GB1500043A - Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion - Google Patents
Benzimidazole derivatives their preparation and their use in affecting gastric acid secretionInfo
- Publication number
- GB1500043A GB1500043A GB6869/75A GB686975A GB1500043A GB 1500043 A GB1500043 A GB 1500043A GB 6869/75 A GB6869/75 A GB 6869/75A GB 686975 A GB686975 A GB 686975A GB 1500043 A GB1500043 A GB 1500043A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid secretion
- gastric acid
- formula
- preparation
- benzimidazole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Compounds of the formula I <IMAGE> whose radicals are specified in Patent Claim 1, are obtained by reaction of a compound of the formula IV <IMAGE> containing radicals as in Patent Claim 1, with a compound of the formula V, Z<1>-B-Het, in which B is the group -CH2- or -CH(CH3)- and Z<1> denotes a reactive, esterified hydroxyl group or -SH. The compounds of the formula I can be used for affecting gastric acid secretion of mammals, in particular humans. They are best suited for the treatment, for example, of gastric ulcers or similar disorders.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7402101A SE418966B (en) | 1974-02-18 | 1974-02-18 | ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1500043A true GB1500043A (en) | 1978-02-08 |
Family
ID=20320233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6869/75A Expired GB1500043A (en) | 1974-02-18 | 1975-02-18 | Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion |
Country Status (23)
Country | Link |
---|---|
JP (1) | JPS5924157B2 (en) |
AT (1) | AT343659B (en) |
AU (1) | AU499639B2 (en) |
BE (1) | BE825655A (en) |
CA (1) | CA1060448A (en) |
CH (1) | CH616160A5 (en) |
CS (1) | CS194715B2 (en) |
DD (1) | DD119422A5 (en) |
DE (1) | DE2504252A1 (en) |
DK (1) | DK141122B (en) |
FI (1) | FI59590C (en) |
FR (1) | FR2261007B1 (en) |
GB (1) | GB1500043A (en) |
HK (1) | HK67080A (en) |
HU (1) | HU172141B (en) |
IE (1) | IE40858B1 (en) |
LU (1) | LU71872A1 (en) |
MY (1) | MY8100208A (en) |
NL (1) | NL7501917A (en) |
NO (1) | NO142401C (en) |
SE (1) | SE418966B (en) |
SU (1) | SU795476A3 (en) |
ZA (1) | ZA75558B (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4182766A (en) * | 1977-09-19 | 1980-01-08 | Hoffmann-La Roche Inc. | Naphth[2,3-d]imidazoles |
GB2134523A (en) * | 1983-02-11 | 1984-08-15 | Haessle Ab | Novel pharmacologically active compounds |
EP0150586A2 (en) * | 1983-12-05 | 1985-08-07 | The Upjohn Company | 2-(Pyridylmethylthio)benzimidazoles and 2-(pyridylmethylsulfinyl)benzimidazoles |
EP0233284A1 (en) * | 1985-10-29 | 1987-08-26 | Haessle Ab | Pharmacological compounds. |
US4746667A (en) * | 1981-08-13 | 1988-05-24 | Aktiebolaget Hassle | Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl) pyridine |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
US5008278A (en) * | 1988-12-22 | 1991-04-16 | Aktiebolaget Hassle | Therapeutically active compound and a process for its preparation |
US5025024A (en) * | 1988-12-22 | 1991-06-18 | Aktiebolaget Hassle | Therapeutically active fluoro-substituted compound |
US5049674A (en) * | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
EP0510719A1 (en) | 1986-11-21 | 1992-10-28 | Aktiebolaget Hässle | Benzimidazole derivatives substituted with a radical group and their use for inhibiting gastric acid secretion |
US5175286A (en) * | 1988-09-20 | 1992-12-29 | Hisamitsu Pharmaceutical Co., Inc. | Dibenz[b,e]oxepin derivatives |
US5441968A (en) * | 1989-12-20 | 1995-08-15 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
LT3810B (en) | 1986-11-21 | 1996-03-25 | Haessle Ab | New benzimidazole derivatives, a process for production thereof and a pharmaceuticalcomposition containing the same |
LT3952B (en) | 1990-06-20 | 1996-05-27 | Astra Ab | Substituted benzimidazoles, process for their preparation and their pharmaceutical use |
LT3981B (en) | 1988-12-22 | 1996-06-25 | Haessle Ab | Therapeutically active substituted benzimidazole and process for its preparation |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE416649B (en) * | 1974-05-16 | 1981-01-26 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion |
JPS5364103A (en) * | 1976-09-24 | 1978-06-08 | Hitachi Ltd | Waste heat recovery boiler |
SE7804231L (en) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Gastric acid secretion |
US4343805A (en) * | 1978-12-16 | 1982-08-10 | John Wyeth & Brother Limited | Heterocyclic compounds |
CH644116A5 (en) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | IMIDAZOLE DERIVATIVES. |
DE3047388A1 (en) * | 1980-12-16 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | ISATOGEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES |
DE3216843C2 (en) * | 1982-05-05 | 1986-10-23 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | 3-Thiomethyl-pyridine derivatives, processes for their preparation and pharmaceuticals containing these compounds |
US4552886A (en) * | 1982-06-07 | 1985-11-12 | Eli Lilly And Company | Fungicidal pyridylmethyl-amines |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
US4503139A (en) * | 1983-05-09 | 1985-03-05 | Polaroid Corporation | Photographic products and processes and novel compounds |
US4767770A (en) * | 1984-06-18 | 1988-08-30 | Eli Lilly And Company | Method of inhibiting aromatase |
FR2593178B1 (en) * | 1986-01-20 | 1988-04-29 | Esteve Labor Dr | 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS. |
SE8600658D0 (en) * | 1986-02-14 | 1986-02-14 | Haessle Ab | NOVEL COMPOSITION OF MATTER |
SE8604566D0 (en) * | 1986-10-27 | 1986-10-27 | Haessle Ab | NOVEL COMPUNDS |
WO1989005643A1 (en) * | 1987-12-18 | 1989-06-29 | Pfizer Inc. | Heterocyclic-substituted quinoline-carboxylic acids |
JPH021280U (en) * | 1988-06-14 | 1990-01-08 | ||
JP2679745B2 (en) * | 1989-06-29 | 1997-11-19 | 明治製菓株式会社 | Azole derivatives and antiulcer agents containing them as active ingredients |
JPH0347053U (en) * | 1989-09-16 | 1991-04-30 | ||
ES2300599T3 (en) | 2002-03-27 | 2008-06-16 | Nycomed Gmbh | ALCOXIPIRIDINE DERIVATIVES. |
JP2006518724A (en) * | 2003-02-25 | 2006-08-17 | アルタナ ファルマ アクチエンゲゼルシャフト | Imidazo (4,5) quinoline derivatives and their use as NO-synthase inhibitors |
ATE399168T1 (en) | 2003-10-01 | 2008-07-15 | Nycomed Gmbh | IMIDAZOPYRIDINE DERIVATIVES AND THEIR USE AS INDUCIBLE NO-SYNTHASE INHIBITORS |
CN1856494A (en) * | 2003-10-01 | 2006-11-01 | 奥坦纳医药公司 | Imidazopyridine-derivatives as inducible NO-synthase inhibitors |
JP2007507463A (en) * | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | Imidazo [4,5-b] pyridine derivatives as inducible NO synthase inhibitors |
NZ546394A (en) | 2003-10-01 | 2009-08-28 | Altana Pharma Ag | Aminopyridine derivatives as inductible NO-synthase inhibitors |
KR20060092220A (en) * | 2003-10-01 | 2006-08-22 | 알타나 파마 아게 | Imidazopyridine-derivatives as inductible no-synthase inhibitors |
EP2070923A1 (en) | 2007-12-11 | 2009-06-17 | Bayer CropScience AG | Insecticide iminoheterocycles |
EP3318561B1 (en) * | 2010-05-26 | 2021-12-22 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1234058A (en) * | 1968-10-21 | 1971-06-03 |
-
1974
- 1974-02-18 SE SE7402101A patent/SE418966B/en not_active IP Right Cessation
-
1975
- 1975-01-27 ZA ZA00750558A patent/ZA75558B/en unknown
- 1975-02-01 DE DE19752504252 patent/DE2504252A1/en active Granted
- 1975-02-14 CH CH182975A patent/CH616160A5/en not_active IP Right Cessation
- 1975-02-14 DD DD184221A patent/DD119422A5/xx unknown
- 1975-02-14 DK DK54075AA patent/DK141122B/en not_active IP Right Cessation
- 1975-02-14 CS CS75987A patent/CS194715B2/en unknown
- 1975-02-14 FI FI750421A patent/FI59590C/en not_active IP Right Cessation
- 1975-02-14 AU AU78206/75A patent/AU499639B2/en not_active Expired
- 1975-02-14 SU SU752106386A patent/SU795476A3/en active
- 1975-02-17 HU HU75HE00000679A patent/HU172141B/en unknown
- 1975-02-17 IE IE307/75A patent/IE40858B1/en unknown
- 1975-02-17 FR FR7504888A patent/FR2261007B1/fr not_active Expired
- 1975-02-17 AT AT113775A patent/AT343659B/en not_active IP Right Cessation
- 1975-02-17 CA CA220,235A patent/CA1060448A/en not_active Expired
- 1975-02-18 GB GB6869/75A patent/GB1500043A/en not_active Expired
- 1975-02-18 NO NO750541A patent/NO142401C/en unknown
- 1975-02-18 NL NL7501917A patent/NL7501917A/en not_active Application Discontinuation
- 1975-02-18 JP JP50020284A patent/JPS5924157B2/en not_active Expired
