HRP20240285T1 - Farmaceutski pripravci koji sadrže sorbitan estere - Google Patents
Farmaceutski pripravci koji sadrže sorbitan estere Download PDFInfo
- Publication number
- HRP20240285T1 HRP20240285T1 HRP20240285TT HRP20240285T HRP20240285T1 HR P20240285 T1 HRP20240285 T1 HR P20240285T1 HR P20240285T T HRP20240285T T HR P20240285TT HR P20240285 T HRP20240285 T HR P20240285T HR P20240285 T1 HRP20240285 T1 HR P20240285T1
- Authority
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- Croatia
- Prior art keywords
- weight
- preparation
- percent
- polysorbate
- disorder
- Prior art date
Links
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 5
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 5
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 5
- 229940068977 polysorbate 20 Drugs 0.000 claims 5
- 229950006451 sorbitan laurate Drugs 0.000 claims 5
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 206010022998 Irritability Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000020186 Schizophreniform disease Diseases 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 239000008135 aqueous vehicle Substances 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (11)
1. Farmaceutski pripravak koji sadrži:
(a) spoj A-7
[image]
ili njegovu farmaceutski prihvatljivu sol, hidrat ili solvat;
(b) sorbitan laurat;
(c) polisorbat 20; i
(d) vodeni vehikul;
pri čemu je odnos komponente (b) prema (c) u opsegu od 3 prema 1 – 2 prema 1, težinski; i
pri čemu pripravak formira vodenu, flokuliranu, suspenziju za injekciju.
2. Pripravak prema zahtjevu 1, koji sadrži ili oko 0.2 - 1 težinskih postotaka sorbitan laurata; oko 0.4 – 0.7 težinskih postotaka sorbitan laurata; ili oko 0.5 težinska postotka sorbitan laurata.
3. Pripravak prema zahtjevu 1, koja sadrži ili oko 0.05 – 0.8 težinskih postotaka polisorbata 20; oko 0.1 – 0.3 težinskih postotaka polisorbata 20, ili oko 0.2 težinska postotka polisorbata 20.
4. Pripravak prema bilo kom od prethodnih zahtjeva, koja sadrži približno 15 - 35 težinskih postotaka spoja A-7, ili njegove farmaceutski prihvatljive soli, hidrata ili solvata, ili približno 20 - 30 težinskih postotaka spoja A-7, ili njegove farmaceutski prihvatljive soli, hidrata ili solvata.
5. Farmaceutski pripravak za injekciju koji sadrži:
(a) spoj A-7, ili njegove farmaceutski prihvatljive soli, hidrate ili solvate,
[image]
pri čemu je komponenta (a) u težinskom odnosu od približno 15 - 35%;
(b) sorbitan laurat u težinskom odnosu od 0.2 - 1%;
(c) polisorbat 20 u težinskom odnosu od 0.05 – 0.8%; i
(d) vodeni nosač;
gdje je odnos komponente (b) prema (c) u opsegu od 3 prema 1 – 2 prema 1, težinski.
6. Pripravak prema zahtjevu 5, gdje je pripravak formulirana za modulaciju reakcije tkiva povezane sa isporukom antipsihotičkog sredstva nerastopljivog u vodi, pri čemu modulacija reakcije tkiva predstavlja smanjenje iritacije na mjestu injekcije.
7. Pripravak prema bilo kojem od zahtjeva 1 do 6, pri čemu vodeni vehikul ili nosač sadrži pufer, gdje je pufer fosfat, citrat, tartarat, acetat ili fosfatno-puferirana fiziološka otopina.
8. Pripravak prema bilo kojem od zahtjeva 1 do 7, za uporabu u liječenju poremećaja centralnog nervnog sustava.
9. Pripravak za uporabu prema zahtjevu 8, pri čemu je poremećaj anksioznost ili depresija; ili gdje je poremećaj bipolarni poremećaj; ili gdje je poremećaj razdražljivost povezana sa autizmom.
