GB2271059B - Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives. - Google Patents

Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives.

Info

Publication number
GB2271059B
GB2271059B GB9319500A GB9319500A GB2271059B GB 2271059 B GB2271059 B GB 2271059B GB 9319500 A GB9319500 A GB 9319500A GB 9319500 A GB9319500 A GB 9319500A GB 2271059 B GB2271059 B GB 2271059B
Authority
GB
United Kingdom
Prior art keywords
derivatives
aconitane
tetrahydroprotoberberine
pharmaceutical compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9319500A
Other versions
GB2271059A (en
GB9319500D0 (en
Inventor
Yueqian Qu
Peng Qu
Ming Qu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB9319500D0 publication Critical patent/GB9319500D0/en
Publication of GB2271059A publication Critical patent/GB2271059A/en
Application granted granted Critical
Publication of GB2271059B publication Critical patent/GB2271059B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB9319500A 1992-09-23 1993-09-21 Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives. Expired - Fee Related GB2271059B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN92112022 1992-09-23
CN93106028A CN1042895C (en) 1992-09-23 1993-05-27 Medicines composition and its method for treating drop syndrome and de-addiction of drugaddict

Publications (3)

Publication Number Publication Date
GB9319500D0 GB9319500D0 (en) 1993-11-03
GB2271059A GB2271059A (en) 1994-04-06
GB2271059B true GB2271059B (en) 1996-09-18

Family

ID=25742810

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9319500A Expired - Fee Related GB2271059B (en) 1992-09-23 1993-09-21 Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives.

Country Status (2)

Country Link
CN (1) CN1042895C (en)
GB (1) GB2271059B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547956A (en) * 1991-07-18 1996-08-20 Yueqian Qu Pharmaceutical composition and the method for treating drug addicts' withdrawal syndromes and detoxifying addicts by the same
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
EP1009407B1 (en) 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
CN1116040C (en) * 2000-01-19 2003-07-30 曲日谦 Medicinal composition and its antalgic purpose
CN100443083C (en) * 2005-03-25 2008-12-17 成都高新区智爽天然产物科技有限责任公司 Use of aconine in medicine manufacture
CN1875968B (en) * 2005-06-08 2010-05-05 郑萍 Application of anisodamine in preparation of smoking-stopping medicament
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
MX2013000733A (en) 2010-07-23 2013-05-30 Demerx Inc Noribogaine compositions.
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
CN102796096B (en) * 2011-05-27 2016-09-14 中国科学院上海药物研究所 Hexahydro dibenzo [a, g] quinolizine compounds, its preparation method, pharmaceutical composition and application thereof
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EP2788003A4 (en) 2011-12-09 2015-05-27 Demerx Inc Phosphate esters of noribogaine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
AU2013212139A1 (en) 2012-01-25 2014-06-26 Demerx, Inc. Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
JP2016508979A (en) 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド Substituted norbogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9345711B2 (en) 2014-02-18 2016-05-24 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
WO2015195673A2 (en) 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
CN110478350A (en) * 2018-07-27 2019-11-22 上海品姗医药咨询有限公司 The application of bulleyaconitine A and its derivative in the preparation inhibition addicted drug of drug

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2053680A (en) * 1979-06-14 1981-02-11 Osaka Chem Lab Aconite root extract
FR2551975A1 (en) * 1983-09-01 1985-03-22 Inst Khim Rastitelnykh Lappaconitine-based medicinal product with antiarrhythmic action

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2053680A (en) * 1979-06-14 1981-02-11 Osaka Chem Lab Aconite root extract
FR2551975A1 (en) * 1983-09-01 1985-03-22 Inst Khim Rastitelnykh Lappaconitine-based medicinal product with antiarrhythmic action

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts 100:44910j & Yaoxue Xuebao,18(8),579-584 (1983) *
Chemical Abstracts 108:81923b & Huaxue Xuebao,45(11),1101-6 (1987) *
Chemical Abstracts 112: 210839n & Zhongguo Yaoli Xuebao 11(1),14-18 (1990) *
Chemical Abstracts 112:172216x & Zhongguo Yaoli Xuebao 11(2),107-112 (1990) *
Chemical Abstracts 78:92484x & Farmakol.Alkaloidov Serdechnykh Glikozidov,202-7 (1971) *
Chemical Abstracts 89:140208m & Farmakol Rastit.Veshchestv, 76-91 (1976) *
The Merck Index,11th Edn.(1989) page 18 entry No.110 "Aconine". *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs

Also Published As

Publication number Publication date
CN1087516A (en) 1994-06-08
GB2271059A (en) 1994-04-06
CN1042895C (en) 1999-04-14
GB9319500D0 (en) 1993-11-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20040921