MX2011013878A - 4-hidroxipirimidina-5-carboxamidas sustituidas. - Google Patents

4-hidroxipirimidina-5-carboxamidas sustituidas.

Info

Publication number
MX2011013878A
MX2011013878A MX2011013878A MX2011013878A MX2011013878A MX 2011013878 A MX2011013878 A MX 2011013878A MX 2011013878 A MX2011013878 A MX 2011013878A MX 2011013878 A MX2011013878 A MX 2011013878A MX 2011013878 A MX2011013878 A MX 2011013878A
Authority
MX
Mexico
Prior art keywords
hydroxypyrimidine
substituted
carboxamides
conditions
relates
Prior art date
Application number
MX2011013878A
Other languages
English (en)
Inventor
Matthew J Clements
John S Debenham
Jeffrey J Hale
Christina Madsen-Duggan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2011013878A publication Critical patent/MX2011013878A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a 4-hidroxipirimidina-5-carboxami das útiles como inhibidores de HIF prolil hidroxilasa para tratar la anemia en condiciones similares.
MX2011013878A 2009-06-30 2010-06-21 4-hidroxipirimidina-5-carboxamidas sustituidas. MX2011013878A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22178909P 2009-06-30 2009-06-30
US23749109P 2009-08-27 2009-08-27
PCT/US2010/039289 WO2011002623A1 (en) 2009-06-30 2010-06-21 Substituted 4-hydroxypyrimidine-5-carboxamides

Publications (1)

Publication Number Publication Date
MX2011013878A true MX2011013878A (es) 2012-02-01

Family

ID=43411372

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011013878A MX2011013878A (es) 2009-06-30 2010-06-21 4-hidroxipirimidina-5-carboxamidas sustituidas.

Country Status (8)

Country Link
US (1) US8815865B2 (es)
EP (1) EP2448583B1 (es)
JP (1) JP2012532127A (es)
CN (1) CN102802629A (es)
AU (1) AU2010266558A1 (es)
CA (1) CA2766056A1 (es)
MX (1) MX2011013878A (es)
WO (1) WO2011002623A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8372857B2 (en) * 2009-06-30 2013-02-12 Merck Sharp & Dohme Corp. Substituted 4-hydroxypyrimidine-5-carboxamides
US9006433B2 (en) * 2010-04-21 2015-04-14 Merck Sharp & Dohme Corp. Substituted pyrimidines
CA2845933C (en) 2011-09-06 2020-06-09 New York Blood Center, Inc. Hiv inhibitors
WO2013043621A1 (en) 2011-09-23 2013-03-28 Merck Sharp & Dohme Corp. Substituted pyrimidines
ES2649905T3 (es) 2012-03-30 2018-01-16 Daiichi Sankyo Company, Limited Derivado de ácido (2-heteroarilamino)succínico
ES2764440T3 (es) 2014-09-19 2020-06-03 New York Blood Center Inc Fenilpirrolcarboxamidas sustituidas con actividad terapéutica en VIH
WO2016054804A1 (en) * 2014-10-10 2016-04-14 Merck Sharp & Dohme Corp. Substituted pyrimidines as inhibitors of hif prolyl hydroxylase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0411055B1 (pt) * 2003-06-06 2018-08-21 Fibrogen, Inc Compostos de heteroarilas contendo nitrogênio. seus usos no aumento da eritropoietina endógena, composição farmacêutica que os compreende e método in vitro de inibição da atividade da enzima hidrolase
EP1931642A4 (en) * 2005-09-15 2011-06-01 Orchid Res Lab Ltd NEW PYRIMIDINE CARBOXAMIDES
WO2007038571A2 (en) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
US7588924B2 (en) * 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
TW200845994A (en) * 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
US8409473B2 (en) 2007-01-30 2013-04-02 Evident Technologies, Inc. Group II alloyed I-III-VI semiconductor nanocrystal compositions and methods of making same
AU2009225869B2 (en) * 2008-03-18 2014-01-23 Merck Sharp & Dohme Llc Substituted 4-hydroxypyrimidine-5-carboxamides

Also Published As

Publication number Publication date
CN102802629A (zh) 2012-11-28
EP2448583A1 (en) 2012-05-09
EP2448583B1 (en) 2014-06-25
EP2448583A4 (en) 2012-12-05
CA2766056A1 (en) 2011-01-06
JP2012532127A (ja) 2012-12-13
WO2011002623A1 (en) 2011-01-06
US8815865B2 (en) 2014-08-26
US20120108600A1 (en) 2012-05-03
AU2010266558A1 (en) 2012-01-12

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Legal Events

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HC Change of company name or juridical status
FG Grant or registration