PL1675573T5 - Sterylny preparat do wstrzykiwań arypiprazolu o kontrolowanym uwalnianiu i sposób - Google Patents
Sterylny preparat do wstrzykiwań arypiprazolu o kontrolowanym uwalnianiu i sposóbInfo
- Publication number
- PL1675573T5 PL1675573T5 PL04795514T PL04795514T PL1675573T5 PL 1675573 T5 PL1675573 T5 PL 1675573T5 PL 04795514 T PL04795514 T PL 04795514T PL 04795514 T PL04795514 T PL 04795514T PL 1675573 T5 PL1675573 T5 PL 1675573T5
- Authority
- PL
- Poland
- Prior art keywords
- controlled release
- sterile injectable
- aripiprazole formulation
- release sterile
- injectable aripiprazole
- Prior art date
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title 1
- 229960004372 aripiprazole Drugs 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51361803P | 2003-10-23 | 2003-10-23 | |
| PCT/US2004/034367 WO2005041937A2 (en) | 2003-10-23 | 2004-10-18 | Controlled release sterile injectable aripiprazole formulation and method |
| EP04795514A EP1675573B2 (en) | 2003-10-23 | 2004-10-18 | Controlled release sterile injectable aripiprazole formulation and method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| PL1675573T3 PL1675573T3 (pl) | 2009-04-30 |
| PL1675573T5 true PL1675573T5 (pl) | 2012-10-31 |
| PL1675573T4 PL1675573T4 (pl) | 2016-04-29 |
Family
ID=34549292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04795514T PL1675573T4 (pl) | 2003-10-23 | 2004-10-18 | Sterylny preparat do wstrzykiwań arypiprazolu o kontrolowanym uwalnianiu i sposób |
Country Status (33)
| Country | Link |
|---|---|
| US (12) | US7807680B2 (pl) |
| EP (1) | EP1675573B2 (pl) |
| JP (2) | JP4836797B2 (pl) |
| KR (1) | KR100931784B1 (pl) |
| CN (1) | CN1870980B (pl) |
| AR (2) | AR046141A1 (pl) |
| AT (1) | ATE411797T2 (pl) |
| AU (1) | AU2004285448C1 (pl) |
| BR (1) | BRPI0415531B8 (pl) |
| CA (1) | CA2543242C (pl) |
| CO (1) | CO5690539A2 (pl) |
| CY (2) | CY1109040T1 (pl) |
| DE (1) | DE602004017342D1 (pl) |
| DK (1) | DK1675573T4 (pl) |
| EC (2) | ECSP066512A (pl) |
| ES (1) | ES2315721T5 (pl) |
| FR (1) | FR14C0039I1 (pl) |
| GE (1) | GEP20115205B (pl) |
| HK (1) | HK1095266A1 (pl) |
| IL (1) | IL175072A (pl) |
| LU (1) | LU92427I2 (pl) |
| MX (1) | MXPA06004489A (pl) |
| MY (1) | MY146093A (pl) |
| NO (2) | NO334919B1 (pl) |
| NZ (1) | NZ546063A (pl) |
| PE (1) | PE20050811A1 (pl) |
| PL (1) | PL1675573T4 (pl) |
| PT (1) | PT1675573E (pl) |
| SI (1) | SI1675573T2 (pl) |
| TW (2) | TWI383810B (pl) |
| UA (1) | UA82561C2 (pl) |
| WO (1) | WO2005041937A2 (pl) |
| ZA (1) | ZA200602347B (pl) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| US20050032811A1 (en) * | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| ZA200602347B (en) | 2003-10-23 | 2007-09-26 | Otsuka Pharma Co Ltd | Controlled release sterile injectable aripiprazole formulation and method |
| WO2006053781A1 (en) * | 2004-11-18 | 2006-05-26 | Synthon B.V. | Process of making crystalline aripiprazole |
| EP2279727A3 (en) * | 2005-09-15 | 2011-10-05 | Elan Pharma International Limited | Nanoparticulate aripiprazole formulations |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| CN101351192A (zh) | 2006-01-05 | 2009-01-21 | 特瓦制药工业有限公司 | 阿立哌唑的湿法制粒的药用组合物 |
| CA2627695A1 (en) * | 2006-01-05 | 2007-07-19 | Teva Pharmaceutical Industries Ltd. | Dry formulations of aripiprazole |
| TR200604349A2 (tr) * | 2006-08-15 | 2008-03-21 | NOBEL İLAÇ SANAYii VE TiCARET A.Ş. | Aripiprazol içeren farmasötik bileşimler |
| GB0618879D0 (en) * | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
| SG182232A1 (en) * | 2007-06-25 | 2012-07-30 | Otsuka Pharma Co Ltd | Microspheres having core/shell structure |
| UA97286C2 (ru) * | 2007-07-31 | 2012-01-25 | Оцука Фармасьютикал Ко., Лтд. | Способ изготовления суспензии арипипразола и лиофилизированного состава |
| US20100316725A1 (en) | 2009-05-27 | 2010-12-16 | Elan Pharma International Ltd. | Reduction of flake-like aggregation in nanoparticulate active agent compositions |
| KR101125210B1 (ko) * | 2009-09-11 | 2012-03-19 | 주식회사 대웅제약 | 아리피프라졸-벤토나이트-ａｅａ 혼성체, 이를 함유하는 약학 조성물 및 그 제조방법 |
| CN103284968B (zh) * | 2010-04-13 | 2015-11-18 | 齐鲁制药有限公司 | 一种阿立哌唑组合物微晶的口腔崩解片及其制备方法 |
| IL206739A (en) * | 2010-06-30 | 2016-06-30 | David Segal | An injectable drug containing silitol as an active substance |
| MY174552A (en) | 2010-08-24 | 2020-04-24 | Otsuka Pharma Co Ltd | Suspension and cake composition containing carbostyryl derivative and silicone oil and/or silicone oil derivative |
| US9469630B2 (en) | 2010-10-18 | 2016-10-18 | Sumitomo Dainippon Pharma Co., Ltd. | Sustained-release formulation for injection |
| AU2011320758B2 (en) * | 2010-10-28 | 2015-09-24 | Alpha To Omega Pharmaceutical Consultants, Inc. | Aripiprazole compositions and methods for its transdermal delivery |
| US9757374B2 (en) * | 2010-10-28 | 2017-09-12 | Aequus Pharmaceuticals Inc. | Aripiprazole compositions and methods for its transdermal delivery |
| AR083884A1 (es) * | 2010-11-16 | 2013-03-27 | Otsuka Pharma Co Ltd | Jeringa prellenable de doble camara y relleno de aripiprazol en la jeringa |
| CN102525915B (zh) * | 2010-12-14 | 2016-09-28 | 江苏豪森药业集团有限公司 | 一种持续释放的注射制剂及其制备方法和用途 |
| SG191892A1 (en) * | 2011-01-24 | 2013-08-30 | Otsuka Pharma Co Ltd | Medical device containing a cake composition comprising aripiprazole as an active ingredient, and a cake composition comprising aripiprazole as an active ingredient |
| RU2627469C2 (ru) | 2011-03-18 | 2017-08-08 | Алкермес Фарма Айэленд Лимитед | Фармацевтические композиции, содержащие водонерастворимое антипсихотическое средство и сложные эфиры сорбита |
| JO3410B1 (ar) * | 2011-06-07 | 2019-10-20 | Otsuka Pharma Co Ltd | تركيبة أريبيبرازول مجفف بالتبريد |
| CN102850268B (zh) * | 2011-06-27 | 2015-07-15 | 上海中西制药有限公司 | 阿立哌唑ⅰ型微晶、阿立哌唑固体制剂及制备方法 |
| CN102846543B (zh) * | 2011-06-27 | 2014-11-19 | 上海中西制药有限公司 | 一种阿立哌唑药物制剂及其制备方法 |
| US10004807B2 (en) | 2012-03-19 | 2018-06-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| NZ630428A (en) | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| AU2013235523B9 (en) | 2012-03-19 | 2018-01-04 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising glycerol esters |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| TWI562991B (en) | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| CN104736561B (zh) * | 2012-08-21 | 2018-06-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
| JP6339569B2 (ja) | 2012-08-21 | 2018-06-06 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンへの抗体及びその使用 |
| EP2888287A4 (en) | 2012-08-21 | 2016-04-20 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE HAPTENES AND THEIR USE |
| AU2013305907B2 (en) | 2012-08-21 | 2018-01-18 | Saladax Biomedical Inc. | Antibodies to quetiapine and use thereof |
| CA2882597C (en) * | 2012-08-21 | 2020-04-14 | Ortho-Clinical Diagnostics, Inc. | Antibodies to quetiapine haptens and use thereof |
| CN108517014A (zh) | 2012-08-21 | 2018-09-11 | 詹森药业有限公司 | 利培酮半抗原的抗体及其用途 |
| NZ748572A (en) | 2012-09-19 | 2020-07-31 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
| AR096131A1 (es) | 2013-04-30 | 2015-12-09 | Otsuka Pharma Co Ltd | Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol |
| CN105246461B (zh) * | 2013-04-30 | 2018-03-30 | 大塚制药株式会社 | 包含阿立哌唑的口服固体制剂以及用于产生包含阿立哌唑的口服固体制剂的方法 |
| US10525057B2 (en) | 2013-09-24 | 2020-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function |
| AU2015231278B2 (en) | 2014-03-20 | 2020-01-23 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| US10016415B2 (en) | 2014-08-18 | 2018-07-10 | Alkermes Pharma Ireland Limited | Aripiprazole prodrug compositions |
| SI3508196T1 (sl) | 2014-08-18 | 2021-12-31 | Alkermes Pharma Ireland Limited, | Sestavki aripiprazolnega predzdravila |
| EP3185867B1 (en) * | 2014-08-25 | 2021-01-13 | Alkermes Pharma Ireland Limited | Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia |
| WO2016189504A1 (en) * | 2015-05-28 | 2016-12-01 | Leiutis Pharmaceuticals Pvt Ltd | Non-lyophilized compositions of aripiprazole and methods of preparation thereof |
| CN106474058B (zh) | 2015-08-31 | 2020-01-07 | 南京诺瑞特医药科技有限公司 | 具有延长的保质期的阿立哌唑可注射悬浮液制剂 |
| TWI584823B (zh) * | 2015-08-31 | 2017-06-01 | 諾瑞特國際藥業股份有限公司 | 具有延長的保存期限的阿立哌唑可注射懸浮液製劑 |
| JP6504019B2 (ja) * | 2015-10-27 | 2019-04-24 | 豊田合成株式会社 | 発光装置 |
| WO2017106508A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| US10444250B2 (en) | 2015-12-17 | 2019-10-15 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| CN105663057A (zh) * | 2015-12-30 | 2016-06-15 | 中国药科大学 | 阿立哌唑长效混悬剂及其制备方法 |
| AU2017303975A1 (en) * | 2016-07-28 | 2019-03-21 | Mylan Laboratories Ltd, | Process for preparing sterile aripiprazole formulation |
| AU2019230014A1 (en) | 2018-03-05 | 2020-09-17 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN108498456B (zh) | 2018-05-16 | 2021-01-01 | 丽珠医药集团股份有限公司 | 一种阿立哌唑缓释微球及其制备方法 |
| CN110327296B (zh) * | 2019-08-06 | 2021-10-22 | 深圳市泛谷药业股份有限公司 | 一种阿立哌唑长效注射制剂及其制备方法 |
| KR102486564B1 (ko) * | 2019-08-23 | 2023-01-19 | 주식회사 대웅테라퓨틱스 | 니클로사마이드 지연방출 조성물 및 이의 항바이러스 용도 |
| WO2021199076A1 (en) | 2020-03-30 | 2021-10-07 | Cipla Limited | Injectable aripiprazole formulation |
| AU2021245713A1 (en) * | 2020-04-01 | 2022-12-01 | Otsuka Pharmaceutical Co., Ltd. | Methods for dose initiation of aripiprazole treatments |
| KR102606504B1 (ko) * | 2020-04-10 | 2023-11-29 | 주식회사 대웅테라퓨틱스 | 니클로사마이드를 포함하는 폐고혈압의 예방 및 치료용 조성물 |
| WO2021233402A1 (zh) * | 2020-05-21 | 2021-11-25 | 江苏先声药业有限公司 | 一种含依匹哌唑药物组合物及其制备方法 |
| CN112656761B (zh) * | 2020-12-30 | 2023-09-08 | 河南合智医药科技有限公司 | 一种低刺激性阿立哌唑前药的油溶缓释注射制剂及其制备方法 |
| EP4043008A1 (en) | 2021-02-15 | 2022-08-17 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Method for the preparation of a pharmaceutical composition comprising aripiprazole |
| HUP2100259A1 (hu) | 2021-07-07 | 2023-01-28 | Richter Gedeon Nyrt | Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények |
| CN115554253B (zh) * | 2022-10-14 | 2024-03-29 | 浙江圣兆药物科技股份有限公司 | 一种平稳释药的注射用阿立哌唑冻干制剂及其制备方法 |
| GR1010656B (el) * | 2023-03-23 | 2024-03-21 | Φαρματεν Α.Β.Ε.Ε., | Φαρμακευτικο σκευασμα που περιλαμβανει εναν ατυπο αντιψυχωσικο παραγοντα και μεθοδος για την παρασκευη αυτου |
| GR1010624B (el) * | 2023-03-23 | 2024-01-30 | Φαρματεν Α.Β.Ε.Ε., | Φαρμακευτικο σκευασμα που περιλαμβανει αριπιπραζολη και μεθοδος για την παρασκευη αυτου |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB209551A (en) | 1922-11-20 | 1924-01-17 | William Mortimer Melmore | Improvements in or relating to petrol and other cans |
| US4038389A (en) | 1975-05-07 | 1977-07-26 | The Upjohn Company | Medroxyprogesterone acetate compositions |
| JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| CA1209477A (en) | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| JPS5832899A (ja) * | 1981-08-18 | 1983-02-25 | Takeda Chem Ind Ltd | オキセンドロン水性懸濁剤 |
| US4352811A (en) | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
| IL68549A (en) * | 1983-05-03 | 1988-05-31 | Kit Medidont Ltd | Method and instrument for measuring moisture |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| JPH03212852A (ja) | 1990-01-18 | 1991-09-18 | Hitachi Electron Eng Co Ltd | 記録媒体カートリッジ搬送装置における送り機構 |
| FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
| JP3282731B2 (ja) * | 1990-06-15 | 2002-05-20 | メルク エンド カムパニー インコーポレーテッド | 結晶の構造および大きさを改良する結晶化方法 |
| IT1244880B (it) | 1990-12-11 | 1994-09-12 | Torre A Farmaceutici | Formulazioni di amminoacidi liofilizzati contenenti glutammina, loro preparazione ed uso nell'alimentazione parenterale |
| US6193983B1 (en) * | 1992-06-01 | 2001-02-27 | The University Of Melbourne | Equine herpesvirus glycoproteins |
| TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
| DK0729357T3 (da) | 1993-11-19 | 2005-06-06 | Janssen Pharmaceutica Nv | Mikroindkapslede 1,2-benzazoler |
| ATE235919T1 (de) | 1994-06-02 | 2003-04-15 | Elan Drug Delivery Ltd | Methode zum verhindern der aggregation von proteinen/peptiden bei rehydratation oder auftauen |
| RU2082401C1 (ru) | 1994-08-18 | 1997-06-27 | Фармацевтическое акционерное общество "Ферейн" | Способ получения лекарственной формы комбинированного препарата |
| US6165442A (en) | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
| TW487572B (en) | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| EP0941066B1 (en) | 1996-08-26 | 2003-10-29 | Transgene S.A. | Cationic lipid-nucleic acid complexes |
| US6297231B1 (en) * | 1996-10-28 | 2001-10-02 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
| GB9705588D0 (en) * | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
| UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
| AU5247599A (en) | 1998-07-30 | 2000-02-21 | Point Biomedical Corporation | A novel excipient for the lyophilization of aqueous suspensions of microparticles |
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
| US6267989B1 (en) * | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
| PL354102A1 (pl) | 1999-12-09 | 2003-12-29 | Syngenta Participations Agsyngenta Participations Ag | Fungicydy pirazolokarboksyamidowe i pirazolotioamiFungicydy pirazolokarboksyamidowe i pirazolotioamidowedowe |
| JP2001187735A (ja) * | 2000-01-05 | 2001-07-10 | Towa Yakuhin Kk | 安定なニコランジル含有粉末の製造法 |
| US6559128B1 (en) * | 2000-01-21 | 2003-05-06 | Northwestern University | Inhibitors of G protein-mediated signaling, methods of making them, and uses thereof |
| RU2169574C1 (ru) | 2000-01-27 | 2001-06-27 | Кобатов Алексей Иванович | Способ получения биопрепарата и сухой биопрепарат |
| AU2001233180A1 (en) | 2000-02-10 | 2001-08-20 | Alkermes Controlled Therapeutics, Inc. | Method of preparing a sustained release composition |
| JP2003528850A (ja) | 2000-03-27 | 2003-09-30 | ザ・スクリプス・リサーチ・インステイチユート | 血管形成および腫瘍成長の阻害 |
| EP1187602A4 (en) | 2000-04-18 | 2004-09-15 | Peptron Inc | SUSTAINABLE RELEASE INJECTABLE PHARMACEUTICAL COMPOSITION AND METHODS OF PREPARING THE SAME |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| JP2002241284A (ja) * | 2001-02-16 | 2002-08-28 | Towa Yakuhin Kk | 全身投与用アルガトロバン注射液 |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| JP2003063965A (ja) * | 2001-06-13 | 2003-03-05 | Otsuka Pharmaceut Factory Inc | 注射用シロスタゾール水性製剤 |
