BRPI0815382A2 - Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento - Google Patents

Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento

Info

Publication number
BRPI0815382A2
BRPI0815382A2 BRPI0815382-5A2A BRPI0815382A BRPI0815382A2 BR PI0815382 A2 BRPI0815382 A2 BR PI0815382A2 BR PI0815382 A BRPI0815382 A BR PI0815382A BR PI0815382 A2 BRPI0815382 A2 BR PI0815382A2
Authority
BR
Brazil
Prior art keywords
aripiprazol
suspension
producing
methods
dry formulation
Prior art date
Application number
BRPI0815382-5A2A
Other languages
English (en)
Inventor
Shogo Hiraoka
Takakuni Matsuda
Junichi Hatanaka
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BRPI0815382A2 publication Critical patent/BRPI0815382A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BRPI0815382-5A2A 2007-07-31 2008-07-30 Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento BRPI0815382A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007200088 2007-07-31
PCT/JP2008/064076 WO2009017250A1 (en) 2007-07-31 2008-07-30 Methods for producing aripiprazole suspension and freeze-dried formulation

Publications (1)

Publication Number Publication Date
BRPI0815382A2 true BRPI0815382A2 (pt) 2015-02-10

Family

ID=39816777

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815382-5A2A BRPI0815382A2 (pt) 2007-07-31 2008-07-30 Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento

Country Status (28)

