DK2307397T3 - 6-substituerede phenoxychroman-carboxylsyrederivater - Google Patents

6-substituerede phenoxychroman-carboxylsyrederivater

Info

Publication number
DK2307397T3
DK2307397T3 DK09770959.6T DK09770959T DK2307397T3 DK 2307397 T3 DK2307397 T3 DK 2307397T3 DK 09770959 T DK09770959 T DK 09770959T DK 2307397 T3 DK2307397 T3 DK 2307397T3
Authority
DK
Denmark
Prior art keywords
acid derivatives
carboxyl acid
phenoxychroman
substituted
substituted phenoxychroman
Prior art date
Application number
DK09770959.6T
Other languages
English (en)
Inventor
Ganghyeok Kim
Laurence E Burgess
Christopher T Clark
Adam Cook
Christopher P Corrette
Robert Kirk Delisle
George A Doherty
Kevin W Hunt
Todd Romoff
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Application granted granted Critical
Publication of DK2307397T3 publication Critical patent/DK2307397T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DK09770959.6T 2008-06-25 2009-06-24 6-substituerede phenoxychroman-carboxylsyrederivater DK2307397T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7561508P 2008-06-25 2008-06-25
PCT/US2009/048499 WO2009158426A1 (en) 2008-06-25 2009-06-24 6-substituted phenoxychroman carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
DK2307397T3 true DK2307397T3 (da) 2014-11-03

Family

ID=40996727

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09770959.6T DK2307397T3 (da) 2008-06-25 2009-06-24 6-substituerede phenoxychroman-carboxylsyrederivater

Country Status (33)

Country Link
US (4) US8569522B2 (da)
EP (3) EP3144303B1 (da)
JP (2) JP5753780B2 (da)
KR (1) KR101728175B1 (da)
CN (2) CN102131794B (da)
AR (1) AR072301A1 (da)
AU (1) AU2009262274B2 (da)
BR (1) BRPI0915513B8 (da)
CA (1) CA2729217C (da)
CL (1) CL2010001528A1 (da)
CO (1) CO6362002A2 (da)
CR (1) CR20110037A (da)
CY (1) CY1115650T1 (da)
DK (1) DK2307397T3 (da)
ES (2) ES2524314T3 (da)
HK (1) HK1155735A1 (da)
HR (1) HRP20140988T1 (da)
IL (2) IL210198A (da)
MX (1) MX2011000173A (da)
MY (2) MY185134A (da)
NZ (1) NZ590437A (da)
PH (1) PH12014500079A1 (da)
PL (1) PL2307397T3 (da)
PT (1) PT2307397E (da)
RS (1) RS53665B1 (da)
RU (1) RU2507200C2 (da)
SG (2) SG2014013528A (da)
SI (1) SI2307397T1 (da)
TW (2) TWI436990B (da)
UA (1) UA104867C2 (da)
UY (1) UY31938A (da)
WO (1) WO2009158426A1 (da)
ZA (1) ZA201100604B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3144303B1 (en) 2008-06-25 2018-09-26 Array Biopharma, Inc. 6-substituted phenoxychroman carboxylic acid derivatives
EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
TW201507722A (zh) * 2013-04-30 2015-03-01 Bayer Cropscience Ag 做為殺線蟲劑及殺體內寄生蟲劑的n-(2-鹵素-2-苯乙基)-羧醯胺類
WO2015126750A1 (en) 2014-02-19 2015-08-27 Array Biopharma Inc. BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
CN111057003A (zh) * 2019-12-06 2020-04-24 广安凯特制药有限公司 一种立他司特中间体5,7-二氯-1,2,3,4-四氢异喹啉的合成方法
SE2151519A1 (en) * 2021-12-10 2023-06-11 Amidea Sweden Ab 2-(2,5-dimethoxyphenyl)ethanamine and uses thereof
CN114181039A (zh) * 2021-12-23 2022-03-15 凯美克(上海)医药科技有限公司 一种4,4-二苯基-3-丁烯-1-醇的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5006550A (en) * 1989-12-29 1991-04-09 Allergan, Inc. Chroman esters of phenols and benzoic acids having retinoid-like activity
US5952326A (en) 1997-12-10 1999-09-14 Pfizer Inc. Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
DE19850131A1 (de) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate
TR200103332T2 (tr) 1999-05-21 2002-04-22 Pfizer Products Inc. 1-Triflorometil-4-hidroksi-7-piperidinil-aminometilkroman türevleri.
CA2422342C (en) * 2000-09-14 2009-12-08 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof
WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
NZ541234A (en) 2002-12-20 2008-06-30 Amgen Inc Asthma and allergic inflammation modulators
CN101128423A (zh) * 2005-02-25 2008-02-20 伊莱利利公司 新型脂氧化酶抑制剂
GB0611781D0 (en) 2006-06-14 2006-07-26 Argenta Discovery Ltd 2-Oxo-2H-Chromene Compounds
RS52627B (en) 2006-08-21 2013-06-28 Array Biopharma Inc. 4-SUBSTITUTED Phenoxyphenylsulfuric acid derivatives
CA2667249A1 (en) * 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
US8362056B2 (en) 2007-11-05 2013-01-29 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid derivatives
EP3144303B1 (en) 2008-06-25 2018-09-26 Array Biopharma, Inc. 6-substituted phenoxychroman carboxylic acid derivatives
EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives

Also Published As

Publication number Publication date
CN103450138B (zh) 2015-04-08
TW201427965A (zh) 2014-07-16
NZ590437A (en) 2012-07-27
EP2307397B1 (en) 2014-08-20
JP2014122241A (ja) 2014-07-03
ES2582161T3 (es) 2016-09-09
MX2011000173A (es) 2011-06-20
TW201022222A (en) 2010-06-16
TWI436990B (zh) 2014-05-11
JP2011526290A (ja) 2011-10-06
WO2009158426A1 (en) 2009-12-30
EP3144303B1 (en) 2018-09-26
IL241754A0 (en) 2015-11-30
CN103450138A (zh) 2013-12-18
US20150232442A1 (en) 2015-08-20
US20140221342A1 (en) 2014-08-07
CA2729217A1 (en) 2009-12-30
ZA201100604B (en) 2015-08-26
PT2307397E (pt) 2014-10-29
ES2524314T3 (es) 2014-12-05
HRP20140988T1 (hr) 2014-12-05
CN102131794A (zh) 2011-07-20
TWI476186B (zh) 2015-03-11
UA104867C2 (uk) 2014-03-25
CY1115650T1 (el) 2017-01-04
AU2009262274A1 (en) 2009-12-30
IL210198A0 (en) 2011-03-31
SG2014013544A (en) 2014-07-30
RU2011102595A (ru) 2012-07-27
KR20110027798A (ko) 2011-03-16
RS53665B1 (en) 2015-04-30
SG2014013528A (en) 2014-07-30
RU2507200C2 (ru) 2014-02-20
US8569522B2 (en) 2013-10-29
US8716498B2 (en) 2014-05-06
US20140005418A1 (en) 2014-01-02
EP2826774A1 (en) 2015-01-21
PL2307397T3 (pl) 2015-02-27
BRPI0915513B8 (pt) 2021-05-25
MY185134A (en) 2021-04-30
PH12014500079B1 (en) 2015-02-09
CN102131794B (zh) 2013-09-25
BRPI0915513A2 (pt) 2016-01-26
SI2307397T1 (sl) 2014-11-28
EP2826774B1 (en) 2016-05-25
AU2009262274B2 (en) 2013-08-01
BRPI0915513B1 (pt) 2019-11-19
CO6362002A2 (es) 2012-01-20
UY31938A (es) 2011-01-31
EP3144303A1 (en) 2017-03-22
EP2307397A1 (en) 2011-04-13
CA2729217C (en) 2016-09-06
JP5753780B2 (ja) 2015-07-22
HK1155735A1 (en) 2012-05-25
CR20110037A (es) 2011-03-14
CL2010001528A1 (es) 2011-07-01
PH12014500079A1 (en) 2015-02-09
US9096567B2 (en) 2015-08-04
AR072301A1 (es) 2010-08-18
US20110105463A1 (en) 2011-05-05
US9556139B2 (en) 2017-01-31
IL241754A (en) 2017-02-28
MY161425A (en) 2017-04-14
IL210198A (en) 2015-10-29
KR101728175B1 (ko) 2017-04-18

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