UA97286C2 - Способ изготовления суспензии арипипразола и лиофилизированного состава - Google Patents

Способ изготовления суспензии арипипразола и лиофилизированного состава

Info

Publication number
UA97286C2
UA97286C2 UAA201002139A UAA201002139A UA97286C2 UA 97286 C2 UA97286 C2 UA 97286C2 UA A201002139 A UAA201002139 A UA A201002139A UA A201002139 A UAA201002139 A UA A201002139A UA 97286 C2 UA97286 C2 UA 97286C2
Authority
UA
Ukraine
Prior art keywords
suspension
aripiprazole
producing
dispersion machine
freeze
Prior art date
Application number
UAA201002139A
Other languages
English (en)
Ukrainian (uk)
Inventor
Сього Хираока
Такакуни Матсуда
Джуничи Хатанака
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютикал Ко., Лтд. filed Critical Оцука Фармасьютикал Ко., Лтд.
Publication of UA97286C2 publication Critical patent/UA97286C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Раскрыт способ изготовления суспензии арипипразола, где арипипразол имеет средний размер частичек от 1 до 10 мкм, причем способ включает этапы, на которые: (а) соединяют массу арипипразола и носитель для формирования первичной суспензии; (b) подвергают первичную суспензию первому измельчению, применяя, например, измельчающее устройство высокого сдвига, диспергатор, который прикладывает усилие сдвига к обрабатываемому материалу.
UAA201002139A 2007-07-31 2008-07-30 Способ изготовления суспензии арипипразола и лиофилизированного состава UA97286C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007200088 2007-07-31
PCT/JP2008/064076 WO2009017250A1 (en) 2007-07-31 2008-07-30 Methods for producing aripiprazole suspension and freeze-dried formulation

Publications (1)

Publication Number Publication Date
UA97286C2 true UA97286C2 (ru) 2012-01-25

Family

ID=39816777

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201002139A UA97286C2 (ru) 2007-07-31 2008-07-30 Способ изготовления суспензии арипипразола и лиофилизированного состава

Country Status (28)

Country Link
US (6) US9457026B2 (ru)
EP (1) EP2170279B1 (ru)
JP (1) JP4879349B2 (ru)
KR (1) KR101546106B1 (ru)
CN (1) CN101801342B (ru)
AR (2) AR067747A1 (ru)
BR (1) BRPI0815382A2 (ru)
CA (1) CA2695178C (ru)
CO (1) CO6290634A2 (ru)
CY (1) CY1120165T1 (ru)
DK (1) DK2170279T3 (ru)
ES (1) ES2661037T3 (ru)
HR (1) HRP20180295T1 (ru)
HU (1) HUE036214T2 (ru)
IL (2) IL244186A0 (ru)
LT (1) LT2170279T (ru)
MX (1) MX2010001311A (ru)
MY (1) MY152789A (ru)
NO (1) NO2170279T3 (ru)
NZ (1) NZ582415A (ru)
PL (1) PL2170279T3 (ru)
PT (1) PT2170279T (ru)
RU (1) RU2483711C2 (ru)
SI (1) SI2170279T1 (ru)
TW (1) TWI410255B (ru)
UA (1) UA97286C2 (ru)
WO (1) WO2009017250A1 (ru)
ZA (1) ZA201000307B (ru)

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CN115554253B (zh) * 2022-10-14 2024-03-29 浙江圣兆药物科技股份有限公司 一种平稳释药的注射用阿立哌唑冻干制剂及其制备方法
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Also Published As

Publication number Publication date
PL2170279T3 (pl) 2018-05-30
AU2008283251A1 (en) 2009-02-05
AR117941A2 (es) 2021-09-08
EP2170279A1 (en) 2010-04-07
PT2170279T (pt) 2018-04-06
JP2010535151A (ja) 2010-11-18
HRP20180295T1 (hr) 2018-03-23
CN101801342A (zh) 2010-08-11
WO2009017250A1 (en) 2009-02-05
ES2661037T3 (es) 2018-03-27
IL244231A0 (en) 2016-04-21
AR067747A1 (es) 2009-10-21
KR101546106B1 (ko) 2015-08-20
MY152789A (en) 2014-11-28
CA2695178A1 (en) 2009-02-05
US20200246333A1 (en) 2020-08-06
RU2009149820A (ru) 2011-09-10
LT2170279T (lt) 2018-03-12
US20210361646A1 (en) 2021-11-25
US20170035752A1 (en) 2017-02-09
CA2695178C (en) 2015-06-23
CY1120165T1 (el) 2018-12-12
JP4879349B2 (ja) 2012-02-22
KR20100057020A (ko) 2010-05-28
EP2170279B1 (en) 2017-12-27
HUE036214T2 (hu) 2018-06-28
NZ582415A (en) 2012-05-25
DK2170279T3 (en) 2018-03-12
TWI410255B (zh) 2013-10-01
RU2483711C2 (ru) 2013-06-10
US9457026B2 (en) 2016-10-04
MX2010001311A (es) 2010-04-21
TW200922636A (en) 2009-06-01
CN101801342B (zh) 2012-07-11
US20100196486A1 (en) 2010-08-05
US20240139177A1 (en) 2024-05-02
ZA201000307B (en) 2011-04-28
NO2170279T3 (ru) 2018-05-26
BRPI0815382A2 (pt) 2015-02-10
US20180185358A1 (en) 2018-07-05
CO6290634A2 (es) 2011-06-20
IL244186A0 (en) 2016-04-21
SI2170279T1 (en) 2018-04-30

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