JPS55127371A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS55127371A
JPS55127371A JP1726480A JP1726480A JPS55127371A JP S55127371 A JPS55127371 A JP S55127371A JP 1726480 A JP1726480 A JP 1726480A JP 1726480 A JP1726480 A JP 1726480A JP S55127371 A JPS55127371 A JP S55127371A
Authority
JP
Japan
Prior art keywords
alkyl
compound
carbostyril derivative
halogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1726480A
Other languages
Japanese (ja)
Other versions
JPS6332069B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP1726480A priority Critical patent/JPS55127371A/en
Publication of JPS55127371A publication Critical patent/JPS55127371A/en
Publication of JPS6332069B2 publication Critical patent/JPS6332069B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A carbostyril derivative of formula I or its acid addition salt [R is H or formula II (R3 is H, OH, alkyl, etc.; R4 is H or alkyl; R5 is cycloalkyl, alkanoyl, phenyl, etc.; l, m are 0W6; r is 2 or 3; x is halogen); n is 0W2; R1 is H, alkyl, alkenyl, etc.; R2 is H, alkyl, phenyl or II; provided that one of R and R2 is II].
EXAMPLE: 5-[2-Hydroxy-3-(4-phenylpiperazinyl)propoxy]-3,4-dihydrocarbostyril.
USE: Antihistaminic agent. Adjuvant remedy for general anaphylaxis. Diagnostic for determining gastric juice secretion ability.
PROCESS: A compound I wherein R is II is prepared, e.g. by reacting a compound III (R2' is H, alkyl, etc.; R6 is H, alkyl, etc.; X1 is halogen, etc.) with a compound IV.
COPYRIGHT: (C)1980,JPO&Japio
JP1726480A 1980-02-14 1980-02-14 Carbostyril derivative Granted JPS55127371A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1726480A JPS55127371A (en) 1980-02-14 1980-02-14 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1726480A JPS55127371A (en) 1980-02-14 1980-02-14 Carbostyril derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP3248679A Division JPS55124766A (en) 1979-03-20 1979-03-20 Antihistaminic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP26694487A Division JPS63119467A (en) 1987-10-21 1987-10-21 Carbostyryl derivative

Publications (2)

Publication Number Publication Date
JPS55127371A true JPS55127371A (en) 1980-10-02
JPS6332069B2 JPS6332069B2 (en) 1988-06-28

Family

ID=11939102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1726480A Granted JPS55127371A (en) 1980-02-14 1980-02-14 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS55127371A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55162774A (en) * 1979-06-06 1980-12-18 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57193461A (en) * 1981-05-22 1982-11-27 Otsuka Pharmaceut Co Ltd Benzazepine derivative
JPS63290821A (en) * 1987-05-25 1988-11-28 Otsuka Pharmaceut Co Ltd Antiarrhythmic
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
WO1995011239A1 (en) * 1993-10-22 1995-04-27 Santen Pharmaceutical Co., Ltd. Novel phenoxyalkylpiperazine derivative
JPH07252153A (en) * 1995-01-25 1995-10-03 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPH1045717A (en) * 1988-10-31 1998-02-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative
US9089567B2 (en) 2001-01-29 2015-07-28 Otsuka Pharmaceutical Co., Ltd. Method of treating cognitive impairments and schizophrenias
US9359302B2 (en) 2001-09-25 2016-06-07 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
US20190031685A1 (en) * 2012-05-09 2019-01-31 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6223750A (en) * 1985-07-24 1987-01-31 今井　和男 Reinforced wood

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6223750A (en) * 1985-07-24 1987-01-31 今井　和男 Reinforced wood

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55162774A (en) * 1979-06-06 1980-12-18 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57193461A (en) * 1981-05-22 1982-11-27 Otsuka Pharmaceut Co Ltd Benzazepine derivative
JPS63290821A (en) * 1987-05-25 1988-11-28 Otsuka Pharmaceut Co Ltd Antiarrhythmic
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
JPH1045717A (en) * 1988-10-31 1998-02-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative
WO1995011239A1 (en) * 1993-10-22 1995-04-27 Santen Pharmaceutical Co., Ltd. Novel phenoxyalkylpiperazine derivative
JPH07252153A (en) * 1995-01-25 1995-10-03 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
US9089567B2 (en) 2001-01-29 2015-07-28 Otsuka Pharmaceutical Co., Ltd. Method of treating cognitive impairments and schizophrenias
US9387207B2 (en) 2001-01-29 2016-07-12 Otsuka Pharmaceutical Co., Ltd. 5-HT1A receptor subtype agonist
US9359302B2 (en) 2001-09-25 2016-06-07 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
US10150735B2 (en) 2001-09-25 2018-12-11 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
US20190031685A1 (en) * 2012-05-09 2019-01-31 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Also Published As

Publication number Publication date
JPS6332069B2 (en) 1988-06-28

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