UY34964A - Derivados de cromano como inhibidores del receptor transitorio potencial de la melastatina 8 (trpm8) - Google Patents
Derivados de cromano como inhibidores del receptor transitorio potencial de la melastatina 8 (trpm8)Info
- Publication number
- UY34964A UY34964A UY0001034964A UY34964A UY34964A UY 34964 A UY34964 A UY 34964A UY 0001034964 A UY0001034964 A UY 0001034964A UY 34964 A UY34964 A UY 34964A UY 34964 A UY34964 A UY 34964A
- Authority
- UY
- Uruguay
- Prior art keywords
- trpm8
- inhibitors
- melastatin
- receiver
- chroman derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de cromano y derivados de Fórmula I son inhibidores útiles del TRPM8. Los compuestos son útiles para tratar una cantidad de trastornos y condiciones mediadas por el TRPM8 y se pueden usar para preparar medicamentos y composiciones farmacéuticas útiles en el tratamiento de tales trastornos y condiciones. Los ejemplos de tales trastornos incluyen, no taxativamente, la migraña y el dolor neuropático. Los compuestos de fórmula I tienen la siguiente estructura, donde las definiciones de las variables se proveen en la presente solicitud.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261680199P | 2012-08-06 | 2012-08-06 | |
US201361847867P | 2013-07-18 | 2013-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34964A true UY34964A (es) | 2014-02-28 |
Family
ID=48949292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001034964A UY34964A (es) | 2012-08-06 | 2013-08-06 | Derivados de cromano como inhibidores del receptor transitorio potencial de la melastatina 8 (trpm8) |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR092064A1 (es) |
TW (1) | TW201418240A (es) |
UY (1) | UY34964A (es) |
WO (1) | WO2014025651A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI674257B (zh) | 2014-03-14 | 2019-10-11 | 日商拉夸里亞創藥股份有限公司 | 作為trpm8拮抗劑之氮雜螺衍生物 |
EP3215510B1 (en) | 2014-11-06 | 2023-06-07 | Bial-R&D Investments, S.A. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
WO2016073895A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
EP3156405A1 (en) * | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
MX2018012207A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
JP7038063B2 (ja) | 2016-04-06 | 2022-03-17 | リソソーマル・セラピューティクス・インコーポレイテッド | ピラゾロ[1,5-a]ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
AU2017261291C1 (en) | 2016-05-05 | 2022-05-26 | Bial - R&D Investments, S.A. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
HRP20231682T1 (hr) | 2017-03-13 | 2024-03-29 | Raqualia Pharma Inc. | Derivati tetrahidrokinolina kao antagonisti p2x7 receptora |
CN112574122B (zh) * | 2019-09-27 | 2024-05-31 | 上海天慈国际药业有限公司 | 一种奥拉帕尼关键中间体的制备方法 |
WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
WO2024099393A1 (zh) * | 2022-11-09 | 2024-05-16 | 中国科学院上海药物研究所 | 一类含芳基的胺类化合物、其制备方法和用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102010002558A1 (de) * | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
-
2013
- 2013-08-02 WO PCT/US2013/053514 patent/WO2014025651A1/en active Application Filing
- 2013-08-06 TW TW102128148A patent/TW201418240A/zh unknown
- 2013-08-06 UY UY0001034964A patent/UY34964A/es not_active Application Discontinuation
- 2013-08-06 AR ARP130102798A patent/AR092064A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014025651A1 (en) | 2014-02-13 |
AR092064A1 (es) | 2015-03-18 |
TW201418240A (zh) | 2014-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20210609 |