DK1330249T3 - Aripiprazol-lægemiddelstof med lav hygroskopicitet og fremgangsmåder til fremstilling deraf - Google Patents

Aripiprazol-lægemiddelstof med lav hygroskopicitet og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1330249T3
DK1330249T3 DK02782507T DK02782507T DK1330249T3 DK 1330249 T3 DK1330249 T3 DK 1330249T3 DK 02782507 T DK02782507 T DK 02782507T DK 02782507 T DK02782507 T DK 02782507T DK 1330249 T3 DK1330249 T3 DK 1330249T3
Authority
DK
Denmark
Prior art keywords
preparation
methods
low hygroscopicity
aripiprazole drug
hygroscopicity aripiprazole
Prior art date
Application number
DK02782507T
Other languages
Danish (da)
English (en)
Inventor
Takuji Bando
Satoshi Aoki
Junichi Kawasaki
Makoto Ishigami
Youichi Taniguchi
Tsuyoshi Yabuuchi
Kiyoshi Fujimoto
Yoshihiro Nishioka
Noriyuki Kobayashi
Tsutomu Fujimura
Masanori Takahashi
Kaoru Abe
Tomonori Nakagawa
Koichi Shinhama
Naoto Utsumi
Yoshihiro Oi
Shohei Yamada
Kenji Tomikawa
Michiaki Tominaga
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1330249(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CA 2379005 external-priority patent/CA2379005A1/en
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of DK1330249T3 publication Critical patent/DK1330249T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
DK02782507T 2001-09-25 2002-09-25 Aripiprazol-lægemiddelstof med lav hygroskopicitet og fremgangsmåder til fremstilling deraf DK1330249T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001290645 2001-09-25
JP2001348276 2001-11-14
CA 2379005 CA2379005A1 (en) 2001-09-25 2002-03-27 Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
DK1330249T3 true DK1330249T3 (da) 2006-08-07

Family

ID=27171631

Family Applications (5)

Application Number Title Priority Date Filing Date
DK04002427.5T DK1419776T4 (en) 2001-09-25 2002-09-25 Low hygroscopic aripiprazole drug substance and method of preparation thereof
DK08000359.3T DK1927356T3 (da) 2001-09-25 2002-09-25 Medikamentsubstans med lav hygroskopisk aripiprazol (krystal D) og fremgangsmåder til fremstilling deraf
DK08000357.7T DK1927355T3 (da) 2001-09-25 2002-09-25 Medikamentsubstans med lav hygroskopisk aripiprazol (krystal F) og fremgangsmåder til fremstilling deraf
DK02782507T DK1330249T3 (da) 2001-09-25 2002-09-25 Aripiprazol-lægemiddelstof med lav hygroskopicitet og fremgangsmåder til fremstilling deraf
DK08000360.1T DK1927357T3 (da) 2001-09-25 2002-09-25 Lavhygroskopisk Aripiprazollægemiddelsubstans (Krystal E) og fremgangsmåder til fremstilling deraf

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK04002427.5T DK1419776T4 (en) 2001-09-25 2002-09-25 Low hygroscopic aripiprazole drug substance and method of preparation thereof
DK08000359.3T DK1927356T3 (da) 2001-09-25 2002-09-25 Medikamentsubstans med lav hygroskopisk aripiprazol (krystal D) og fremgangsmåder til fremstilling deraf
DK08000357.7T DK1927355T3 (da) 2001-09-25 2002-09-25 Medikamentsubstans med lav hygroskopisk aripiprazol (krystal F) og fremgangsmåder til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08000360.1T DK1927357T3 (da) 2001-09-25 2002-09-25 Lavhygroskopisk Aripiprazollægemiddelsubstans (Krystal E) og fremgangsmåder til fremstilling deraf

Country Status (23)

Country Link
US (20) US20040058935A1 (no)
EP (6) EP1927356B1 (no)
JP (3) JP3760264B2 (no)
CN (16) CN106692151A (no)
AR (2) AR033485A1 (no)
AT (5) ATE465736T1 (no)
AU (1) AU2002334413C1 (no)
BR (1) BR0205391A (no)
CA (6) CA2689051C (no)
CY (1) CY1118195T1 (no)
DE (5) DE60235995D1 (no)
DK (5) DK1419776T4 (no)
ES (5) ES2343602T3 (no)
HU (1) HUP0600141A3 (no)
IL (3) IL153838A0 (no)
MX (1) MXPA03000440A (no)
NO (7) NO328134B1 (no)