| MXPA03011538A (es) | 2001-06-14 | 2004-03-09 | Otsuka Pharma Co Ltd | Composicion medicinal que sustancialmente no causaria dano a la mucosa intestinal. |
| WO2003024426A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Controlled release solid dispersions |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| MY138669A (en) * | 2001-09-25 | 2009-07-31 | Otsuka Pharma Co Ltd | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| ITMI20020808A1 (it) | 2002-04-17 | 2003-10-17 | Chiesi Farma Spa | Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| WO2004006959A1 (en) * | 2002-07-16 | 2004-01-22 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
| BR0313602A (pt) * | 2002-08-20 | 2005-06-21 | Bristol Myers Squibb Co | Método e formulação de complexo de aripiprazol |
| WO2004064752A2 (en) * | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
| US20050032811A1 (en) * | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| ZA200602347B (en) | 2003-10-23 | 2007-09-26 | Otsuka Pharma Co Ltd | Controlled release sterile injectable aripiprazole formulation and method |
| WO2005041897A2 (en) | 2003-10-31 | 2005-05-12 | Point Biomedical Corporation | Reconstitutable microsphere compositions useful as ultrasonic contrast agents |
-
2004
- 2004-10-18 ZA ZA200602347A patent/ZA200602347B/en unknown
- 2004-10-18 UA UAA200604046A patent/UA82561C2/uk unknown
- 2004-10-18 AU AU2004285448A patent/AU2004285448C1/en active Active
- 2004-10-18 KR KR1020067007890A patent/KR100931784B1/ko active IP Right Grant
- 2004-10-18 NZ NZ546063A patent/NZ546063A/en unknown
- 2004-10-18 DE DE602004017342T patent/DE602004017342D1/de not_active Expired - Lifetime
- 2004-10-18 CA CA2543242A patent/CA2543242C/en not_active Expired - Lifetime
- 2004-10-18 PT PT04795514T patent/PT1675573E/pt unknown
- 2004-10-18 GE GEAP20049360A patent/GEP20115205B/en unknown
- 2004-10-18 ES ES04795514T patent/ES2315721T5/es not_active Expired - Lifetime
- 2004-10-18 CN CN2004800308144A patent/CN1870980B/zh not_active Expired - Lifetime
- 2004-10-18 PL PL04795514T patent/PL1675573T4/pl unknown
- 2004-10-18 WO PCT/US2004/034367 patent/WO2005041937A2/en active Application Filing
- 2004-10-18 BR BRPI0415531A patent/BRPI0415531B8/pt active IP Right Grant
- 2004-10-18 JP JP2006536693A patent/JP4836797B2/ja not_active Expired - Lifetime
- 2004-10-18 MX MXPA06004489A patent/MXPA06004489A/es active IP Right Grant
- 2004-10-18 AT AT04795514T patent/ATE411797T2/de active
- 2004-10-18 SI SI200430966T patent/SI1675573T2/sl unknown
- 2004-10-18 EP EP04795514A patent/EP1675573B2/en not_active Expired - Lifetime
- 2004-10-18 DK DK04795514.1T patent/DK1675573T4/da active
- 2004-10-19 US US10/968,482 patent/US7807680B2/en not_active Expired - Lifetime
- 2004-10-20 TW TW093131836A patent/TWI383810B/zh active
- 2004-10-20 TW TW100136057A patent/TWI421101B/zh active
- 2004-10-22 MY MYPI20044358A patent/MY146093A/en unknown
- 2004-10-22 AR ARP040103849A patent/AR046141A1/es not_active Application Discontinuation
- 2004-10-25 PE PE2004001021A patent/PE20050811A1/es active IP Right Grant
-
2006
- 2006-04-18 EC EC2006006512A patent/ECSP066512A/es unknown
- 2006-04-19 CO CO06036842A patent/CO5690539A2/es active IP Right Grant
- 2006-04-20 IL IL175072A patent/IL175072A/en not_active IP Right Cessation
- 2006-05-22 NO NO20062319A patent/NO334919B1/no active Protection Beyond IP Right Term
