CL2010001528A1 - Compuestos derivados del acido 7-fenoxicroman-4-carboxilico sustituido; proceso de preparacion; compuesto intermediario; composicion farmaceutica de dicho compuesto; y su uso como antagonista de los receptores de prostaglandina d2 (pgd2) para tratar trastornos inmunologicos, enfermedades alergicas, trastornos inflamatorios. - Google Patents

Compuestos derivados del acido 7-fenoxicroman-4-carboxilico sustituido; proceso de preparacion; compuesto intermediario; composicion farmaceutica de dicho compuesto; y su uso como antagonista de los receptores de prostaglandina d2 (pgd2) para tratar trastornos inmunologicos, enfermedades alergicas, trastornos inflamatorios.

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Publication number
CL2010001528A1
CL2010001528A1 CL2010001528A CL2010001528A CL2010001528A1 CL 2010001528 A1 CL2010001528 A1 CL 2010001528A1 CL 2010001528 A CL2010001528 A CL 2010001528A CL 2010001528 A CL2010001528 A CL 2010001528A CL 2010001528 A1 CL2010001528 A1 CL 2010001528A1
Authority
CL
Chile
Prior art keywords
compound
phenoxychroman
pgd2
prostaglandin
antagonist
Prior art date
Application number
CL2010001528A
Other languages
English (en)
Inventor
Christopher T Clark
Adam Cook
Robert Kirk Delisle
George A Doherty
Kevin W Hunt
Ganghyeok Kim
Todd Romoff
Laurence E Burgess
Christopher P Corrette
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CL2010001528A1 publication Critical patent/CL2010001528A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FÓRMULA I, E INTERMEDIARIOS DE FÓRMULA LE, VI Y IV, SEGÚN EN DONDE A1, A2, PG, W, L, G, R7A, R7B, R8, R9, R10, P3, P2 Y Z2 TIENEN LAS DEFINICIONES QUE SE DIERON EN LA MEMORIA DESCRIPTIVA, SON MODULADORES DE RECEPTOR DE DP2 QUE SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLÓGICAS.
CL2010001528A 2008-06-25 2010-12-23 Compuestos derivados del acido 7-fenoxicroman-4-carboxilico sustituido; proceso de preparacion; compuesto intermediario; composicion farmaceutica de dicho compuesto; y su uso como antagonista de los receptores de prostaglandina d2 (pgd2) para tratar trastornos inmunologicos, enfermedades alergicas, trastornos inflamatorios. CL2010001528A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7561508P 2008-06-25 2008-06-25

Publications (1)

Publication Number Publication Date
CL2010001528A1 true CL2010001528A1 (es) 2011-07-01

Family

ID=40996727

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010001528A CL2010001528A1 (es) 2008-06-25 2010-12-23 Compuestos derivados del acido 7-fenoxicroman-4-carboxilico sustituido; proceso de preparacion; compuesto intermediario; composicion farmaceutica de dicho compuesto; y su uso como antagonista de los receptores de prostaglandina d2 (pgd2) para tratar trastornos inmunologicos, enfermedades alergicas, trastornos inflamatorios.

Country Status (33)

Country Link
US (4) US8569522B2 (es)
EP (3) EP2826774B1 (es)
JP (2) JP5753780B2 (es)
KR (1) KR101728175B1 (es)
CN (2) CN102131794B (es)
AR (1) AR072301A1 (es)
AU (1) AU2009262274B2 (es)
BR (1) BRPI0915513B8 (es)
CA (1) CA2729217C (es)
CL (1) CL2010001528A1 (es)
CO (1) CO6362002A2 (es)
CR (1) CR20110037A (es)
CY (1) CY1115650T1 (es)
DK (1) DK2307397T3 (es)
ES (2) ES2582161T3 (es)
HK (1) HK1155735A1 (es)
HR (1) HRP20140988T1 (es)
IL (2) IL210198A (es)
MX (1) MX2011000173A (es)
MY (2) MY185134A (es)
NZ (1) NZ590437A (es)
PH (1) PH12014500079B1 (es)
PL (1) PL2307397T3 (es)
PT (1) PT2307397E (es)
RS (1) RS53665B1 (es)
RU (1) RU2507200C2 (es)
SG (2) SG2014013544A (es)
SI (1) SI2307397T1 (es)
TW (2) TWI476186B (es)
UA (1) UA104867C2 (es)
UY (1) UY31938A (es)
WO (1) WO2009158426A1 (es)
ZA (1) ZA201100604B (es)