PE (1) PE20090124A1 (no)
PL (1) PL225415B1 (no)
PT (5) PT1927357E (no)
SI (4) SI1330249T1 (no)
UA (1) UA84764C2 (no)
WO (1) WO2003026659A1 (no)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
WO2004017897A2 (en) 2002-08-20 2004-03-04 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
US20040185110A1 (en) * 2002-11-08 2004-09-23 Ronald Harland Formulations of low solubility bioactive agents and processes for making the same
RU2356554C2 (ru) 2002-12-27 2009-05-27 Оцука Фармасьютикал Ко., Лтд. Производные карбостирила и ингибиторы обратного захвата серотонина для лечения эмоциональных расстройств
AR042806A1 (es) * 2002-12-27 2005-07-06 Otsuka Pharma Co Ltd Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo
TWI258470B (en) † 2003-01-09 2006-07-21 Otsuka Pharma Co Ltd Process for preparing aripiprazole
US20060270683A1 (en) * 2003-04-25 2006-11-30 Lohray Braj B Polymorphs of aripiprazole
CA2526562C (en) * 2003-05-23 2011-06-28 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and mood stabilizers for treating mood disorders
US7456181B2 (en) 2003-07-25 2008-11-25 Hetero Drugs Limited Aripiprazole crystalline forms
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
BRPI0415531B8 (pt) 2003-10-23 2021-05-25 Otsuka Pharma Co Ltd formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação
TWI371274B (en) * 2003-10-23 2012-09-01 Bristol Myers Squibb Co Process for making sterile aripiprazole of desired mean particle size
US7714129B2 (en) 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
PL1613598T3 (pl) 2003-12-16 2012-03-30 Teva Pharma Sposób wytwarzania krystalicznych form aripiprazolu
DE202005020539U1 (de) * 2004-02-05 2006-09-28 Teva Pharmaceutical Industries Ltd. Aripiprazol
MXPA06008829A (es) 2004-02-05 2007-04-25 Teva Pharma Metodo de fabricar 7-(4-bromobutoxi)-3,4-dihidrocarboestirilo.
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
US20090198059A1 (en) * 2004-09-13 2009-08-06 Chava Satyanarayana Process for the preparation of polymorphs, solvates of aripiprazole using aripirazole acid salts
EP1812395B1 (en) 2004-10-08 2008-05-21 Suven Life Sciences Limited Method for the preparation of aripiprazole, and corresponding intermediates and their preparation
CN100338038C (zh) * 2004-10-14 2007-09-19 重庆医药工业研究院有限责任公司 阿立派唑的新晶型及其制备方法
EP1812396A1 (en) 2004-11-18 2007-08-01 Synthon B.V. Crystalline aripiprazole solvates
CN101111481A (zh) * 2004-11-18 2008-01-23 斯索恩有限公司 制备结晶阿立哌唑的方法
US7884205B2 (en) 2005-01-27 2011-02-08 Sandoz Ag Salts of aripiprazole
EP1686117A1 (en) * 2005-01-27 2006-08-02 Sandoz AG Polymorph and solvates of aripiprazole
CA2600542A1 (en) 2005-03-17 2006-09-21 Synthon B.V. Pharmaceutical tablets of crystalline type ii aripiprazole
WO2006097343A1 (en) † 2005-03-17 2006-09-21 Synthon B.V. Process of making crystalline type ii aripiprazole
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CA2605128A1 (en) * 2005-04-15 2007-01-11 Medichem, S.A. Syntheses and preparations of polymorphs of crystalline aripiprazole
CN100432053C (zh) * 2005-06-07 2008-11-12 上海医药工业研究院 阿立哌唑晶型及其制备方法
HUP0500683A3 (en) * 2005-07-14 2009-03-30 Egis Gyogyszergyar Nyilvanosan New arylpiprazole salts for producing pharmaceutical composition
US20070014864A1 (en) * 2005-07-15 2007-01-18 Teva Pharmaceutical Industries, Ltd. Novel pharmaceutical granulate
CA2614468A1 (en) * 2005-07-15 2007-01-25 Teva Pharmaceutical Industries Ltd. Novel granulation process and granulate produced therefrom
US20070014853A1 (en) * 2005-07-15 2007-01-18 Ilan Zalit Pharmaceutical dosage form containing novel pharmaceutical granulate
US20070014854A1 (en) * 2005-07-15 2007-01-18 Ilan Zalit Novel granulation process
CA2622758A1 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
KR20070088750A (ko) 2005-09-29 2007-08-29 테바 파마슈티컬 인더스트리즈 리미티드 무수 아리피프라졸 제ｉｉ형의 제조 방법
CZ299485B6 (cs) * 2005-10-11 2008-08-13 Zentiva, A. S. Zpusob výroby aripiprazolu
TW200800202A (en) * 2005-12-22 2008-01-01 Teva Pharma Processes for reducing particle size of aripiprazole
DK1808165T3 (da) * 2006-01-05 2009-08-03 Teva Pharma Törre formuleringer af aripiprazol
DK1808164T3 (da) 2006-01-05 2009-04-20 Teva Pharma Vådgranuleringsmetode til fremstilling af farmaceutiske sammensætninger af aripiprazol
TWI394753B (zh) * 2006-03-17 2013-05-01 Otsuka Pharma Co Ltd 新穎替妥牟拉（ｔｅｔｏｍｉｌａｓｔ）晶體
US20060223820A1 (en) * 2006-03-21 2006-10-05 Chemagis Ltd. Crystalline aripiprazole salts and processes for preparation and purification thereof
EP1880714A1 (en) 2006-07-20 2008-01-23 Helm AG Amorphous Aripiprazole and Process for the Preparation thereof
US7799790B2 (en) 2006-07-20 2010-09-21 Helm Ag Amorphous aripiprazole and process for the preparation thereof
TR200604349A2 (tr) 2006-08-15 2008-03-21 NOBEL İLAÇ SANAYii VE TiCARET A.Ş. Aripiprazol içeren farmasötik bileşimler
GB0618879D0 (en) 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
US20100113784A1 (en) * 2006-09-28 2010-05-06 Niraj Shyamlal Shah Process for preparing crystalline aripiprazole
ES2401603T3 (es) * 2006-10-24 2013-04-23 Cambrex Charles City, Inc. Procedimiento para preparar aripiprazol anhidro de tipo l
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
SG182232A1 (en) * 2007-06-25 2012-07-30 Otsuka Pharma Co Ltd Microspheres having core/shell structure
AR067747A1 (es) 2007-07-31 2009-10-21 Otsuka Pharma Co Ltd Metodos para producir suspension de aripiprazol y formulacion liofilizada
PL2082735T3 (pl) * 2008-01-23 2011-05-31 Helm Ag Amorficzny arypiprazol i sposób jego wytwarzania
WO2010079506A2 (en) 2008-06-23 2010-07-15 Torrent Pharmaceuticals Ltd. Pharmaceutical composition of aripiprazole
EP2233471A1 (en) 2009-02-06 2010-09-29 Adamed Sp. z o.o. A salt of 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4.dihydro-2(1h)-quinolinone with 5-sulfosalicylic acid and its preparation process
WO2010106551A2 (en) * 2009-03-09 2010-09-23 Neuland Laboratories Ltd. A process for the manufacture of pure anhydrous aripiprazole form b
EP2238976B1 (en) 2009-04-03 2012-06-27 Hexal AG Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof
EA201200485A1 (ru) 2009-09-15 2012-10-30 Рациофарм Гмбх Перорально распадающаяся фармацевтическая лекарственная форма, содержащая арипипразол
CN102372672B (zh) * 2010-08-24 2014-06-04 重庆圣华曦药业股份有限公司 低吸湿性阿立哌唑晶体iv、制备方法及其应用
CN101948426A (zh) * 2010-09-13 2011-01-19 浙江华海药业股份有限公司 一种制备阿立哌唑晶型b的新方法
JP2012121850A (ja) * 2010-12-09 2012-06-28 Otsuka Pharmaceut Co Ltd アリピプラゾールの経口速溶性組成物
CN102060763B (zh) * 2010-12-27 2012-11-14 齐鲁制药有限公司 微粉型阿立哌唑晶型ⅰ或ⅱ的制备方法
FI3156056T3 (fi) 2011-03-18 2024-03-01 Alkermes Pharma Ireland Ltd Sorbitaaniestereitä käsittäviä farmaseuttisia koostumuksia
WO2012131451A1 (en) 2011-03-30 2012-10-04 Jubilant Life Sciences Limited Process for producing aripiprazole in anhydrous type i crystals
KR101340214B1 (ko) 2011-03-31 2013-12-10 주식회사 대웅제약 무수 아리피프라졸 ⅱ형 결정의 제조방법
JO3410B1 (ar) 2011-06-07 2019-10-20 Otsuka Pharma Co Ltd تركيبة أريبيبرازول مجفف بالتبريد
CN102850268B (zh) * 2011-06-27 2015-07-15 上海中西制药有限公司 阿立哌唑ⅰ型微晶、阿立哌唑固体制剂及制备方法
GB2505860B (en) * 2011-06-27 2018-10-31 Shanghai Zhongxi Pharmaceutical Corp Aripiprazole medicament formulation and preparation method therefor
TW201309651A (zh) 2011-06-29 2013-03-01 Otsuka Pharma Co Ltd 阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）無水物Ｂ形結晶微粒子之製造方法
CN103172563B (zh) * 2011-12-26 2015-03-25 北京京卫燕康药物研究所有限公司 小粒径的晶型i阿立哌唑的工业化制备
