MX2010010209A - 4-hidroxipirimidina-5-carboxamidas sustituidas. - Google Patents

4-hidroxipirimidina-5-carboxamidas sustituidas.

Info

Publication number
MX2010010209A
MX2010010209A MX2010010209A MX2010010209A MX2010010209A MX 2010010209 A MX2010010209 A MX 2010010209A MX 2010010209 A MX2010010209 A MX 2010010209A MX 2010010209 A MX2010010209 A MX 2010010209A MX 2010010209 A MX2010010209 A MX 2010010209A
Authority
MX
Mexico
Prior art keywords
hydroxypyrimidine
substituted
carboxamides
conditions
relates
Prior art date
Application number
MX2010010209A
Other languages
English (en)
Inventor
Matthew J Clements
John S Debenham
Jeffrey J Hale
Christina B Madsen-Duggan
Thomas F Walsh
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2010010209A publication Critical patent/MX2010010209A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a 4-hidroxipirimidina-5-carboxami das sustituidas útiles como inhibidores de prolilhidroxilasas de HIF para tratar anemia y afecciones similares.
MX2010010209A 2008-03-18 2009-03-09 4-hidroxipirimidina-5-carboxamidas sustituidas. MX2010010209A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6986408P 2008-03-18 2008-03-18
US19291808P 2008-09-23 2008-09-23
PCT/US2009/036501 WO2009117269A1 (en) 2008-03-18 2009-03-09 Substituted 4-hydroxypyrimidine-5-carboxamides

Publications (1)

Publication Number Publication Date
MX2010010209A true MX2010010209A (es) 2010-10-05

Family

ID=40627533

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010209A MX2010010209A (es) 2008-03-18 2009-03-09 4-hidroxipirimidina-5-carboxamidas sustituidas.

Country Status (13)

Country Link
US (1) US8278304B2 (es)
EP (1) EP2257539B1 (es)
JP (1) JP5557832B2 (es)
CN (1) CN102036981B (es)
AR (1) AR070925A1 (es)
AU (1) AU2009225869B2 (es)
CA (1) CA2718528C (es)
CL (1) CL2009000639A1 (es)
ES (1) ES2524883T3 (es)
MX (1) MX2010010209A (es)
PE (1) PE20091627A1 (es)
TW (1) TW200944511A (es)
WO (1) WO2009117269A1 (es)

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WO2013040789A1 (en) * 2011-09-23 2013-03-28 Merck Sharp & Dohme Corp. Substituted pyrimidines
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CN103450194B (zh) * 2012-06-05 2015-07-08 首都医科大学 四氢-β-咔啉-3-甲酰脂肪链胺、其制备、纳米结构、免疫抑制作用及应用
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MX370388B (es) * 2013-03-29 2019-12-11 Takeda Pharmaceuticals Co Derivados de 6-(5-hidroxi-1h-pirazol-1-il)nicotinamida y su uso como inhibidores de la enzima propil hidroxilasa (phd).
AU2014368945C1 (en) 2013-12-20 2019-05-16 Sagimet Biosciences Inc. Heterocyclic modulators of lipid synthesis and combinations thereof
JP2017114765A (ja) * 2014-04-25 2017-06-29 大正製薬株式会社 トリアゾリルで置換されたヘテロアリール化合物
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TWI794994B (zh) * 2020-09-25 2023-03-01 大陸商上海美悅生物科技發展有限公司 嘧啶甲醯胺類化合物及其應用
CN116635370A (zh) * 2020-12-21 2023-08-22 英特维特国际股份有限公司 制备n-(双(4-甲氧基苯基)甲基)-6-氧代-2-(哒嗪-3-基)-1,6-二氢嘧啶-5-甲酰胺的方法
CN114835687B (zh) * 2021-04-02 2023-09-05 北京华森英诺生物科技有限公司 AhR抑制剂
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Also Published As

Publication number Publication date
CA2718528C (en) 2016-10-25
AU2009225869B2 (en) 2014-01-23
CA2718528A1 (en) 2009-09-24
CL2009000639A1 (es) 2009-07-17
EP2257539A1 (en) 2010-12-08
US20090239876A1 (en) 2009-09-24
PE20091627A1 (es) 2009-10-30
AU2009225869A1 (en) 2009-09-24
CN102036981A (zh) 2011-04-27
JP2011515402A (ja) 2011-05-19
EP2257539B1 (en) 2014-09-10
JP5557832B2 (ja) 2014-07-23
TW200944511A (en) 2009-11-01
US8278304B2 (en) 2012-10-02
WO2009117269A1 (en) 2009-09-24
CN102036981B (zh) 2015-04-08
ES2524883T3 (es) 2014-12-15
AR070925A1 (es) 2010-05-12

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Legal Events

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GB Transfer or rights

Owner name: MERCK SHARP & DOHME CORP.*

HC Change of company name or juridical status

Owner name: MERCK SHARP & DOHME CORP.*

FA Abandonment or withdrawal