EA200970835A1 - Индазолы, применяемые для лечения расстройств, опосредуемых эстрогеновым рецептором бета - Google Patents

Индазолы, применяемые для лечения расстройств, опосредуемых эстрогеновым рецептором бета

Info

Publication number
EA200970835A1
EA200970835A1 EA200970835A EA200970835A EA200970835A1 EA 200970835 A1 EA200970835 A1 EA 200970835A1 EA 200970835 A EA200970835 A EA 200970835A EA 200970835 A EA200970835 A EA 200970835A EA 200970835 A1 EA200970835 A1 EA 200970835A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
indazols
applicable
beta receptor
disorders mediated
Prior art date
Application number
EA200970835A
Other languages
English (en)
Inventor
Кристофер Норберт Джонсон
Дэвид Дж. Джоунз
Си Лян
Дэвид Тимоти Макферсон
Аарон Б. Миллер
Антуанетт Нэйлор
Стивен Джеймс Стэнвэй
Эндрю Кеннет Тэкл
Джанкарло Трани
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA200970835A1 publication Critical patent/EA200970835A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Настоящее изобретение относится к новым производным индазола (I), обладающим фармакологической активностью, способам их получения, композициям, содержащим указанные соединения, и применению указанных соединений в лечении заболеваний, опосредуемых эстрогеновым рецептором бета.
EA200970835A 2007-03-07 2008-03-05 Индазолы, применяемые для лечения расстройств, опосредуемых эстрогеновым рецептором бета EA200970835A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0704407.6A GB0704407D0 (en) 2007-03-07 2007-03-07 Compounds
PCT/EP2008/052664 WO2008107455A1 (en) 2007-03-07 2008-03-05 Indazoles used to treat estrogen receptor beta mediated disorders

Publications (1)

Publication Number Publication Date
EA200970835A1 true EA200970835A1 (ru) 2010-04-30

Family

ID=37988543

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970835A EA200970835A1 (ru) 2007-03-07 2008-03-05 Индазолы, применяемые для лечения расстройств, опосредуемых эстрогеновым рецептором бета

Country Status (16)

Country Link
US (1) US7960563B2 (ru)
EP (1) EP2118068A1 (ru)
JP (1) JP2010520259A (ru)
KR (1) KR20090118998A (ru)
CN (1) CN101679288A (ru)
AR (1) AR065605A1 (ru)
AU (1) AU2008223850A1 (ru)
BR (1) BRPI0808464A2 (ru)
CA (1) CA2680109A1 (ru)
CL (1) CL2008000647A1 (ru)
EA (1) EA200970835A1 (ru)
GB (1) GB0704407D0 (ru)
MX (1) MX2009009581A (ru)
PE (1) PE20081878A1 (ru)
TW (1) TW200848025A (ru)
WO (1) WO2008107455A1 (ru)

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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
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Also Published As

Publication number Publication date
TW200848025A (en) 2008-12-16
AR065605A1 (es) 2009-06-17
PE20081878A1 (es) 2009-03-05
KR20090118998A (ko) 2009-11-18
AU2008223850A1 (en) 2008-09-12
CN101679288A (zh) 2010-03-24
US7960563B2 (en) 2011-06-14
GB0704407D0 (en) 2007-04-18
CL2008000647A1 (es) 2009-01-02
WO2008107455A1 (en) 2008-09-12
CA2680109A1 (en) 2008-09-12
MX2009009581A (es) 2009-09-16
EP2118068A1 (en) 2009-11-18
BRPI0808464A2 (pt) 2014-07-15
US20100087502A1 (en) 2010-04-08
JP2010520259A (ja) 2010-06-10

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