SG10201506492PA - Improved antibodies of the class igg4 - Google Patents
Improved antibodies of the class igg4Info
- Publication number
- SG10201506492PA SG10201506492PA SG10201506492PA SG10201506492PA SG10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA
- Authority
- SG
- Singapore
- Prior art keywords
- improved antibodies
- class igg4
- igg4
- class
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1014033.3A GB201014033D0 (en) | 2010-08-20 | 2010-08-20 | Biological products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201506492PA true SG10201506492PA (en) | 2015-10-29 |
Family
ID=42984480
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201506492PA SG10201506492PA (en) | 2010-08-20 | 2011-08-19 | Improved antibodies of the class igg4 |
| SG2013007950A SG187677A1 (en) | 2010-08-20 | 2011-08-19 | Improved antibodies of the class igg4 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013007950A SG187677A1 (en) | 2010-08-20 | 2011-08-19 | Improved antibodies of the class igg4 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10562966B2 (es) |
| EP (1) | EP2606063B1 (es) |
| JP (1) | JP5894160B2 (es) |
| KR (1) | KR101883792B1 (es) |
| CN (2) | CN105859876B (es) |
| AU (1) | AU2011290581B2 (es) |
| BR (1) | BR112013003262B1 (es) |
| CA (2) | CA3080547C (es) |
| DK (1) | DK2606063T3 (es) |
| ES (1) | ES2632571T3 (es) |
| GB (1) | GB201014033D0 (es) |
| MX (1) | MX344040B (es) |
| SG (2) | SG10201506492PA (es) |
| WO (1) | WO2012022982A2 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| GB201203071D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| GB201203051D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| EA201591465A1 (ru) | 2013-02-08 | 2015-12-30 | АйАрЭм ЭлЭлСи | Специфичные участки для модификации антител для получения иммуноконъюгатов |
| KR101895634B1 (ko) | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | 변이된 힌지 영역을 포함하는 IgG4 Fc 단편 |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| EP2944962A1 (en) * | 2014-05-14 | 2015-11-18 | UCB Biopharma SPRL | Method for determining antibody specificity |
| MX360295B (es) * | 2014-05-29 | 2018-10-29 | Medimmune Llc | Proteinas de fusion del ligando de ox40 (ox40l) y sus usos. |
| KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
| TWI691512B (zh) * | 2015-02-20 | 2020-04-21 | 日商橘生藥品工業股份有限公司 | Ｆｃ融合高親和性ＩｇＥ受體α鏈 |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| US11091543B2 (en) * | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| SG10202108996PA (en) | 2015-05-07 | 2021-09-29 | Swedish Orphan Biovitrum Ag | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
| AU2016274989A1 (en) * | 2015-06-12 | 2017-11-02 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
| US20180271998A1 (en) * | 2015-12-04 | 2018-09-27 | Merrimack Pharmaceuticals, Inc. | Disulfide-stabilized fabs |
| GB201521746D0 (en) * | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
| SG11201901468SA (en) * | 2016-10-06 | 2019-03-28 | Glaxosmithkline Ip Dev Ltd | Antibodies with reduced binding to process impurities |
| EP3532497A4 (en) | 2016-10-26 | 2020-05-13 | The Board of Trustees of the Leland Stanford Junior University | MODIFIED IMMUNOGLOBULIN BAND REGIONS TO REDUCE HEMAGGLUTINATION |
| US11542337B2 (en) | 2016-12-23 | 2023-01-03 | Bristol Myers Squibb Company | Therapeutic immunoglobulin G4 for improved bioanalytical and bioprocessing properties |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| KR20220167342A (ko) * | 2017-05-25 | 2022-12-20 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 중쇄 불변 영역을 포함하는 항체 |