CN102584858B (zh) * 2011-12-31 2014-11-12 广州医药工业研究院 乳酸左旋尤利沙星晶体及其制备方法和用途
AR090245A1 (es) 2012-03-06 2014-10-29 Otsuka Pharma Co Ltd Preparacion solida oral de liberacion sostenida, metodo de preparacion
EP2827868B8 (en) 2012-03-19 2019-12-18 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
CA2867123C (en) 2012-03-19 2021-02-16 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters
ES2950418T3 (es) 2012-03-19 2023-10-09 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden alcohol bencílico
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
WO2014002553A1 (ja) 2012-06-29 2014-01-03 丸石製薬株式会社 アリピプラゾールの経口医薬製剤
KR101372840B1 (ko) * 2012-08-02 2014-03-12 주식회사 에스텍파마 무수 아리피프라졸 결정의 제조방법
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
JP6007169B2 (ja) * 2012-11-30 2016-10-12 大原薬品工業株式会社 アリピプラゾール無水物を含有する固形製剤の製造方法
JP2014114243A (ja) * 2012-12-11 2014-06-26 Ohara Yakuhin Kogyo Kk 安定な固形製剤の製造方法
CN107129467A (zh) * 2013-03-26 2017-09-05 江苏恩华药业股份有限公司 阿立哌唑结晶b
AR096131A1 (es) 2013-04-30 2015-12-09 Otsuka Pharma Co Ltd Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol
KR101759017B1 (ko) * 2013-04-30 2017-07-17 오쓰까 세이야꾸 가부시키가이샤 아리피프라졸을 포함하는 경구 고형 제제 및 아리피프라졸을 포함하는 경구 고형 제제의 제조방법
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US20150093441A1 (en) * 2013-09-30 2015-04-02 Otsuka Pharmaceutical Co., Ltd Oral solid preparation comprising aripiprazole and method for producing oral solid preparation comprising aripiprazole
WO2015067313A1 (en) 2013-11-07 2015-05-14 Synthon B.V. Orodispersible pharmaceutical compositions comprising aripiprazole
CA2943213C (en) 2014-03-20 2022-07-05 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
AU2015304148A1 (en) * 2014-08-18 2017-02-02 Samsung Electronics Co., Ltd. Antenna of electronic device
EP3865476B1 (en) * 2014-08-25 2024-08-14 Alkermes Pharma Ireland Limited Crystallization process of aripiprazole derivatives in extended release formulations for treatment of schizophrenia
JP6023770B2 (ja) * 2014-10-01 2016-11-09 株式会社パーマケム・アジア アリピプラゾール無水物ｂ形結晶の製造方法
WO2016138536A2 (en) * 2015-02-27 2016-09-01 Tactual Labs Co. Alterable ground plane for touch surfaces
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size
JP6071083B2 (ja) * 2015-06-12 2017-02-01 大原薬品工業株式会社 安定性が改善された、アリピプラゾールを含有する散剤
JP2015172084A (ja) * 2015-07-06 2015-10-01 大塚製薬株式会社 アリピプラゾールの経口速溶性組成物
CN106474058B (zh) 2015-08-31 2020-01-07 南京诺瑞特医药科技有限公司 具有延长的保质期的阿立哌唑可注射悬浮液制剂
TWI665194B (zh) * 2016-02-19 2019-07-11 諾瑞特國際藥業股份有限公司 阿立哌唑的新晶型
CN108602774B (zh) * 2016-02-19 2021-07-27 南京诺瑞特医药科技有限公司 阿立哌唑的新晶型
US20190070174A1 (en) * 2016-03-10 2019-03-07 The Regents Of The University Of Michigan Methods of treating neurodegenerative diseases
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
JP6572257B2 (ja) * 2017-05-16 2019-09-04 大塚製薬株式会社 アリピプラゾールの経口速溶性組成物
EP3761983A1 (en) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
JP7211136B2 (ja) * 2019-02-14 2023-01-24 ニプロ株式会社 錠剤、および、その製造方法
CN110128337A (zh) * 2019-06-10 2019-08-16 岳阳新华达制药有限公司 一种阿立哌唑晶型b的制备方法
KR102128883B1 (ko) 2019-10-02 2020-07-01 (주)삼화바이오팜 고순도 아리피프라졸의 신규 결정형 및 이의 제조방법
CN115379842A (zh) 2020-04-01 2022-11-22 大塚制药株式会社 阿立哌唑注射制剂的施用方法
EP4043008A1 (en) 2021-02-15 2022-08-17 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Method for the preparation of a pharmaceutical composition comprising aripiprazole
CN117309825B (zh) * 2023-11-30 2024-04-09 四川蜀道建筑科技有限公司 一种透光检测亚甲蓝mb值的设备

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS62149664A (ja) 1978-03-30 1987-07-03 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体の製造法
JPS5646812A (en) 1979-09-27 1981-04-28 Otsuka Pharmaceut Co Ltd Central nervous system depressant