Country Link
US (6) US9457026B2 (pt)
EP (1) EP2170279B1 (pt)
JP (1) JP4879349B2 (pt)
KR (1) KR101546106B1 (pt)
CN (1) CN101801342B (pt)
AR (2) AR067747A1 (pt)
BR (1) BRPI0815382A2 (pt)
CA (1) CA2695178C (pt)
CO (1) CO6290634A2 (pt)
CY (1) CY1120165T1 (pt)
DK (1) DK2170279T3 (pt)
ES (1) ES2661037T3 (pt)
HR (1) HRP20180295T1 (pt)
HU (1) HUE036214T2 (pt)
IL (2) IL244186A0 (pt)
LT (1) LT2170279T (pt)
MX (1) MX2010001311A (pt)
MY (1) MY152789A (pt)
NO (1) NO2170279T3 (pt)
NZ (1) NZ582415A (pt)
PL (1) PL2170279T3 (pt)
PT (1) PT2170279T (pt)
RU (1) RU2483711C2 (pt)
SI (1) SI2170279T1 (pt)
TW (1) TWI410255B (pt)
UA (1) UA97286C2 (pt)
WO (1) WO2009017250A1 (pt)
ZA (1) ZA201000307B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2483711C2 (ru) * 2007-07-31 2013-06-10 Оцука Фармасьютикал Ко., Лтд. Способы получения суспензии арипипразола и лиофилизированного состава
PT105058B (pt) 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos
BR112012028368B8 (pt) * 2010-08-24 2022-07-19 Otsuka Pharma Co Ltd Processo para prevenção de aglomeração de partículas de ingrediente ativo em uma suspensão, suspensão e composição de torta contendo derivado carbo estirila e óleo de silicone e/ou derivado de óleo de silicone
HUE055836T2 (hu) * 2011-01-24 2021-12-28 Otsuka Pharma Co Ltd Aripiprazolt hatóanyagként tartalmazó pogácsakészítményt tartalmazó orvostechnikai eszköz és aripiprazolt hatóanyagként tartalmazó pogácsakészítmény
JO3410B1 (ar) * 2011-06-07 2019-10-20 Otsuka Pharma Co Ltd تركيبة أريبيبرازول مجفف بالتبريد
KR101103011B1 (ko) * 2011-10-13 2012-01-05 (주)일신오토클레이브 스크루 형 고압 발생 장치
CN102524261B (zh) * 2011-12-16 2014-12-03 辽宁师范大学 一种强力生根剂纳米制剂、其制备方法及应用
CN102450269A (zh) * 2011-12-27 2012-05-16 辽宁师范大学 三唑酮纳米胶体悬浮剂及其制备方法
AR090775A1 (es) 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
JOP20200109A1 (ar) * 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
WO2014002553A1 (ja) * 2012-06-29 2014-01-03 丸石製薬株式会社 アリピプラゾールの経口医薬製剤
JP5341282B1 (ja) * 2012-06-29 2013-11-13 丸石製薬株式会社 アリピプラゾールの経口医薬製剤
JP6007169B2 (ja) * 2012-11-30 2016-10-12 大原薬品工業株式会社 アリピプラゾール無水物を含有する固形製剤の製造方法
US9655951B2 (en) * 2013-01-23 2017-05-23 Cartilast II LLC Preservation of the biological activity of undenatured type II collagen
AR096131A1 (es) 2013-04-30 2015-12-09 Otsuka Pharma Co Ltd Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol
WO2017025930A1 (en) 2015-08-12 2017-02-16 Ftf Pharma Private Limited Oral solution of aripiprazole
CN106474058B (zh) * 2015-08-31 2020-01-07 南京诺瑞特医药科技有限公司 具有延长的保质期的阿立哌唑可注射悬浮液制剂
EP3490529A1 (en) 2016-07-28 2019-06-05 Mylan Laboratories Ltd. Process for preparing sterile aripiprazole formulation
US10821200B2 (en) 2016-12-05 2020-11-03 Hyalo Technologies, LLC Method of sterilization of microparticles
CN108938578A (zh) * 2017-05-25 2018-12-07 万全万特制药（厦门）有限公司 阿立哌唑分散片及其制备方法
US20230310417A1 (en) * 2020-03-30 2023-10-05 Cipla Limited Injectable aripiprazole formulation
EP4043008A1 (en) 2021-02-15 2022-08-17 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Method for the preparation of a pharmaceutical composition comprising aripiprazole
CN115554253B (zh) * 2022-10-14 2024-03-29 浙江圣兆药物科技股份有限公司 一种平稳释药的注射用阿立哌唑冻干制剂及其制备方法
CN117281784B (zh) * 2023-11-24 2024-02-27 山东则正医药技术有限公司 一种阿立哌唑注射剂及其制备方法和应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB209551A (en) 1922-11-20 1924-01-17 William Mortimer Melmore Improvements in or relating to petrol and other cans
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
CA1209477A (en) 1981-03-26 1986-08-12 Bruce E. Haeger Composition of matter comprising a lyophilized preparation of a penicillin derivative
JPS5832899A (ja) * 1981-08-18 1983-02-25 Takeda Chem Ind Ltd オキセンドロン水性懸濁剤
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
IL68549A (en) * 1983-05-03 1988-05-31 Kit Medidont Ltd Method and instrument for measuring moisture
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JP2608788B2 (ja) 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
FR2663223B1 (fr) * 1990-06-14 1994-12-02 Af Aplicaciones Far Lab Forme galenique parenterale.
DE69112917T2 (de) * 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
IT1244880B (it) 1990-12-11 1994-09-12 Torre A Farmaceutici Formulazioni di amminoacidi liofilizzati contenenti glutammina, loro preparazione ed uso nell'alimentazione parenterale
US6193983B1 (en) * 1992-06-01 2001-02-27 The University Of Melbourne Equine herpesvirus glycoproteins
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
ES2236700T3 (es) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
