JPS5643280A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5643280A
JPS5643280A JP12045279A JP12045279A JPS5643280A JP S5643280 A JPS5643280 A JP S5643280A JP 12045279 A JP12045279 A JP 12045279A JP 12045279 A JP12045279 A JP 12045279A JP S5643280 A JPS5643280 A JP S5643280A
Authority
JP
Japan
Prior art keywords
formula
compound shown
halogen
phenyl
antihistaminic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12045279A
Other languages
Japanese (ja)
Other versions
JPS6320233B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12045279A priority Critical patent/JPS5643280A/en
Priority to DE19803034237 priority patent/DE3034237A1/en
Priority to AU62381/80A priority patent/AU518144B2/en
Priority to FR8019708A priority patent/FR2465732A1/en
Priority to ZA00805693A priority patent/ZA805693B/en
Priority to SU802982853A priority patent/SU1091857A3/en
Priority to FI802905A priority patent/FI76322C/en
Priority to DK394080A priority patent/DK158984C/en
Priority to NO802762A priority patent/NO154841C/en
Priority to CA000360402A priority patent/CA1151172A/en
Priority to BE0/202126A priority patent/BE885264A/en
Priority to NLAANVRAGE8005188,A priority patent/NL187912C/en
Priority to SE8006498A priority patent/SE439632B/en
Priority to AT0465780A priority patent/AT376972B/en
Priority to CH694080A priority patent/CH645892A5/en
Priority to AR282565A priority patent/AR230280A1/en
Priority to PT71810A priority patent/PT71810B/en
Priority to MX809034U priority patent/MX6806E/en
Priority to ES495163A priority patent/ES495163A0/en
Priority to IT68445/80A priority patent/IT1129263B/en
Priority to GB8030207A priority patent/GB2063869B/en
Publication of JPS5643280A publication Critical patent/JPS5643280A/en
Priority to US06/357,769 priority patent/US4482560A/en
Priority to AR289431A priority patent/AR230059A1/en
Priority to AT68884A priority patent/AT376973B/en
Publication of JPS6320233B2 publication Critical patent/JPS6320233B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Abstract