- 1975-02-18 BE BE153453A patent/BE825655A/en not_active IP Right Cessation
- 1975-02-18 LU LU71872A patent/LU71872A1/xx unknown
-
1980
- 1980-11-27 HK HK670/80A patent/HK67080A/en unknown
-
1981
- 1981-12-30 MY MY208/81A patent/MY8100208A/en unknown
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4248880A (en) | 1977-09-19 | 1981-02-03 | Hoffmann-La Roche Inc. | Treatment of gastric ulcers with naphthimidazole derivatives |
US4182766A (en) * | 1977-09-19 | 1980-01-08 | Hoffmann-La Roche Inc. | Naphth[2,3-d]imidazoles |
US4746667A (en) * | 1981-08-13 | 1988-05-24 | Aktiebolaget Hassle | Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl) pyridine |
GB2134523A (en) * | 1983-02-11 | 1984-08-15 | Haessle Ab | Novel pharmacologically active compounds |
AU578891B2 (en) * | 1983-02-11 | 1988-11-10 | Aktiebolaget Hassle | Substituted 2-pyridylobenzimidazole derivatives |
EP0150586A2 (en) * | 1983-12-05 | 1985-08-07 | The Upjohn Company | 2-(Pyridylmethylthio)benzimidazoles and 2-(pyridylmethylsulfinyl)benzimidazoles |
EP0150586B1 (en) * | 1983-12-05 | 1991-05-08 | The Upjohn Company | 2-(pyridylmethylthio)benzimidazoles and 2-(pyridylmethylsulfinyl)benzimidazoles |
EP0233284B1 (en) * | 1985-10-29 | 1992-08-19 | Aktiebolaget Hässle | Pharmacological compounds |
EP0233284A1 (en) * | 1985-10-29 | 1987-08-26 | Haessle Ab | Pharmacological compounds. |
LT3810B (en) | 1986-11-21 | 1996-03-25 | Haessle Ab | New benzimidazole derivatives, a process for production thereof and a pharmaceuticalcomposition containing the same |
EP0510719A1 (en) | 1986-11-21 | 1992-10-28 | Aktiebolaget Hässle | Benzimidazole derivatives substituted with a radical group and their use for inhibiting gastric acid secretion |
US5175286A (en) * | 1988-09-20 | 1992-12-29 | Hisamitsu Pharmaceutical Co., Inc. | Dibenz[b,e]oxepin derivatives |
US5025024A (en) * | 1988-12-22 | 1991-06-18 | Aktiebolaget Hassle | Therapeutically active fluoro-substituted compound |
US5008278A (en) * | 1988-12-22 | 1991-04-16 | Aktiebolaget Hassle | Therapeutically active compound and a process for its preparation |
LT3914B (en) | 1988-12-22 | 1996-04-25 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
LT3981B (en) | 1988-12-22 | 1996-06-25 | Haessle Ab | Therapeutically active substituted benzimidazole and process for its preparation |
LT3980B (en) | 1988-12-22 | 1996-06-25 | Haessle Ab | New therapeutically active compound and a process for its preparation |
US5049674A (en) * | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US5441968A (en) * | 1989-12-20 | 1995-08-15 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
LT3809B (en) | 1989-12-20 | 1996-03-25 | Haessle Ab | Therapeutically active fluoro substituted benzimidazoles, process for their preparation as well as their use |
LT3952B (en) | 1990-06-20 | 1996-05-27 | Astra Ab | Substituted benzimidazoles, process for their preparation and their pharmaceutical use |
LT3977B (en) | 1990-06-20 | 1996-06-25 | Astra Ab | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
Also Published As
Publication number | Publication date |
---|---|
FI59590C (en) | 1981-09-10 |
AT343659B (en) | 1978-06-12 |
BE825655A (en) | 1975-08-18 |
DE2504252A1 (en) | 1975-08-21 |
DK54075A (en) | 1975-10-20 |
DE2504252C2 (en) | 1989-02-02 |
FR2261007B1 (en) | 1978-11-24 |
LU71872A1 (en) | 1975-12-09 |
IE40858L (en) | 1975-08-18 |
FI59590B (en) | 1981-05-29 |
MY8100208A (en) | 1981-12-31 |
CS194715B2 (en) | 1979-12-31 |
SE418966B (en) | 1981-07-06 |
ZA75558B (en) | 1976-01-28 |
CH616160A5 (en) | 1980-03-14 |
NO750541L (en) | 1975-08-19 |
SU795476A3 (en) | 1981-01-07 |
FR2261007A1 (en) | 1975-09-12 |
JPS50116474A (en) | 1975-09-11 |
SE7402101L (en) | 1975-08-19 |
JPS5924157B2 (en) | 1984-06-07 |
DK141122C (en) | 1980-07-07 |
AU7820675A (en) | 1976-08-19 |
HK67080A (en) | 1980-12-05 |
NO142401B (en) | 1980-05-05 |
FI750421A (en) | 1975-08-19 |
HU172141B (en) | 1978-06-28 |
IE40858B1 (en) | 1979-08-29 |
ATA113775A (en) | 1977-10-15 |
NO142401C (en) | 1980-08-13 |
CA1060448A (en) | 1979-08-14 |
NL7501917A (en) | 1975-08-20 |
DK141122B (en) | 1980-01-21 |
DD119422A5 (en) | 1976-04-20 |
AU499639B2 (en) | 1979-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |