NO20081633L - Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav - Google Patents

Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav

Info

Publication number
NO20081633L
NO20081633L NO20081633A NO20081633A NO20081633L NO 20081633 L NO20081633 L NO 20081633L NO 20081633 A NO20081633 A NO 20081633A NO 20081633 A NO20081633 A NO 20081633A NO 20081633 L NO20081633 L NO 20081633L
Authority
NO
Norway
Prior art keywords
preparation
drug compound
aripiprazole drug
hygroscopic aripiprazole
make hygroscopic
Prior art date
Application number
NO20081633A
Other languages
English (en)
Inventor
Michiaki Tominaga
Takuji Bando
Satoshi Aoki
Makoto Ishigami
Youichi Taniguchi
Tsuyoshi Yabuuchi
Kiyoshi Fujimoto
Yoshihiro Nishioka
Noriyuki Kobayashi
Tsutomo Fujimura
Masanori Takahashi
Kaoru Abe
Tomonori Nakagawa
Koichi Shinhama
Naoto Utsumi
Yoshihiro Oi
Shohei Yamada
Kenji Tomikawa
Junichi Kawasaki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081633(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CA 2379005 external-priority patent/CA2379005A1/en
Publication of NO20081633L publication Critical patent/NO20081633L/no
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)

Abstract

[116185]/[EH] SAMMENDRAG Foreliggende oppfinnelse tilveiebringer lav-hygroskopiske former av Aripiprazol og prosesser for fremstilling derav, som ikke omdannes til et hydrat eller taper deres opprinnelige oppløselighet selv når et medisinsk preparat inneholdende Aripiprazolanhydrid-krystallene blir lagret i en forlenget periode. 1
NO20081633A 2001-09-25 2008-04-02 Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav NO20081633L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001290645 2001-09-25
JP2001348276 2001-11-14
CA 2379005 CA2379005A1 (en) 2001-09-25 2002-03-27 Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
PCT/JP2002/009858 WO2003026659A1 (en) 2001-09-25 2002-09-25 Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
NO20081633L true NO20081633L (no) 2003-01-17

Family

ID=27171631

Family Applications (7)

Application Number Title Priority Date Filing Date
NO20030247A NO328134B1 (no) 2001-09-25 2003-01-17 Vannfrie aripiprazol krystaller B og hydrat A av aripiprazol samt fremgangsmater for fremstilling og anvendelse derav, samt farmsoytisk preparat.
NO20081626A NO336264B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller C, fremgangsmåte for fremstilling derav samt farmasøytisk preparat
NO20081633A NO20081633L (no) 2001-09-25 2008-04-02 Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav
NO20081631A NO336263B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller E, fremgangsmåte for fremstilling derav, samt farmasøytisk preparat
NO20081627A NO336265B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller D, fremgangsmåte for fremstilling derav, samt farmasøytisk preparat
NO20081632A NO336262B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller F, fremgangsmåte for fremstilling derav samt farmasøytisk preparat
NO20091689A NO336679B1 (no) 2001-09-25 2009-04-28 Fremgangsmåte for fremstilling av et fast oralt preparat av granuler, fremgangsmåte for fremstilling av et fast oral preparat, og farmasøytisk fast oralt preparat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO20030247A NO328134B1 (no) 2001-09-25 2003-01-17 Vannfrie aripiprazol krystaller B og hydrat A av aripiprazol samt fremgangsmater for fremstilling og anvendelse derav, samt farmsoytisk preparat.
NO20081626A NO336264B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller C, fremgangsmåte for fremstilling derav samt farmasøytisk preparat

Family Applications After (4)

Application Number Title Priority Date Filing Date
NO20081631A NO336263B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller E, fremgangsmåte for fremstilling derav, samt farmasøytisk preparat
NO20081627A NO336265B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller D, fremgangsmåte for fremstilling derav, samt farmasøytisk preparat
NO20081632A NO336262B1 (no) 2001-09-25 2008-04-02 Vannfrie aripiprazol-krystaller F, fremgangsmåte for fremstilling derav samt farmasøytisk preparat
NO20091689A NO336679B1 (no) 2001-09-25 2009-04-28 Fremgangsmåte for fremstilling av et fast oralt preparat av granuler, fremgangsmåte for fremstilling av et fast oral preparat, og farmasøytisk fast oralt preparat

Country Status (23)

