ATE411797T2 - Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren - Google Patents

Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren Download PDF

Info

Publication number
ATE411797T2
ATE411797T2 AT04795514T AT04795514T ATE411797T2 AT E411797 T2 ATE411797 T2 AT E411797T2 AT 04795514 T AT04795514 T AT 04795514T AT 04795514 T AT04795514 T AT 04795514T AT E411797 T2 ATE411797 T2 AT E411797T2
Authority
AT
Austria
Prior art keywords
methods
controlled release
release injectable
aripiprazole formulation
sterile controlled
Prior art date
Application number
AT04795514T
Other languages
English (en)
Inventor
Janusz W Kostanski
Takakuni Matsuda
Manoj Nerurkar
Vijay H Naringrekar
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34549292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE411797(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of ATE411797T2 publication Critical patent/ATE411797T2/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT04795514T 2003-10-23 2004-10-18 Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren ATE411797T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51361803P 2003-10-23 2003-10-23

Publications (1)

Publication Number Publication Date
ATE411797T2 true ATE411797T2 (de) 2008-11-15

Family

ID=34549292

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04795514T ATE411797T2 (de) 2003-10-23 2004-10-18 Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren

Country Status (32)

Country Link
US (12) US7807680B2 (de)
EP (1) EP1675573B2 (de)
JP (2) JP4836797B2 (de)
KR (1) KR100931784B1 (de)
CN (1) CN1870980B (de)
AR (2) AR046141A1 (de)
AT (1) ATE411797T2 (de)
AU (1) AU2004285448C1 (de)
BR (1) BRPI0415531B8 (de)
CA (1) CA2543242C (de)
CO (1) CO5690539A2 (de)
CY (2) CY1109040T1 (de)
DE (1) DE602004017342D1 (de)
DK (1) DK1675573T4 (de)
EC (2) ECSP066512A (de)
ES (1) ES2315721T5 (de)
FR (1) FR14C0039I1 (de)
GE (1) GEP20115205B (de)
IL (1) IL175072A (de)
LU (1) LU92427I2 (de)
MX (1) MXPA06004489A (de)
MY (1) MY146093A (de)
NO (2) NO334919B1 (de)
NZ (1) NZ546063A (de)
PE (1) PE20050811A1 (de)
PL (1) PL1675573T4 (de)
PT (1) PT1675573E (de)
SI (1) SI1675573T2 (de)
TW (2) TWI421101B (de)
UA (1) UA82561C2 (de)
WO (1) WO2005041937A2 (de)
ZA (1) ZA200602347B (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US20050032811A1 (en) * 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
ATE411797T2 (de) * 2003-10-23 2008-11-15 Otsuka Pharma Co Ltd Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren
EP1812397A1 (de) * 2004-11-18 2007-08-01 Synthon B.V. Verfahren zur herstellung von kristallinem aripiprazol
CA2622758A1 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
DE602006006536D1 (de) * 2006-01-05 2009-06-10 Teva Pharma Trockene Aripiprazolformulierungen
PT1808164E (pt) 2006-01-05 2009-03-17 Teva Pharma Método de granulação húmida para a preparação de composições farmacêuticas de aripiprazole
TR200604349A2 (tr) 2006-08-15 2008-03-21 NOBEL İLAÇ SANAYii VE TiCARET A.Ş. Aripiprazol içeren farmasötik bileşimler
