MX2019006188A - Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. - Google Patents

Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo.

Info

Publication number
MX2019006188A
MX2019006188A MX2019006188A MX2019006188A MX2019006188A MX 2019006188 A MX2019006188 A MX 2019006188A MX 2019006188 A MX2019006188 A MX 2019006188A MX 2019006188 A MX2019006188 A MX 2019006188A MX 2019006188 A MX2019006188 A MX 2019006188A
Authority
MX
Mexico
Prior art keywords
antigen
binding
binding molecule
immune response
fcrn
Prior art date
Application number
MX2019006188A
Other languages
English (en)
Inventor
Maeda Atsuhiko
Haraya Kenta
Tachibana Tatsuhiko
Igawa Tomoyuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2019006188A publication Critical patent/MX2019006188A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Los inventores descubrieron que una inmunorespuesta a un antígeno se indujo en un organismo vivo que tienen una molécula de unión al antígeno administrada al mismo, dicha molécula de unión al antígeno incluye un dominio de unión al antígeno donde la actividad de unión al antígeno con relación al antígeno cambia dependiendo de las condiciones de concentración de ion y un dominio de unión a FcRn que tiene la actividad de unión a FcRn al pH neutro. Los inventores también encontraron que, además de las inmunorespuestas al antígeno inducida, también se descubrió una acción tóxica o una acción inhibidora del crecimiento en organismos extraños, células cancerosas, o similares que expresan el antígeno al cual dicha molécula de unión al antígeno se une en el organismo vivo que tiene la molécula de unión al antígeno administrada al mismo, dicha molécula de unión al antígeno incluye el dominio de unión al antígeno donde la actividad de unión al antígeno con relación al antígeno cambia dependiendo de las condiciones de concentración de ión, y el dominio de unión a FcRn que tiene la actividad de unión a FcRn al pH neutro.
MX2019006188A 2011-09-30 2014-03-28 Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo. MX2019006188A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011216958 2011-09-30

Publications (1)

Publication Number Publication Date
MX2019006188A true MX2019006188A (es) 2019-10-02

Family

ID=47995754

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014003832A MX366968B (es) 2011-09-30 2012-09-28 Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo.
MX2019006188A MX2019006188A (es) 2011-09-30 2014-03-28 Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014003832A MX366968B (es) 2011-09-30 2012-09-28 Molecula de union al antigeno que induce la inmunorespuesta al antigeno objetivo.

Country Status (14)

Country Link
US (2) US10556949B2 (es)
EP (1) EP2752200B1 (es)
JP (3) JP6352634B2 (es)
KR (3) KR102366029B1 (es)
CN (4) CN110680920A (es)
AU (1) AU2012317395B2 (es)
BR (1) BR112014007484A2 (es)
CA (1) CA2850322C (es)
HK (1) HK1198813A1 (es)
MX (2) MX366968B (es)
RU (1) RU2722829C9 (es)
SG (2) SG10201510341XA (es)
TW (2) TW201945034A (es)
WO (1) WO2013047729A1 (es)

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CN112852744A (zh) * 2021-01-27 2021-05-28 河南省华隆生物技术有限公司 一种nk滋养层细胞及其制备方法和应用
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