JP6204350B2 - 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 - Google Patents

抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 Download PDF

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JP6204350B2
JP6204350B2 JP2014514947A JP2014514947A JP6204350B2 JP 6204350 B2 JP6204350 B2 JP 6204350B2 JP 2014514947 A JP2014514947 A JP 2014514947A JP 2014514947 A JP2014514947 A JP 2014514947A JP 6204350 B2 JP6204350 B2 JP 6204350B2
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antigen
binding
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amino acid
antibody
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JP2014528906A (ja
JP2014528906A5 (enExample
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智之 井川
智之 井川
敦彦 前田
敦彦 前田
風太 味元
風太 味元
太一 倉持
太一 倉持
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Chugai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2014514947A 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 Active JP6204350B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014514947A JP6204350B2 (ja) 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP2011218736 2011-09-30
JP2011218736 2011-09-30
JPPCT/JP2012/058603 2012-03-30
PCT/JP2012/058603 WO2012133782A1 (ja) 2011-03-30 2012-03-30 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
JP2012123781 2012-05-30
JP2012123782 2012-05-30
JP2012123773 2012-05-30
JP2012123782 2012-05-30
JP2012123773 2012-05-30
JP2012123781 2012-05-30
JP2012139211 2012-06-20
JP2012139211 2012-06-20
JP2012177311 2012-08-09
JP2012177311 2012-08-09
JP2014514947A JP6204350B2 (ja) 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
PCT/JP2012/006218 WO2013046704A2 (en) 2011-09-30 2012-09-28 THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE

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JP2017166638A Division JP6541730B2 (ja) 2011-09-30 2017-08-31 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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JP2014528906A5 JP2014528906A5 (enExample) 2015-11-12
JP6204350B2 true JP6204350B2 (ja) 2017-09-27

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JP2017166638A Active JP6541730B2 (ja) 2011-09-30 2017-08-31 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2019108321A Active JP7001637B2 (ja) 2011-09-30 2019-06-11 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2021211155A Pending JP2022034037A (ja) 2011-09-30 2021-12-24 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2024072301A Pending JP2024097064A (ja) 2011-09-30 2024-04-26 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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JP2019108321A Active JP7001637B2 (ja) 2011-09-30 2019-06-11 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2021211155A Pending JP2022034037A (ja) 2011-09-30 2021-12-24 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2024072301A Pending JP2024097064A (ja) 2011-09-30 2024-04-26 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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US (3) US10253100B2 (enExample)
EP (3) EP3549956A3 (enExample)
JP (5) JP6204350B2 (enExample)
KR (1) KR20140069332A (enExample)
CN (2) CN108948197A (enExample)
AU (2) AU2012313670B2 (enExample)
BR (1) BR112014007290A2 (enExample)
CA (1) CA2850035A1 (enExample)
HK (1) HK1257946A1 (enExample)
MX (1) MX2014003891A (enExample)
RU (2) RU2018118993A (enExample)
SG (2) SG10201808187TA (enExample)
TW (3) TW201817744A (enExample)
WO (1) WO2013046704A2 (enExample)

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JP2018048120A (ja) * 2011-09-30 2018-03-29 中外製薬株式会社 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
US11780912B2 (en) 2016-08-05 2023-10-10 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of IL-8 related diseases
US12415857B2 (en) 2021-06-25 2025-09-16 Chugai Seiyaku Kabushiki Kaisha Anti-CTLA-4 antibody and use thereof
US12595299B2 (en) 2015-02-05 2026-04-07 Chugai Seiyaku Kabushiki Kaisha FC variants

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