PE20091627A1 - 4-hidroxipirimidina-5-carboxamidas sustituidas - Google Patents
4-hidroxipirimidina-5-carboxamidas sustituidasInfo
- Publication number
- PE20091627A1 PE20091627A1 PE2009000390A PE2009000390A PE20091627A1 PE 20091627 A1 PE20091627 A1 PE 20091627A1 PE 2009000390 A PE2009000390 A PE 2009000390A PE 2009000390 A PE2009000390 A PE 2009000390A PE 20091627 A1 PE20091627 A1 PE 20091627A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- hydroxypyrimidine
- compounds
- phenylethyl
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 4-HIDROXIPIRIMIDINA-5-CARBOXAMIDA SUSTITUIDAS DE FORMULA (I) DONDE A ES HETEROCICLILO OPCIONALMENTE SUSTITUIDO CON R9, DONDE R9 ES OH, HALOGENO, OXO, ALQUILO(C1-C6), ENTRE OTROS; R1 ES -ALQUIL(C1-C10), -ALQUIL(C1-C10)-CICLOALQUILO(C3-C10), -ALQUENIL(C2-C10), ENTRE OTROS; R2 ES H, -ALQUIL(C1-C10), -O-ALQUILARIL(C1-C10), ARILO, ENTRE OTROS; R3 ES H, OH, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS; R4 ES H, -ALQUIL(C1-C10), -ALQUENIL(C2-C10), -CICLOALQUIL(C3-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-BROMOPIRIDIN-2-IL)-4-HIDROXI-N-(1-METIL-1-FENILETIL)PIRIMIDINA-5-CARBOXAMIDA, ACIDO 2-(4-HIDROXI-5-{[(1-METIL-1-FENILETIL)AMINO]CARBONIL}PIRIMIDIN-2-IL)ISONICOTINICO, ACIDO 6-(5-{[(4-FLUOROBENCIL)AMINO]CARBONIL}-4-HIDROXIPIRIMIDIN-2-IL)NICOTINICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROLILHIDROXILASA DEL FACTOR INDUCIBLE POR HIPOXIA (HIF) PARA POTENCIAR LA PRODUCCION ENDOGENA DE ERITROPOYETINA SIENDO UTILES PARA EL TRATAMIENTO DE ANEMIA, ISQUEMIA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6986408P | 2008-03-18 | 2008-03-18 | |
US19291808P | 2008-09-23 | 2008-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091627A1 true PE20091627A1 (es) | 2009-10-30 |
Family
ID=40627533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000390A PE20091627A1 (es) | 2008-03-18 | 2009-03-17 | 4-hidroxipirimidina-5-carboxamidas sustituidas |
Country Status (13)
Country | Link |
---|---|
US (1) | US8278304B2 (es) |
EP (1) | EP2257539B1 (es) |
JP (1) | JP5557832B2 (es) |
CN (1) | CN102036981B (es) |
AR (1) | AR070925A1 (es) |
AU (1) | AU2009225869B2 (es) |
CA (1) | CA2718528C (es) |
CL (1) | CL2009000639A1 (es) |
ES (1) | ES2524883T3 (es) |
MX (1) | MX2010010209A (es) |
PE (1) | PE20091627A1 (es) |
TW (1) | TW200944511A (es) |
WO (1) | WO2009117269A1 (es) |
Families Citing this family (40)
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PT2294066E (pt) | 2008-04-28 | 2014-11-21 | Janssen Pharmaceutica Nv | Benzoimidazoles como inibidores da prolil-hidroxilase |
CN102099339A (zh) * | 2008-07-18 | 2011-06-15 | 武田药品工业株式会社 | 苯并氮杂衍生物及其作为组胺h3拮抗剂的用途 |
WO2010093727A1 (en) | 2009-02-10 | 2010-08-19 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
US8372857B2 (en) | 2009-06-30 | 2013-02-12 | Merck Sharp & Dohme Corp. | Substituted 4-hydroxypyrimidine-5-carboxamides |
JP2012532127A (ja) | 2009-06-30 | 2012-12-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換4−ヒドロキシピリミジン−5−カルボキサミド |
AR077999A1 (es) * | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
CA2777565C (en) * | 2009-10-13 | 2019-06-18 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic diphenylamine small molecule compounds and their uses |
US20120202787A1 (en) * | 2009-10-20 | 2012-08-09 | Pfizer Inc. | Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators |
PT2492266E (pt) * | 2009-10-21 | 2015-11-18 | Daiichi Sankyo Co Ltd | Derivado de 5-hidroxipirimidino-4-carboxamida |
WO2011083314A1 (en) * | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives for the treatment of central nervous system disorders |
US9006433B2 (en) | 2010-04-21 | 2015-04-14 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
CN103068821B (zh) | 2010-08-13 | 2015-02-25 | 詹森药业有限公司 | 作为脯氨酰羟化酶抑制剂的4-氨基喹唑啉-2-基-1-吡唑-4-羧酸化合物 |
BR112013009365B1 (pt) | 2010-10-18 | 2021-10-26 | Raqualia Pharma Inc | Composto e seu uso, composição farmacêutica e processo para preparar uma composição farmacêutica |
GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
MY157429A (en) | 2011-06-24 | 2016-06-15 | Amgen Inc | Trpm8 antagonists and their use in treatments |
CA2839703A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
CA2845933C (en) | 2011-09-06 | 2020-06-09 | New York Blood Center, Inc. | Hiv inhibitors |
WO2013043621A1 (en) | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013040789A1 (en) * | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013043624A1 (en) | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
WO2013040790A1 (en) * | 2011-09-23 | 2013-03-28 | Merck Sharp & Dohme Corp. | Substituted pyrimidines |
BR112014009910B1 (pt) | 2011-10-25 | 2020-06-30 | Janssen Pharmaceutica N.V. | sal di-hidrato de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico, composição farmacêuticae pomada tópica |
ES2649905T3 (es) | 2012-03-30 | 2018-01-16 | Daiichi Sankyo Company, Limited | Derivado de ácido (2-heteroarilamino)succínico |
CN103450194B (zh) * | 2012-06-05 | 2015-07-08 | 首都医科大学 | 四氢-β-咔啉-3-甲酰脂肪链胺、其制备、纳米结构、免疫抑制作用及应用 |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
EP3336084B1 (en) * | 2013-03-29 | 2021-03-17 | Takeda Pharmaceutical Company Limited | 6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors |
JP6820097B2 (ja) | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
JP2017114765A (ja) * | 2014-04-25 | 2017-06-29 | 大正製薬株式会社 | トリアゾリルで置換されたヘテロアリール化合物 |
ES2764440T3 (es) | 2014-09-19 | 2020-06-03 | New York Blood Center Inc | Fenilpirrolcarboxamidas sustituidas con actividad terapéutica en VIH |
US10323029B2 (en) * | 2014-09-29 | 2019-06-18 | The Scripps Research Institute | Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders |
WO2016054804A1 (en) * | 2014-10-10 | 2016-04-14 | Merck Sharp & Dohme Corp. | Substituted pyrimidines as inhibitors of hif prolyl hydroxylase |
CN111349077B (zh) * | 2019-02-02 | 2022-06-28 | 杭州华东医药集团新药研究院有限公司 | 一种哒嗪衍生物及其制备方法和医药用途 |
GB201908511D0 (en) * | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
IL301556A (en) * | 2020-09-25 | 2023-05-01 | Shanghai Meiyue Biotech Dev Co Ltd | Pyrimidine carboxamide compound and its use |
EP4365162A2 (en) | 2020-12-21 | 2024-05-08 | Intervet International B.V. | A process for the preparation of n-(bis(4-methoxyphenyl)methyl)-6-oxo-2-(pyridazin-3-yl)-1,6-dihydropyrimidine-5-carboxamide |
CN114835687B (zh) * | 2021-04-02 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂 |
EP4301744A1 (en) | 2021-08-10 | 2024-01-10 | AbbVie Inc. | Nicotinamide ripk1 inhibitors |
WO2023057394A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer |
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DK0557879T3 (da) * | 1992-02-22 | 1997-06-16 | Hoechst Ag | 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse |
PT1219609E (pt) * | 1999-09-16 | 2007-06-19 | Tanabe Seiyaku Co | ''compostos cíclicos aromático azotados de seis membros'' |
EP1223170B1 (en) * | 1999-10-12 | 2005-12-28 | Takeda Pharmaceutical Company Limited | Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof |
US7273868B2 (en) * | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
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WO2002066036A1 (en) * | 2001-02-20 | 2002-08-29 | Bristol-Myers Squibb Company | 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators |
ES2285517T3 (es) * | 2003-10-31 | 2007-11-16 | Warner-Lambert Company Llc | Pirimidinas como inhibidores de fosfoinositida-3-cinasas(pi3k). |
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MX2008009581A (es) * | 2006-01-27 | 2009-01-07 | Fibrogen Inc | Compuestos de cianoisoquinolina que estabilizan el factor inducible hipoxia (fih). |
JP2009537558A (ja) * | 2006-05-16 | 2009-10-29 | スミスクライン・ビーチャム・コーポレイション | プロリルヒドロキシラーゼ阻害剤 |
AR061570A1 (es) | 2006-06-23 | 2008-09-03 | Smithkline Beecham Corp | Compuesto de glicina sustituido en el n heteroaromatico composicion farmaceutica que lo comprende, su uso para preparar un medicamento, procedimientos para preparar dicha composicion farmaceutica y para preparar el compuesto |
EP2327696A1 (en) * | 2006-06-26 | 2011-06-01 | Warner Chilcott Company, LLC | Prolyl hydroxylase inhibitors and methods of use |
EP2081888A1 (en) * | 2006-09-08 | 2009-07-29 | Novartis AG | N-biaryl (hetero) arylsulphonamide derivatives useful in the treatment of diseases mediated by lymphocytes interactions |
-
2009
- 2009-03-09 AU AU2009225869A patent/AU2009225869B2/en active Active
- 2009-03-09 ES ES09722697.1T patent/ES2524883T3/es active Active
- 2009-03-09 MX MX2010010209A patent/MX2010010209A/es not_active Application Discontinuation
- 2009-03-09 JP JP2011500864A patent/JP5557832B2/ja active Active
- 2009-03-09 CA CA2718528A patent/CA2718528C/en active Active
- 2009-03-09 EP EP09722697.1A patent/EP2257539B1/en active Active
- 2009-03-09 WO PCT/US2009/036501 patent/WO2009117269A1/en active Application Filing
- 2009-03-09 CN CN200980118093.5A patent/CN102036981B/zh active Active
- 2009-03-12 US US12/381,468 patent/US8278304B2/en active Active
- 2009-03-17 PE PE2009000390A patent/PE20091627A1/es not_active Application Discontinuation
- 2009-03-17 TW TW098108639A patent/TW200944511A/zh unknown
- 2009-03-17 CL CL2009000639A patent/CL2009000639A1/es unknown
- 2009-03-17 AR ARP090100958A patent/AR070925A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2257539A1 (en) | 2010-12-08 |
CL2009000639A1 (es) | 2009-07-17 |
CN102036981A (zh) | 2011-04-27 |
EP2257539B1 (en) | 2014-09-10 |
MX2010010209A (es) | 2010-10-05 |
JP2011515402A (ja) | 2011-05-19 |
TW200944511A (en) | 2009-11-01 |
AU2009225869B2 (en) | 2014-01-23 |
JP5557832B2 (ja) | 2014-07-23 |
WO2009117269A1 (en) | 2009-09-24 |
AR070925A1 (es) | 2010-05-12 |
CA2718528C (en) | 2016-10-25 |
CA2718528A1 (en) | 2009-09-24 |
US8278304B2 (en) | 2012-10-02 |
US20090239876A1 (en) | 2009-09-24 |
CN102036981B (zh) | 2015-04-08 |
AU2009225869A1 (en) | 2009-09-24 |
ES2524883T3 (es) | 2014-12-15 |
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Legal Events
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