KR100612981B1 - 다치환된 프로테아제 변이체 - Google Patents

다치환된 프로테아제 변이체 Download PDF

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Publication number
KR100612981B1
KR100612981B1 KR1020007004382A KR20007004382A KR100612981B1 KR 100612981 B1 KR100612981 B1 KR 100612981B1 KR 1020007004382 A KR1020007004382 A KR 1020007004382A KR 20007004382 A KR20007004382 A KR 20007004382A KR 100612981 B1 KR100612981 B1 KR 100612981B1
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South Korea
Prior art keywords
protease
residue
amino acid
positions
subtilisin
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Expired - Fee Related
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KR1020007004382A
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English (en)
Korean (ko)
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KR20010031374A (ko
Inventor
볼커 셀렌버거
제임스 티. 쥬니어 켈리스
크리스티안 패치
조안 나더니
도날드 피. 나키
아이루카란 제이. 풀로스
카테린 디. 콜리어
로버트 엠. 칼드웰
앙드레 씨. 백
Original Assignee
제넨코 인터내셔날 인코포레이티드
더 프락타 앤드 갬블 컴파니
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Application filed by 제넨코 인터내셔날 인코포레이티드, 더 프락타 앤드 갬블 컴파니 filed Critical 제넨코 인터내셔날 인코포레이티드
Publication of KR20010031374A publication Critical patent/KR20010031374A/ko
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Publication of KR100612981B1 publication Critical patent/KR100612981B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38609—Protease or amylase in solid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
  • Confectionery (AREA)
  • Exhaust Gas After Treatment (AREA)
KR1020007004382A 1997-10-23 1998-10-23 다치환된 프로테아제 변이체 Expired - Fee Related KR100612981B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US95632397A 1997-10-23 1997-10-23
US95632497A 1997-10-23 1997-10-23
US95656497A 1997-10-23 1997-10-23
US8/956,323 1997-10-23
US8/956,324 1997-10-23
US8/956,564 1997-10-23
US08/956,323 1997-10-23
US08/956,324 1997-10-23
US08/956,564 1997-10-23
PCT/US1998/022572 WO1999020770A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants

Publications (2)

Publication Number Publication Date
KR20010031374A KR20010031374A (ko) 2001-04-16
KR100612981B1 true KR100612981B1 (ko) 2006-08-14

Family

ID=27420734

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020007004382A Expired - Fee Related KR100612981B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체
KR1020007004389A Ceased KR20010024554A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 포함하는 표백 조성물
KR1020007004380A Expired - Fee Related KR100564039B1 (ko) 1997-10-23 1998-10-23 변경된 총전하를 갖는 세정제에 사용되기 위한 다중-치환된 프로테아제 변이체
KR1020007004391A Ceased KR20010024555A (ko) 1997-10-23 1998-10-23 다중 치환된 프로테아제 변이체 및 아밀라제 변이체를함유하는 세정 조성물
KR1020007004388A Abandoned KR20010031380A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 함유하는 세정 조성물
KR1020007004385A Expired - Fee Related KR100616143B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020007004389A Ceased KR20010024554A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 포함하는 표백 조성물
KR1020007004380A Expired - Fee Related KR100564039B1 (ko) 1997-10-23 1998-10-23 변경된 총전하를 갖는 세정제에 사용되기 위한 다중-치환된 프로테아제 변이체
KR1020007004391A Ceased KR20010024555A (ko) 1997-10-23 1998-10-23 다중 치환된 프로테아제 변이체 및 아밀라제 변이체를함유하는 세정 조성물
KR1020007004388A Abandoned KR20010031380A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 함유하는 세정 조성물
KR1020007004385A Expired - Fee Related KR100616143B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체

Country Status (26)

