MX344040B - Anticuerpos mejorados de la clase inmonoglubina g4 (igg4). - Google Patents

Anticuerpos mejorados de la clase inmonoglubina g4 (igg4).

Info

Publication number
MX344040B
MX344040B MX2013001948A MX2013001948A MX344040B MX 344040 B MX344040 B MX 344040B MX 2013001948 A MX2013001948 A MX 2013001948A MX 2013001948 A MX2013001948 A MX 2013001948A MX 344040 B MX344040 B MX 344040B
Authority
MX
Mexico
Prior art keywords
class igg4
improved antibodies
domain
substituted
cysteine
Prior art date
Application number
MX2013001948A
Other languages
English (en)
Other versions
MX2013001948A (es
Inventor
Jane Peters Shirley
Paul Humphreys David
Adams Ralph
Heads James
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of MX2013001948A publication Critical patent/MX2013001948A/es
Publication of MX344040B publication Critical patent/MX344040B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un anticuerpo de la clase IgG4 que comprende por lo menos una cadena pesada la cual comprende un dominio Ch1 y una región de bisagra, caracterizado porque en cada cadena pesada: a. el dominio CH1 comprende residuos 1 a 98 de la SEQ ID NO: 2 en donde una cisteína intercadena en la posición 127, numerada de acuerdo con el sistema de numeración de Kabat, en el dominio CH1 está sustituida con otro aminoácido y b. uno o más de los aminoácidos colocados en la región de bisagra superior están sustituida con cisteína.
MX2013001948A 2010-08-20 2011-08-19 Anticuerpos mejorados de la clase inmonoglubina g4 (igg4). MX344040B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1014033.3A GB201014033D0 (en) 2010-08-20 2010-08-20 Biological products
PCT/GB2011/051563 WO2012022982A2 (en) 2010-08-20 2011-08-19 Improved antibodies of the class igg4

Publications (2)

Publication Number Publication Date
MX2013001948A MX2013001948A (es) 2013-06-28
MX344040B true MX344040B (es) 2016-12-02

Family

ID=42984480

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001948A MX344040B (es) 2010-08-20 2011-08-19 Anticuerpos mejorados de la clase inmonoglubina g4 (igg4).

Country Status (14)

Country Link
US (2) US10562966B2 (es)
EP (1) EP2606063B1 (es)
JP (1) JP5894160B2 (es)
KR (1) KR101883792B1 (es)
CN (2) CN105859876B (es)
AU (1) AU2011290581B2 (es)
BR (1) BR112013003262B1 (es)
CA (2) CA2807227C (es)
DK (1) DK2606063T3 (es)
ES (1) ES2632571T3 (es)
GB (1) GB201014033D0 (es)
MX (1) MX344040B (es)
SG (2) SG10201506492PA (es)
WO (1) WO2012022982A2 (es)

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GB201014033D0 (en) 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
GB201203051D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
GB201203071D0 (en) * 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
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KR101895634B1 (ko) 2013-05-31 2018-09-05 한미약품 주식회사 변이된 힌지 영역을 포함하는 IgG4 Fc 단편
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
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Also Published As

Publication number Publication date
WO2012022982A3 (en) 2012-06-21
AU2011290581A1 (en) 2013-04-04
US20200157204A1 (en) 2020-05-21
ES2632571T3 (es) 2017-09-14
MX2013001948A (es) 2013-06-28
CA3080547A1 (en) 2012-02-23
KR20130099950A (ko) 2013-09-06
EP2606063B1 (en) 2017-05-17
CN105859876A (zh) 2016-08-17
BR112013003262B1 (pt) 2022-07-26
AU2011290581B2 (en) 2015-04-16
US10562966B2 (en) 2020-02-18
SG10201506492PA (en) 2015-10-29
SG187677A1 (en) 2013-03-28
EP2606063A2 (en) 2013-06-26
JP5894160B2 (ja) 2016-03-23
JP2013538052A (ja) 2013-10-10
BR112013003262A2 (pt) 2016-06-14
CN103097410A (zh) 2013-05-08
CA2807227C (en) 2021-03-23
GB201014033D0 (en) 2010-10-06
CA2807227A1 (en) 2012-02-23
DK2606063T3 (en) 2017-08-14
CN103097410B (zh) 2016-06-01
CN105859876B (zh) 2021-04-02
KR101883792B1 (ko) 2018-07-31
US20130323236A1 (en) 2013-12-05
CA3080547C (en) 2023-10-24
WO2012022982A2 (en) 2012-02-23
US12091450B2 (en) 2024-09-17

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