HRP20161549T1 - Injektabilni farmaceutski pripravci koji sadrže antipsihotik koji je netopljiv u vodi, sorbitan laurat i polisorbat 20 - Google Patents
Injektabilni farmaceutski pripravci koji sadrže antipsihotik koji je netopljiv u vodi, sorbitan laurat i polisorbat 20 Download PDFInfo
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- HRP20161549T1 HRP20161549T1 HRP20161549TT HRP20161549T HRP20161549T1 HR P20161549 T1 HRP20161549 T1 HR P20161549T1 HR P20161549T T HRP20161549T T HR P20161549TT HR P20161549 T HRP20161549 T HR P20161549T HR P20161549 T1 HRP20161549 T1 HR P20161549T1
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- Prior art keywords
- preparation
- weight
- polysorbate
- composition according
- approximately
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- 229920001213 Polysorbate 20 Polymers 0.000 title claims 7
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 title claims 7
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 title claims 7
- 229940068977 polysorbate 20 Drugs 0.000 title claims 7
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 title claims 6
- 229950006451 sorbitan laurate Drugs 0.000 title claims 6
- 235000011067 sorbitan monolaureate Nutrition 0.000 title claims 6
- 230000000561 anti-psychotic effect Effects 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000013049 sediment Substances 0.000 claims 3
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000020186 Schizophreniform disease Diseases 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 229940102213 injectable suspension Drugs 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (23)
1. Farmaceutski pripravak koji sadrži:
(a) spoj A-7
[image]
(b) sorbitan laurat;
(c) polisorbat 20; i
(d) vodeni nosač;
pri čemu pripravak formira vodenu, flokuliranu, injektabilnu suspenziju.
2. Pripravak prema zahtjevu 1, pri čemu pripravak sadrži komponente (b) i (c) u odnosu koji rezultira flokulama koje sadrže komponentu (a), pri čemu se flokule talože do visine koja je veća od unaprijed određene visine sedimenta, tako da se komponente (a), (b) i (c) mogu resuspendirati radi injektiranja.
3. Pripravak prema zahtjevu 2, pri čemu visina sedimenta ima najmanje povećanje visine sedimenta od 20 do 80% u usporedbi sa neflokuliranom kompozicijom poslije 24 sata neometanog mirovanja.
4. Pripravak prema zahtjevu 2, pri čemu se komponente (a), (b) i (c) mogu resuspendirati radi injektiranja protresanjem rukom između 1-60 sekundi.
5. Pripravak prema bilo kojem od prethodnih zahtjeva, pri čemu je odnos komponenata (b) do (c) takav da se pripravak može injektirati uz korištenje igle veličine od 20 do 25 G.
6. Pripravak prema zahtjevu 2, pri čemu (a), (b), i (c) formiraju flokule koje imaju slijedeće veličine: Dv[10]: 2-10 μm, Dv[50]: 10-30 μm, i Dv[90]: manje od 65 μmM.
7. Pripravak prema bilo kojem od prethodnih zahtjeva, pri čemu je odnos komponenata (b) prema (c) približno od 5 do 2, težinski.
8. Pripravak prema bilo kojem od prethodnih zahtjeva, koji sadrži oko 0.2 - 1 težinskih postotaka sorbitan laurata.
9. Pripravak prema zahtjevu 1, koji sadrži oko 0,05 - 0,8 težinskih postotaka polisorbata 20.
10. Pripravak prema zahtjevu 1, koji sadrži oko 0,1 - 0,3 težinskih postotaka polisorbata 20.
11. Pripravak prema bilo kojem od prethodnih zahtjeva, koji sadrži približno 15 - 35 težinskih postotaka spoja A-7.
12. Pripravak prema bilo kom od prethodnih zahtjeva, koji sadrži približno 20 - 30 težinskih postotaka spoja A-7.
13. Injektabilni farmaceutski pripravak koji sadrži:
(a) spoj A-7:
[image]
pri čemu je komponenta (a) u težinskom odnosu približno od 15 - 35%;
(b) sorbitan laurat u težinskom odnosu približno od 0,2 - 1%
(c) polisorbat 20 u težinskom odnosu približno od 0,05 - 0,8%; i
(d) vodeni nosač.
