JPS55124766A - Antihistaminic - Google Patents

Antihistaminic

Info

Publication number
JPS55124766A
JPS55124766A JP3248679A JP3248679A JPS55124766A JP S55124766 A JPS55124766 A JP S55124766A JP 3248679 A JP3248679 A JP 3248679A JP 3248679 A JP3248679 A JP 3248679A JP S55124766 A JPS55124766 A JP S55124766A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
compound shown
proviso
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3248679A
Other languages
Japanese (ja)
Other versions
JPS6331445B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP3248679A priority Critical patent/JPS55124766A/en
Publication of JPS55124766A publication Critical patent/JPS55124766A/en
Publication of JPS6331445B2 publication Critical patent/JPS6331445B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A carbostyryl derivative shown by the formula I [R is H, the formula II (R3 is H, OH, lower alkyl, etc.; R4 is H or lower alkyl; R5 is cycloalkyl, benzoyl, etc.; l and m are 0, 1W6 with the proviso that l+m is not more than 6; r is 2 or 3); X is halogen, n is 0, 1, or 2; R1 or H or lower alkyl; R2 is H, the formula II, etc.; with the proviso that either is R and R2 is necessarily the formula II] or its salt.
EXAMPLE: 5-[2-Hydroxy-3-( 4-phenylpiperazinyl ), propoxy]-3, 4-dihydrocarbostyryl
USE: Antihistaminics. Curing and prevention of an allergic disease, a curing adjuvant for anaphylaxis of whole body, and a diagnostic drug for measuring the acid secretory function of the stomach.
PROCESS: For example, a compound shown by the formula III (R2' is H, lower alkyl, etc.; R6 is H or OH, etc.; X1 is halogen, etc.) is reacted with a compound shown by the formula IV to gibe a compound shown by the formula Ia.
COPYRIGHT: (C)1980,JPO&Japio
JP3248679A 1979-03-20 1979-03-20 Antihistaminic Granted JPS55124766A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3248679A JPS55124766A (en) 1979-03-20 1979-03-20 Antihistaminic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3248679A JPS55124766A (en) 1979-03-20 1979-03-20 Antihistaminic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP1726480A Division JPS55127371A (en) 1980-02-14 1980-02-14 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS55124766A true JPS55124766A (en) 1980-09-26
JPS6331445B2 JPS6331445B2 (en) 1988-06-23

Family

ID=12360306

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3248679A Granted JPS55124766A (en) 1979-03-20 1979-03-20 Antihistaminic

Country Status (1)

Country Link
JP (1) JPS55124766A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS552693A (en) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it
EP0226441A2 (en) * 1985-12-09 1987-06-24 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
WO1995011239A1 (en) * 1993-10-22 1995-04-27 Santen Pharmaceutical Co., Ltd. Novel phenoxyalkylpiperazine derivative
JPH1045717A (en) * 1988-10-31 1998-02-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS552693A (en) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it
JPS6331465B2 (en) * 1978-06-23 1988-06-23 Boehringer Mannheim Gmbh
EP0226441A2 (en) * 1985-12-09 1987-06-24 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
US4914094A (en) * 1985-12-09 1990-04-03 Otsuka Pharmaceutical Co., Ltd. Method for treating hypoxia
EP0226441A3 (en) * 1985-12-09 1990-04-04 Otsuka Pharmaceutical Co., Ltd. Preparation of pharmaceutical compositions for the treatment of hypoxia
JPH02191256A (en) * 1988-10-31 1990-07-27 Otsuka Pharmaceut Co Ltd Carbostyryl derivative and remedy for schizophrenia containing the same
JPH1045717A (en) * 1988-10-31 1998-02-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative
WO1995011239A1 (en) * 1993-10-22 1995-04-27 Santen Pharmaceutical Co., Ltd. Novel phenoxyalkylpiperazine derivative

Also Published As

Publication number Publication date
JPS6331445B2 (en) 1988-06-23

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