GB0618879D0 (en) * 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
MX2009014115A (es) * 2007-06-25 2010-04-21 Otsuka Pharma Co Ltd Microesferas que tienen estructura de nucleo/corteza.
MY152789A (en) * 2007-07-31 2014-11-28 Otsuka Pharma Co Ltd Methods for producing aripiprazole suspension and freeze-dried formulation
HUE032426T2 (en) 2009-05-27 2017-09-28 Alkermes Pharma Ireland Ltd Inhibition of flake aggregation in nanoparticulate meloxicam formulations
KR101125210B1 (ko) * 2009-09-11 2012-03-19 주식회사 대웅제약 아리피프라졸-벤토나이트-ａｅａ 혼성체, 이를 함유하는 약학 조성물 및 그 제조방법
CN103284968B (zh) * 2010-04-13 2015-11-18 齐鲁制药有限公司 一种阿立哌唑组合物微晶的口腔崩解片及其制备方法
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
CN103025318B (zh) * 2010-08-24 2016-07-06 大塚制药株式会社 含有喹啉酮衍生物、和硅油和/或硅油衍生物的悬浮液和块状组合物
JP5893616B2 (ja) 2010-10-18 2016-03-23 大日本住友製薬株式会社 注射用徐放性製剤
US9757374B2 (en) * 2010-10-28 2017-09-12 Aequus Pharmaceuticals Inc. Aripiprazole compositions and methods for its transdermal delivery
BR112013010190B1 (pt) * 2010-10-28 2019-12-31 Aequus Pharmaceuticals Inc composição farmacêutica
AR083884A1 (es) * 2010-11-16 2013-03-27 Otsuka Pharma Co Ltd Jeringa prellenable de doble camara y relleno de aripiprazol en la jeringa
CN102525915B (zh) * 2010-12-14 2016-09-28 江苏豪森药业集团有限公司 一种持续释放的注射制剂及其制备方法和用途
JP5980215B2 (ja) * 2011-01-24 2016-08-31 大塚製薬株式会社 アリピプラゾールを有効成分とするケーキ状組成物が含有された医療用器具、及びアリピプラゾールを有効成分とするケーキ状組成物
BR112013023847B1 (pt) 2011-03-18 2021-02-23 Alkermes Pharma Ireland Limited composições farmacêuticas compreendendo ésteres de sorbitano e uso das mesmas
JO3410B1 (ar) 2011-06-07 2019-10-20 Otsuka Pharma Co Ltd تركيبة أريبيبرازول مجفف بالتبريد
US9241876B2 (en) * 2011-06-27 2016-01-26 Shanghai Zhongxi Pharmaceutical Corporation Aripiprazole medicament formulation and preparation method therefor
CN102850268B (zh) * 2011-06-27 2015-07-15 上海中西制药有限公司 阿立哌唑ⅰ型微晶、阿立哌唑固体制剂及制备方法
AU2013235526B2 (en) 2012-03-19 2017-11-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
AU2013235523B9 (en) 2012-03-19 2018-01-04 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
CA2867121C (en) * 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
TWI562991B (en) 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
JOP20200109A1 (ar) * 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
CN104736565B (zh) 2012-08-21 2019-03-12 詹森药业有限公司 利培酮半抗原的抗体及其用途
ES2654413T3 (es) 2012-08-21 2018-02-13 Janssen Pharmaceutica, N.V. Anticuerpos a quetiapina y uso de los mismos
ES2788716T3 (es) 2012-08-21 2020-10-22 Janssen Pharmaceutica Nv Anticuerpos para haptenos de quetiapina y uso de los mismos
CA2882490A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone and use thereof
EP3462173B1 (de) * 2012-08-21 2021-03-31 Janssen Pharmaceutica NV Antikörper gegen risperidon und verwendung davon
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
CA2910665C (en) * 2013-04-30 2018-05-22 Otsuka Pharmaceutical Co., Ltd. Oral solid preparation comprising aripiprazole and method for producing oral solid preparation comprising aripiprazole
