PT1330249E - Substancia farmaceutica de aripiprazole fracamente higroscopica e processos para a preparacao da mesma - Google Patents
Substancia farmaceutica de aripiprazole fracamente higroscopica e processos para a preparacao da mesmaInfo
- Publication number
- PT1330249E PT1330249E PT02782507T PT02782507T PT1330249E PT 1330249 E PT1330249 E PT 1330249E PT 02782507 T PT02782507 T PT 02782507T PT 02782507 T PT02782507 T PT 02782507T PT 1330249 E PT1330249 E PT 1330249E
- Authority
- PT
- Portugal
- Prior art keywords
- aripiprazole
- processes
- preparation
- hyproscopic
- failly
- Prior art date
Links
- 229960004372 aripiprazole Drugs 0.000 title abstract 3
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 aripiprazole anhydride Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001290645 | 2001-09-25 | ||
JP2001348276 | 2001-11-14 | ||
CA 2379005 CA2379005A1 (en) | 2001-09-25 | 2002-03-27 | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1330249E true PT1330249E (pt) | 2006-06-30 |
Family
ID=27171631
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT04002427T PT1419776E (pt) | 2001-09-25 | 2002-09-25 | Aripiprazole de baixa higroscopicidade e processos para a sua preparação |
PT08000357T PT1927355E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal f) com baixa higroscopicidade e processos para a sua preparação |
PT08000360T PT1927357E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal e) com baixa higroscopicidade e processos para a sua preparação |
PT08000359T PT1927356E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal d) com baixa higroscopicidade e processos para a sua preparação |
PT02782507T PT1330249E (pt) | 2001-09-25 | 2002-09-25 | Substancia farmaceutica de aripiprazole fracamente higroscopica e processos para a preparacao da mesma |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT04002427T PT1419776E (pt) | 2001-09-25 | 2002-09-25 | Aripiprazole de baixa higroscopicidade e processos para a sua preparação |
PT08000357T PT1927355E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal f) com baixa higroscopicidade e processos para a sua preparação |
PT08000360T PT1927357E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal e) com baixa higroscopicidade e processos para a sua preparação |
PT08000359T PT1927356E (pt) | 2001-09-25 | 2002-09-25 | Substância de fármaco aripiprazole (cristal d) com baixa higroscopicidade e processos para a sua preparação |
Country Status (23)
Country | Link |
---|---|
US (20) | US20040058935A1 (pt) |
EP (6) | EP1927356B1 (pt) |
JP (3) | JP3760264B2 (pt) |
CN (16) | CN106420640A (pt) |
AR (2) | AR033485A1 (pt) |
AT (5) | ATE464050T1 (pt) |
AU (1) | AU2002334413C1 (pt) |
BR (1) | BR0205391A (pt) |
CA (6) | CA2688915C (pt) |
CY (1) | CY1118195T1 (pt) |
DE (5) | DE60236229D1 (pt) |
DK (5) | DK1330249T3 (pt) |
ES (5) | ES2261750T3 (pt) |
HU (1) | HUP0600141A3 (pt) |
IL (3) | IL153838A0 (pt) |
MX (1) | MXPA03000440A (pt) |
NO (7) | NO328134B1 (pt) |
PE (1) | PE20090124A1 (pt) |
PL (1) | PL225415B1 (pt) |
PT (5) | PT1419776E (pt) |
SI (4) | SI1927356T1 (pt) |
UA (1) | UA84764C2 (pt) |
WO (1) | WO2003026659A1 (pt) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR032641A1 (es) * | 2001-01-29 | 2003-11-19 | Otsuka Pharma Co Ltd | Agonista de subtipo de receptor 5-ht 1a. |
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
RU2342931C2 (ru) * | 2002-08-20 | 2009-01-10 | Бристол-Маерс Сквибб Компани | Состав на основе комплекса арипипразола |
US20040185110A1 (en) * | 2002-11-08 | 2004-09-23 | Ronald Harland | Formulations of low solubility bioactive agents and processes for making the same |
PT1575590E (pt) | 2002-12-27 | 2007-12-06 | Otsuka Pharma Co Ltd | Derivados de carboestirilo e inibidores da reabsorção de serotonina para o tratamento de distúrbios de humor |
AR042806A1 (es) | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
EP1480953B2 (en) † | 2003-01-09 | 2010-08-18 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing aripiprazole |
EP1618103A2 (en) * | 2003-04-25 | 2006-01-25 | Cadila Healthcare Ltd. | Polymorphs of aripiprazole |
PL1626721T3 (pl) | 2003-05-23 | 2017-05-31 | Otsuka Pharmaceutical Co., Ltd. | Pochodne karbostyrylu i stabilizatory nastroju do leczenia zaburzeń nastroju |
WO2005009990A1 (en) * | 2003-07-25 | 2005-02-03 | Hetero Drugs Limited | Aripiprazole crystalline forms |
UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
ATE411797T2 (de) | 2003-10-23 | 2008-11-15 | Otsuka Pharma Co Ltd | Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren |
TWI371274B (en) * | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
PT1613598E (pt) | 2003-12-16 | 2012-01-13 | Teva Pharma | Métodos para preparar formas cristalinas de aripiprazol |