Country Link
US (5) US6482628B1 (https=)
EP (10) EP1398367B1 (https=)
JP (7) JP4346237B2 (https=)
KR (6) KR100612981B1 (https=)
CN (9) CN100558871C (https=)
AR (10) AR015977A1 (https=)
AT (9) ATE314478T1 (https=)
AU (7) AU1276299A (https=)
BR (6) BR9813260A (https=)
CA (9) CA2307640C (https=)
CZ (6) CZ300347B6 (https=)
DE (7) DE69841226D1 (https=)
DK (9) DK1624050T3 (https=)
EG (2) EG22075A (https=)
ES (7) ES2319401T3 (https=)
HK (1) HK1039159B (https=)
HU (3) HUP0104539A3 (https=)
ID (4) ID25637A (https=)
MA (2) MA24811A1 (https=)
NO (3) NO327607B1 (https=)
NZ (3) NZ519204A (https=)
PL (1) PL191529B1 (https=)
PT (8) PT1025239E (https=)
TR (8) TR200002014T2 (https=)
TW (2) TW585912B (https=)
WO (5) WO1999020726A1 (https=)

Families Citing this family (627)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
BR9811248B1 (pt) * 1997-08-29 2011-10-04 variante de enzima subtilase derivada de uma subtilase originária selecionada a partir do sub-grupo i-s1 ou do sub-grupo i-s2, dita variante tendo melhorado desempenho de lavagem em detergentes em comparação com a subtilase originária, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processo para produzir uma variante, composição, uso de uma variante de subtilase.
ES2368718T3 (es) * 1997-10-23 2011-11-21 Danisco Us Inc. Variantes de subtilisina con múltiples sustituciones.
AR015977A1 (es) * 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
DE69939538D1 (de) 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
AU1223000A (en) * 1998-10-23 2000-05-15 Procter & Gamble Company, The Methods for screening protease variants for use in detergent compositions
WO2000028007A2 (en) 1998-11-10 2000-05-18 Genencor International, Inc. Chemically modified mutant serine hydrolases
EP1185302B1 (en) * 1999-04-28 2013-07-24 Genencor International, Inc. Specifically targeted catalytic antagonists and uses thereof
US6627744B2 (en) 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
MXPA02000842A (es) * 1999-07-22 2002-07-30 Procter & Gamble Conjugados de proteasa que tienen sitios de corte protegidos estericamente.
BR0012660A (pt) * 1999-07-22 2002-04-09 Procter & Gamble Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
BR9917481A (pt) * 1999-09-09 2002-05-21 Procter & Gamble Composição detergente contendo uma protease
US6899961B2 (en) * 1999-12-15 2005-05-31 Samsung Sdi Co., Ltd. Organic electroluminescence device
US7067049B1 (en) * 2000-02-04 2006-06-27 Exxonmobil Oil Corporation Formulated lubricant oils containing high-performance base oils derived from highly paraffinic hydrocarbons
DE10007608A1 (de) * 2000-02-18 2001-08-30 Henkel Kgaa Protease und Percarbonat enthaltende Wasch- und Reinigungsmittel
AU3724801A (en) * 2000-03-03 2001-09-12 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
US6777218B1 (en) 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
JP2004508011A (ja) * 2000-04-03 2004-03-18 マキシジェン，　インコーポレイテッド スブチリシン変異体
EP1280817A2 (en) * 2000-04-28 2003-02-05 Novozymes A/S Production and use of protein variants having modified immunogenecity
EP1294845A1 (en) * 2000-06-30 2003-03-26 The Procter & Gamble Company Detergent compositions comprising a maltogenic alpha-amylase enzyme