14. Injektabilni pripravak koja sadrži:
(a) spoj A-7:
[image]
(b) sorbitan laurat;
(c) polisorbat 20; i
(d) vodeni nosač.
15. Pripravak prema zahtjevu 14, pri čemu je pripravak formuliran za modulaciju reakcije tkiva povezane sa davanjem antipsihotika netopljivog u vodi.
16. Pripravak prema zahtjevu 15, pri čemu je modulacija reakcije tkiva smanjenje iritacije na mestu injekcije.
17. Pripravak prema bilo kjeom od zahtjeva 1 do 16 za primjenu u metodi liječenja poremećaja središnjeg živčanog sustava.
18. Pripravak za primjenu prema zahtjevu 17, pri čemu je poremećaj psihotično stanje.
19. Pripravak za primjenu prema zahtjevu 18, pri čemu je psihotično stanje shiizofrenija ili shiizofreniformne bolesti.
20. Farmaceutski pripravak koja sadrži:
(a) 24 - 30 težinskih postotaka spoja A-7:
[image]
(b) 0,2 - 1 težinskih postotaka sorbitan laurata;
(c) 0,1 - 0,3 težinskih postotaka polisorbata 20; i
(d) vodeni nosač.
21. Pripravak prema bilo kojem od zahtjeva 1, 13, 14 ili 20, pri čemu je vodeni nosač pufer.
22. Pripravak prema zahtjevu 21, pri čemu je pufer fosfatni, citratni, tartratni ili acetatni pufer.
23. Pripravak prema zahtjevu 21 ili 22, pri čemu je vodeni nosač fosfatna puferirana slana otopina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161454008P | 2011-03-18 | 2011-03-18 | |
| PCT/US2012/029625 WO2012129156A1 (en) | 2011-03-18 | 2012-03-19 | Pharmaceutical compositions comprising sorbitan esters |
| EP12712189.5A EP2685979B1 (en) | 2011-03-18 | 2012-03-19 | Injectable pharmaceutical compositions comprising a water-insoluble anti-psychotic, sorbitan laurate and polysorbate 20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161549T1 true HRP20161549T1 (hr) | 2016-12-30 |
Family
ID=45929620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240285TT HRP20240285T1 (hr) | 2011-03-18 | 2012-03-19 | Farmaceutski pripravci koji sadrže sorbitan estere |
| HRP20161549TT HRP20161549T1 (hr) | 2011-03-18 | 2016-11-22 | Injektabilni farmaceutski pripravci koji sadrže antipsihotik koji je netopljiv u vodi, sorbitan laurat i polisorbat 20 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240285TT HRP20240285T1 (hr) | 2011-03-18 | 2012-03-19 | Farmaceutski pripravci koji sadrže sorbitan estere |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US9034867B2 (hr) |
| EP (3) | EP2685979B1 (hr) |
| JP (3) | JP6138703B2 (hr) |
| CN (3) | CN107252414B (hr) |
| AU (4) | AU2012231160B2 (hr) |
| BR (1) | BR112013023847B1 (hr) |
| CA (1) | CA2830511C (hr) |
| CY (1) | CY1118252T1 (hr) |
| DK (2) | DK2685979T3 (hr) |
| ES (2) | ES2972387T3 (hr) |
| FI (1) | FI3156056T3 (hr) |
| HR (2) | HRP20240285T1 (hr) |
| HU (2) | HUE032109T2 (hr) |
| IL (4) | IL296695B1 (hr) |
| LT (2) | LT2685979T (hr) |
| MX (1) | MX358344B (hr) |
| PL (2) | PL2685979T3 (hr) |
| PT (2) | PT2685979T (hr) |
| RS (2) | RS65237B1 (hr) |
| RU (2) | RU2627469C2 (hr) |
| SI (2) | SI2685979T1 (hr) |
| SM (1) | SMT201600423B (hr) |
| WO (1) | WO2012129156A1 (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2445502T (pt) | 2009-06-25 | 2017-09-22 | Alkermes Pharma Ireland Ltd | Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos |
| RU2627469C2 (ru) | 2011-03-18 | 2017-08-08 | Алкермес Фарма Айэленд Лимитед | Фармацевтические композиции, содержащие водонерастворимое антипсихотическое средство и сложные эфиры сорбита |
