PE20091627A1 - 4-hidroxipirimidina-5-carboxamidas sustituidas - Google Patents

4-hidroxipirimidina-5-carboxamidas sustituidas

Info

Publication number
PE20091627A1
PE20091627A1 PE2009000390A PE2009000390A PE20091627A1 PE 20091627 A1 PE20091627 A1 PE 20091627A1 PE 2009000390 A PE2009000390 A PE 2009000390A PE 2009000390 A PE2009000390 A PE 2009000390A PE 20091627 A1 PE20091627 A1 PE 20091627A1
Authority
PE
Peru
Prior art keywords
alkyl
hydroxypyrimidine
compounds
phenylethyl
carbonyl
Prior art date
Application number
PE2009000390A
Other languages
English (en)
Inventor
Matthew J Clements
John S Debenham
Jeffrey J Hale
Christina Madsen-Duggan
Thomas F Walsh
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20091627A1 publication Critical patent/PE20091627A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 4-HIDROXIPIRIMIDINA-5-CARBOXAMIDA SUSTITUIDAS DE FORMULA (I) DONDE A ES HETEROCICLILO OPCIONALMENTE SUSTITUIDO CON R9, DONDE R9 ES OH, HALOGENO, OXO, ALQUILO(C1-C6), ENTRE OTROS; R1 ES -ALQUIL(C1-C10), -ALQUIL(C1-C10)-CICLOALQUILO(C3-C10), -ALQUENIL(C2-C10), ENTRE OTROS; R2 ES H, -ALQUIL(C1-C10), -O-ALQUILARIL(C1-C10), ARILO, ENTRE OTROS; R3 ES H, OH, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS; R4 ES H, -ALQUIL(C1-C10), -ALQUENIL(C2-C10), -CICLOALQUIL(C3-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-BROMOPIRIDIN-2-IL)-4-HIDROXI-N-(1-METIL-1-FENILETIL)PIRIMIDINA-5-CARBOXAMIDA, ACIDO 2-(4-HIDROXI-5-{[(1-METIL-1-FENILETIL)AMINO]CARBONIL}PIRIMIDIN-2-IL)ISONICOTINICO, ACIDO 6-(5-{[(4-FLUOROBENCIL)AMINO]CARBONIL}-4-HIDROXIPIRIMIDIN-2-IL)NICOTINICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROLILHIDROXILASA DEL FACTOR INDUCIBLE POR HIPOXIA (HIF) PARA POTENCIAR LA PRODUCCION ENDOGENA DE ERITROPOYETINA SIENDO UTILES PARA EL TRATAMIENTO DE ANEMIA, ISQUEMIA
PE2009000390A 2008-03-18 2009-03-17 4-hidroxipirimidina-5-carboxamidas sustituidas PE20091627A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6986408P 2008-03-18 2008-03-18
US19291808P 2008-09-23 2008-09-23

Publications (1)

Publication Number Publication Date
PE20091627A1 true PE20091627A1 (es) 2009-10-30

Family

ID=40627533

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000390A PE20091627A1 (es) 2008-03-18 2009-03-17 4-hidroxipirimidina-5-carboxamidas sustituidas

Country Status (13)

Country Link
US (1) US8278304B2 (es)
EP (1) EP2257539B1 (es)
JP (1) JP5557832B2 (es)
CN (1) CN102036981B (es)
AR (1) AR070925A1 (es)
AU (1) AU2009225869B2 (es)
CA (1) CA2718528C (es)
CL (1) CL2009000639A1 (es)
ES (1) ES2524883T3 (es)
MX (1) MX2010010209A (es)
PE (1) PE20091627A1 (es)
TW (1) TW200944511A (es)
WO (1) WO2009117269A1 (es)

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Also Published As

Publication number Publication date
CL2009000639A1 (es) 2009-07-17
AU2009225869A1 (en) 2009-09-24
CN102036981B (zh) 2015-04-08
ES2524883T3 (es) 2014-12-15
AU2009225869B2 (en) 2014-01-23
EP2257539A1 (en) 2010-12-08
AR070925A1 (es) 2010-05-12
US20090239876A1 (en) 2009-09-24
CA2718528C (en) 2016-10-25
CA2718528A1 (en) 2009-09-24
EP2257539B1 (en) 2014-09-10
JP5557832B2 (ja) 2014-07-23
CN102036981A (zh) 2011-04-27
MX2010010209A (es) 2010-10-05
JP2011515402A (ja) 2011-05-19
US8278304B2 (en) 2012-10-02
WO2009117269A1 (en) 2009-09-24
TW200944511A (en) 2009-11-01

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