JPS55127371A (en) 1980-02-14 1980-10-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
US4438119A (en) 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
DK588486A (da) 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi
US4687772A (en) 1986-10-07 1987-08-18 Bristol-Myers Company Method for improvement of short term memory
US4771053A (en) 1987-03-02 1988-09-13 Bristol-Myers Company Method for alleviation of primary depressive disorders
US5162375A (en) * 1988-05-06 1992-11-10 Beecham Group P.L.C. Treatment of neuronal degeneration with 5HT1A agonists
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
DE3831888A1 (de) 1988-09-20 1990-03-29 Troponwerke Gmbh & Co Kg Arzneimittel zur behandlung von apoplexia cerebri
US5200410A (en) * 1988-09-20 1993-04-06 Troponwerke Gmbh & Co. Medicaments for the treatment of cerebral apoplexy
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5073377A (en) * 1988-11-03 1991-12-17 Miles Inc. Method of preparing oral dosage forms with a granulating composition
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
GB9026389D0 (en) * 1990-12-05 1991-01-23 Merck Sharp & Dohme Therapeutic agents
WO1992010200A1 (en) 1990-12-14 1992-06-25 New York University Functional interactions between glial s-100b and central nervous system serotonergic neurons
CA2067475C (en) * 1991-05-08 2000-10-10 Yasuo Oshiro Carbostyril derivatives and their use
EP0586525B1 (en) 1991-05-20 1997-04-16 PHARMACIA & UPJOHN COMPANY Carboxamido-(1,2n)-carbocyclic-2-aminotetralin derivatives
DE4135551A1 (de) 1991-08-31 1993-03-04 Schering Ag Verwendung von antagonisten oder partiellen agonisten am 5-ht1a-rezeptor zur behandlung und praevention von kognitiven stoerungen
US5824680A (en) * 1991-08-31 1998-10-20 Bayer Aktiengesellschaft Ipsapirone for the treatment of alzheimer's disease by improving memory
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
US5292766A (en) 1992-03-25 1994-03-08 Eli Lilly And Company Method for improving primary memory and/or learning
AU5446894A (en) 1992-10-23 1994-05-24 New York University Functional interactions between glial s-100b and central nervous system serotonergic neurons
DK148292D0 (da) 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
JP2506547B2 (ja) 1993-06-16 1996-06-12 ミナミ産業株式会社 豆腐のパック詰め装置
JP2959615B2 (ja) 1993-06-24 1999-10-06 吉富製薬株式会社 縮合型チオフェン化合物およびその医薬用途
JPH07247271A (ja) * 1994-01-21 1995-09-26 Otsuka Pharmaceut Co Ltd ３，４−ジヒドロカルボスチリル誘導体
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
JP2987484B2 (ja) 1995-03-16 1999-12-06 大塚製薬 株式会社 カルボスチリル誘導体の製造方法
JPH0940648A (ja) 1995-08-02 1997-02-10 Yamanouchi Pharmaceut Co Ltd 新規な８−（２−アミノアルコキシ）キノリン誘導体
EP0776927B1 (en) 1995-11-30 2001-05-30 Mitsui Chemicals, Inc. Stretched film of lactic acid-based polymer
JPH09291034A (ja) 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
US5688950A (en) 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands
WO1997042190A1 (en) 1996-05-07 1997-11-13 Pfizer Inc. Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1h)-indol-2-one (=ziprasidone), its preparation and its use as dopamine d2 antagonist
JP4012994B2 (ja) 1996-05-08 2007-11-28 大塚製薬株式会社 抗不安薬
JP2001527520A (ja) 1996-08-22 2001-12-25 グラクソ グループ，リミテッド ドーパミン作動性遺伝子の対立遺伝子変異に由来する、前兆を伴う片頭痛、抑鬱、および不安の診断
DK0923548T3 (da) 1996-08-27 2003-06-23 Wyeth Corp 4-Aminoethoxyindoler som dopamin-D2-agonister og som 5HT 1A-ligander
CA2317515A1 (en) 1998-02-03 1999-08-05 Frances Christy Nelson Oxazole derivatives as serotonin-1a receptor agonists
JP2001089128A (ja) * 1998-04-10 2001-04-03 Asahi Glass Co Ltd 球状シリカ粒子の製造方法
ZA992670B (en) 1998-04-13 2000-10-12 American Home Prod 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists.