| JO3227B1 (ar) | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| AU2013235523B9 (en) | 2012-03-19 | 2018-01-04 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising glycerol esters |
| US10004807B2 (en) | 2012-03-19 | 2018-06-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| NZ630428A (en) | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| AR090775A1 (es) | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| US10052319B2 (en) | 2012-04-26 | 2018-08-21 | Sumitomo Dainippon Pharma Co., Ltd. | Medicament for treating mental and behavioural disorders |
| NZ748572A (en) | 2012-09-19 | 2020-07-31 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
| WO2014143201A1 (en) | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| AU2015231278B2 (en) * | 2014-03-20 | 2020-01-23 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| US10016415B2 (en) | 2014-08-18 | 2018-07-10 | Alkermes Pharma Ireland Limited | Aripiprazole prodrug compositions |
| SI3508196T1 (sl) | 2014-08-18 | 2021-12-31 | Alkermes Pharma Ireland Limited, | Sestavki aripiprazolnega predzdravila |
| EP3185867B1 (en) * | 2014-08-25 | 2021-01-13 | Alkermes Pharma Ireland Limited | Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia |
| EP3223906B1 (en) | 2014-11-26 | 2021-01-06 | DemeRx, Inc. | Methods and compositions for potentiating the action of opioid analgesics using iboga alkaloids |
| WO2016200830A1 (en) * | 2015-06-08 | 2016-12-15 | Corium International, Inc. | Formulations for aripiprazole delivery transdermally |
| WO2017119928A1 (en) | 2016-01-08 | 2017-07-13 | Abon Pharmaceuticals, Llc | Long acting injectable formulations |
| US10159671B2 (en) * | 2016-02-17 | 2018-12-25 | Alkermes Pharma Ireland Limited | Compositions of multiple aripiprazole prodrugs |
| WO2017188260A1 (en) * | 2016-04-25 | 2017-11-02 | Otsuka Pharmaceutical Co., Ltd. | Compositions of pharmaceutical product with ingestible event marker |
| CN111315722B (zh) * | 2017-07-28 | 2023-06-16 | 因特奎姆私人控股公司 | 制备月桂酰阿立哌唑的方法 |
| CN110025572A (zh) * | 2018-01-11 | 2019-07-19 | 四川科伦药物研究院有限公司 | 月桂酰阿立哌唑混悬剂及其制备方法 |
| AU2019230014A1 (en) | 2018-03-05 | 2020-09-17 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN109984999B (zh) * | 2019-04-28 | 2021-12-24 | 重庆仁泽医药科技有限公司 | 一种药物组合物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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- 2016-11-23 CY CY20161101213T patent/CY1118252T1/el unknown
- 2016-12-22 US US15/388,554 patent/US10226458B2/en active Active
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2017
- 2017-04-26 JP JP2017087067A patent/JP2017141292A/ja active Pending
- 2017-06-28 IL IL253221A patent/IL253221B/en active IP Right Grant
- 2017-06-30 AU AU2017204486A patent/AU2017204486B2/en active Active
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2019
- 2019-01-15 US US16/248,259 patent/US20190216805A1/en not_active Abandoned
- 2019-02-15 JP JP2019025516A patent/JP6765464B2/ja active Active
- 2019-04-16 AU AU2019202633A patent/AU2019202633A1/en not_active Abandoned
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2020
- 2020-07-13 IL IL276012A patent/IL276012B2/en unknown
- 2020-10-09 AU AU2020250309A patent/AU2020250309B2/en active Active
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2023
- 2023-03-14 US US18/183,257 patent/US20240058327A1/en active Pending
- 2023-10-31 US US18/498,553 patent/US20240131024A1/en active Pending
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