CO6852073A2 - Antagonistas trpm8 y su uso en tratamientos - Google Patents

Antagonistas trpm8 y su uso en tratamientos

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Publication number
CO6852073A2
CO6852073A2 CO14004185A CO14004185A CO6852073A2 CO 6852073 A2 CO6852073 A2 CO 6852073A2 CO 14004185 A CO14004185 A CO 14004185A CO 14004185 A CO14004185 A CO 14004185A CO 6852073 A2 CO6852073 A2 CO 6852073A2
Authority
CO
Colombia
Prior art keywords
treatments
trpm8
compounds
disorders
useful
Prior art date
Application number
CO14004185A
Other languages
English (en)
Inventor
Kaustav Biswas
James Brown
Jian J Chen
Vijay Keshav Gore
Scott Harried
Daniel Horne
Matthew R Kaller
Qingyian Liu
Vu Van Ma
Holger Monenschein
Thomas T Nguyen
Chester Chenguang Yuan
Wenge Zhong
Jean David J St Jr
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CO6852073A2 publication Critical patent/CO6852073A2/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Los compuestos de la Fórmula l son útiles como antagonistas de TRPM8. Tales compuestos son útiles al tratar un número de trastornos y afecciones mediados por TRPM8 y pueden usarse para preparar medicamentos y composiciones farmacéuticas útiles para tratar tales trastornos y afecciones. Los ejemplos de tales trastornos incluyen, pero no se limitan a, migrañas y dolor neuropático. Los compuestos de la Fórmula l tienen la siguiente estructura:
CO14004185A 2011-06-24 2014-01-10 Antagonistas trpm8 y su uso en tratamientos CO6852073A2 (es)

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US201161500843P 2011-06-24 2011-06-24

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CO6852073A2 true CO6852073A2 (es) 2014-01-30

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US (3) US8710043B2 (es)
EP (1) EP2723717A2 (es)
JP (1) JP2014527511A (es)
KR (1) KR20140045507A (es)
CN (1) CN103906733A (es)
AP (1) AP2013007331A0 (es)
AR (1) AR086750A1 (es)
AU (1) AU2012272895B2 (es)
BR (1) BR112013033316A2 (es)
CA (1) CA2839699A1 (es)
CL (1) CL2013003715A1 (es)
CO (1) CO6852073A2 (es)
CR (1) CR20140037A (es)
EA (1) EA201490152A1 (es)
MA (1) MA35271B1 (es)
MX (1) MX2013015274A (es)
MY (1) MY157429A (es)
PE (1) PE20140868A1 (es)
TN (1) TN2013000529A1 (es)
TW (2) TWI448454B (es)
UY (1) UY34160A (es)
WO (1) WO2012177893A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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KR20140045507A (ko) 2014-04-16
AR086750A1 (es) 2014-01-22
TW201311643A (zh) 2013-03-16
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CA2839699A1 (en) 2012-12-27
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MA35271B1 (fr) 2014-07-03
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US20140171406A1 (en) 2014-06-19
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