NEW MATERIAL:A compound shown by the formula I (R1 is H, lower alkenyl, lower alkynyl, etc.; R2 is H, lower alkyl, or phenyl; R3 is phenyl or lower alkyl having phenyl as a substituent; X is halogen; Y is lower alkylene; n is 0W2; dotted line is single or double bond).
EXAMPLE: 5-[2-Hydroxy-3-(4-phenylpiperidinyl)propoxy]-3,4-dihydrocarbostyril.
USE: An antihistaminic having antihistaminic action and inhibition of central nervous system.
PROCESS: A compound shown by the formula II (X1 is halogen) is reacted with a piperidine derivative shown by the formula III in the absence of a solvent or in an inert solvent (e.g., dioxane, THF, etc.) at room temperature to 200°C, preferably 60W120°C, to give a compound shown by the formula I. The compound shown by the formula II as a starting material is obtained by reacting a compound shown by the formula IV with a compound shown by the formula V (X2 is halogen).
COPYRIGHT: (C)1981,JPO&Japio
JP12045279A 1979-09-18 1979-09-18 Carbostyril derivative Granted JPS5643280A (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
JP12045279A JPS5643280A (en) 1979-09-18 1979-09-18 Carbostyril derivative
DE19803034237 DE3034237A1 (en) 1979-09-18 1980-09-11 CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS
AU62381/80A AU518144B2 (en) 1979-09-18 1980-09-12 Process
FR8019708A FR2465732A1 (en) 1979-09-18 1980-09-12 NOVEL CARBOSTYRILE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
ZA00805693A ZA805693B (en) 1979-09-18 1980-09-15 Carbostyril derivatives, process for producing thereof and antihistaminic agents containing the same
SU802982853A SU1091857A3 (en) 1979-09-18 1980-09-16 Process for preparing derivatives of carbostyrene or their pharmaceutically acceptable acid addition salts
FI802905A FI76322C (en) 1979-09-18 1980-09-16 Process for the preparation of novel, therapeutically useful carboxylic acid derivatives
AT0465780A AT376972B (en) 1979-09-18 1980-09-17 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND ACID ADDITIONAL SALTS AND QUATERNAUS SALTS HIEVON AND THEIR OPTICAL ISOMERS
PT71810A PT71810B (en) 1979-09-18 1980-09-17 Carbostyril derivatives process for producing thereof and antihistaminic agents containing the same
CA000360402A CA1151172A (en) 1979-09-18 1980-09-17 3-piperidinopropoxy carbostyril derivatives
BE0/202126A BE885264A (en) 1979-09-18 1980-09-17 NOVEL CARBOSTYRILE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
NLAANVRAGE8005188,A NL187912C (en) 1979-09-18 1980-09-17 PHARMACEUTICAL PREPARATION CONTAINING A CARBOSTYRIL DERIVATIVE AND CARBOSTYRIL DERIVATIVE SUBSTITUTED BY A (1-PIPERIDYL) ALKOXY GROUP.
SE8006498A SE439632B (en) 1979-09-18 1980-09-17 CARBOSTYRIL DERIVATIVES, PROCEDURE FOR PREPARING IT AND ANTIHISTAMINE AGENTS
DK394080A DK158984C (en) 1979-09-18 1980-09-17 ANALOGY PROCEDURE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES
CH694080A CH645892A5 (en) 1979-09-18 1980-09-17 CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS.
AR282565A AR230280A1 (en) 1979-09-18 1980-09-17 PROCEDURE FOR OBTAINING CARBOESTIRILE DERIVATIVES AND THEIR SALTS
NO802762A NO154841C (en) 1979-09-18 1980-09-17 ANALOGUE PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE CARBO STYRIC DERIVATIVES.
MX809034U MX6806E (en) 1979-09-18 1980-09-18 PROCEDURE FOR PRODUCING CARBOESTIRILE DERIVATIVES
ES495163A ES495163A0 (en) 1979-09-18 1980-09-18 A PROCEDURE FOR THE PREPARATION OF CARBOESTIRILE DERIVATIVES.
IT68445/80A IT1129263B (en) 1979-09-18 1980-09-18 CARBOSTYRILIC DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND ANTIHISTAMINIC PRODUCTS CONTAINING SUCH DERIVATIVES
GB8030207A GB2063869B (en) 1979-09-18 1980-09-18 Carbostyril derivatives processes for their production and antihistaminic agents containing them
US06/357,769 US4482560A (en) 1979-09-18 1982-03-12 Carbostyril derivatives, and antihistaminic agents containing the same
AR289431A AR230059A1 (en) 1979-09-18 1982-05-18 PROCEDURE FOR OBTAINING DERIVATIVES OF PIPERIDIL-1-IL-ALCOXI OR HIDROXIALCOXI-CARBOESTIRILO OR 3,4-DIHIDROCARBOESTIRILO
AT68884A AT376973B (en) 1979-09-18 1984-02-29 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND ACID ADDITIONAL SALTS AND QUATERNAUS SALTS HIEVON AND THEIR OPTICAL ISOMERS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12045279A JPS5643280A (en) 1979-09-18 1979-09-18 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5643280A true JPS5643280A (en) 1981-04-21
JPS6320233B2 JPS6320233B2 (en) 1988-04-26

Family

ID=14786531

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12045279A Granted JPS5643280A (en) 1979-09-18 1979-09-18 Carbostyril derivative

Country Status (3)

Country Link
JP (1) JPS5643280A (en)
BE (1) BE885264A (en)
ZA (1) ZA805693B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60155298A (en) * 1983-12-22 1985-08-15 ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ Perfume and composition
JPH0743252U (en) * 1991-06-14 1995-08-18 タカラベルモント株式会社 Pressure compensation type flow control valve in hydraulic control system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60155298A (en) * 1983-12-22 1985-08-15 ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ Perfume and composition
JPH0357960B2 (en) * 1983-12-22 1991-09-03 Unilever Nv
JPH0743252U (en) * 1991-06-14 1995-08-18 タカラベルモント株式会社 Pressure compensation type flow control valve in hydraulic control system

Also Published As

Publication number Publication date
BE885264A (en) 1981-03-17
ZA805693B (en) 1981-09-30
JPS6320233B2 (en) 1988-04-26

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