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NZ590437A (en) 2008-06-25 2012-07-27 Array Biopharma Inc 6-substituted phenoxychroman carboxylic acid derivatives
EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
TW201507722A (zh) * 2013-04-30 2015-03-01 Bayer Cropscience Ag 做為殺線蟲劑及殺體內寄生蟲劑的ｎ－（２－鹵素－２－苯乙基）－羧醯胺類
WO2015126750A1 (en) 2014-02-19 2015-08-27 Array Biopharma Inc. BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
CN111057003A (zh) * 2019-12-06 2020-04-24 广安凯特制药有限公司 一种立他司特中间体5,7-二氯-1,2,3,4-四氢异喹啉的合成方法
SE2151519A1 (en) * 2021-12-10 2023-06-11 Amidea Sweden Ab 2-(2,5-dimethoxyphenyl)ethanamine and uses thereof
CN114181039A (zh) * 2021-12-23 2022-03-15 凯美克(上海)医药科技有限公司 一种4,4-二苯基-3-丁烯-1-醇的合成方法

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US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5006550A (en) * 1989-12-29 1991-04-09 Allergan, Inc. Chroman esters of phenols and benzoic acids having retinoid-like activity
US5952326A (en) 1997-12-10 1999-09-14 Pfizer Inc. Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
DE19850131A1 (de) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate
EE04719B1 (et) 1999-05-21 2006-10-16 Pfizer Products Inc. 1-trifluorometüül-4-hüdroksü-7-piperidinüül-aminometüülkromaani derivaadid
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WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
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UA96459C2 (uk) * 2006-08-21 2011-11-10 Еррей Біофарма Інк. 4-заміщені похідні феноксифенілоцтової кислоти
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EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives

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Publication number Publication date
IL210198A (en) 2015-10-29
SG2014013544A (en) 2014-07-30
EP2307397B1 (en) 2014-08-20
US20110105463A1 (en) 2011-05-05
JP2011526290A (ja) 2011-10-06
JP5753780B2 (ja) 2015-07-22
SG2014013528A (en) 2014-07-30
TWI476186B (zh) 2015-03-11
US9096567B2 (en) 2015-08-04
BRPI0915513B8 (pt) 2021-05-25
WO2009158426A1 (en) 2009-12-30
IL241754A0 (en) 2015-11-30
EP3144303B1 (en) 2018-09-26
SI2307397T1 (sl) 2014-11-28
UA104867C2 (uk) 2014-03-25
US9556139B2 (en) 2017-01-31
TW201427965A (zh) 2014-07-16
EP2307397A1 (en) 2011-04-13
EP2826774B1 (en) 2016-05-25
BRPI0915513B1 (pt) 2019-11-19
RU2011102595A (ru) 2012-07-27
TWI436990B (zh) 2014-05-11
KR101728175B1 (ko) 2017-04-18
ES2524314T3 (es) 2014-12-05
HRP20140988T1 (hr) 2014-12-05
PT2307397E (pt) 2014-10-29
DK2307397T3 (da) 2014-11-03
JP2014122241A (ja) 2014-07-03
AU2009262274B2 (en) 2013-08-01
TW201022222A (en) 2010-06-16
CN102131794B (zh) 2013-09-25
MY185134A (en) 2021-04-30
PH12014500079A1 (en) 2015-02-09
CN103450138B (zh) 2015-04-08
EP2826774A1 (en) 2015-01-21
ES2582161T3 (es) 2016-09-09
RU2507200C2 (ru) 2014-02-20
RS53665B1 (en) 2015-04-30
AR072301A1 (es) 2010-08-18
BRPI0915513A2 (pt) 2016-01-26
US8716498B2 (en) 2014-05-06
KR20110027798A (ko) 2011-03-16
CA2729217A1 (en) 2009-12-30
IL241754A (en) 2017-02-28
AU2009262274A1 (en) 2009-12-30
PH12014500079B1 (en) 2015-02-09
CA2729217C (en) 2016-09-06
CN102131794A (zh) 2011-07-20
US8569522B2 (en) 2013-10-29
CO6362002A2 (es) 2012-01-20
PL2307397T3 (pl) 2015-02-27
US20150232442A1 (en) 2015-08-20
MX2011000173A (es) 2011-06-20
UY31938A (es) 2011-01-31
US20140221342A1 (en) 2014-08-07
ZA201100604B (en) 2015-08-26
IL210198A0 (en) 2011-03-31
CR20110037A (es) 2011-03-14
HK1155735A1 (en) 2012-05-25
CN103450138A (zh) 2013-12-18
CY1115650T1 (el) 2017-01-04
US20140005418A1 (en) 2014-01-02
EP3144303A1 (en) 2017-03-22
NZ590437A (en) 2012-07-27
MY161425A (en) 2017-04-14

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