DE69530196T2 (de) 1994-06-02 2003-11-20 Elan Drug Delivery Ltd Methode zum verhindern der aggregation von proteinen/peptiden bei rehydratation oder auftauen
RU2082401C1 (ru) 1994-08-18 1997-06-27 Фармацевтическое акционерное общество "Ферейн" Способ получения лекарственной формы комбинированного препарата
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US6165442A (en) * 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
PT941066E (pt) 1996-08-26 2004-03-31 Transgene Sa Complexos de lipido cationico - acido nucleico
US6297231B1 (en) * 1996-10-28 2001-10-02 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
GB9705588D0 (en) * 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
WO1999049846A2 (en) 1998-03-30 1999-10-07 Rtp Pharma Inc. Compositions containing microparticles of water-insoluble substances and method for their preparation
WO2000006124A2 (en) * 1998-07-30 2000-02-10 Point Biomedical Corporation A novel excipient for the lyophilization of aqueous suspensions of microparticles
DE19857609A1 (de) * 1998-12-14 2000-06-15 Hannelore Ehrenreich Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
US6455526B1 (en) * 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
US6267989B1 (en) * 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
WO2000072835A2 (en) * 1999-05-27 2000-12-07 El Khoury George F Topical application of muscarinic and opioid agents for treatment of tinnitus
JP2001187735A (ja) 2000-01-05 2001-07-10 Towa Yakuhin Kk 安定なニコランジル含有粉末の製造法
US6559128B1 (en) * 2000-01-21 2003-05-06 Northwestern University Inhibitors of G protein-mediated signaling, methods of making them, and uses thereof
RU2169574C1 (ru) 2000-01-27 2001-06-27 Кобатов Алексей Иванович Способ получения биопрепарата и сухой биопрепарат
WO2001058428A1 (en) 2000-02-10 2001-08-16 Alkermes Controlled Therapeutics, Inc. Method of preparing a sustained release composition
HUP0301797A3 (en) 2000-03-27 2010-09-28 Scripps Research Inst Inhibition of angiogenesis and tumor growth
JP5102423B2 (ja) 2000-04-20 2012-12-19 オバン・エナジー・リミテッド 改善された水不溶性薬剤粒子の処理
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
JP2002241284A (ja) 2001-02-16 2002-08-28 Towa Yakuhin Kk 全身投与用アルガトロバン注射液
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
JP2003063965A (ja) 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
WO2002102414A1 (en) 2001-06-14 2002-12-27 Otsuka Pharmaceutical Co., Ltd. Medicinal compositions
WO2003024426A1 (en) 2001-09-21 2003-03-27 Egalet A/S Controlled release solid dispersions
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
ITMI20020808A1 (it) * 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
EP1551457A1 (en) * 2002-07-16 2005-07-13 Elan Pharma International Limited Liquid dosage compositions of stable nanoparticulate active agents
US7115587B2 (en) * 2002-08-20 2006-10-03 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
CA2511523C (en) * 2002-12-31 2013-10-15 Nektar Therapeutics Pharmaceutical formulation with an insoluble active agent for pulmonary administration
US7658998B2 (en) 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
JP2005022989A (ja) 2003-06-30 2005-01-27 Otsuka Pharmaceut Factory Inc 可溶化または分散化された難溶性化合物を含む組成物
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
US20050032811A1 (en) 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
PT1675573E (pt) * 2003-10-23 2008-12-30 Otsuka Pharma Co Ltd Formulação de iripiprazole injectável estéril de libertação controlada e um processo para a sua preparação
TWI371274B (en) 2003-10-23 2012-09-01 Bristol Myers Squibb Co Process for making sterile aripiprazole of desired mean particle size
WO2005041897A2 (en) * 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
WO2005072702A2 (en) 2004-01-20 2005-08-11 Alkermes Controlled Therapeutics, Inc. Method for milling frozen microparticles
AU2005224030B2 (en) * 2004-03-23 2008-09-25 Novartis Ag Pharmaceutical compositions
DE102005011786A1 (de) * 2005-03-11 2006-09-14 Pharmasol Gmbh Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen
WO2006097343A1 (en) * 2005-03-17 2006-09-21 Synthon B.V. Process of making crystalline type ii aripiprazole
EP2279727A3 (en) * 2005-09-15 2011-10-05 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
WO2007053904A1 (en) * 2005-11-10 2007-05-18 Alphapharm Pty Ltd Process to control particle size
US20070148245A1 (en) * 2005-12-22 2007-06-28 Ilan Zalit Compressed solid dosage forms with drugs of low solubility and process for making the same
RU2483711C2 (ru) * 2007-07-31 2013-06-10 Оцука Фармасьютикал Ко., Лтд. Способы получения суспензии арипипразола и лиофилизированного состава