| MX2021002190A (es) | 2018-08-31 | 2021-05-14 | Regeneron Pharma | Estrategia de dosificacion que mitiga el sindrome de liberacion de citoquinas para los anticuerpos biespecificos cd3/cd20. |
| JP2023519602A (ja) * | 2020-03-31 | 2023-05-11 | メディミューン，エルエルシー | 安定化ＩｇＧ４抗体及びその使用 |
| GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| WO2022152308A1 (en) * | 2021-01-18 | 2022-07-21 | Wuxi Biologics (Shanghai) Co., Ltd. | Engineered anti-trop2 antibody and antibody-drug conjugate thereof |
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| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| EP4119579A1 (en) | 2007-05-31 | 2023-01-18 | Genmab A/S | Stable igg4 antibodies |
| AR068563A1 (es) * | 2007-09-26 | 2009-11-18 | Chugai Pharmaceutical Co Ltd | Region constante de anticuerpo mutante |
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| GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
-
2010
- 2010-08-20 GB GBGB1014033.3A patent/GB201014033D0/en not_active Ceased
-
2011
- 2011-08-19 EP EP11763754.6A patent/EP2606063B1/en active Active
- 2011-08-19 US US13/817,961 patent/US10562966B2/en active Active
- 2011-08-19 DK DK11763754.6T patent/DK2606063T3/en active
- 2011-08-19 AU AU2011290581A patent/AU2011290581B2/en active Active
- 2011-08-19 JP JP2013525359A patent/JP5894160B2/ja active Active
- 2011-08-19 CN CN201610285782.7A patent/CN105859876B/zh active Active
- 2011-08-19 BR BR112013003262-6A patent/BR112013003262B1/pt active IP Right Grant
- 2011-08-19 SG SG10201506492PA patent/SG10201506492PA/en unknown
- 2011-08-19 CA CA3080547A patent/CA3080547C/en active Active
- 2011-08-19 WO PCT/GB2011/051563 patent/WO2012022982A2/en active Application Filing
- 2011-08-19 CA CA2807227A patent/CA2807227C/en active Active
- 2011-08-19 KR KR1020137007054A patent/KR101883792B1/ko active IP Right Grant
- 2011-08-19 ES ES11763754.6T patent/ES2632571T3/es active Active
- 2011-08-19 SG SG2013007950A patent/SG187677A1/en unknown
- 2011-08-19 CN CN201180040277.1A patent/CN103097410B/zh active Active
- 2011-08-19 MX MX2013001948A patent/MX344040B/es active IP Right Grant
-
2019
- 2019-12-17 US US16/717,671 patent/US20200157204A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN105859876A (zh) | 2016-08-17 |
| WO2012022982A2 (en) | 2012-02-23 |
| MX344040B (es) | 2016-12-02 |
| US10562966B2 (en) | 2020-02-18 |
| JP5894160B2 (ja) | 2016-03-23 |
| EP2606063A2 (en) | 2013-06-26 |
| GB201014033D0 (en) | 2010-10-06 |
| AU2011290581A1 (en) | 2013-04-04 |
| AU2011290581B2 (en) | 2015-04-16 |
| CA3080547A1 (en) | 2012-02-23 |
| US20200157204A1 (en) | 2020-05-21 |
| CA2807227A1 (en) | 2012-02-23 |
| CN103097410B (zh) | 2016-06-01 |
| DK2606063T3 (en) | 2017-08-14 |
| KR101883792B1 (ko) | 2018-07-31 |
| ES2632571T3 (es) | 2017-09-14 |
| MX2013001948A (es) | 2013-06-28 |
| CA2807227C (en) | 2021-03-23 |
| BR112013003262A2 (pt) | 2016-06-14 |
| CA3080547C (en) | 2023-10-24 |
| SG187677A1 (en) | 2013-03-28 |
| US20130323236A1 (en) | 2013-12-05 |
| EP2606063B1 (en) | 2017-05-17 |
| CN105859876B (zh) | 2021-04-02 |
| CN103097410A (zh) | 2013-05-08 |
| KR20130099950A (ko) | 2013-09-06 |
| BR112013003262B1 (pt) | 2022-07-26 |
| JP2013538052A (ja) | 2013-10-10 |
| WO2012022982A3 (en) | 2012-06-21 |
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