IE40858B1 - New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion - Google Patents

New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion

Info

Publication number
IE40858B1
IE40858B1 IE307/75A IE30775A IE40858B1 IE 40858 B1 IE40858 B1 IE 40858B1 IE 307/75 A IE307/75 A IE 307/75A IE 30775 A IE30775 A IE 30775A IE 40858 B1 IE40858 B1 IE 40858B1
Authority
IE
Ireland
Prior art keywords
acid secretion
gastric acid
preparation
formula
benzimidazole derivatives
Prior art date
Application number
IE307/75A
Other versions
IE40858L (en
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IE40858L publication Critical patent/IE40858L/en
Publication of IE40858B1 publication Critical patent/IE40858B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula I <IMAGE> whose radicals are specified in Patent Claim 1, are obtained by reaction of a compound of the formula IV <IMAGE> containing radicals as in Patent Claim 1, with a compound of the formula V, Z<1>-B-Het, in which B is the group -CH2- or -CH(CH3)- and Z<1> denotes a reactive, esterified hydroxyl group or -SH. The compounds of the formula I can be used for affecting gastric acid secretion of mammals, in particular humans. They are best suited for the treatment, for example, of gastric ulcers or similar disorders. [SE7402101L]
IE307/75A 1974-02-18 1975-02-17 New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion IE40858B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7402101A SE418966B (en) 1974-02-18 1974-02-18 ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects

Publications (2)

Publication Number Publication Date
IE40858L IE40858L (en) 1975-08-18
IE40858B1 true IE40858B1 (en) 1979-08-29

Family

ID=20320233

Family Applications (1)

Application Number Title Priority Date Filing Date
IE307/75A IE40858B1 (en) 1974-02-18 1975-02-17 New benzimidazole derivatives,their preparation,and their use in affecting gastric acid secretion

Country Status (23)

Country Link
JP (1) JPS5924157B2 (en)
AT (1) AT343659B (en)
AU (1) AU499639B2 (en)
BE (1) BE825655A (en)
CA (1) CA1060448A (en)
CH (1) CH616160A5 (en)
CS (1) CS194715B2 (en)
DD (1) DD119422A5 (en)
DE (1) DE2504252A1 (en)
DK (1) DK141122B (en)
FI (1) FI59590C (en)
FR (1) FR2261007B1 (en)
GB (1) GB1500043A (en)
HK (1) HK67080A (en)
HU (1) HU172141B (en)
IE (1) IE40858B1 (en)
LU (1) LU71872A1 (en)
MY (1) MY8100208A (en)
NL (1) NL7501917A (en)
NO (1) NO142401C (en)
SE (1) SE418966B (en)
SU (1) SU795476A3 (en)
ZA (1) ZA75558B (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (en) * 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
JPS5364103A (en) * 1976-09-24 1978-06-08 Hitachi Ltd Waste heat recovery boiler
IN148930B (en) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (en) * 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
US4343805A (en) * 1978-12-16 1982-08-10 John Wyeth & Brother Limited Heterocyclic compounds
CH644116A5 (en) * 1980-08-21 1984-07-13 Hoffmann La Roche IMIDAZOLE DERIVATIVES.
DE3047388A1 (en) * 1980-12-16 1982-07-15 Basf Ag, 6700 Ludwigshafen ISATOGEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
DE3216843C2 (en) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridine derivatives, processes for their preparation and pharmaceuticals containing these compounds
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
SE8300736D0 (en) * 1983-02-11 1983-02-11 Haessle Ab NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US4503139A (en) * 1983-05-09 1985-03-05 Polaroid Corporation Photographic products and processes and novel compounds
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
US4767770A (en) * 1984-06-18 1988-08-30 Eli Lilly And Company Method of inhibiting aromatase
SE8505112D0 (en) * 1985-10-29 1985-10-29 Haessle Ab NOVEL PHARMACOLOGICAL COMPOUNDS
FR2593178B1 (en) * 1986-01-20 1988-04-29 Esteve Labor Dr 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.
SE8600658D0 (en) * 1986-02-14 1986-02-14 Haessle Ab NOVEL COMPOSITION OF MATTER
SE8604566D0 (en) * 1986-10-27 1986-10-27 Haessle Ab NOVEL COMPUNDS
SE8604998D0 (en) 1986-11-21 1986-11-21 Haessle Ab NOVEL PHARMACOLOGICAL COMPOUNDS
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH021280U (en) * 1988-06-14 1990-01-08
KR920003928B1 (en) * 1988-09-20 1992-05-18 히사미쯔세이야꾸 가부시기가이샤 NOVEL DIBENZ |b,e¨ OXEPIN DERIVATIVES
SE8804629D0 (en) 1988-12-22 1988-12-22 Ab Haessle NEW THERAPEUTICALLY ACTIVE COMPOUNDS
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804628D0 (en) 1988-12-22 1988-12-22 Ab Haessle NEW COMPOUNDS
JP2679745B2 (en) * 1989-06-29 1997-11-19 明治製菓株式会社 Azole derivatives and antiulcer agents containing them as active ingredients
JPH0347053U (en) * 1989-09-16 1991-04-30
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (en) 1990-06-20 1990-06-20 Haessle Ab NEW COMPOUNDS
PL372409A1 (en) * 2002-03-27 2005-07-25 Altana Pharma Ag Novel alkoxypyridine-derivatives
CA2516522A1 (en) * 2003-02-25 2004-09-10 Altana Pharma Ag Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors
JP2007507463A (en) * 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト Imidazo [4,5-b] pyridine derivatives as inducible NO synthase inhibitors
BRPI0414873A (en) * 2003-10-01 2006-12-12 Altana Pharma Ag imidazopyridine derivatives as inducible no-synthase inhibitors
WO2005030770A1 (en) * 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inducible no-synthase inhibitors
BRPI0415034A (en) * 2003-10-01 2006-12-12 Altana Pharma Ag aminopyridine derivatives as inducible non-synthase inhibitors
MXPA06003349A (en) * 2003-10-01 2006-06-08 Altana Pharma Ag Imidazopyridine-derivatives as inductible no-synthase inhibitors.
EP2070923A1 (en) 2007-12-11 2009-06-17 Bayer CropScience AG Insecticide iminoheterocycles
NZ603789A (en) * 2010-05-26 2015-03-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (en) * 1968-10-21 1971-06-03

Also Published As

Publication number Publication date
ATA113775A (en) 1977-10-15
IE40858L (en) 1975-08-18
SE7402101L (en) 1975-08-19
BE825655A (en) 1975-08-18
NO142401B (en) 1980-05-05
FI59590B (en) 1981-05-29
CA1060448A (en) 1979-08-14
CS194715B2 (en) 1979-12-31
DK54075A (en) 1975-10-20
DE2504252A1 (en) 1975-08-21
LU71872A1 (en) 1975-12-09
MY8100208A (en) 1981-12-31
DK141122C (en) 1980-07-07
DE2504252C2 (en) 1989-02-02
AT343659B (en) 1978-06-12
AU499639B2 (en) 1979-04-26
FI750421A (en) 1975-08-19
HU172141B (en) 1978-06-28
JPS5924157B2 (en) 1984-06-07
SU795476A3 (en) 1981-01-07
FR2261007B1 (en) 1978-11-24
NO142401C (en) 1980-08-13
FR2261007A1 (en) 1975-09-12
NO750541L (en) 1975-08-19
GB1500043A (en) 1978-02-08
AU7820675A (en) 1976-08-19
FI59590C (en) 1981-09-10
HK67080A (en) 1980-12-05
CH616160A5 (en) 1980-03-14
JPS50116474A (en) 1975-09-11
NL7501917A (en) 1975-08-20
SE418966B (en) 1981-07-06
ZA75558B (en) 1976-01-28
DD119422A5 (en) 1976-04-20
DK141122B (en) 1980-01-21

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