AU4534593A - Compositions and methods for enhanced drug delivery - Google Patents
Compositions and methods for enhanced drug deliveryInfo
- Publication number
- AU4534593A AU4534593A AU45345/93A AU4534593A AU4534593A AU 4534593 A AU4534593 A AU 4534593A AU 45345/93 A AU45345/93 A AU 45345/93A AU 4534593 A AU4534593 A AU 4534593A AU 4534593 A AU4534593 A AU 4534593A
- Authority
- AU
- Australia
- Prior art keywords
- compositions
- methods
- drug delivery
- enhanced drug
- enhanced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89821992A | 1992-06-12 | 1992-06-12 | |
US898219 | 1992-06-12 | ||
US946393A | 1993-01-27 | 1993-01-27 | |
US009463 | 1993-01-27 | ||
PCT/US1993/005631 WO1993025197A1 (en) | 1992-06-12 | 1993-06-11 | Compositions and methods for enhanced drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
AU4534593A true AU4534593A (en) | 1994-01-04 |
Family
ID=26679515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU45345/93A Abandoned AU4534593A (en) | 1992-06-12 | 1993-06-11 | Compositions and methods for enhanced drug delivery |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0647133A4 (en) |
AU (1) | AU4534593A (en) |
WO (1) | WO1993025197A1 (en) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
US6610841B1 (en) | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
DK0688333T3 (en) * | 1993-03-10 | 1999-02-08 | Magainin Pharma | Steroid derivatives, pharmaceutical compositions containing them and their use as antibiotics or disinfectants |
US5505715A (en) * | 1994-02-25 | 1996-04-09 | Bristol-Myers Squibb Company | Iontophoretic transdermal delivery of deoxyspergualin compounds |
US6468981B1 (en) | 1994-07-29 | 2002-10-22 | Emory University | Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors |
US5840740A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds and a method of treating infection using the aminosterol compounds |
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
FR2727117A1 (en) * | 1994-11-18 | 1996-05-24 | Geffard Michel | USE OF POLYLYSIN CONJUGATES FOR THE PREPARATION OF MEDICAMENTS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES AND DEGENERATIVE DISORDERS OF AUTOIMMUN CHARACTER |
NZ302723A (en) † | 1995-03-02 | 1998-04-27 | Scherer Ltd R P | Composition comprising monoamine oxidase b inhibitor and a carrier formulated for pre-gastric absorption of the monoamine oxidase b inhibitor |
US8071737B2 (en) | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
US5747453A (en) * | 1995-06-06 | 1998-05-05 | Alza Corporation | Method for increasing the electrotransport flux of polypeptides |
IT1285405B1 (en) * | 1995-06-06 | 1998-06-03 | Alza Corp | MODIFICATION OF POLYPEPTIDE DRUGS TO INCREASE FLOW BY ELECTROTRANSPORT. |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US5763430A (en) * | 1995-06-07 | 1998-06-09 | Magainin Pharmaceuticals Inc. | Method of treating a viral infection by administering a steroid compound |
US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
US5840936A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) |
US5795885A (en) * | 1995-06-07 | 1998-08-18 | Magainin Pharmaceuticals Inc. | Method of inhibiting profileration of cells by administering an aminosterol compound |
US5874597A (en) * | 1995-06-07 | 1999-02-23 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
IT1283955B1 (en) * | 1996-03-20 | 1998-05-07 | Sigma Tau Ind Farmaceuti | BIS ALCANOIL ESTERS OF CARNITINE WITH ANTIBACTERIAL, ANTIMICOTIC AND ANTIPROTZOARY ACTIVITY. |
WO1997040835A1 (en) * | 1996-04-26 | 1997-11-06 | Magainin Pharmaceuticals Inc. | Treatment of carcinomas using squalamine in combination with other anti-cancer agents |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
US6333189B1 (en) | 1996-06-06 | 2001-12-25 | Alza Corporation | Method of making an electrotransport device |
US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
IT1299266B1 (en) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | REVERSIBLE CARNITINE PALMITOIL INHIBITORS TRANSFERRED |
DE60123939T2 (en) | 2000-04-12 | 2007-05-31 | Genaera Corp. | A PROCESS FOR THE PREPARATION OF 7.ALPHA.-HYDROXY 3-AMINO-SUBSTITUTED STEROL COMPOUNDS, WITHOUT PROTECTION OF THE 7.ALPHA.-HYDROXY GROUP |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US6833140B2 (en) | 2001-06-11 | 2004-12-21 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
GB0116047D0 (en) * | 2001-06-29 | 2001-08-22 | Implyx Ltd | Peptide motif for therapy |
DE10303669A1 (en) * | 2003-01-28 | 2004-07-29 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | New quaternary ammonioalkyl carbonate esters useful for treating bacterial and fungal infections and potentially useful for regulating cholesterol biosynthesis |
CN101068538A (en) | 2004-11-04 | 2007-11-07 | 什诺波特有限公司 | Gaba analog prodrug sustained release oral dosage forms |
JP5227593B2 (en) * | 2005-02-04 | 2013-07-03 | アメリカ合衆国 | Nandrolone 17β-carbonate |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US7531572B2 (en) | 2006-07-28 | 2009-05-12 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
CN101522692A (en) * | 2006-10-11 | 2009-09-02 | 于崇曦 | Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate |
ES2607901T3 (en) | 2007-01-31 | 2017-04-04 | Chongxi Yu | Water-soluble prodrugs positively charged with 1H-imidazo [4,5-c] quinolin-4-amines and compounds related to very high skin penetration rats |
JP5276020B2 (en) * | 2007-02-13 | 2013-08-28 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | Cationic estradiol derivative, synthesis method thereof, and pharmaceutical composition |
RU2509076C2 (en) | 2007-06-04 | 2014-03-10 | Текфилдз Инк | Prodrugs of nonsteroid anti-inflammatory agents (nsaia) with very high speed of penetration through skin and membranes, and new medical applications of above said prodrugs |
EP2219587A4 (en) * | 2007-11-14 | 2012-11-21 | Univ California | Sterol-modified amphiphilic lipids |
KR101753296B1 (en) | 2008-12-04 | 2017-07-03 | 충시 위 | High Penetration Compositions and Their Applications |
WO2010151711A1 (en) | 2009-06-25 | 2010-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
EP2445502B2 (en) | 2009-06-25 | 2022-09-28 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
CA2786465C (en) | 2010-01-15 | 2018-09-25 | Suzhou Neupharma Co., Ltd. | Bufalin derivatives for the treatment of cancer |
JP5848761B2 (en) | 2010-06-24 | 2016-01-27 | アルカーメス ファーマ アイルランド リミテッド | Prodrugs of NH acidic compounds: derivatives of esters, carbonates, carbamates and phosphonates |
WO2012027957A1 (en) | 2010-08-28 | 2012-03-08 | Suzhou Neupharma Co., Ltd. | Bufalin derivatives, pharmaceutical compositions and use thereof |
EP2670763B1 (en) * | 2011-02-02 | 2018-08-01 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
EP3156056B1 (en) | 2011-03-18 | 2023-12-06 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
CN103607888A (en) * | 2011-04-08 | 2014-02-26 | 斯法尔制药私人有限公司 | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
EP2790734B1 (en) | 2011-12-15 | 2019-02-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
WO2013142205A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising benzyl alcohol |
NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
JP6219918B2 (en) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | Pharmaceutical composition comprising glycerol ester |
EP3453713B1 (en) | 2012-04-29 | 2021-09-08 | Neupharma, Inc. | Bufadienolide compounds substituted in position 3 by an amine group for use in the treatment of cancer |
JP6654042B2 (en) | 2012-09-19 | 2020-02-26 | アルカームス ファーマ アイルランド リミテッド | Pharmaceutical composition with improved storage stability |
CN103896791B (en) * | 2012-12-25 | 2016-12-28 | 广东隆赋药业股份有限公司 | The preparation method of acetyl levocarnitine hydrochlorate |
GB201308363D0 (en) | 2013-05-09 | 2013-06-19 | Bagshawe Kenneth D | Tumour therapy |
CA2943213C (en) | 2014-03-20 | 2022-07-05 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
CN104151452B (en) * | 2014-07-16 | 2017-02-01 | 西北大学 | Poly(N-(2-hydroxypropyl)methacrylamide)-lonidamine macromolecular prodrug and preparation method thereof |
US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
CN115851076B (en) * | 2022-12-21 | 2023-10-31 | 湖北航天化学技术研究所 | Graphene zinc-containing antirust paint and preparation method thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3023206A1 (en) * | 1979-11-02 | 1982-01-14 | Efeka Friedrich & Kaufmann GmbH & Co KG, 3000 Hannover | Antiinflammatory indomethacin di:alkylamino-ethyl ester derivs. - prepd. by heating indomethacin with an O-di:alkyl:aminoethyl-N,N'-di:isopropyl isourea in benzene |
US4386026A (en) * | 1981-04-20 | 1983-05-31 | Merck & Co., Inc. | Cell-specific glycopeptide ligands |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US4866040A (en) * | 1986-01-06 | 1989-09-12 | Alfred Stracher | Aminocarnitine directed pharmaceutical agents |
US5042975A (en) * | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
JPS6452742A (en) * | 1987-04-27 | 1989-02-28 | Syntex Pharma Int | Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory |
US5085749A (en) * | 1989-03-14 | 1992-02-04 | Massachusetts Institute Of Technology | Dynamically controlled membrane |
CA2072360A1 (en) * | 1989-12-26 | 1991-06-27 | Abraham J. Domb | Prodrug anhydride compositions |
-
1993
- 1993-06-11 WO PCT/US1993/005631 patent/WO1993025197A1/en not_active Application Discontinuation
- 1993-06-11 EP EP93915319A patent/EP0647133A4/en not_active Withdrawn
- 1993-06-11 AU AU45345/93A patent/AU4534593A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0647133A4 (en) | 1997-10-29 |
WO1993025197A1 (en) | 1993-12-23 |
EP0647133A1 (en) | 1995-04-12 |
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