Also Published As

Publication number Publication date
MX2010001311A (es) 2010-04-21
JP4879349B2 (ja) 2012-02-22
LT2170279T (lt) 2018-03-12
IL244231A0 (en) 2016-04-21
EP2170279A1 (en) 2010-04-07
CO6290634A2 (es) 2011-06-20
PL2170279T3 (pl) 2018-05-30
EP2170279B1 (en) 2017-12-27
US9457026B2 (en) 2016-10-04
JP2010535151A (ja) 2010-11-18
MY152789A (en) 2014-11-28
TW200922636A (en) 2009-06-01
AR117941A2 (es) 2021-09-08
RU2009149820A (ru) 2011-09-10
CA2695178A1 (en) 2009-02-05
DK2170279T3 (en) 2018-03-12
ZA201000307B (en) 2011-04-28
US20170035752A1 (en) 2017-02-09
KR20100057020A (ko) 2010-05-28
CN101801342A (zh) 2010-08-11
US20200246333A1 (en) 2020-08-06
CN101801342B (zh) 2012-07-11
TWI410255B (zh) 2013-10-01
IL244186A0 (en) 2016-04-21
HUE036214T2 (hu) 2018-06-28
UA97286C2 (ru) 2012-01-25
CA2695178C (en) 2015-06-23
US20210361646A1 (en) 2021-11-25
ES2661037T3 (es) 2018-03-27
KR101546106B1 (ko) 2015-08-20
PT2170279T (pt) 2018-04-06
RU2483711C2 (ru) 2013-06-10
NO2170279T3 (pt) 2018-05-26
CY1120165T1 (el) 2018-12-12
AU2008283251A1 (en) 2009-02-05
AR067747A1 (es) 2009-10-21
US20100196486A1 (en) 2010-08-05
SI2170279T1 (en) 2018-04-30
WO2009017250A1 (en) 2009-02-05
US20180185358A1 (en) 2018-07-05
HRP20180295T1 (hr) 2018-03-23
US20240139177A1 (en) 2024-05-02
NZ582415A (en) 2012-05-25

Similar Documents

Publication Publication Date Title
BRPI0815382A2 (pt) Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento
BRPI0923760A2 (pt) artigos nanoestruturados e métodos para fabricação de artigos nanoestruturados
BRPI0819368A2 (pt) Pneus e métodos para as suas manufaturas
BRPI0909973A2 (pt) "sistemas de acionamento de aerossol e métodos para fabricação do mesmo"
BRPI0812818A2 (pt) Turbo-reator para aeronave
BRPI0812446A2 (pt) Métodos para aperfeiçoamento de propriedades de proteína múltiplas
BRPI0815138A2 (pt) Métodos e organismos para a produção acoplada a crescimento de 1,4-butanodiol
DOS2006000058S (es) Masticador para animales
BRPI0919975A2 (pt) imunoensaio para galectina-3
BRPI0810108A2 (pt) Pneumático para veículos
BRPI0815469A2 (pt) Não-tecido e método para produção do mesmo
BRPI0817492A2 (pt) Método para secagem de gás comprimido
BRPI0915492A2 (pt) sistemas e métodos para transferir valores
BRPI0820548A2 (pt) Métodos para a formação de artigos microsporosos e microbicidas
BRPI0815602A2 (pt) Composições de liberação prolongada de trimetazidina e processo para a preparação das mesmas
BRPI0814438A2 (pt) Agente de gelificação para baterias
ES1068363Y (es) Neumatico para automoviles
BRPI0820594A2 (pt) Artigo estampado e método para fabricação de artigo estampado
ES1063735Y (es) Testero para persiana
ES1065835Y (es) Caperuza para cetreria
ES1066304Y (es) Bisagra para canapes
ES1063784Y (es) Camion transformable para autoescuelas
ES1063891Y (es) Bisagra para m0biliario
DOS2007000015S (es) Carrocerias para automoviles
DOS2007000041S (es) Carrocerías para automóviles

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]