CL2013003715A1 - Compuestos derivados de heterociclos nitrogenados, antagonistas trpm8; composicion farmaceutica; y su uso en el tratamiento de la migraña, dolor agudo, inflamatorio o neuropatico, entre otros - Google Patents
Compuestos derivados de heterociclos nitrogenados, antagonistas trpm8; composicion farmaceutica; y su uso en el tratamiento de la migraña, dolor agudo, inflamatorio o neuropatico, entre otrosInfo
- Publication number
- CL2013003715A1 CL2013003715A1 CL2013003715A CL2013003715A CL2013003715A1 CL 2013003715 A1 CL2013003715 A1 CL 2013003715A1 CL 2013003715 A CL2013003715 A CL 2013003715A CL 2013003715 A CL2013003715 A CL 2013003715A CL 2013003715 A1 CL2013003715 A1 CL 2013003715A1
- Authority
- CL
- Chile
- Prior art keywords
- migraine
- inflammatory
- acute
- treatment
- pharmaceutical composition
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D498/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161500843P | 2011-06-24 | 2011-06-24 |
Publications (1)
Publication Number | Publication Date |
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CL2013003715A1 true CL2013003715A1 (es) | 2014-06-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2013003715A CL2013003715A1 (es) | 2011-06-24 | 2013-12-24 | Compuestos derivados de heterociclos nitrogenados, antagonistas trpm8; composicion farmaceutica; y su uso en el tratamiento de la migraña, dolor agudo, inflamatorio o neuropatico, entre otros |
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US (3) | US8710043B2 (es) |
EP (1) | EP2723717A2 (es) |
JP (1) | JP2014527511A (es) |
KR (1) | KR20140045507A (es) |
CN (1) | CN103906733A (es) |
AP (1) | AP2013007331A0 (es) |
AR (1) | AR086750A1 (es) |
AU (1) | AU2012272895B2 (es) |
BR (1) | BR112013033316A2 (es) |
CA (1) | CA2839699A1 (es) |
CL (1) | CL2013003715A1 (es) |
CO (1) | CO6852073A2 (es) |
CR (1) | CR20140037A (es) |
EA (1) | EA201490152A1 (es) |
MA (1) | MA35271B1 (es) |
MX (1) | MX2013015274A (es) |
MY (1) | MY157429A (es) |
PE (1) | PE20140868A1 (es) |
TN (1) | TN2013000529A1 (es) |
TW (2) | TWI448454B (es) |
UY (1) | UY34160A (es) |
WO (1) | WO2012177893A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
ES2895174T3 (es) | 2014-09-29 | 2022-02-17 | Scripps Research Inst | Moduladores del receptor de esfingosina-1-fosfato para el tratamiento de trastornos cardiopulmonares |
US9765026B2 (en) * | 2015-08-28 | 2017-09-19 | Scinopharm Taiwan, Ltd. | Forms of apremilast and the process of making the same |
ES2957232T3 (es) * | 2016-06-13 | 2024-01-15 | Mitsubishi Tanabe Pharma Corp | Composiciones para el tratamiento o la prevención de síntomas vasomotores |
MX2019015468A (es) | 2017-06-22 | 2020-08-03 | Curadev Pharma Ltd | Moduladores de moleculas pequeñas de sting humana. |
WO2018234805A1 (en) * | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | SMALL MOLECULAR MODULATORS OF HUMAN STING |
AU2018391882A1 (en) * | 2017-12-19 | 2020-07-02 | Mitsubishi Tanabe Pharma Corporation | Compositions and methods for treating or preventing vasomotor symptoms |
WO2019180627A1 (en) * | 2018-03-21 | 2019-09-26 | Piramal Enterprises Limited | AN IMPROVED ASYMMETRIC SYNTHESIS OF alpha-(DIARYLMETHYL) ALKYL AMINES |
EP3781547A4 (en) * | 2018-04-18 | 2022-04-13 | Piramal Pharma Limited | IMPROVED ASYMMETRIC SYNTHESIS OF ALPHA-BRANCHED CHIRAL AMINES |
