NO20045469L - (S)-4-amino-5-klor-2-metoksy-N-[I-[ 1-(2-tetrahydrofurylkarbonyl)-4-piperidinylmetyl]-4-piperidinyl]benzamid, fremgangsmate for fremstilling, farmasoytiske sammensetninger inneholdende denne og intermediater derav - Google Patents

(S)-4-amino-5-klor-2-metoksy-N-[I-[ 1-(2-tetrahydrofurylkarbonyl)-4-piperidinylmetyl]-4-piperidinyl]benzamid, fremgangsmate for fremstilling, farmasoytiske sammensetninger inneholdende denne og intermediater derav

Info

Publication number
NO20045469L
NO20045469L NO20045469A NO20045469A NO20045469L NO 20045469 L NO20045469 L NO 20045469L NO 20045469 A NO20045469 A NO 20045469A NO 20045469 A NO20045469 A NO 20045469A NO 20045469 L NO20045469 L NO 20045469L
Authority
NO
Norway
Prior art keywords
tetrahydrofurylcarbonyl
piperidinylmethyl
benzamide
piperidinyl
chloro
Prior art date
Application number
NO20045469A
Other languages
English (en)
Inventor
Shiro Kato
Kazuo Morikage
Yukiko Morikage
Yoshimi Hirokawa
Naoyuki Yoshida
Hiroshi Yamazaki
Yoko Kan
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of NO20045469L publication Critical patent/NO20045469L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Forbindelsen (S) 4-amino-5-klor-2-metoksy-N-[1-[1-(2-tetrahydrofurylkarbonyl)-4-piperidinyl-metyl]-4-piperidinyl]benzamid med den følgende formel eller et farmasøytisk akseptabelt syreaddisjonssalt derav, eller et hydrat derav, er anvendbar som en gastrointestinal motilitetsforbedrer eller et gastrointestinalt, prokinetisk middel, som oppviser en potent affinitet for 5-HT4-reseptor, og viser få effekter på hjertet, og videre oppviser få bieffekter på sentralnervesystemet basert på dopamin D2-reseptoren. En fremgangsmåte for fremstilling av forbindelsen, et farmasøytisk preparat inneholdende den og et mellomprodukt for den er også beskrevet.
NO20045469A 2002-05-16 2004-12-15 (S)-4-amino-5-klor-2-metoksy-N-[I-[ 1-(2-tetrahydrofurylkarbonyl)-4-piperidinylmetyl]-4-piperidinyl]benzamid, fremgangsmate for fremstilling, farmasoytiske sammensetninger inneholdende denne og intermediater derav NO20045469L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002141262 2002-05-16
PCT/JP2003/006051 WO2003097638A1 (en) 2002-05-16 2003-05-15 (s)-4-amino-5-chloro-2-methoxy-n-[1-[1-(2-tetrahydrofurylcarbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor

Publications (1)

Publication Number Publication Date
NO20045469L true NO20045469L (no) 2005-02-16

Family

ID=29267809

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045469A NO20045469L (no) 2002-05-16 2004-12-15 (S)-4-amino-5-klor-2-metoksy-N-[I-[ 1-(2-tetrahydrofurylkarbonyl)-4-piperidinylmetyl]-4-piperidinyl]benzamid, fremgangsmate for fremstilling, farmasoytiske sammensetninger inneholdende denne og intermediater derav

Country Status (27)

Country Link
US (1) US6696468B2 (no)
EP (1) EP1362857B1 (no)
JP (1) JP3643107B2 (no)
KR (1) KR20040107520A (no)
CN (1) CN1653063A (no)
AR (1) AR040021A1 (no)
AT (1) ATE273304T1 (no)
AU (1) AU2003230245A1 (no)
BR (1) BR0309933A (no)
CA (1) CA2483368A1 (no)
CZ (1) CZ20041084A3 (no)
DE (1) DE60300021T2 (no)
DK (1) DK1362857T3 (no)
ES (1) ES2227500T3 (no)
HK (1) HK1060118A1 (no)
HU (1) HUP0501016A2 (no)
IL (1) IL165012A0 (no)
MX (1) MXPA04011332A (no)
NO (1) NO20045469L (no)
PL (1) PL372724A1 (no)
PT (1) PT1362857E (no)
RU (1) RU2004136853A (no)
SK (1) SK50192004A3 (no)
TR (1) TR200403020T2 (no)
TW (1) TW200400186A (no)
WO (1) WO2003097638A1 (no)
ZA (1) ZA200409053B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0300957D0 (sv) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
BRPI0608392A2 (pt) * 2005-03-02 2009-12-29 Theravance Inc compostos de quinolinona como agonistas do receptor 5-ht4
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
US7256294B2 (en) * 2005-05-25 2007-08-14 Theravance, Inc. Crystalline form of a benzimidazole-carboxamide medicinal compound
US20080200505A1 (en) * 2005-05-27 2008-08-21 Astrazeneca Ab Piperidines for the Treatment of Chemokine Mediated Diseases
TW200722419A (en) * 2005-05-27 2007-06-16 Astrazeneca Ab Chemical compounds
US8314127B2 (en) 2005-07-21 2012-11-20 Astrazeneca Ab Piperidine derivatives
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
TWI423967B (zh) * 2008-02-21 2014-01-21 Dainippon Sumitomo Pharma Co 醯胺衍生物及含有其之醫藥組合物
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
US8546416B2 (en) 2011-05-27 2013-10-01 Novartis Ag 3-spirocyclic piperidine derivatives as ghrelin receptor agonists
AU2013255458A1 (en) 2012-05-03 2014-10-09 Novartis Ag L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH111472A (ja) 1996-04-30 1999-01-06 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びそれを含有する医薬組成物
US6294555B1 (en) * 1998-04-28 2001-09-25 Dainippon Pharmaceutical Co., Ltd. 1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
JP2000080081A (ja) 1998-06-24 2000-03-21 Dainippon Pharmaceut Co Ltd １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物
JP2001122784A (ja) 1999-10-27 2001-05-08 Dainippon Pharmaceut Co Ltd １−［（１−置換−４−ピペリジニル）メチル］−４−ピペリジン誘導体からなる医薬

Also Published As

Publication number Publication date
CZ20041084A3 (cs) 2005-02-16
RU2004136853A (ru) 2005-06-27
TR200403020T2 (tr) 2005-05-23
PT1362857E (pt) 2004-11-30
EP1362857A1 (en) 2003-11-19
DK1362857T3 (da) 2004-12-20
DE60300021T2 (de) 2005-09-08
US20030216433A1 (en) 2003-11-20
HK1060118A1 (en) 2004-07-30
AR040021A1 (es) 2005-03-09
US6696468B2 (en) 2004-02-24
WO2003097638A1 (en) 2003-11-27
EP1362857B1 (en) 2004-08-11
KR20040107520A (ko) 2004-12-20
SK50192004A3 (sk) 2005-04-01
MXPA04011332A (es) 2005-02-14
ATE273304T1 (de) 2004-08-15
JP2004043453A (ja) 2004-02-12
ES2227500T3 (es) 2005-04-01
ZA200409053B (en) 2005-07-12
TW200400186A (en) 2004-01-01
BR0309933A (pt) 2005-02-09
IL165012A0 (en) 2005-12-18
CN1653063A (zh) 2005-08-10
PL372724A1 (en) 2005-07-25
HUP0501016A2 (en) 2006-02-28
CA2483368A1 (en) 2003-11-27
JP3643107B2 (ja) 2005-04-27
DE60300021D1 (de) 2004-09-16
AU2003230245A1 (en) 2003-12-02

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