10. Pripravak za uporabu prema zahtjevu 8, pri čemu je poremećaj psihotično stanje.
11. Pripravak za uporabu prema zahtjevu 10, pri čemu je psihotično stanje shizofrenija ili shizofreniformne bolesti; ili gdje je psihotično stanje akutna manija.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161454008P | 2011-03-18 | 2011-03-18 | |
| EP16185202.5A EP3156056B1 (en) | 2011-03-18 | 2012-03-19 | Pharmaceutical compositions comprising sorbitan esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240285T1 true HRP20240285T1 (hr) | 2024-05-24 |
Family
ID=45929620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240285TT HRP20240285T1 (hr) | 2011-03-18 | 2012-03-19 | Farmaceutski pripravci koji sadrže sorbitan estere |
| HRP20161549TT HRP20161549T1 (hr) | 2011-03-18 | 2016-11-22 | Injektabilni farmaceutski pripravci koji sadrže antipsihotik koji je netopljiv u vodi, sorbitan laurat i polisorbat 20 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161549TT HRP20161549T1 (hr) | 2011-03-18 | 2016-11-22 | Injektabilni farmaceutski pripravci koji sadrže antipsihotik koji je netopljiv u vodi, sorbitan laurat i polisorbat 20 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US9034867B2 (hr) |
| EP (3) | EP4327872A3 (hr) |
| JP (3) | JP6138703B2 (hr) |
| CN (3) | CN112451477B (hr) |
| AU (4) | AU2012231160B2 (hr) |
| BR (1) | BR112013023847B1 (hr) |
| CA (1) | CA2830511C (hr) |
| CY (1) | CY1118252T1 (hr) |
| DK (2) | DK3156056T3 (hr) |
| ES (2) | ES2972387T3 (hr) |
| FI (1) | FI3156056T3 (hr) |
| HR (2) | HRP20240285T1 (hr) |
| HU (2) | HUE065359T2 (hr) |
| IL (4) | IL296695B1 (hr) |
| LT (2) | LT3156056T (hr) |
| MX (1) | MX358344B (hr) |
| PL (2) | PL3156056T3 (hr) |
| PT (2) | PT3156056T (hr) |
| RS (2) | RS65237B1 (hr) |
| RU (2) | RU2627469C2 (hr) |
| SI (2) | SI3156056T1 (hr) |
| SM (1) | SMT201600423B (hr) |
| WO (1) | WO2012129156A1 (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010266018B2 (en) | 2009-06-25 | 2014-01-09 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| EP4327872A3 (en) | 2011-03-18 | 2024-07-10 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
| JO3227B1 (ar) | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
| ES2764383T3 (es) | 2012-03-19 | 2020-06-03 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que comprenden ésteres de glicerol |
| NZ630428A (en) | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| AR090775A1 (es) | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| US10052319B2 (en) * | 2012-04-26 | 2018-08-21 | Sumitomo Dainippon Pharma Co., Ltd. | Medicament for treating mental and behavioural disorders |
| CA2885196C (en) * | 2012-09-19 | 2021-06-22 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| WO2014143201A1 (en) | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| WO2015143145A1 (en) | 2014-03-20 | 2015-09-24 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| RS58746B2 (sr) * | 2014-08-18 | 2022-07-29 | Alkermes Pharma Ireland Ltd | Kompozicije proleka aripiprazola |
| US10016415B2 (en) | 2014-08-18 | 2018-07-10 | Alkermes Pharma Ireland Limited | Aripiprazole prodrug compositions |
| EP3865476B1 (en) | 2014-08-25 | 2024-08-14 | Alkermes Pharma Ireland Limited | Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia |
| PT3223906T (pt) | 2014-11-26 | 2021-05-05 | Demerx Inc | Métodos e composições para potencializar a ação de analgésicos de opioides usando alcaloides de iboga |
| WO2016200830A1 (en) * | 2015-06-08 | 2016-12-15 | Corium International, Inc. | Formulations for aripiprazole delivery transdermally |
| WO2017119928A1 (en) | 2016-01-08 | 2017-07-13 | Abon Pharmaceuticals, Llc | Long acting injectable formulations |
| EP3416616B1 (en) * | 2016-02-17 | 2021-08-04 | Alkermes Pharma Ireland Limited | Compositions of multiple aripiprazole prodrugs |
| EP3448387A4 (en) * | 2016-04-25 | 2019-12-11 | Otsuka Pharmaceutical Co., Ltd. | PHARMACEUTICAL PRODUCT COMPOSITIONS COMPRISING AN INGREDIENT EVENT MARKER |
| WO2019020821A1 (en) * | 2017-07-28 | 2019-01-31 | Interquim, S.A. | PROCESS FOR THE PREPARATION OF LAUROXIL ARIPIPRAZOLE |
| CN110025572A (zh) * | 2018-01-11 | 2019-07-19 | 四川科伦药物研究院有限公司 | 月桂酰阿立哌唑混悬剂及其制备方法 |
| US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN109984999B (zh) * | 2019-04-28 | 2021-12-24 | 重庆仁泽医药科技有限公司 | 一种药物组合物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2418499A (en) | 1944-06-20 | 1947-04-08 | Du Pont | 2-alkoxymethylmercapto-thiazoles and thiazolines and a process for preparing the same |
| GB849541A (en) | 1956-02-23 | 1960-09-28 | Rohm & Haas | Preparation of unsaturated cyclic urea derivatives |
| DE1273533B (de) | 1962-09-08 | 1968-07-25 | Hoechst Ag | Verfahren zur Herstellung von N-(ª‡-Alkoxy-alkyl)-carbonsaeureamiden |
| NL128370C (hr) | 1964-08-28 | |||
| US3452034A (en) | 1967-03-09 | 1969-06-24 | American Cyanamid Co | Substituted 2-(1,3,4-thiadiazol-2-yl)-4(5)-nitroimidazoles |
| US3573308A (en) | 1969-04-03 | 1971-03-30 | Hoffmann La Roche | 3-lower alkoxy methyl-3,4-dihydro-4-hydroxy-4-aryl quinazolin-2(1h) ones and related compounds |
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