CN110981795B (zh) * | 2019-12-18 | 2021-02-12 | 武汉世纪久海检测技术有限公司 | 一种利用2-氰基异烟酸甲酯制备2-氨酰基异烟酸的方法 |
CN116134018A (zh) | 2020-06-17 | 2023-05-16 | 默沙东有限责任公司 | 作为nav1.8抑制剂的2-氧代咪唑烷-4-甲酰胺 |
CN115108980B (zh) * | 2022-06-22 | 2023-06-16 | 济南大学 | 一种2-甲基喹啉类化合物的4号位酰基化衍生物的制备方法 |
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-
2012
- 2012-06-21 EA EA201490152A patent/EA201490152A1/ru unknown
- 2012-06-21 CN CN201280041145.5A patent/CN103906733A/zh active Pending
- 2012-06-21 MY MYPI2013004627A patent/MY157429A/en unknown
- 2012-06-21 AU AU2012272895A patent/AU2012272895B2/en not_active Ceased
- 2012-06-21 KR KR1020147001927A patent/KR20140045507A/ko not_active Application Discontinuation
- 2012-06-21 US US13/529,860 patent/US8710043B2/en active Active
- 2012-06-21 WO PCT/US2012/043566 patent/WO2012177893A2/en active Application Filing
- 2012-06-21 AP AP2013007331A patent/AP2013007331A0/xx unknown
- 2012-06-21 PE PE2013002869A patent/PE20140868A1/es not_active Application Discontinuation
- 2012-06-21 JP JP2014517168A patent/JP2014527511A/ja active Pending
- 2012-06-21 MX MX2013015274A patent/MX2013015274A/es not_active Application Discontinuation
- 2012-06-21 CA CA2839699A patent/CA2839699A1/en not_active Abandoned
- 2012-06-21 EP EP12730134.9A patent/EP2723717A2/en not_active Withdrawn
- 2012-06-21 BR BR112013033316A patent/BR112013033316A2/pt not_active IP Right Cessation
- 2012-06-22 TW TW101122538A patent/TWI448454B/zh not_active IP Right Cessation
- 2012-06-22 TW TW103114426A patent/TW201429948A/zh unknown
- 2012-06-25 UY UY0001034160A patent/UY34160A/es not_active Application Discontinuation
- 2012-06-25 AR ARP120102273A patent/AR086750A1/es not_active Application Discontinuation
-
2013
- 2013-12-23 TN TNP2013000529A patent/TN2013000529A1/fr unknown
- 2013-12-24 CL CL2013003715A patent/CL2013003715A1/es unknown
-
2014
- 2014-01-10 CO CO14004185A patent/CO6852073A2/es active IP Right Grant
- 2014-01-20 MA MA36692A patent/MA35271B1/fr unknown
- 2014-01-24 CR CR20140037A patent/CR20140037A/es unknown
- 2014-02-24 US US14/187,732 patent/US20140171406A1/en not_active Abandoned
- 2014-02-24 US US14/187,677 patent/US9096527B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CO6852073A2 (es) | 2014-01-30 |
US20140171406A1 (en) | 2014-06-19 |
CA2839699A1 (en) | 2012-12-27 |
CR20140037A (es) | 2014-03-13 |
TWI448454B (zh) | 2014-08-11 |
UY34160A (es) | 2012-08-31 |
EA201490152A1 (ru) | 2014-05-30 |
MA35271B1 (fr) | 2014-07-03 |
US9096527B2 (en) | 2015-08-04 |
MY157429A (en) | 2016-06-15 |
AR086750A1 (es) | 2014-01-22 |
MX2013015274A (es) | 2014-03-31 |
TN2013000529A1 (en) | 2015-03-30 |
AP2013007331A0 (en) | 2013-12-31 |
US8710043B2 (en) | 2014-04-29 |
AU2012272895B2 (en) | 2015-01-22 |
KR20140045507A (ko) | 2014-04-16 |
TW201311643A (zh) | 2013-03-16 |
PE20140868A1 (es) | 2014-07-18 |
BR112013033316A2 (pt) | 2017-01-31 |
JP2014527511A (ja) | 2014-10-16 |
US20130157996A1 (en) | 2013-06-20 |
WO2012177893A3 (en) | 2013-06-13 |
TW201429948A (zh) | 2014-08-01 |
CN103906733A (zh) | 2014-07-02 |
US20140171639A1 (en) | 2014-06-19 |
EP2723717A2 (en) | 2014-04-30 |
AU2012272895A1 (en) | 2013-04-11 |
WO2012177893A2 (en) | 2012-12-27 |
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