BR112014007484A2 - molécula de ligação a antígeno de indução de resposta imune a antígeno alvo - Google Patents

molécula de ligação a antígeno de indução de resposta imune a antígeno alvo

Info

Publication number
BR112014007484A2
BR112014007484A2 BR112014007484A BR112014007484A BR112014007484A2 BR 112014007484 A2 BR112014007484 A2 BR 112014007484A2 BR 112014007484 A BR112014007484 A BR 112014007484A BR 112014007484 A BR112014007484 A BR 112014007484A BR 112014007484 A2 BR112014007484 A2 BR 112014007484A2
Authority
BR
Brazil
Prior art keywords
antigen
binding
fcrn
binding molecule
binding domain
Prior art date
Application number
BR112014007484A
Other languages
English (en)
Inventor
Maeda Atsuhiko
Haraya Kenta
Tachibana Tatsuhiko
Igawa Tomoyuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112014007484A2 publication Critical patent/BR112014007484A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

abstract the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an fcrn-binding domain having fcrn-binding activity in a neutral ph range, immune responses to the antigen are induced. furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an fcrn-binding domain having fcrn-binding activity in a neutral ph range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds. tradução do resumo resumo patente de invenção: "molécula de ligação a antígeno de indução de resposta imune a antígeno alvo". a presente invenção refere-se à constatação pelos inventores que em organismos vivos que receberam uma molécula de ligação a antígeno contendo um domínio de ligação a antígeno cuja atividade de ligação a um antígeno muda dependendo das condições de concentração de íon e contendo um domínio de ligação de fcrn tendo atividade de ligação de fcrn em uma faixa de ph neutro, respostas imunes ao antígeno são induzidas. ainda, os presentes inventores constataram que em organismos vivos que receberam uma molécula de ligação a antígeno contendo um domínio de ligação a antígeno cuja atividade de ligação a um antígeno muda dependendo das condições de concentração de íon e contendo um domínio de ligação a fcrn tendo atividade de ligação a fcrn em uma faixa de ph neutro, respostas imunes ao antígeno são induzidas, e também a molécula de ligação a antígeno tem citotoxidez ou ação antiproliferativa contra células de câncer, espécies biológicas estranhas ou similar que expressam o antígeno ao qual a molécula de ligação a antígeno se liga.
BR112014007484A 2011-09-30 2012-09-28 molécula de ligação a antígeno de indução de resposta imune a antígeno alvo BR112014007484A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011216958 2011-09-30
PCT/JP2012/075043 WO2013047729A1 (ja) 2011-09-30 2012-09-28 標的抗原に対する免疫応答を誘導する抗原結合分子

Publications (1)

Publication Number Publication Date
BR112014007484A2 true BR112014007484A2 (pt) 2017-04-04

Family

ID=47995754

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007484A BR112014007484A2 (pt) 2011-09-30 2012-09-28 molécula de ligação a antígeno de indução de resposta imune a antígeno alvo

Country Status (14)

Country Link
US (2) US10556949B2 (pt)
EP (1) EP2752200B1 (pt)
JP (3) JP6352634B2 (pt)
KR (3) KR102366029B1 (pt)
CN (4) CN110680920A (pt)
AU (1) AU2012317395B2 (pt)
BR (1) BR112014007484A2 (pt)
CA (1) CA2850322C (pt)
HK (1) HK1198813A1 (pt)
MX (2) MX366968B (pt)
RU (1) RU2722829C9 (pt)
SG (2) SG11201401100UA (pt)
TW (2) TW201945034A (pt)
WO (1) WO2013047729A1 (pt)

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