AR096131A1 (es) 2013-04-30 2015-12-09 Otsuka Pharma Co Ltd Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
CN106132415A (zh) 2014-03-20 2016-11-16 奥克梅斯制药爱尔兰有限公司 具有增加的注射速度的阿立哌唑制剂
ES2884849T3 (es) 2014-08-18 2021-12-13 Alkermes Pharma Ireland Ltd Composiciones de profármaco de aripiprazol
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
WO2016032950A1 (en) * 2014-08-25 2016-03-03 Alkermes Pharma Ireland Limited Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia
WO2016189504A1 (en) * 2015-05-28 2016-12-01 Leiutis Pharmaceuticals Pvt Ltd Non-lyophilized compositions of aripiprazole and methods of preparation thereof
TWI584823B (zh) * 2015-08-31 2017-06-01 諾瑞特國際藥業股份有限公司 具有延長的保存期限的阿立哌唑可注射懸浮液製劑
CN106474058B (zh) 2015-08-31 2020-01-07 南京诺瑞特医药科技有限公司 具有延长的保质期的阿立哌唑可注射悬浮液制剂
JP6504019B2 (ja) * 2015-10-27 2019-04-24 豊田合成株式会社 発光装置
EP3390455A1 (de) 2015-12-17 2018-10-24 Janssen Pharmaceutica NV Antikörper gegen quetiapin und verwendung davon
CN108431040B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 利培酮的抗体及其用途
CN105663057A (zh) * 2015-12-30 2016-06-15 中国药科大学 阿立哌唑长效混悬剂及其制备方法
AU2017303975A1 (en) * 2016-07-28 2019-03-21 Mylan Laboratories Ltd, Process for preparing sterile aripiprazole formulation
EP3761983A1 (de) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Dosierstrategie für aripiprazol
CN108498456B (zh) 2018-05-16 2021-01-01 丽珠医药集团股份有限公司 一种阿立哌唑缓释微球及其制备方法
CN110327296B (zh) * 2019-08-06 2021-10-22 深圳市泛谷药业股份有限公司 一种阿立哌唑长效注射制剂及其制备方法
KR102486564B1 (ko) * 2019-08-23 2023-01-19 주식회사 대웅테라퓨틱스 니클로사마이드 지연방출 조성물 및 이의 항바이러스 용도
WO2021140424A1 (en) * 2020-01-06 2021-07-15 Shilpa Medicare Limited Fingolimod extended release injectable suspension
WO2021199076A1 (en) 2020-03-30 2021-10-07 Cipla Limited Injectable aripiprazole formulation
TWI865760B (zh) * 2020-04-01 2024-12-11 日商大塚製藥股份有限公司 阿立哌唑注射用製劑之投予方法
KR102606504B1 (ko) * 2020-04-10 2023-11-29 주식회사 대웅테라퓨틱스 니클로사마이드를 포함하는 폐고혈압의 예방 및 치료용 조성물
CN115768407A (zh) * 2020-05-21 2023-03-07 江苏先声药业有限公司 一种含依匹哌唑药物组合物及其制备方法
KR102785446B1 (ko) * 2020-09-09 2025-03-25 주식회사 대웅테라퓨틱스 니클로사마이드를 포함하는 항인플루엔자 바이러스용 조성물
CN112656761B (zh) * 2020-12-30 2023-09-08 河南合智医药科技有限公司 一种低刺激性阿立哌唑前药的油溶缓释注射制剂及其制备方法
EP4043008A1 (de) 2021-02-15 2022-08-17 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Verfahren zur herstellung einer pharmazeutischen zusammensetzung mit aripiprazol
HUP2100259A1 (hu) 2021-07-07 2023-01-28 Richter Gedeon Nyrt Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
JP2024016759A (ja) * 2022-07-26 2024-02-07 ニプロ株式会社 アリピプラゾール懸濁液の製造方法
CN115554253B (zh) * 2022-10-14 2024-03-29 浙江圣兆药物科技股份有限公司 一种平稳释药的注射用阿立哌唑冻干制剂及其制备方法
GR1010624B (el) * 2023-03-23 2024-01-30 Φαρματεν Α.Β.Ε.Ε., Φαρμακευτικο σκευασμα που περιλαμβανει αριπιπραζολη και μεθοδος για την παρασκευη αυτου
GR1010656B (el) * 2023-03-23 2024-03-21 Φαρματεν Α.Β.Ε.Ε., Φαρμακευτικο σκευασμα που περιλαμβανει εναν ατυπο αντιψυχωσικο παραγοντα και μεθοδος για την παρασκευη αυτου
AU2024263986A1 (en) 2023-04-26 2025-10-09 Otsuka Pharmaceutical Co., Ltd. Dose initiation for schizophrenia or bipolar i disorder treatment with aripiprazole