AU2000260630A1 (en) * 2000-06-30 2002-01-14 The Procter & Gamble Company Detergent compositions comprising a cyclodextrin glucanotransferase enzyme
CN100491525C (zh) 2000-07-28 2009-05-27 汉高两合股份公司 从芽孢杆菌a7-7(dsm 12368)中提取的新型淀粉分解酶以及含有该新型淀粉分解酶的洗涤剂和清洗剂
US20020155574A1 (en) 2000-08-01 2002-10-24 Novozymes A/S Alpha-amylase mutants with altered properties
US6893855B2 (en) * 2000-10-13 2005-05-17 Novozymes A/S Subtilase variants
US6803222B2 (en) * 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
EP1241112A3 (en) 2001-03-15 2003-02-26 The Procter & Gamble Company Flexible multiple compartment pouch
PL210859B1 (pl) * 2001-03-23 2012-03-30 Genencor Int Odmiana subtylizyny zawierająca zmieniony epitop limfocytów T, kwas nukleinowy kodujący tę odmianę subtylizyny, wektor ekspresyjny i komórka gospodarza zawierająca kwas nukleinowy oraz kompozycje zawierające tę odmianę subtylizyny
ATE449840T1 (de) 2001-05-15 2009-12-15 Novozymes As Alpha-amylasevariante mit veränderten eigenschaften
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE10153792A1 (de) 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
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AU1276299A (en) 1999-05-10
AU742694B2 (en) 2002-01-10
DE69839057T2 (de) 2009-03-12
PT1025241E (pt) 2005-08-31
EP1571199B1 (en) 2011-06-22
KR20010031377A (ko) 2001-04-16
TR200001113T2 (tr) 2002-05-21
NO20001900L (no) 2000-06-15
CN1286723A (zh) 2001-03-07
NZ519204A (en) 2004-02-27
JP2001520044A (ja) 2001-10-30
NO20001899L (no) 2000-06-19
CA2308113C (en) 2011-07-26
CN1306577A (zh) 2001-08-01
AU1197199A (en) 1999-05-10
ATE416624T1 (de) 2008-12-15
HUP0103080A2 (hu) 2001-12-28
CA2306794C (en) 2009-07-07
DE69840335D1 (de) 2009-01-22
AR052355A2 (es) 2007-03-14
CA2306794A1 (en) 1999-04-29
DE69840346D1 (de) 2009-01-22
CA2308113A1 (en) 1999-04-29
US20030073222A1 (en) 2003-04-17
AU1199699A (en) 1999-05-10
EG21711A (en) 2002-02-27
MA24811A1 (fr) 1999-12-31
EP1398367A1 (en) 2004-03-17
AR052282A2 (es) 2007-03-07
KR100616143B1 (ko) 2006-08-25
ES2310014T5 (es) 2011-05-24
NZ520771A (en) 2004-06-25
CA2618389A1 (en) 1999-04-29
ATE511540T1 (de) 2011-06-15
CN1597899A (zh) 2005-03-23
ID28256A (id) 2001-05-10
BR9813879A (pt) 2000-09-26
CN1327476A (zh) 2001-12-19
AU1118199A (en) 1999-05-10
HUP0104539A2 (hu) 2002-04-29
KR20010031380A (ko) 2001-04-16
CN1279721A (zh) 2001-01-10
JP5612026B2 (ja) 2014-10-22
ATE417099T1 (de) 2008-12-15
KR20010024555A (ko) 2001-03-26
JP2001520305A (ja) 2001-10-30
EP1571199A2 (en) 2005-09-07
CN100506963C (zh) 2009-07-01
EP1612271A3 (en) 2009-02-25
KR20010024554A (ko) 2001-03-26
CA2308206A1 (en) 1999-04-29
AR052453A2 (es) 2007-03-21
PT1025239E (pt) 2008-04-30
CA2672492A1 (en) 1999-04-29
DE69829577T3 (de) 2010-05-20
EP1025240B1 (en) 2005-12-28
CN1198912C (zh) 2005-04-27
WO1999020771A3 (en) 1999-07-01
BR9814097A (pt) 2000-10-03
ES2255189T3 (es) 2006-06-16
HK1039159B (zh) 2008-05-09
CN1295313C (zh) 2007-01-17
DK1027418T3 (da) 2008-11-10
WO1999020723A9 (en) 1999-09-02
AR013718A1 (es) 2001-01-10
ES2241180T5 (es) 2010-03-26
PT1571199E (pt) 2011-09-27
EP1025240A2 (en) 2000-08-09
JP4346237B2 (ja) 2009-10-21
CN1279720A (zh) 2001-01-10
US6312936B1 (en) 2001-11-06
CZ301469B6 (cs) 2010-03-17
TR200002057T2 (tr) 2001-03-21

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