-
2007
- 2007-01-16 HK HK07100526.6A patent/HK1095266A1/xx unknown
- 2007-08-17 US US11/889,935 patent/US20080221121A1/en not_active Abandoned
- 2007-10-31 US US11/979,149 patent/US8030313B2/en active Active
- 2007-10-31 US US11/979,144 patent/US20080112985A1/en not_active Abandoned
- 2007-10-31 US US11/979,145 patent/US8722679B2/en active Active
-
2008
- 2008-12-31 CY CY20081101518T patent/CY1109040T1/el unknown
-
2011
- 2011-01-14 JP JP2011006037A patent/JP5372032B2/ja not_active Expired - Lifetime
- 2011-12-28 US US13/338,827 patent/US8952013B2/en active Active
-
2012
- 2012-01-20 EC EC2012006512A patent/ECSP12006512A/es unknown
-
2013
- 2013-09-19 US US14/031,571 patent/US20140018369A1/en not_active Abandoned
-
2014
- 2014-04-11 LU LU92427C patent/LU92427I2/fr unknown
- 2014-05-13 FR FR14C0039C patent/FR14C0039I1/fr active Active
- 2014-05-13 CY CY2014021C patent/CY2014021I2/el unknown
- 2014-10-06 US US14/507,303 patent/US9763935B2/en active Active
- 2014-10-27 NO NO2014027C patent/NO2014027I1/no not_active IP Right Cessation
-
2016
- 2016-10-21 AR ARP160103230A patent/AR106449A2/es not_active Application Discontinuation
-
2017
- 2017-08-18 US US15/680,291 patent/US20170348308A1/en not_active Abandoned
-
2019
- 2019-10-30 US US16/668,008 patent/US20200061057A1/en not_active Abandoned
-
2021
- 2021-07-16 US US17/377,898 patent/US20210338663A1/en not_active Abandoned
-
2024
- 2024-04-10 US US18/631,828 patent/US20240261280A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL175072A0 (en) | Controlled release sterile injectable aripiprazole formulation and method | |
| ZA200501064B (en) | Aripiprazole complex formulation and method | |
| GB2406283B (en) | Compliance monitor and method | |
| SG114709A1 (en) | Collagen device and method of preparing the same | |
| EP1734866A4 (en) | ULTRASONIC INTRACAVITARY MEDICAL SYSTEM AND METHOD THEREOF | |
| EP1766596A4 (en) | SYSTEM AND METHOD FOR MEDICAL SIMULATION | |
| ZA200701398B (en) | System and method for staffing temporary medical positions | |
| EP1729649A4 (en) | BONE COLLECTION DEVICE AND METHOD | |
| EP1849448A4 (en) | SYRINGE DEVICE AND METHOD FOR PREPARING A MEDICAMENT USING THE DEVICE | |
| EP1618838A4 (en) | DEVICE FOR MONITORING THE EYE BACKGROUNDS AND METHOD FOR OBSERVING THE EYES BACKGROUND | |
| IL175287A0 (en) | Method for preparing drug eluting medical devices and devices obtained therefrom | |
| GB0219642D0 (en) | Method and device for preparing tissues sections | |
| EP1669051A4 (en) | MEDICAL CONTAINER AND METHOD OF USE THEREOF | |
| AU2003243663A8 (en) | Vaccines for suppressing ige-mediated allergic disease and methods for using the same | |
| HK1104800A1 (en) | Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases | |
| PL378496A1 (pl) | Sposób sterylizacji i urządzenie sterylizujące | |
| PT1848447E (pt) | Agente de regeneração de tecido biológico e método para a preparação e utilização do mesmo | |
| GB0510854D0 (en) | Surgical system and method | |
| GB0416872D0 (en) | System and method for medical treatment | |
| AU2004904679A0 (en) | Oral killed vaccines and method for providing same | |
| AU2003904729A0 (en) | Device and method for treating tissue injuries | |
| AU2003901252A0 (en) | Device and method for treating tissue injuries | |
| PL378518A1 (pl) | Gwóźdź chirurgiczny i sposób wytwarzania gwoździa chirurgicznego | |
| AU2004906053A0 (en) | Medical implant distribution method and system | |
| GB0403943D0 (en) | Safe surgery and bed management system |