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB209551A (en) 1922-11-20 1924-01-17 William Mortimer Melmore Improvements in or relating to petrol and other cans
US4038389A (en) 1975-05-07 1977-07-26 The Upjohn Company Medroxyprogesterone acetate compositions
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
CA1209477A (en) 1981-03-26 1986-08-12 Bruce E. Haeger Composition of matter comprising a lyophilized preparation of a penicillin derivative
JPS5832899A (ja) 1981-08-18 1983-02-25 Takeda Chem Ind Ltd オキセンドロン水性懸濁剤
US4352811A (en) 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
IL68549A (en) * 1983-05-03 1988-05-31 Kit Medidont Ltd Method and instrument for measuring moisture
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JPH03212852A (ja) 1990-01-18 1991-09-18 Hitachi Electron Eng Co Ltd 記録媒体カートリッジ搬送装置における送り機構
FR2663223B1 (fr) 1990-06-14 1994-12-02 Af Aplicaciones Far Lab Forme galenique parenterale.
DE69112917T2 (de) 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
IT1244880B (it) 1990-12-11 1994-09-12 Torre A Farmaceutici Formulazioni di amminoacidi liofilizzati contenenti glutammina, loro preparazione ed uso nell'alimentazione parenterale
US6193983B1 (en) 1992-06-01 2001-02-27 The University Of Melbourne Equine herpesvirus glycoproteins
TW376319B (en) 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
CN1188171C (zh) 1994-06-02 2005-02-09 廓德伦特控股剑桥有限公司 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物
RU2082401C1 (ru) 1994-08-18 1997-06-27 Фармацевтическое акционерное общество "Ферейн" Способ получения лекарственной формы комбинированного препарата
US6165442A (en) 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
TW487572B (en) 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
PT941066E (pt) 1996-08-26 2004-03-31 Transgene Sa Complexos de lipido cationico - acido nucleico
US6297231B1 (en) 1996-10-28 2001-10-02 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
GB9705588D0 (en) * 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
WO2000006124A2 (en) 1998-07-30 2000-02-10 Point Biomedical Corporation A novel excipient for the lyophilization of aqueous suspensions of microparticles
DE19857609A1 (de) 1998-12-14 2000-06-15 Hannelore Ehrenreich Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
US6455526B1 (en) 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
US6267989B1 (en) 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
CA2382921A1 (en) 1999-12-09 2001-06-14 Syngenta Participations Ag Pyrazolecarboxamide and pyrazolethioamide as fungicide
JP2001187735A (ja) * 2000-01-05 2001-07-10 Towa Yakuhin Kk 安定なニコランジル含有粉末の製造法
US6559128B1 (en) 2000-01-21 2003-05-06 Northwestern University Inhibitors of G protein-mediated signaling, methods of making them, and uses thereof
RU2169574C1 (ru) 2000-01-27 2001-06-27 Кобатов Алексей Иванович Способ получения биопрепарата и сухой биопрепарат
WO2001058428A1 (en) 2000-02-10 2001-08-16 Alkermes Controlled Therapeutics, Inc. Method of preparing a sustained release composition
PL358272A1 (en) 2000-03-27 2004-08-09 The Scripps Research Institute Methods for inhibiting angiogenesis and tumor growth
WO2001078687A1 (en) 2000-04-18 2001-10-25 Peptron Inc. Injectable sustained release pharmaceutical composition and processes for preparing the same
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
JP2002241284A (ja) * 2001-02-16 2002-08-28 Towa Yakuhin Kk 全身投与用アルガトロバン注射液
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
CN1813699B (zh) 2001-06-14 2012-04-18 大塚制药株式会社 药物组合物
ATE381924T1 (de) 2001-09-21 2008-01-15 Egalet As Feste dispersionen mit kontrollierter freisetzung von carvedilol
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
MY138669A (en) * 2001-09-25 2009-07-31 Otsuka Pharma Co Ltd Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
ITMI20020808A1 (it) 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
CA2495864C (en) * 2002-08-20 2011-09-27 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
US7658998B2 (en) * 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
US20050032811A1 (en) 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
ATE411797T2 (de) * 2003-10-23 2008-11-15 Otsuka Pharma Co Ltd Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren
CA2543296A1 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents

Also Published As

Publication number Publication date
JP5372032B2 (ja) 2013-12-18
JP2007509148A (ja) 2007-04-12
US8030313B2 (en) 2011-10-04
TW201204413A (en) 2012-02-01
CN1870980B (zh) 2010-06-23
JP4836797B2 (ja) 2011-12-14
US20170348308A1 (en) 2017-12-07
US20140018369A1 (en) 2014-01-16
CY2014021I2 (el) 2017-03-15
EP1675573B2 (de) 2012-06-13
NO2014027I2 (no) 2014-10-27
US9763935B2 (en) 2017-09-19
ES2315721T3 (es) 2009-04-01
US20080112985A1 (en) 2008-05-15
NO20062319L (no) 2006-07-21
US20210338663A1 (en) 2021-11-04
LU92427I9 (de) 2019-01-17
RU2006109111A (ru) 2007-09-27
AU2004285448C1 (en) 2021-08-19
PL1675573T3 (pl) 2009-04-30
MY146093A (en) 2012-06-29
GEP20115205B (en) 2011-04-26
DK1675573T3 (da) 2009-01-05
SI1675573T2 (sl) 2012-08-31
WO2005041937A2 (en) 2005-05-12
KR20060118450A (ko) 2006-11-23
HK1095266A1 (zh) 2007-05-04
US20080112986A1 (en) 2008-05-15
US20240261280A1 (en) 2024-08-08
PE20050811A1 (es) 2005-09-25
AR106449A2 (es) 2018-01-17
PL1675573T5 (pl) 2012-10-31
FR14C0039I1 (fr) 2014-06-27
LU92427I2 (fr) 2014-06-11
WO2005041937A3 (en) 2006-04-06
US8952013B2 (en) 2015-02-10
ES2315721T5 (es) 2012-08-24
UA82561C2 (uk) 2008-04-25
AR046141A1 (es) 2005-11-23
ECSP12006512A (es) 2012-02-29
CY2014021I1 (el) 2014-07-02
NZ546063A (en) 2009-05-31
BRPI0415531A (pt) 2006-12-26
PT1675573E (pt) 2008-12-30
ZA200602347B (en) 2007-09-26
CO5690539A2 (es) 2006-10-31
NO2014027I1 (no) 2014-11-10
DE602004017342D1 (de) 2008-12-04
US20200061057A1 (en) 2020-02-27
AU2004285448B2 (en) 2009-06-11
US20050148597A1 (en) 2005-07-07
TWI421101B (zh) 2014-01-01
ECSP066512A (es) 2006-10-10
US20080221121A1 (en) 2008-09-11
IL175072A0 (en) 2006-08-20
US20120100190A1 (en) 2012-04-26
MXPA06004489A (es) 2006-06-20
TW200524638A (en) 2005-08-01
DK1675573T4 (da) 2012-08-06
EP1675573B1 (de) 2008-10-22
KR100931784B1 (ko) 2009-12-14
BRPI0415531B1 (pt) 2019-07-30
CA2543242C (en) 2015-04-14
ES2315721T9 (es) 2015-11-05
SI1675573T1 (sl) 2009-02-28
TWI383810B (zh) 2013-02-01
US20080107745A1 (en) 2008-05-08
BRPI0415531B8 (pt) 2021-05-25
PL1675573T4 (pl) 2016-04-29
EP1675573A2 (de) 2006-07-05
AU2004285448A1 (en) 2005-05-12
CA2543242A1 (en) 2005-05-12
CN1870980A (zh) 2006-11-29
NO334919B1 (no) 2014-07-14
US8722679B2 (en) 2014-05-13
JP2011102316A (ja) 2011-05-26
CY1109040T1 (el) 2014-07-02
US7807680B2 (en) 2010-10-05
IL175072A (en) 2015-06-30
US20150024056A1 (en) 2015-01-22
RU2342927C2 (ru) 2009-01-10

Similar Documents

Publication Publication Date Title
ATE411797T2 (de) Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren
ATE428423T1 (de) Aripiprazol-komplex-formulierung und verfahren
DE602004001515D1 (de) Absorbierende polymerzusammensetzung, medizinische artikel und verfahren
DE112005003826A5 (de) Chirurgisches Werkzeug und Verfahren
DE602004015456D1 (de) Patiententemperatur-wiederholungssystem und verfahren
ATE398455T1 (de) Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
DE602005015421D1 (de) Direktkomprimierte formulierung und verfahren
DE60325715D1 (de) Methoden und darreichungsformen zur kontrollierten freisetzung von oxykodon
FI20030647L (fi) Menetelmä ja laite ihmisen painon hallintaan
DE602005027138D1 (de) Schnappschuss-System und Verfahren
EP1893265A4 (de) Verfahren und gerät zur verbesserung der compliance von cpap-patienten
DE602004022776D1 (de) Vorrichtung mit verlängerter freisetzung und verfahren zur okularen verabreichung von adrenergen wirkstoffen
EP1824410A4 (de) Systeme und verfahren zur intraoralen arzneimittelabgabe
DE602004013567D1 (de) Datenabrufende und -übertragende vorrichtungen und verfahren
EP1951762A4 (de) Zusammensetzungen und verfahren zur verbesserten hautpflege
DE602004026552D1 (de) Verfahren, vorrichtung und system zur kommunikation mit medizinischen geräten
DE602004024642D1 (de) Vorrichtung zur verlängerten freisetzung und methode zur okularen verabreichung von carboanhydrase inhibitoren
DE602004022036D1 (de) Verfahren zur behandlung von atherosklerose, dyslipidämie und verwandten erkrankungen und pharmazeutische zusammensetzungen
ATE546994T1 (de) Steuergerät und verfahren
DE60330080D1 (de) Pin Halterung und Verfahren
DE60327856D1 (de) Zusammensetzungen und verfahren zur hautbräunung
DE602004027703D1 (de) Schwefelfreie zusammensetzung und schmiermittelzusammensetzung und verfahren davon
EP1385947A4 (de) Zusammensetzungen und verfahren zur blutungskontrolle
DE60317443D1 (de) H-Brückenvorrichtung und Verfahren
ATE459726T1 (de) Verfahren und produkte

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1675573

Country of ref document: EP