CL2009000639A1 - Pirimidinas-5-acarboxamidas sustituidas; la composicion farmceutica que la contiene; y sus usos. - Google Patents
Pirimidinas-5-acarboxamidas sustituidas; la composicion farmceutica que la contiene; y sus usos.Info
- Publication number
- CL2009000639A1 CL2009000639A1 CL2009000639A CL2009000639A CL2009000639A1 CL 2009000639 A1 CL2009000639 A1 CL 2009000639A1 CL 2009000639 A CL2009000639 A CL 2009000639A CL 2009000639 A CL2009000639 A CL 2009000639A CL 2009000639 A1 CL2009000639 A1 CL 2009000639A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical composition
- acarboxamides
- substituted pyrimidines
- compounds
- prolylhydrolases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de pirimidina-5-carboxamidas sustituidas o una sal o solvato farmacéuticamente aceptable de éstas, composición farmacéutica que comprende a uno de estos compuestos y su uso para prevenir o tratar afecciones mediadas por las prolilhidrolasas de hif, como anemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6986408P | 2008-03-18 | 2008-03-18 | |
US19291808P | 2008-09-23 | 2008-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000639A1 true CL2009000639A1 (es) | 2009-07-17 |
Family
ID=40627533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000639A CL2009000639A1 (es) | 2008-03-18 | 2009-03-17 | Pirimidinas-5-acarboxamidas sustituidas; la composicion farmceutica que la contiene; y sus usos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US8278304B2 (es) |
EP (1) | EP2257539B1 (es) |
JP (1) | JP5557832B2 (es) |
CN (1) | CN102036981B (es) |
AR (1) | AR070925A1 (es) |
AU (1) | AU2009225869B2 (es) |
CA (1) | CA2718528C (es) |
CL (1) | CL2009000639A1 (es) |
ES (1) | ES2524883T3 (es) |
MX (1) | MX2010010209A (es) |
PE (1) | PE20091627A1 (es) |
TW (1) | TW200944511A (es) |
WO (1) | WO2009117269A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2294066B9 (en) | 2008-04-28 | 2015-03-11 | Janssen Pharmaceutica, N.V. | Benzoimidazoles as prolyl hydroxylase inhibitors |
MX2011000460A (es) * | 2008-07-18 | 2011-03-15 | Takeda Pharmaceutical | Derivados de benzazepina y su uso como antagonistas de histamina h3. |
WO2010093727A1 (en) | 2009-02-10 | 2010-08-19 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
EP2448584B1 (en) * | 2009-06-30 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted 4-hydroxypyrimidine-5-carboxamides |
AU2010266558A1 (en) * | 2009-06-30 | 2012-01-12 | Merck Sharp & Dohme Corp. | Substituted 4-hydroxypyrimidine-5-carboxamides |
AR077999A1 (es) * | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
AU2010307006B2 (en) * | 2009-10-13 | 2016-08-11 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
EP2491026A1 (en) * | 2009-10-20 | 2012-08-29 | Pfizer Inc. | Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators |
JP5718236B2 (ja) | 2009-10-21 | 2015-05-13 | 第一三共株式会社 | 5−ヒドロキシピリミジン−4−カルボキサミド誘導体 |
UY33172A (es) * | 2010-01-08 | 2011-07-29 | Takeda Pharmaceutical | Derivados de benzazepina y su uso como antagonistas de histamina h3 |
EP2560655B1 (en) | 2010-04-21 | 2016-08-24 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
WO2012021830A1 (en) | 2010-08-13 | 2012-02-16 | Janssen Pharmaceutica Nv | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
CN106478497B (zh) | 2010-10-18 | 2020-05-08 | 拉夸里亚创药株式会社 | 作为ttx-s阻滞剂的芳胺衍生物 |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
CA2839703A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
US8710043B2 (en) * | 2011-06-24 | 2014-04-29 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
US9309237B2 (en) | 2011-09-06 | 2016-04-12 | New York Blood Center, Inc. | HIV inhibitors |
EP2758058B1 (en) * | 2011-09-23 | 2017-04-26 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
EP2758059B1 (en) | 2011-09-23 | 2018-10-24 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013040789A1 (en) * | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013040790A1 (en) * | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
ES2689481T3 (es) | 2011-10-25 | 2018-11-14 | Janssen Pharmaceutica Nv | Formulaciones de sal de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico |
IN2014DN08653A (es) | 2012-03-30 | 2015-05-22 | Daiichi Sankyo Companyltd | |
CN103450194B (zh) * | 2012-06-05 | 2015-07-08 | 首都医科大学 | 四氢-β-咔啉-3-甲酰脂肪链胺、其制备、纳米结构、免疫抑制作用及应用 |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
CN105492433B (zh) * | 2013-03-29 | 2018-11-23 | 武田药品工业株式会社 | 6-(5-羟基-1h-吡唑-1-基)烟碱酰胺衍生物和其作为phd抑制剂的用途 |
CN106061963B (zh) | 2013-12-20 | 2019-10-22 | 3-V生物科学股份有限公司 | 脂质合成的杂环调节剂和其组合 |
JP2017114765A (ja) * | 2014-04-25 | 2017-06-29 | 大正製薬株式会社 | トリアゾリルで置換されたヘテロアリール化合物 |
ES2764440T3 (es) | 2014-09-19 | 2020-06-03 | New York Blood Center Inc | Fenilpirrolcarboxamidas sustituidas con actividad terapéutica en VIH |
SG11201702483QA (en) * | 2014-09-29 | 2017-04-27 | Scripps Research Inst | Sphingosine-1-phospate receptor modulators for treatment of cardiopulmonary disorders |
WO2016054804A1 (en) * | 2014-10-10 | 2016-04-14 | Merck Sharp & Dohme Corp. | Substituted pyrimidines as inhibitors of hif prolyl hydroxylase |
WO2020156571A1 (zh) * | 2019-02-02 | 2020-08-06 | 杭州华东医药集团新药研究院有限公司 | 一种哒嗪衍生物及其制备方法和医药用途 |
GB201908511D0 (en) * | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
TWI794994B (zh) * | 2020-09-25 | 2023-03-01 | 大陸商上海美悅生物科技發展有限公司 | 嘧啶甲醯胺類化合物及其應用 |
EP4263528A1 (en) | 2020-12-21 | 2023-10-25 | Intervet International B.V. | A process for the preparation of n-(bis(4-methoxyphenyl)methyl)-6-oxo-2-(pyridazin-3-yl)-1,6-dihydropyrimidine-5-carboxamide |
CN114835687B (zh) * | 2021-04-02 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂 |
TW202321211A (zh) | 2021-08-10 | 2023-06-01 | 美商艾伯維有限公司 | 菸鹼醯胺ripk1抑制劑 |
WO2023057394A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2853220A1 (de) * | 1978-12-09 | 1980-07-03 | Hoechst Ag | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
DE59305012D1 (de) * | 1992-02-22 | 1997-02-20 | Hoechst Ag | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
CA2383466C (en) * | 1999-09-16 | 2009-08-25 | Tanabe Seiyaku Co., Ltd. | Aromatic nitrogen-containing 6-membered cyclic compounds |
US7087597B1 (en) * | 1999-10-12 | 2006-08-08 | Takeda Pharmaceutical Company Limited | Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof |
US7273868B2 (en) * | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
KR100750554B1 (ko) * | 2001-02-15 | 2007-08-20 | 다나베 세이야꾸 가부시키가이샤 | 구강 내 속붕괴성 정제 |
EP1361879A1 (en) * | 2001-02-20 | 2003-11-19 | Bristol-Myers Squibb Company | 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators |
ES2285517T3 (es) * | 2003-10-31 | 2007-11-16 | Warner-Lambert Company Llc | Pirimidinas como inhibidores de fosfoinositida-3-cinasas(pi3k). |
US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
EP1931642A4 (en) * | 2005-09-15 | 2011-06-01 | Orchid Res Lab Ltd | NEW PYRIMIDINE CARBOXAMIDES |
JP2009519937A (ja) * | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用イソオキサゾリン |
ZA200806752B (en) * | 2006-01-27 | 2009-10-28 | Fibrogen Inc | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF) |
WO2007136990A2 (en) * | 2006-05-16 | 2007-11-29 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
JO2934B1 (en) * | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
KR101130592B1 (ko) * | 2006-06-26 | 2012-04-02 | 워너 칠콧 컴퍼니 엘엘씨 | 프롤릴 히드록실라제 저해제 및 사용 방법 |
JP2010502675A (ja) * | 2006-09-08 | 2010-01-28 | ノバルティス アクチエンゲゼルシャフト | リンパ球相互作用が介在する疾患または障害を処置するために有用なn−ビアリール(ヘテロ)アリールスルホンアミド誘導体 |
-
2009
- 2009-03-09 AU AU2009225869A patent/AU2009225869B2/en active Active
- 2009-03-09 WO PCT/US2009/036501 patent/WO2009117269A1/en active Application Filing
- 2009-03-09 CA CA2718528A patent/CA2718528C/en active Active
- 2009-03-09 MX MX2010010209A patent/MX2010010209A/es not_active Application Discontinuation
- 2009-03-09 JP JP2011500864A patent/JP5557832B2/ja active Active
- 2009-03-09 CN CN200980118093.5A patent/CN102036981B/zh active Active
- 2009-03-09 ES ES09722697.1T patent/ES2524883T3/es active Active
- 2009-03-09 EP EP09722697.1A patent/EP2257539B1/en active Active
- 2009-03-12 US US12/381,468 patent/US8278304B2/en active Active
- 2009-03-17 PE PE2009000390A patent/PE20091627A1/es not_active Application Discontinuation
- 2009-03-17 TW TW098108639A patent/TW200944511A/zh unknown
- 2009-03-17 AR ARP090100958A patent/AR070925A1/es unknown