US7714129B2 (en) | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
US7361756B2 (en) | 2004-02-05 | 2008-04-22 | Teva Pharmaceutical Industries Ltd. | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril |
WO2005077904A1 (en) * | 2004-02-05 | 2005-08-25 | Teva Pharmaceutical Industries, Ltd. | Process for preparing aripiprazole |
US7507823B2 (en) * | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
EP1797039A1 (en) * | 2004-09-13 | 2007-06-20 | Matrix Laboratories Ltd | Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts |
US7872132B2 (en) | 2004-10-08 | 2011-01-18 | Suven Life Sciences Limited | Intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole |
CN100338038C (zh) * | 2004-10-14 | 2007-09-19 | 重庆医药工业研究院有限责任公司 | 阿立派唑的新晶型及其制备方法 |
EP1812397A1 (en) | 2004-11-18 | 2007-08-01 | Synthon B.V. | Process of making crystalline aripiprazole |
CN101087760B (zh) * | 2004-11-18 | 2011-09-28 | 斯索恩有限公司 | 结晶的阿立哌唑溶剂化物 |
PL1844036T3 (pl) | 2005-01-27 | 2016-02-29 | Sandoz Ag | Sposób otrzymywania arypiprazolu |
EP1686117A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Polymorph and solvates of aripiprazole |
AU2006224759A1 (en) † | 2005-03-17 | 2006-09-21 | Synthon B.V. | Process of making crystalline Type II aripiprazole |
ES2526415T3 (es) | 2005-03-17 | 2015-01-12 | Synthon B.V. | Comprimidos farmacéuticos de aripiprazol cristalino de tipo II |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
CA2605128A1 (en) * | 2005-04-15 | 2007-01-11 | Medichem, S.A. | Syntheses and preparations of polymorphs of crystalline aripiprazole |
CN100432053C (zh) * | 2005-06-07 | 2008-11-12 | 上海医药工业研究院 | 阿立哌唑晶型及其制备方法 |
HUP0500683A3 (en) * | 2005-07-14 | 2009-03-30 | Egis Gyogyszergyar Nyilvanosan | New arylpiprazole salts for producing pharmaceutical composition |
US20070014853A1 (en) * | 2005-07-15 | 2007-01-18 | Ilan Zalit | Pharmaceutical dosage form containing novel pharmaceutical granulate |
EP1793801A1 (en) * | 2005-07-15 | 2007-06-13 | Teva Pharmaceutical Industries Ltd. | Novel granulation process and granulate produced therefrom |
US20070014864A1 (en) * | 2005-07-15 | 2007-01-18 | Teva Pharmaceutical Industries, Ltd. | Novel pharmaceutical granulate |
US20070014854A1 (en) * | 2005-07-15 | 2007-01-18 | Ilan Zalit | Novel granulation process |
JP2009508859A (ja) * | 2005-09-15 | 2009-03-05 | エラン ファーマ インターナショナル リミテッド | ナノ粒子アリピプラゾール製剤 |
MX2007006368A (es) | 2005-09-29 | 2007-07-11 | Teva Pharma | Metodos de preparacion de aripiprazol anhidro forma ii. |
CZ299485B6 (cs) * | 2005-10-11 | 2008-08-13 | Zentiva, A. S. | Zpusob výroby aripiprazolu |
EP1919453A2 (en) * | 2005-12-22 | 2008-05-14 | Teva Pharmaceutical Industries Ltd | Processes for reducing particle size of aripiprazole |
US8865722B2 (en) | 2006-01-05 | 2014-10-21 | Teva Pharmaceutical Industries Ltd. | Wet formulations of aripiprazole |
CA2627695A1 (en) * | 2006-01-05 | 2007-07-19 | Teva Pharmaceutical Industries Ltd. | Dry formulations of aripiprazole |
TWI394753B (zh) * | 2006-03-17 | 2013-05-01 | Otsuka Pharma Co Ltd | 新穎替妥牟拉(tetomilast)晶體 |
US20060223820A1 (en) * | 2006-03-21 | 2006-10-05 | Chemagis Ltd. | Crystalline aripiprazole salts and processes for preparation and purification thereof |
US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
EP1880714A1 (en) | 2006-07-20 | 2008-01-23 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
TR200604349A2 (tr) | 2006-08-15 | 2008-03-21 | NOBEL İLAÇ SANAYii VE TiCARET A.Ş. | Aripiprazol içeren farmasötik bileşimler |
GB0618879D0 (en) | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
WO2008059518A2 (en) * | 2006-09-28 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing crystalline aripiprazole |
US8039621B2 (en) | 2006-10-24 | 2011-10-18 | Cambrex Charles City, Inc. | Process for preparing anhydrous Aripirazole type I |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
US10632079B2 (en) * | 2007-06-25 | 2020-04-28 | Otsuka Pharmaceuticals Co., Ltd. | Microspheres having core/shell structure |
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2004
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2006
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2007
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2008
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2009
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2011
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2012
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2013
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2015
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2016
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2018
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2019
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2021
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