JPS5646812A - Central nervous system depressant - Google Patents
Central nervous system depressantInfo
- Publication number
- JPS5646812A JPS5646812A JP12487879A JP12487879A JPS5646812A JP S5646812 A JPS5646812 A JP S5646812A JP 12487879 A JP12487879 A JP 12487879A JP 12487879 A JP12487879 A JP 12487879A JP S5646812 A JPS5646812 A JP S5646812A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- nervous system
- central nervous
- depressant
- carbostyrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: A central nervous system depressant that contains a specific carbostyrile derivative as an effective component, thus showing high effectiveness and low toxicity and being suitably applied to various kinds of symptoms.
CONSTITUTION: Said depressant contains, as an effective component, a carbostyrile derivative of formula I [R is H, group of formula II (R3 is H, hydroxyl, lower alkyl, lower alkanoyloxy; R4 is H, lower alkyl; R5 is cycloalkyl, lower alkanoyl; 1, m are 0,1W6; r is 2,3); X is halogen; n is 0,1,2; R1 is H, lower alkyl; R2 is H, lower alkyl] or its acid adduct such as 6-[2-hydroxy-3-(4-phenylpiperazinyl)propoxy]-3, 4-dihydrocarbostyrile. It has high effects of tranquilizing, antianxiety, central muscle relax, anesthia, hypnosis, antiemetic, etc. and shows low side-effects. It is administered orally or parenterally.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12487879A JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12487879A JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5646812A true JPS5646812A (en) | 1981-04-28 |
JPH0212204B2 JPH0212204B2 (en) | 1990-03-19 |
Family
ID=14896321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12487879A Granted JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5646812A (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02191256A (en) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative and remedy for schizophrenia containing the same |
JPH04352723A (en) * | 1991-05-31 | 1992-12-07 | Otsuka Pharmaceut Co Ltd | Akathisia therapeutic agent |
JPH05279256A (en) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | Platelet aggregation suppressor |
WO1995011239A1 (en) * | 1993-10-22 | 1995-04-27 | Santen Pharmaceutical Co., Ltd. | Novel phenoxyalkylpiperazine derivative |
JPH07165720A (en) * | 1988-10-31 | 1995-06-27 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative |
JPH07304741A (en) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative |
JPH07304740A (en) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPH1045717A (en) * | 1988-10-31 | 1998-02-17 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JP2007297405A (en) * | 2001-01-29 | 2007-11-15 | Otsuka Pharmaceut Co Ltd | 5-ht1a receptor subtype agonist |
JP2011520815A (en) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | NMDA receptor antagonist for the treatment of neuropsychiatric disorders |
US8017615B2 (en) | 2001-09-25 | 2011-09-13 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
USRE48059E1 (en) | 2005-04-14 | 2020-06-23 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
-
1979
- 1979-09-27 JP JP12487879A patent/JPS5646812A/en active Granted
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02191256A (en) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative and remedy for schizophrenia containing the same |
JPH07165720A (en) * | 1988-10-31 | 1995-06-27 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative |
JPH1045717A (en) * | 1988-10-31 | 1998-02-17 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPH05279256A (en) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | Platelet aggregation suppressor |
JPH04352723A (en) * | 1991-05-31 | 1992-12-07 | Otsuka Pharmaceut Co Ltd | Akathisia therapeutic agent |
WO1995011239A1 (en) * | 1993-10-22 | 1995-04-27 | Santen Pharmaceutical Co., Ltd. | Novel phenoxyalkylpiperazine derivative |
JPH07304741A (en) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative and therapeutic agent for schizophrenia containing the same derivative |
JPH07304740A (en) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JP2987484B2 (en) * | 1995-03-16 | 1999-12-06 | 大塚製薬 株式会社 | Method for producing carbostyril derivative |
US8604041B2 (en) | 2001-01-29 | 2013-12-10 | Otsuka Pharmaceutical Co., Ltd. | Method of treating panic disorder |
US8680105B2 (en) | 2001-01-29 | 2014-03-25 | Otsuka Pharmaceutical Co., Ltd. | Method of treating down's syndrome |
US9387207B2 (en) | 2001-01-29 | 2016-07-12 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US9089567B2 (en) | 2001-01-29 | 2015-07-28 | Otsuka Pharmaceutical Co., Ltd. | Method of treating cognitive impairments and schizophrenias |
US8426423B2 (en) | 2001-01-29 | 2013-04-23 | Otsuka Pharmaceutical Co., Ltd. | Method of treating Attention Deficit Hyper-Activity Disorder |
US9006248B2 (en) | 2001-01-29 | 2015-04-14 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
JP2007297405A (en) * | 2001-01-29 | 2007-11-15 | Otsuka Pharmaceut Co Ltd | 5-ht1a receptor subtype agonist |
US8623874B2 (en) | 2001-01-29 | 2014-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
US8642600B2 (en) | 2001-01-29 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Method of treating autism |
US8722680B2 (en) | 2001-01-29 | 2014-05-13 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
US8580796B2 (en) | 2001-09-25 | 2013-11-12 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8703773B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8642760B2 (en) | 2001-09-25 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8901303B2 (en) | 2001-09-25 | 2014-12-02 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8901130B2 (en) | 2001-09-25 | 2014-12-02 | Ostuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation |
US8993761B2 (en) | 2001-09-25 | 2015-03-31 | Otsuka Pharamceutical Co. Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8399469B2 (en) | 2001-09-25 | 2013-03-19 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US9359302B2 (en) | 2001-09-25 | 2016-06-07 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8017615B2 (en) | 2001-09-25 | 2011-09-13 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US10150735B2 (en) | 2001-09-25 | 2018-12-11 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
USRE48059E1 (en) | 2005-04-14 | 2020-06-23 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
JP2011520815A (en) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | NMDA receptor antagonist for the treatment of neuropsychiatric disorders |
Also Published As
Publication number | Publication date |
---|---|
JPH0212204B2 (en) | 1990-03-19 |
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