- 2009-03-17 CL CL2009000639A patent/CL2009000639A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009117269A1 (en) | 2009-09-24 |
AU2009225869B2 (en) | 2014-01-23 |
CN102036981A (zh) | 2011-04-27 |
US8278304B2 (en) | 2012-10-02 |
ES2524883T3 (es) | 2014-12-15 |
AU2009225869A1 (en) | 2009-09-24 |
EP2257539A1 (en) | 2010-12-08 |
CA2718528A1 (en) | 2009-09-24 |
CN102036981B (zh) | 2015-04-08 |
EP2257539B1 (en) | 2014-09-10 |
JP5557832B2 (ja) | 2014-07-23 |
PE20091627A1 (es) | 2009-10-30 |
TW200944511A (en) | 2009-11-01 |
CA2718528C (en) | 2016-10-25 |
JP2011515402A (ja) | 2011-05-19 |
US20090239876A1 (en) | 2009-09-24 |
AR070925A1 (es) | 2010-05-12 |
MX2010010209A (es) | 2010-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2009000639A1 (es) | Pirimidinas-5-acarboxamidas sustituidas; la composicion farmceutica que la contiene; y sus usos. | |
CO2018004124A2 (es) | Compuestos heterocíclicos | |
CL2017002650A1 (es) | Compuestos novedosos | |
CL2018000542A1 (es) | Nuevos derivados de fenoximetilo. | |
CL2018003135A1 (es) | Derivados aromáticos de sulfonamida. | |
NI201600058A (es) | Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de fgfr4 | |
GT201400111A (es) | Triazolopiridinas sustituidas | |
UY36121A (es) | ?pirazolopiridinas y pirazolopirimidinas?. | |
UY36530A (es) | Métodos para purificar cannabinoides, composiciones y kits de estos | |
CL2013001338A1 (es) | Compuestos derivados de benzotieno-piridinas sustituidas, inhibidores de la replicacion del vih; composicion farmaceutica que los comprende; combinacion farmaceutica; kit farmaceutico; y su uso para el tratamiento del vih. | |
SV2011003903A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa iv para el tratamiento o prevencion de diabetes | |
GT201400230A (es) | Necleòsidos de espìrooxetano de uracilo | |
CL2016000408A1 (es) | Composiciones farmaceuticas que contienen diastereomeros macrolidos, metodos para su sintesis y usos terapeuticos. | |
CL2018000107A1 (es) | Moléculas de anticuerpo que se unen a cd79 | |
CL2012001422A1 (es) | Compuestos derivados de sulfonil benzamidas sustituidas, inductores de apoptosis con selectividad por bcl-2; composicion farmaceutica que los comprende; y su uso para el tratamiento del cancer. | |
CL2011000527A1 (es) | Compuestos derivados de benzofurano; composicion farmaceutica que los comprende;y su uso en el tratamiento de la hepatitis c. | |
CL2008003690A1 (es) | Compuestos derivados de amonobenzamida; composicion farmceutica que comprende los compuestos; y uso para controlar parasitos. | |
CL2013000304A1 (es) | Compuestos derivados de 2-arilamino-bencimidazoles inhibidores de prostaglandina e2 (mpges-1); composicion farmaceutica que los comprende; compuestos intermediarios; uso en el tratamiento de enfermedades inflamatorias y/o afecciones asociadas, en particular el dolor. | |
CL2008000789A1 (es) | Compuestos derivados de adenina; composicion farmaceutica que comprende a dichos compuestos, utiles para tratar enfermedades alergicas, virales o cancer, entre otras. | |
CL2015001279A1 (es) | Compuestos derivados de piridina, inhibidores del transportador de uratos urat 1; composicion farmaceutica que los comprende; uso para el tratamiento o prevencion de enfermedades tales como gota, hiperuricemia, hipertensión, enfermedades renales, entre otras. | |
CL2012003226A1 (es) | Compuestos derivados de 5-fluoro-1h-pirazolopiridina ; procedimiento de preparacion de estos; composicion framaceutica que los comprende; y su uso en el tratamiento de enfermedades cardiovasculares, sexuales y metabolicas. | |
CL2012002782A1 (es) | Compuestos derivados de pirazol-4-il-heterociclil-carboxamida, inhibidores de los trastornos mediados por las quinasas pim-1, pim-2 y pim-3; composición farmacéutica; mètodo de tratamiento; y su uso para el tratamiento del càncer, trastornos inmunes, enfermedades cardiovasculares e infecciones virales , entre otros. | |
CL2011000846A1 (es) | Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c. | |
CL2008002295A1 (es) | Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c. | |
CL2015003357A1 (es) | Derivados de nucleósidos 4'-fluoro-2'-metil sustituidos |