Country Link
US (20) US20040058935A1 (no)
EP (6) EP1927356B1 (no)
JP (3) JP3760264B2 (no)
CN (16) CN106420627A (no)
AR (2) AR033485A1 (no)
AT (5) ATE465736T1 (no)
AU (1) AU2002334413C1 (no)
BR (1) BR0205391A (no)
CA (6) CA2688860A1 (no)
CY (1) CY1118195T1 (no)
DE (5) DE60236229D1 (no)
DK (5) DK1330249T3 (no)
ES (5) ES2343219T3 (no)
HU (1) HUP0600141A3 (no)
IL (3) IL153838A0 (no)
MX (1) MXPA03000440A (no)
NO (7) NO328134B1 (no)
PE (1) PE20090124A1 (no)
PL (1) PL225415B1 (no)
PT (5) PT1927357E (no)
SI (4) SI1927355T1 (no)
UA (1) UA84764C2 (no)
WO (1) WO2003026659A1 (no)

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US10150735B2 (en) 2018-12-11
CN106692151A (zh) 2017-05-24
CN106420640A (zh) 2017-02-22
ES2261750T3 (es) 2006-11-16
US20190225584A1 (en) 2019-07-25
ATE465737T1 (de) 2010-05-15
CN101792415A (zh) 2010-08-04
ATE467416T1 (de) 2010-05-15
US8580796B2 (en) 2013-11-12
JP2003212852A (ja) 2003-07-30
CA2689052C (en) 2011-02-15
SI1419776T1 (sl) 2010-07-30
US20150225347A1 (en) 2015-08-13
US20070203151A1 (en) 2007-08-30
NO336263B1 (no) 2015-07-06
ATE464050T1 (de) 2010-04-15
DK1330249T3 (da) 2006-08-07
US8993761B2 (en) 2015-03-31
US20160251315A1 (en) 2016-09-01
EP1419776A2 (en) 2004-05-19
NO336264B1 (no) 2015-07-06
EP1927356A1 (en) 2008-06-04
CN101579344A (zh) 2009-11-18
AU2002334413C1 (en) 2021-08-12
CN1463191A (zh) 2003-12-24
JP4614870B2 (ja) 2011-01-19
CN1817882A (zh) 2006-08-16
CA2689051A1 (en) 2003-04-03
CN106420627A (zh) 2017-02-22
CN101574348B (zh) 2012-02-22
DE60236231D1 (de) 2010-06-10
SI1330249T1 (sl) 2006-10-31
US8901303B2 (en) 2014-12-02
EP1419776A8 (en) 2004-09-01
EP1927355B1 (en) 2010-04-28
US20070213343A1 (en) 2007-09-13
US20070203152A1 (en) 2007-08-30
NO20081631L (no) 2003-01-17
CA2688934C (en) 2011-05-17
US8703773B2 (en) 2014-04-22
NO20081627L (no) 2003-01-17
NO328134B1 (no) 2009-12-14
DK1927356T3 (da) 2010-07-26
PL225415B1 (pl) 2017-04-28
US7910589B2 (en) 2011-03-22
DK1419776T4 (en) 2017-09-04
CN101579343A (zh) 2009-11-18
ES2343220T3 (es) 2010-07-26
IL153838A (en) 2008-04-13
CN1817882B (zh) 2011-09-07
CN101579343B (zh) 2012-04-18
DK1927357T3 (da) 2010-08-16
PT1330249E (pt) 2006-06-30
CN101434575A (zh) 2009-05-20
CN101423492A (zh) 2009-05-06
NO336679B1 (no) 2015-10-19
JP2006070045A (ja) 2006-03-16
PT1927356E (pt) 2010-05-24
JP3760264B2 (ja) 2006-03-29
CA2689052A1 (en) 2003-04-03
CN101574347A (zh) 2009-11-11
CA2688934A1 (en) 2003-04-03
WO2003026659A1 (en) 2003-04-03
PL360900A1 (en) 2004-09-20
PT1419776E (pt) 2010-04-28
DE60235995D1 (de) 2010-05-27
EP1419776B2 (en) 2017-07-19
US20210395204A1 (en) 2021-12-23
CN101434574A (zh) 2009-05-20
NO20081626L (no) 2003-01-17
PT1927355E (pt) 2010-06-11
ES2343602T3 (es) 2010-08-04
JP3750023B2 (ja) 2006-03-01
CN101574347B (zh) 2012-02-29
AR056503A2 (es) 2007-10-10
US9359302B2 (en) 2016-06-07
AR033485A1 (es) 2003-12-26
CA2688915C (en) 2011-02-01
AU2002334413B2 (en) 2004-11-04
US20120316180A1 (en) 2012-12-13
CA2426921C (en) 2011-03-15
EP1419776A3 (en) 2004-06-16
EP1927357A3 (en) 2008-06-11
US20120000998A1 (en) 2012-01-05
DE60210409D1 (de) 2006-05-18
CN1699346A (zh) 2005-11-23
DE60236383D1 (de) 2010-06-24
EP1927357A2 (en) 2008-06-04

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