WO1999055672A2 (en) * 1998-04-29 1999-11-04 American Home Products Corporation Antipsychotic indolyl derivatives
JPH11335286A (ja) 1998-05-25 1999-12-07 Mitsui Chem Inc ドーパミン拮抗薬の効果増強剤
US20030027817A1 (en) * 1998-05-29 2003-02-06 Tollefson Gary Dennis Combination therapy for treatment of bipolar disorders
HN1999000146A (es) 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US6267989B1 (en) 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
RU2268725C2 (ru) 2000-01-19 2006-01-27 Акцо Нобель Н.В. Комбинация лекарственных препаратов, включающая миртазапин, для лечения депрессии и связанных расстройств
CA2311734C (en) 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Flash-melt oral dosage formulation
WO2003030868A1 (en) 2001-10-09 2003-04-17 Bristol-Myers Squibb Company Flashmelt oral dosage formulation
JP4197088B2 (ja) 2000-06-05 2008-12-17 電気化学工業株式会社 低密度かつ低ガス透過性六方晶窒化硼素焼結体及びその製造方法
EP1353675A2 (en) 2001-01-02 2003-10-22 PHARMACIA & UPJOHN COMPANY New drug combinations of norepinehrine reuptake inhibitors and neuroleptic agents
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
SI1627639T1 (sl) 2001-06-19 2010-04-30 Mueller Norbert Uporaba inhibitorjev COX-2 za zdravljenje afektivnih motenj
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
JP2003238393A (ja) 2002-02-15 2003-08-27 Otsuka Pharmaceut Co Ltd 施錠性が改善された錠剤及びその製造方法
AR042806A1 (es) 2002-12-27 2005-07-06 Otsuka Pharma Co Ltd Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo
CA2526562C (en) 2003-05-23 2011-06-28 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and mood stabilizers for treating mood disorders
BRPI0415531B8 (pt) 2003-10-23 2021-05-25 Otsuka Pharma Co Ltd formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação
CA2658146A1 (en) 2006-07-12 2008-01-17 Nerviano Medical Sciences S.R.L. Crystalline nemorubicin hydrochloride
JPWO2009072334A1 (ja) 2007-12-03 2011-04-21 富田製薬株式会社 製剤用核粒子
GB2456183A (en) 2008-01-04 2009-07-08 Gw Pharma Ltd Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament

Also Published As

Publication number Publication date
IL153838A (en) 2008-04-13
PL225415B1 (pl) 2017-04-28
PE20090124A1 (es) 2009-03-07
CN101579343B (zh) 2012-04-18
NO336265B1 (no) 2015-07-06
EP1330249B1 (en) 2006-04-05
CA2426921A1 (en) 2003-04-03
US8993761B2 (en) 2015-03-31
EP1419776A3 (en) 2004-06-16
EP1927357B1 (en) 2010-05-12
EP1925308A1 (en) 2008-05-28
CN106692151A (zh) 2017-05-24
CN101434574A (zh) 2009-05-20
EP1927357A3 (en) 2008-06-11
US20070212421A1 (en) 2007-09-13
SI1927355T1 (sl) 2010-07-30
DE60210409D1 (de) 2006-05-18
EP1927357A2 (en) 2008-06-04
PT1927356E (pt) 2010-05-24
EP1927356B1 (en) 2010-04-28
CA2689051C (en) 2011-03-08
NO336262B1 (no) 2015-07-06
CY1118195T1 (el) 2017-06-28
SI1927356T1 (sl) 2010-07-30
CA2688860A1 (en) 2003-04-03
CN101579344A (zh) 2009-11-18
US9359302B2 (en) 2016-06-07
EP1927355B1 (en) 2010-04-28
JP3760264B2 (ja) 2006-03-29
US8703773B2 (en) 2014-04-22
ES2343179T5 (es) 2017-10-19
CN101574348B (zh) 2012-02-22
AU2002334413C9 (en) 2015-04-09
