОСЛЕДОВАТЕЛЬНОСТЬЮ

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US (1) US9902768B2 (ru)
EP (2) EP3670531A1 (ru)
JP (3) JP6308953B2 (ru)
KR (2) KR102077332B1 (ru)
CN (1) CN104245729B (ru)
AU (2) AU2013224004B2 (ru)
CA (1) CA2865261A1 (ru)
DK (1) DK2817333T3 (ru)
EA (1) EA033720B1 (ru)
ES (1) ES2773123T3 (ru)
GB (1) GB201203071D0 (ru)
HK (1) HK1202565A1 (ru)
IL (2) IL234107B (ru)
MX (1) MX356301B (ru)
SG (1) SG11201404900YA (ru)
WO (1) WO2013124451A1 (ru)

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