AR040021A1 - (s)-4-amino-5-cloro-2-metoxi-n-[1-[1-(2-tetrahidrofuril-carbonil)-4-piperidinilmetil]-4-piperidinil]benzamida, procedimiento para su preparacion, composicion farmaceutica que la contiene, e intermediarios para su preparacion - Google Patents
(s)-4-amino-5-cloro-2-metoxi-n-[1-[1-(2-tetrahidrofuril-carbonil)-4-piperidinilmetil]-4-piperidinil]benzamida, procedimiento para su preparacion, composicion farmaceutica que la contiene, e intermediarios para su preparacionInfo
- Publication number
- AR040021A1 AR040021A1 ARP030101702A ARP030101702A AR040021A1 AR 040021 A1 AR040021 A1 AR 040021A1 AR P030101702 A ARP030101702 A AR P030101702A AR P030101702 A ARP030101702 A AR P030101702A AR 040021 A1 AR040021 A1 AR 040021A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- chloro
- amino
- pharmaceutical composition
- tetrahidrofuril
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describe el compuesto (S)-4-amino-5-cloro-2-metoxi-N-[1-[1-(2-tetrahidrofurilcarbonil)-4-piperidinilmetil]-4-piperidinil]benzamida de la siguiente fórmula (1), o una sal de adición de un ácido farmacéuticamente aceptable, o un hidrato de ésta. Dicho compuesto es útil como mejorador de la motilidad gastrointestinal o como agente procinético gastrointestinal, que manifiesta una potente afinidad por el receptor 5-HT4 y presenta poco efecto sobre el corazón y además presenta pocos efectos secundarios en el sistema nervioso central, basados en el receptor de dopamina D2. También se describen un procedimiento para preparar el compuesto, una composición farmacéutica que lo contiene y un intermediario para ese fin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002141262 | 2002-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040021A1 true AR040021A1 (es) | 2005-03-09 |
Family
ID=29267809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101702A AR040021A1 (es) | 2002-05-16 | 2003-05-15 | (s)-4-amino-5-cloro-2-metoxi-n-[1-[1-(2-tetrahidrofuril-carbonil)-4-piperidinilmetil]-4-piperidinil]benzamida, procedimiento para su preparacion, composicion farmaceutica que la contiene, e intermediarios para su preparacion |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6696468B2 (es) |
| EP (1) | EP1362857B1 (es) |
| JP (1) | JP3643107B2 (es) |
| KR (1) | KR20040107520A (es) |
| CN (1) | CN1653063A (es) |
| AR (1) | AR040021A1 (es) |
| AT (1) | ATE273304T1 (es) |
| AU (1) | AU2003230245A1 (es) |
| BR (1) | BR0309933A (es) |
| CA (1) | CA2483368A1 (es) |
| CZ (1) | CZ20041084A3 (es) |
| DE (1) | DE60300021T2 (es) |
| DK (1) | DK1362857T3 (es) |
| ES (1) | ES2227500T3 (es) |
| HK (1) | HK1060118A1 (es) |
| HU (1) | HUP0501016A2 (es) |
| IL (1) | IL165012A0 (es) |
| MX (1) | MXPA04011332A (es) |
| NO (1) | NO20045469L (es) |
| PL (1) | PL372724A1 (es) |
| PT (1) | PT1362857E (es) |
| RU (1) | RU2004136853A (es) |
| SK (1) | SK50192004A3 (es) |
| TR (1) | TR200403020T2 (es) |
| TW (1) | TW200400186A (es) |
| WO (1) | WO2003097638A1 (es) |
| ZA (1) | ZA200409053B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904377D0 (sv) * | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| ATE441646T1 (de) * | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス， インコーポレーテッド | キノリノン−カルボキサミド化合物 |
| US7419989B2 (en) * | 2004-12-22 | 2008-09-02 | Theravance, Inc. | Indazole-carboxamide compounds |
| EP1871772B1 (en) * | 2005-03-02 | 2014-09-10 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| MY147756A (en) * | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7256294B2 (en) * | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