US20140030523A1 (en) 2014-01-30
ATE464050T1 (de) 2010-04-15
CN101434573A (zh) 2009-05-20
CN101434575A (zh) 2009-05-20
JP4614870B2 (ja) 2011-01-19
US20070203152A1 (en) 2007-08-30
CA2689051A1 (en) 2003-04-03
NO20081633L (no) 2003-01-17
US20070203151A1 (en) 2007-08-30
HUP0600141A3 (en) 2008-03-28
EP1419776B2 (en) 2017-07-19
US20120000998A1 (en) 2012-01-05
US20120316180A1 (en) 2012-12-13
US20120316179A1 (en) 2012-12-13
DE60236231D1 (de) 2010-06-10
DK1927356T3 (da) 2010-07-26
MXPA03000440A (es) 2003-10-06
US20200123110A1 (en) 2020-04-23
CN101434573B (zh) 2011-12-07
EP1330249A1 (en) 2003-07-30
CN101423493A (zh) 2009-05-06
US20070203150A1 (en) 2007-08-30
ES2343602T3 (es) 2010-08-04
CN1817882A (zh) 2006-08-16
US8901303B2 (en) 2014-12-02
NO20030247L (no) 2003-01-17
CN106420640A (zh) 2017-02-22
NO20081627L (no) 2003-01-17
US20040058935A1 (en) 2004-03-25
DE60236229D1 (de) 2010-06-10
CA2688915A1 (en) 2003-04-03
US8901130B2 (en) 2014-12-02
WO2003026659A1 (en) 2003-04-03
DK1927355T3 (da) 2010-07-19
EP1925308B1 (en) 2016-08-31
EP1419776A9 (en) 2004-09-08
EP1419776A8 (en) 2004-09-01
HUP0600141A2 (hu) 2006-05-29
US20190225584A1 (en) 2019-07-25
NO328134B1 (no) 2009-12-14
NO336679B1 (no) 2015-10-19
CA2689052C (en) 2011-02-15
BR0205391A (pt) 2003-07-29
CA2426921C (en) 2011-03-15
ES2261750T3 (es) 2006-11-16
AR056503A2 (es) 2007-10-10
ATE465737T1 (de) 2010-05-15
CA2688934A1 (en) 2003-04-03
NO20081632L (no) 2003-01-17
PT1419776E (pt) 2010-04-28
UA84764C2 (en) 2008-11-25
CN101574348A (zh) 2009-11-11
ES2343179T3 (es) 2010-07-26
EP1419776A2 (en) 2004-05-19
IL153838A0 (en) 2003-07-31
NO336263B1 (no) 2015-07-06
ATE467416T1 (de) 2010-05-15
IL188455A0 (en) 2008-03-20
US8399469B2 (en) 2013-03-19
CN101574347B (zh) 2012-02-29
US20140309236A1 (en) 2014-10-16
ES2343219T3 (es) 2010-07-26
CN101423492A (zh) 2009-05-06
CN106420627A (zh) 2017-02-22
DK1419776T4 (en) 2017-09-04
NO20030247D0 (no) 2003-01-17
EP1927355A1 (en) 2008-06-04
JP3750023B2 (ja) 2006-03-01
CA2689052A1 (en) 2003-04-03
EP1419776B1 (en) 2010-04-14
CN101423492B (zh) 2013-08-28
DE60210409T2 (de) 2006-11-16
US8642760B2 (en) 2014-02-04
NO336264B1 (no) 2015-07-06
DK1419776T3 (da) 2010-07-05
PT1330249E (pt) 2006-06-30
US20070213343A1 (en) 2007-09-13
US20160251315A1 (en) 2016-09-01
CN101579343A (zh) 2009-11-18
US8580796B2 (en) 2013-11-12
US20120315302A1 (en) 2012-12-13
DE60235995D1 (de) 2010-05-27
CN101792415A (zh) 2010-08-04
JP2004256555A (ja) 2004-09-16
CN101579344B (zh) 2012-05-30
JP2006070045A (ja) 2006-03-16
CN101574347A (zh) 2009-11-11
SI1330249T1 (sl) 2006-10-31
CA2688934C (en) 2011-05-17
CN101434574B (zh) 2011-12-14
JP2003212852A (ja) 2003-07-30
PT1927357E (pt) 2010-06-08
US20120016123A1 (en) 2012-01-19
NO20091689L (no) 2003-01-17
CN1699346A (zh) 2005-11-23
US10150735B2 (en) 2018-12-11
SI1419776T1 (sl) 2010-07-30
US20150225347A1 (en) 2015-08-13
NO20081631L (no) 2003-01-17
AU2002334413C1 (en) 2021-08-12
CN1463191A (zh) 2003-12-24
EP1927356A1 (en) 2008-06-04
US8017615B2 (en) 2011-09-13
NO20081626L (no) 2003-01-17
PT1927355E (pt) 2010-06-11
ES2343220T3 (es) 2010-07-26
AU2002334413B2 (en) 2004-11-04
ATE322269T1 (de) 2006-04-15
CN1817882B (zh) 2011-09-07
ATE465736T1 (de) 2010-05-15
CA2688915C (en) 2011-02-01
US7910589B2 (en) 2011-03-22
DE60236383D1 (de) 2010-06-24
US20070213344A1 (en) 2007-09-13
US20070202181A1 (en) 2007-08-30
DK1927357T3 (da) 2010-08-16
AR033485A1 (es) 2003-12-26
US20210395204A1 (en) 2021-12-23
SI1419776T2 (sl) 2017-12-29
PL360900A1 (en) 2004-09-20

Similar Documents

Publication Publication Date Title
DK1330249T3 (da) Aripiprazol-lægemiddelstof med lav hygroskopicitet og fremgangsmåder til fremstilling deraf
DK1542668T3 (da) Formulering af aripiprazolkompleks og fremgangsmåde
DK1539224T3 (da) Antimikrobielt præparat og fremgangsmåde til anvendelse
DK1478339T3 (da) Farmaceutiske formuleringer af antineoplastiske midler, specielt temozolomid, fremgangsmåder til fremstilling og anvendelse heraf
DK1414816T3 (da) Stabil polymorf af flibanserin, teknisk fremgangsmåde til fremstilling deraf og anvendelse deraf til lægemiddelfremstilling
IS7188A (is) Asabísýklísk-setin samtengd heteróarýl efnasambönd, aðferð til framleiðslu þeirra og notkun
NO20055317D0 (no) Fremgangsmate og system for medisinsk undersokelse hjemme
DK1400518T3 (da) Heterocycliske forbindelser og lægemidler
NO20030832D0 (no) Kondenserte cykliske forbindelser og medisinsk anvendelse derav
DK1381351T3 (da) Fremgangsmåde til kontinuerlig fremstilling af inhalerbare medikamenter
NO20053874L (no) Formulering og metoder for behandling av thrombocytemi
IS7089A (is) Lyfjasamsetningar amlódipíns og atórvastatíns
NO20033854D0 (no) N-but-3-enyl-norbuprenorfin og fremgangsmåter for anvendelse
NO20032332L (no) Benzodiazepinderivatforbindelser, fremgangsmåte til fremstilling og anvendelse derav
EE05385B1 (et) LaiaspektrilisedÁ2-(asendatudÁamino)bensotiasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁvalmistamismeetodÁjaÁkasutamineÁningÁfarmatseutilineÁkompositsioon
DK1417189T3 (da) Acylaminothiazolderivater, fremstilling og terapeutisk anvendelse heraf
DE60236743D1 (de) Zur behandlung androgenabhängiger krankheiten
NO20033506L (no) Parasitticidale preparater og metoder for anvendelse
DK1556382T3 (da) 3-Phenylpyridoindolderivater, fremstilling og terapeutisk anvendelse deraf
DK1520587T3 (da) Allergivaccinesammensætning, fremgangsmåde til fremstilling deraf og anvendelse deraf til allergibehandling
IS7424A (is) Oxasólídínónafleiður, aðferðir til að framleiða þær og lyfjablöndur sem innihalda þær
DK1355668T3 (da) Anvendelse af IL-18 inhibitorer til behandling og/eller forebyggelsen af hjertesygdom
IS2331B (is) 2-arýlimínó-2,3-díhýdróþíasólafleiður, aðferðir til að framleiða þær og meðferðarfræðileg notkun þeirra
NO20033117D0 (no) Farmasoytiske blandinger som inhiberer vaskulor proliferasjon og metoder for anvendelse derav
DK1696913T3 (da) Vinfluninholdigt farmaceutisk præparat til parenteral administration, fremgangsmåde til fremstilling deraf og dets anvendelse