UY34964A - CHROMAN DERIVATIVES AS INHIBITORS OF THE MELASTATIN POTENTIAL TRANSITORY RECEIVER 8 (TRPM8) - Google Patents

CHROMAN DERIVATIVES AS INHIBITORS OF THE MELASTATIN POTENTIAL TRANSITORY RECEIVER 8 (TRPM8)

Info

Publication number
UY34964A
UY34964A UY0001034964A UY34964A UY34964A UY 34964 A UY34964 A UY 34964A UY 0001034964 A UY0001034964 A UY 0001034964A UY 34964 A UY34964 A UY 34964A UY 34964 A UY34964 A UY 34964A
Authority
UY
Uruguay
Prior art keywords
trpm8
inhibitors
melastatin
receiver
chroman derivatives
Prior art date
Application number
UY0001034964A
Other languages
Spanish (es)
Inventor
Brown James
Thomas T Nguyen
Zhong Wenge
Biswas Kaustav
Jian J Chen
Gore Vijay Keshav
Harried Scott
Daniel B Horne
Matthew R Kaller
Ma Vu Van
Sham Kelvin
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of UY34964A publication Critical patent/UY34964A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos de cromano y derivados de Fórmula I son inhibidores útiles del TRPM8. Los compuestos son útiles para tratar una cantidad de trastornos y condiciones mediadas por el TRPM8 y se pueden usar para preparar medicamentos y composiciones farmacéuticas útiles en el tratamiento de tales trastornos y condiciones. Los ejemplos de tales trastornos incluyen, no taxativamente, la migraña y el dolor neuropático. Los compuestos de fórmula I tienen la siguiente estructura, donde las definiciones de las variables se proveen en la presente solicitud.Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. The compounds are useful for treating a number of disorders and conditions mediated by TRPM8 and can be used to prepare medicaments and pharmaceutical compositions useful in the treatment of such disorders and conditions. Examples of such disorders include, but are not limited to, migraine and neuropathic pain. The compounds of formula I have the following structure, where definitions of the variables are provided in the present application.

UY0001034964A 2012-08-06 2013-08-06 CHROMAN DERIVATIVES AS INHIBITORS OF THE MELASTATIN POTENTIAL TRANSITORY RECEIVER 8 (TRPM8) UY34964A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261680199P 2012-08-06 2012-08-06
US201361847867P 2013-07-18 2013-07-18

Publications (1)

Publication Number Publication Date
UY34964A true UY34964A (en) 2014-02-28

Family

ID=48949292

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034964A UY34964A (en) 2012-08-06 2013-08-06 CHROMAN DERIVATIVES AS INHIBITORS OF THE MELASTATIN POTENTIAL TRANSITORY RECEIVER 8 (TRPM8)

Country Status (4)

Country Link
AR (1) AR092064A1 (en)
TW (1) TW201418240A (en)
UY (1) UY34964A (en)
WO (1) WO2014025651A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2940621C (en) 2014-03-14 2022-03-15 Raqualia Pharma Inc. Azaspiro derivatives as trpm8 antagonists
EP3215510B1 (en) 2014-11-06 2023-06-07 Bial-R&D Investments, S.A. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
CA2966581A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
WO2016073895A1 (en) * 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
CA3020305A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
CA3020310A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
EP3440080A4 (en) 2016-04-06 2020-01-22 Lysosomal Therapeutics Inc. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
CN109311902B (en) 2016-05-05 2022-07-15 Bial研发投资股份有限公司 Substituted imidazo [1,2-b ] pyridazines, imidazo [1,5-b ] pyridazines, related compounds, and uses thereof
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
PL3609868T3 (en) 2017-03-13 2024-04-02 Raqualia Pharma Inc. Tetrahydroquinoline derivatives as p2x7 receptor antagonists
CN112574122B (en) * 2019-09-27 2024-05-31 上海天慈国际药业有限公司 Preparation method of Olaparib key intermediate
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
CN118598822A (en) * 2022-11-09 2024-09-06 中国科学院上海药物研究所 Aryl-containing amine compound, preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010002558A1 (en) * 2009-11-20 2011-06-01 Symrise Ag Use of physiological cooling agents and agents containing such agents

Also Published As

Publication number Publication date
AR092064A1 (en) 2015-03-18
TW201418240A (en) 2014-05-16
WO2014025651A1 (en) 2014-02-13

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20210609