| WO2006126948A1 (en) * | 2005-05-27 | 2006-11-30 | Astrazeneca Ab | Piperidines for the treatment of chemokine mediated diseases |
| TW200722419A (en) * | 2005-05-27 | 2007-06-16 | Astrazeneca Ab | Chemical compounds |
| EP1912941B1 (en) | 2005-07-21 | 2012-11-14 | AstraZeneca AB | Piperidine derivatives |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
| AU2013255458A1 (en) | 2012-05-03 | 2014-10-09 | Novartis Ag | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH111472A (ja) | 1996-04-30 | 1999-01-06 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びそれを含有する医薬組成物 |
| HUP0101511A3 (en) * | 1998-04-28 | 2002-12-28 | Dainippon Pharmaceutical Co | 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds |
| JP2000080081A (ja) | 1998-06-24 | 2000-03-21 | Dainippon Pharmaceut Co Ltd | １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物 |
| JP2001122784A (ja) | 1999-10-27 | 2001-05-08 | Dainippon Pharmaceut Co Ltd | １−［（１−置換−４−ピペリジニル）メチル］−４−ピペリジン誘導体からなる医薬 |
-
2002
- 2002-12-18 US US10/321,615 patent/US6696468B2/en not_active Expired - Fee Related
-
2003
- 2003-01-03 AT AT03250050T patent/ATE273304T1/de not_active IP Right Cessation
- 2003-01-03 DE DE60300021T patent/DE60300021T2/de not_active Expired - Fee Related
- 2003-01-03 ES ES03250050T patent/ES2227500T3/es not_active Expired - Lifetime
- 2003-01-03 DK DK03250050T patent/DK1362857T3/da active
- 2003-01-03 EP EP03250050A patent/EP1362857B1/en not_active Expired - Lifetime
- 2003-01-03 PT PT03250050T patent/PT1362857E/pt unknown
- 2003-05-08 TW TW092112525A patent/TW200400186A/zh unknown
- 2003-05-15 TR TR2004/03020T patent/TR200403020T2/xx unknown
- 2003-05-15 AU AU2003230245A patent/AU2003230245A1/en not_active Abandoned
- 2003-05-15 SK SK5019-2004A patent/SK50192004A3/sk unknown
- 2003-05-15 KR KR10-2004-7018158A patent/KR20040107520A/ko not_active Application Discontinuation
- 2003-05-15 WO PCT/JP2003/006051 patent/WO2003097638A1/en not_active Application Discontinuation
- 2003-05-15 RU RU2004136853/04A patent/RU2004136853A/ru not_active Application Discontinuation
- 2003-05-15 HU HU0501016A patent/HUP0501016A2/hu unknown
- 2003-05-15 CZ CZ20041084A patent/CZ20041084A3/cs unknown
- 2003-05-15 PL PL03372724A patent/PL372724A1/xx not_active Application Discontinuation
- 2003-05-15 CA CA002483368A patent/CA2483368A1/en not_active Abandoned
- 2003-05-15 CN CNA03811089XA patent/CN1653063A/zh active Pending
- 2003-05-15 MX MXPA04011332A patent/MXPA04011332A/es unknown
- 2003-05-15 BR BR0309933-4A patent/BR0309933A/pt not_active Application Discontinuation
- 2003-05-15 AR ARP030101702A patent/AR040021A1/es unknown
- 2003-05-15 JP JP2003137413A patent/JP3643107B2/ja not_active Expired - Fee Related
- 2003-05-15 IL IL16501203A patent/IL165012A0/xx unknown
-
2004
- 2004-04-22 HK HK04102812A patent/HK1060118A1/xx not_active IP Right Cessation
- 2004-11-09 ZA ZA200409035A patent/ZA200409053B/en unknown
- 2004-12-15 NO NO20045469A patent/NO20045469L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE273304T1 (de) | 2004-08-15 |
| ES2227500T3 (es) | 2005-04-01 |
| CA2483368A1 (en) | 2003-11-27 |
| PT1362857E (pt) | 2004-11-30 |
| US20030216433A1 (en) | 2003-11-20 |
| JP2004043453A (ja) | 2004-02-12 |
| BR0309933A (pt) | 2005-02-09 |
| US6696468B2 (en) | 2004-02-24 |
| DK1362857T3 (da) | 2004-12-20 |
| TR200403020T2 (tr) | 2005-05-23 |
| RU2004136853A (ru) | 2005-06-27 |
| DE60300021D1 (de) | 2004-09-16 |
| EP1362857B1 (en) | 2004-08-11 |
| IL165012A0 (en) | 2005-12-18 |
| WO2003097638A1 (en) | 2003-11-27 |
| ZA200409053B (en) | 2005-07-12 |
| HUP0501016A2 (en) | 2006-02-28 |
| HK1060118A1 (en) | 2004-07-30 |
| MXPA04011332A (es) | 2005-02-14 |
| NO20045469L (no) | 2005-02-16 |
| DE60300021T2 (de) | 2005-09-08 |
| SK50192004A3 (sk) | 2005-04-01 |
| EP1362857A1 (en) | 2003-11-19 |
| JP3643107B2 (ja) | 2005-04-27 |
| KR20040107520A (ko) | 2004-12-20 |
| AU2003230245A1 (en) | 2003-12-02 |
| CZ20041084A3 (cs) | 2005-02-16 |
| PL372724A1 (en) | 2005-07-25 |
| TW200400186A (en) | 2004-01-01 |
| CN1653063A (zh) | 2005-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR040021A1 (es) | (s)-4-amino-5-cloro-2-metoxi-n-[1-[1-(2-tetrahidrofuril-carbonil)-4-piperidinilmetil]-4-piperidinil]benzamida, procedimiento para su preparacion, composicion farmaceutica que la contiene, e intermediarios para su preparacion | |
| DK1675591T3 (da) | Farmaceutisk sammensætning omfattende en monoamin-neurotransmitter-genoptagelseshæmmer og en acetylcholinesterase-hæmmer | |
| PA8591701A1 (es) | Derivados de pirrolopirimidina | |
| BR0312975A (pt) | Forma cristalina de agonista de receptor adrenérgico ß2 | |
| WO2004106279A3 (en) | CRYSTALLINE FORM OF β2 ADRENERGIC RECEPTOR AGONIST | |
| BRPI0415657A (pt) | derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c | |
| PE20070521A1 (es) | 7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a | |
| NO20050664L (no) | 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer | |
| EA200701687A1 (ru) | Гидрохлорид аморфного лерканидипина | |
| NO20075920L (no) | Assosiasjon mellom ferroquin og et artemisininderivat for behandling av malaria | |
| NO20064240L (no) | Farmasoytiske forbindelser for oral administrasjon og fremgangsmate for fremstilling derav | |
| AR029942A1 (es) | Compuestos derivados de 1,3-dihidro-2h-indol-2-ona, su utilizacion, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden, medicamentos constituidos por dichos compuestos y compuestos intermediarios | |
| BRPI0606639A2 (pt) | novo processo para a preparação de indóis substituìdos | |
| ATE386725T1 (de) | Heterocyclylverbindungen | |
| AR004158A1 (es) | Compuesto de ftalizin-pirido dionas; composición farmacéutica que lo contiene; y proceso para la preparación de dicho compuesto. | |
| DE60217843D1 (de) | Ein dioxinoä2,3-güchinolin-9-carbonsäure derivat als nk3 rezeptor antagonist | |
| DE602004024383D1 (de) | Kristalline formen eines arylanilin-beta-2-adrenergenrezeptor-agonists | |
| ATE318266T1 (de) | 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten | |
| PE20040767A1 (es) | Derivado hemisulfato de azido citosina cristalino anhidro | |
| CA2406266A1 (en) | A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds | |
| BR0318242A (pt) | derivados de azabiciclo hexano substituìdo como antagonistas de receptores muscarìnicos e processo para sua preparação | |
| NO980333L (no) | (R)-5-brom-N-(1-etyl-4-metylheksahydro-1H-1,4-diazepin-6-yl)-2-metoksy-6-metylamino-3-pyridinkarboksamid, fremgangsmåte ved fremstilling derav og farmasöytisk sammensetning inneholdende forbindelsen | |
| DE60214830D1 (de) | C2,8-disubstituierte adenosinderivate und ihre verschiedenen verwendungen | |
| UY38055A (es) | Composiciones oftálmicas de compuestos de bencimidazol para uso unico diario | |
| BR0210063A (pt) | Composição estável e uso da mesma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |