JP6217938B2 - 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 - Google Patents
小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 Download PDFInfo
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- JP6217938B2 JP6217938B2 JP2014539087A JP2014539087A JP6217938B2 JP 6217938 B2 JP6217938 B2 JP 6217938B2 JP 2014539087 A JP2014539087 A JP 2014539087A JP 2014539087 A JP2014539087 A JP 2014539087A JP 6217938 B2 JP6217938 B2 JP 6217938B2
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161553094P | 2011-10-28 | 2011-10-28 | |
| US61/553,094 | 2011-10-28 | ||
| US201261607487P | 2012-03-06 | 2012-03-06 | |
| US201261607503P | 2012-03-06 | 2012-03-06 | |
| US61/607,503 | 2012-03-06 | ||
| US61/607,487 | 2012-03-06 | ||
| PCT/US2012/062284 WO2013063512A1 (en) | 2011-10-28 | 2012-10-26 | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017174408A Division JP6443950B2 (ja) | 2011-10-28 | 2017-09-11 | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532662A JP2014532662A (ja) | 2014-12-08 |
| JP6217938B2 true JP6217938B2 (ja) | 2017-10-25 |
Family
ID=48168608
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539087A Active JP6217938B2 (ja) | 2011-10-28 | 2012-10-26 | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| JP2017174408A Active JP6443950B2 (ja) | 2011-10-28 | 2017-09-11 | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| JP2018218627A Active JP7237544B2 (ja) | 2011-10-28 | 2018-11-21 | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| JP2022181456A Pending JP2023022082A (ja) | 2011-10-28 | 2022-11-11 | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018030854A (ja) * | 2011-10-28 | 2018-03-01 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| US10226171B2 (en) | 2007-04-13 | 2019-03-12 | Nike, Inc. | Vision cognition and coordination testing and training |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201800453T1 (it) | 2010-11-04 | 2018-11-09 | Albireo Ab | Inibitori di ibat per il trattamento delle epatopatie |
| MX363161B (es) | 2011-10-28 | 2019-03-13 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
| EP2968230A2 (en) * | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| RU2016148364A (ru) | 2014-05-12 | 2018-06-13 | Конатус Фармасьютикалз, Инк. | Лечение осложнений хронического заболевания печени |
| JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Eaファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| KR101674806B1 (ko) | 2014-10-20 | 2016-11-10 | 씨제이헬스케어 주식회사 | 신규한 아미노알킬벤조티아제핀 유도체 및 이의 용도 |
| CN104324307A (zh) * | 2014-10-24 | 2015-02-04 | 济南高达信息技术有限公司 | 一种治疗脂肪泻的中药口服液制剂及其制备方法 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| EP3300500B9 (en) | 2015-05-20 | 2021-01-13 | Amgen Inc. | Triazole agonists of the apj receptor |
| KR101632839B1 (ko) | 2015-07-10 | 2016-06-23 | 아주대학교산학협력단 | 레스베라트톨 유도체를 유효성분으로 포함하는 간경화 또는 간섬유화 예방 또는 치료용 약학 조성물 |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| EP3452466B1 (en) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| WO2018097945A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| EP3541804B1 (en) | 2016-11-16 | 2025-01-22 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| BR112019017314A2 (pt) * | 2017-02-24 | 2020-04-14 | Genfit | composições farmacêuticas para terapia de combinação |
| CA3071285A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine granules, oral cholestyramine formulations and use thereof |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| TW201943410A (zh) * | 2018-04-10 | 2019-11-16 | 荷蘭商帝斯曼知識產權資產管理有限公司 | 具有彈性結構之多顆粒固體劑型 |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| FI3810581T3 (fi) | 2018-06-20 | 2025-02-28 | Albireo Ab | Odeviksibaatin kiteiset modifikaatiot |
| US11801226B2 (en) * | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11273123B2 (en) | 2018-07-18 | 2022-03-15 | USpharma Ltd | Chewable pharmaceutical dosage forms |
| US12390416B2 (en) | 2018-07-18 | 2025-08-19 | USpharma Ltd | Chewable pharmaceutical dosage forms |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| ES2937153T3 (es) | 2019-02-06 | 2023-03-24 | Albireo Ab | Compuestos de benzotiadiazepinas y su uso como moduladores de ácidos biliares |
| US20220133738A1 (en) | 2019-02-12 | 2022-05-05 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
| AR120682A1 (es) * | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| KR20220109450A (ko) | 2019-12-04 | 2022-08-04 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症(pfic)を処置するためのオデビキシバット |
| CN116710100A (zh) * | 2020-11-12 | 2023-09-05 | 阿尔比里奥公司 | 用于治疗进行性家族性肝内胆汁淤积(pfic)的奥德昔巴特 |
| CN116583504A (zh) | 2020-12-04 | 2023-08-11 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| PH12023553216A1 (en) * | 2021-05-24 | 2024-04-29 | Astellas Gene Therapies Inc | Compositions and methods for improved treatment of x-linked myotubular myopathy |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| TW202333722A (zh) * | 2021-10-26 | 2023-09-01 | 美商米魯姆製藥公司 | 頂端鈉依賴型轉運蛋白抑制劑組合物 |
| TW202333723A (zh) * | 2021-10-26 | 2023-09-01 | 美商米魯姆製藥公司 | 頂端鈉依賴型膽酸轉運蛋白抑制劑(asbti)之給藥方法 |
| EP4511038A1 (en) | 2022-04-22 | 2025-02-26 | Albireo AB | Subcutaneous administration of an asbt inhibitor |
| CN116421590B (zh) * | 2023-06-14 | 2023-08-29 | 深圳市第二人民医院(深圳市转化医学研究院) | 二乙酸氯己定在制备预防或/和治疗肝癌的药物中的用途 |
Family Cites Families (293)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE580490A (fr) | 1958-07-15 | 1960-01-08 | Merck & Co Inc | Compositions et procédés pour abaisser la teneur en cholestérol du sang |
| US3383281A (en) | 1961-09-22 | 1968-05-14 | Merck & Co Inc | Method for binding bile acids in vivo |
| US3308020A (en) | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
| US3389144A (en) | 1965-06-08 | 1968-06-18 | Mcneilab Inc | 5-pyridyl-2, 3, 4, 5-tetrahydrobenzothiepin-5-ols |
| US3287370A (en) | 1965-06-08 | 1966-11-22 | Mcneilab Inc | Tetrahydrobenzothiepins |
| DE1593760A1 (de) | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
| US3444176A (en) | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
| GB1269551A (en) | 1969-03-27 | 1972-04-06 | Science Union & Cie | New tricyclic derivatives and process for their manufacture |
| NL7017227A (enExample) | 1969-12-27 | 1971-06-29 | ||
| US3694446A (en) | 1970-02-24 | 1972-09-26 | William J Houlihan | 5-(substituted-benzyl)-benzocycloheptenes and-1-benzthiepines |
| CH537404A (de) | 1970-09-24 | 1973-05-31 | Sandoz Ag | Verfahren zur Herstellung neuer Thiophenderivate |
| CH531000A (de) | 1970-03-11 | 1972-11-30 | Sandoz Ag | Verfahren zur Herstellung neuer Benzocycloheptathiophene |
| US3821249A (en) | 1970-03-13 | 1974-06-28 | En Nom Collectif Science Union | Dibenzothiazefin derivatives |
| US3758528A (en) | 1970-03-13 | 1973-09-11 | Science Union & Cie | Tricyclic compounds |
| GB1348642A (en) | 1970-10-15 | 1974-03-20 | Howard A N | Hypocholesterolaemic compositions |
| US3769399A (en) | 1971-03-05 | 1973-10-30 | L Hagerman | Intestinal bile acid binding process and compositions |
| GB1428110A (en) | 1972-05-30 | 1976-03-17 | Reckitt & Colmann Prod Ltd | Pharmaceutical antihypertensive and vasodilator compositions |
| US3974272A (en) | 1972-09-01 | 1976-08-10 | Merck & Co., Inc. | Palatable cholestyramine coacervate compositions |
| CH582699A5 (enExample) | 1973-03-26 | 1976-12-15 | Sandoz Ag | |
| CH593970A5 (en) | 1973-03-30 | 1977-12-30 | Hoffmann La Roche | 10-(4-Substd. piperazino) dibenzo (b,f) thiepins - CNS depressants without cataleptic side-effects |
| US3954764A (en) | 1973-03-30 | 1976-05-04 | Hoffmann-La Roche Inc. | Dibenzo [b,f]thiepins bearing piperazinyl substitution |
| US4044010A (en) | 1973-03-30 | 1977-08-23 | Hoffmann-La Roche Inc. | Dibenzo[b,f] thiepins bearing piperazinyl substitution |
| US3928383A (en) | 1973-06-08 | 1975-12-23 | Hoffmann La Roche | Propynylamine-substituted dibenzo{8 b,f{9 thiepins and dibenz{8 b,f{9 oxepins |
| DK169075A (da) | 1974-05-10 | 1975-11-11 | Ciba Geigy | Fremgangsmade til fremstilling af heterocycliske s-imino-s-oxider syreadditionssalte deraf samt anvendelse deraf |
| SE420725B (sv) | 1974-09-26 | 1981-10-26 | Ciba Geigy Ag | Sett att framstella 2,3-dihydro-1-benstiepin-4-karboxylsyraamider |
| US4252790A (en) | 1974-10-23 | 1981-02-24 | Interx Research Corporation | Method for treating gastric ulcer-prone patients |
| GB1566609A (en) | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
| US4247553A (en) | 1977-10-31 | 1981-01-27 | The Upjohn Company | Methods of treating psychosis |
| US4153612A (en) | 1977-10-31 | 1979-05-08 | The Upjohn Company | 2-Benzoxepins |
| US4207239A (en) | 1977-10-31 | 1980-06-10 | The Upjohn Company | Benzothiepins |
| US4251526A (en) | 1977-10-31 | 1981-02-17 | Mccall John M | 2-Benzothiepins and compositions and methods of use therefore |
| US4247533A (en) | 1978-05-01 | 1981-01-27 | The Rockefeller University | Hemoglobin A1c radioimmunoassay |
| IT1106718B (it) | 1978-12-21 | 1985-11-18 | Alfa Farmaceutici Spa | Composizioni a base di resine anioniche salificate farmacologicamente attive |
| US5169857A (en) | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| AU548253B2 (en) | 1981-05-11 | 1985-12-05 | Pierre Fabre S.A. | Benzoxepine derivatives and sulphur and nitrogen analogues thereof |
| US4647459A (en) | 1983-07-20 | 1987-03-03 | Warner-Lambert Company | Confectionery compositions containing magnesium trisilicate adsorbates |
| US4771072A (en) | 1985-01-10 | 1988-09-13 | Tanabe Seiyaku Co., Ltd. | Alkoxynaphthalene derivatives |
| US4747881A (en) | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| AU597671B2 (en) | 1986-06-20 | 1990-06-07 | Suntory Limited | 2-Phenylbenzoxepin derivative |
| JPS6310746A (ja) | 1986-07-01 | 1988-01-18 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体 |
| US4895723A (en) | 1986-09-08 | 1990-01-23 | Amer And Company | Cholestyramine compositions and method for preparation thereof |
| US4814354A (en) | 1986-09-26 | 1989-03-21 | Warner-Lambert Company | Lipid regulating agents |
| ZA876930B (en) | 1986-10-07 | 1988-05-25 | Hoffmann La Roche | Pharmaceutical compositions |
| AU626881B2 (en) | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| US5164387A (en) | 1988-07-14 | 1992-11-17 | Hoffmann-Laroche Inc. | Condensed heterocyclic compounds |
| US5158943A (en) | 1988-11-21 | 1992-10-27 | Takeda Chemical Industries, Ltd. | Sulfur-containing heterocyclic compounds |
| US4874744A (en) | 1989-03-13 | 1989-10-17 | University Of Cincinnati | Method of using melanocyte stimulating hormone as dermatis treatment |
| US5275823A (en) | 1989-04-27 | 1994-01-04 | Smith Kline & French Laboratories Ltd. | Pharmaceutical compositions |
| DE3930696A1 (de) | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US4997665A (en) * | 1989-10-05 | 1991-03-05 | Michigan Biotechnology Institute | Dietary fibers and a process for their production |
| FR2661676A1 (fr) | 1990-05-02 | 1991-11-08 | Lipha | Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant. |
| ATE144988T1 (de) | 1990-12-06 | 1996-11-15 | Hoechst Ag | Gallensäurederivate, verfahren zu ihrer herstellung und verwendung dieser verbindung als arzneimittel |
| IT1245890B (it) | 1991-04-12 | 1994-10-25 | Alfa Wassermann Spa | Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari. |
| AU1886892A (en) | 1991-04-12 | 1992-11-17 | Schering Corporation | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase |
| DK0701991T3 (da) | 1991-10-17 | 1999-09-13 | Shionogi & Co | Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil |
| FI108451B (fi) | 1991-12-20 | 2002-01-31 | Hoechst Ag | Menetelmõ polymeeristen ja oligomeeristen sappihappojohdannaisten valmistamiseksi |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| ES2111092T3 (es) | 1992-06-12 | 1998-03-01 | Hoechst Ag | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos. |
| US5415872A (en) | 1992-06-22 | 1995-05-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| FR2698873B1 (fr) | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| IL108633A (en) | 1993-02-15 | 1998-07-15 | Wellcome Found | History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| US5594001A (en) | 1993-04-08 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders |
| DK0646570T3 (da) | 1993-04-16 | 1998-10-26 | Shionogi & Co | Fremgansmåde til fremstilling af lignanforbindelser |
| DE4314583A1 (de) | 1993-04-29 | 1994-11-03 | Astra Chem Gmbh | Colestyramin enthaltende Zusammensetzung und Verfahren zu deren Herstellung |
| TW289020B (enExample) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| TW289021B (enExample) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| ES2121599T3 (es) * | 1993-08-30 | 1998-12-01 | Medichemie Ag | Medicamento que contiene acido ursodeoxicolico en forma de administracion liquida. |
| US5589358A (en) | 1993-12-29 | 1996-12-31 | Univ Wake Forest | Ileal bile acid transporter compositions and methods |
| US5491152A (en) | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| KR970005178Y1 (ko) | 1994-07-06 | 1997-05-24 | 김상수 | 개량형 노통연관 보일러 |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| PT781278E (pt) | 1994-09-13 | 2001-08-30 | Monsanto Co | Novas benzotiepinas com actividade inibidora do transporte de acido biliar ileal e da remocao do taurocolato |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6107494A (en) | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5547975A (en) | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US6034118A (en) | 1994-11-04 | 2000-03-07 | Gilead Sciences, Inc. | Thiepane compounds |
| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| US6083977A (en) | 1994-12-30 | 2000-07-04 | Ligand Pharmaceuticals Incorporated | Trienoic retinoid compounds and methods |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US5798374A (en) | 1995-06-07 | 1998-08-25 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith |
| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US5886016A (en) | 1995-09-15 | 1999-03-23 | G.D. Searle & Co. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| JPH11515025A (ja) | 1995-11-02 | 1999-12-21 | ワーナー−ランバート・コンパニー | 脂質濃度を調節するための方法および医薬組成物 |
| ATE293883T1 (de) * | 1996-01-16 | 2005-05-15 | Ronald J Sokol | Verwendung von antioxidantien zur behandlung cholestatischer lebererkrankungen |
| GB9601697D0 (en) | 1996-01-27 | 1996-03-27 | Pfizer Ltd | Therapeutic agents |
| JP2001526627A (ja) | 1996-03-11 | 2001-12-18 | ジー.ディー.サール アンド カンパニー | 回腸胆汁酸輸送及びタウロコール酸塩吸収の阻害剤としての活性を有する新規ベンゾチエピン類 |
| DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| EP0929575A4 (en) | 1996-08-23 | 2004-09-08 | Human Genome Sciences Inc | NEW HUMAN GROWTH FACTORS. |
| JPH1072371A (ja) | 1996-08-28 | 1998-03-17 | Sankyo Co Ltd | 回腸型胆汁酸トランスポーター阻害剤 |
| US6251852B1 (en) | 1996-09-18 | 2001-06-26 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
| US5908830A (en) | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| GB9704208D0 (en) | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
| NZ337830A (en) | 1997-03-11 | 2001-07-27 | G | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| DE69815180T2 (de) | 1997-03-14 | 2004-04-29 | Aventis Pharma Deutschland Gmbh | Hypolipidemische 1,4-Benzothiazepin-1,1-dioxide |
| DK0869121T3 (da) | 1997-04-04 | 2004-09-20 | Aventis Pharma Gmbh | Hypolipidæmiske propanolaminderivater |
| DE19845402B4 (de) | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| IT1292092B1 (it) | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
| AU7552198A (en) | 1997-06-11 | 1998-12-30 | Sankyo Company Limited | Benzylamine derivatives |
| GB9714274D0 (en) | 1997-07-08 | 1997-09-10 | Zeneca Ltd | Pharmaceutical composition |
| US6180660B1 (en) | 1997-08-26 | 2001-01-30 | Merck & Co., Inc. | Cholesterol-lowering therapy |
| US6066336A (en) | 1997-09-29 | 2000-05-23 | Bristol-Myers Squibb Company | Cholesterol-lowering tablets |
| US5900233A (en) | 1997-10-16 | 1999-05-04 | Day; Charles E. | Epichlorohydrin and 1-(3-aminopropyl) imidazole copolymer and its use in treating irritable bowel syndrome |
| US6245797B1 (en) | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
| US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
| DE19755480A1 (de) | 1997-12-13 | 1999-06-24 | Gruenenthal Gmbh | Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen |
| WO1999032478A1 (en) | 1997-12-19 | 1999-07-01 | G.D. Searle & Co. | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
| GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
| JP2002501889A (ja) | 1998-02-02 | 2002-01-22 | トラスティーズ オブ タフツ カレッジ | グルコース代謝を調節する方法、およびそれに関連する試薬 |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19825804C2 (de) | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JP2000026300A (ja) | 1998-07-02 | 2000-01-25 | Pola Chem Ind Inc | 血管内皮細胞保護医薬組成物 |
| AU5194999A (en) | 1998-08-07 | 2000-02-28 | Takeda Chemical Industries Ltd. | Benzothiepin derivatives, process for the preparation of the same and uses thereof |
| EP1104416A2 (en) | 1998-08-20 | 2001-06-06 | Takeda Chemical Industries, Ltd. | Quaternary ammonium salts and their use as anti-hiv agents |
| DE19845403B4 (de) | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| DE19845406C2 (de) | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| AU1684400A (en) | 1998-12-11 | 2000-07-03 | Sankyo Company Limited | Substituted benzylamines |
| EP1140896A1 (en) | 1998-12-21 | 2001-10-10 | Takeda Chemical Industries, Ltd. | Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5 |
| KR20010102964A (ko) | 1998-12-23 | 2001-11-17 | 윌리암스 로저 에이 | 심장혈관 징후를 위한 회장 담즙산 수송 억제인자 및피브린산 유도체의 조합물 |
| EA200100704A1 (ru) | 1998-12-23 | 2002-02-28 | Джи.Ди.Сирл Ллс | Комбинация для применения по сердечно-сосудистым показаниям |
| CA2356422C (en) | 1998-12-23 | 2008-09-16 | G.D. Searle Llc | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| CN1338945A (zh) * | 1998-12-23 | 2002-03-06 | G·D·瑟尔有限公司 | 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合 |
| CN1195748C (zh) | 1999-02-12 | 2005-04-06 | G.D.瑟尔有限公司 | 具有作为回肠胆汁酸转运和牛磺胆酸摄取抑制剂活性的新的1,2-苯并硫氮杂 |
| CN1095238C (zh) | 1999-02-23 | 2002-11-27 | 东京零件工业株式会社 | 适应回流锡焊的小型电动机 |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| SE9901387D0 (sv) * | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| CZ290178B6 (cs) | 1999-07-22 | 2002-06-12 | Sankyo Company Limited | Deriváty cyklobutenu |
| EP1212619B1 (en) | 1999-09-14 | 2007-05-23 | Xenoport, Inc. | Substrates and screening methods for transport proteins |
| AU1302301A (en) | 1999-11-08 | 2001-06-06 | Sankyo Company Limited | Nitrogenous heterocycle derivatives |
| WO2001052823A2 (en) * | 2000-01-20 | 2001-07-26 | Noven Pharmaceuticals, Inc. | Compositions to effect the release profile in the transdermal administration of drugs |
| DE60132723T2 (de) | 2000-01-21 | 2009-01-29 | Novartis Pharma Ag | Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica |
| WO2001066096A2 (en) | 2000-03-06 | 2001-09-13 | Immune Network Ltd. | Compositions for prevention and treatment of dementia |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| WO2001068096A2 (en) | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| HK1052183A1 (zh) * | 2000-03-10 | 2003-09-05 | Pharmacia Corporation | 制造tetrahydrobenzothiepines的方法 |
| WO2001077325A1 (fr) | 2000-04-12 | 2001-10-18 | Takeda Chemical Industries, Ltd. | Nouvelle proteine de recepteur couple aux proteines g et adn de celle-ci |
| IT1316130B1 (it) | 2000-05-18 | 2003-03-28 | High Technology Investiments B | Impianto motore con apparecchiatura per il comando di disinserimento efermata regolato e/o modulato di una funivia. |
| NZ524049A (en) | 2000-07-17 | 2004-09-24 | Basf Ag | Process for the preparation of 4-thioalkylbromobenzene derivatives |
| US20020183307A1 (en) | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| AU2001289699B2 (en) | 2000-07-28 | 2006-06-01 | Cheplapharm Arzneimittel Gmbh | New pharmaceutical composition |
| AU2001264325A1 (en) | 2000-10-13 | 2002-04-29 | Bridgestone Corporation | Polyurethane foam compound for ink holder, ink holder and method for securing close contact of ink holder |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| CA2429214A1 (en) | 2000-11-17 | 2003-05-15 | Banyu Pharmaceutical Co., Ltd. | Guanosine triphosphate (gtp)-binding protein-coupled receptor protein, bg37 |
| MXPA03005155A (es) | 2000-12-21 | 2003-09-10 | Aventis Pharma Gmbh | 1,2-difenilazetidinonas novedosas, procesos para su preparacion, farmacos que contienen compuestos y su uso para el tratamiento del metabolismo afectado de los lipidos. |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| NZ542090A (en) | 2001-01-26 | 2006-09-29 | Schering Corp | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
| AU2002306868A1 (en) | 2001-03-28 | 2002-10-15 | Pharmacia Corporation | Therapeutic combinations for cardiovascular and inflammatory indications |
| AP2004002951A0 (en) | 2001-07-19 | 2004-03-31 | Pharmacia Corp | "Combination of Eplerenone and an HMG CoA Reductase Inhibitor". |
| HRP20040171A2 (en) | 2001-08-22 | 2004-10-31 | Aventis Pharma Gmbh | Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| CN1582151A (zh) * | 2001-09-08 | 2005-02-16 | 阿斯特拉曾尼卡有限公司 | 用于治疗高脂血症、具有回肠胆汁酸转运(ibat)抑制活性的苯并硫氮杂䓬和苯并硫杂二氮杂䓬衍生物 |
| EP1432721A4 (en) | 2001-09-13 | 2008-02-20 | Bristol Myers Squibb Co | PROCESS FOR THE PREPARATION OF REBECCAMYCIN AND ANALOGUE THEREOF |
| US7132415B2 (en) | 2001-09-21 | 2006-11-07 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
| ES2307093T3 (es) | 2001-10-01 | 2008-11-16 | THE GOVERNMENT OF THE USA, AS REPR. BY SECRETARY, DEPT. HEALTH & HUMAN SERVICES, NAT. INST OF HEALTH | Desarrollo de un vacuna preventiva para la infeccion por filovirus en primates. |
| US7342117B2 (en) | 2001-10-30 | 2008-03-11 | Astellas Pharma Inc. | α-form or β-form crystal of acetanilide derivative |
| JP2005518347A (ja) | 2001-11-02 | 2005-06-23 | ジー.ディー. サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送(asbt)およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
| JP2005521653A (ja) | 2002-01-17 | 2005-07-21 | ファルマシア コーポレイション | 先端ナトリウム同時依存性胆汁酸輸送(asbt)およびタウロコール酸塩取込みの阻害剤としての新規アルキル/アリールヒドロキシまたはケトチエピン化合物 |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| US20040014806A1 (en) | 2002-03-08 | 2004-01-22 | Pharmacia Corporation | Methods and compositions for lowering levels of blood lipids |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| US6987121B2 (en) | 2002-04-25 | 2006-01-17 | Smithkline Beecham Corporation | Compositions and methods for hepatoprotection and treatment of cholestasis |
| BR0311530A (pt) | 2002-05-23 | 2005-05-10 | Umd Inc | Compostos e método de liberação para droga transmucosal e para crio-proteção |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| US6861464B2 (en) | 2002-07-19 | 2005-03-01 | Diversified Chemical Technologies, Inc. | Two component, curable, hot melt adhesive |
| US7312208B2 (en) * | 2002-08-28 | 2007-12-25 | Asahi Kasei Pharma Corporation | Quaternary ammonium compounds |
| KR100990524B1 (ko) * | 2002-08-28 | 2010-10-29 | 아사히 가세이 파마 가부시키가이샤 | 신규한 4급 암모늄 화합물 |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| US20040122033A1 (en) | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
| FR2848452B1 (fr) | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
| US20040138145A1 (en) | 2002-12-12 | 2004-07-15 | Aventis Pharma S.A. | Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease |
| BR0316606A (pt) | 2002-12-12 | 2005-10-11 | Aventis Pharma Sa | Derivados de aminoindazóis e sua utilização como inibidores de quinases |
| US20040147774A1 (en) | 2002-12-20 | 2004-07-29 | Aventis Pharma S.A. | Novel chiral compounds derived from hexanoic acid esters, preparation process and intermediates, use in the synthesis of chiral 2-(bromomethyl)-2-ethylhexanoic acid |
| US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| WO2004081003A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| ATE474611T1 (de) | 2003-05-08 | 2010-08-15 | Novo Nordisk As | Eine auf die haut aufbringbare injektionsvorrichtung mit abtrennbarem betätigungsteil zum einführen der nadel |
| JP2005044778A (ja) | 2003-07-19 | 2005-02-17 | Samsung Sdi Co Ltd | 電界発光素子 |
| JP2005097216A (ja) | 2003-09-26 | 2005-04-14 | Kaneka Corp | PPARγリガンド剤 |
| CA2544309A1 (en) | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| EP1564554A1 (en) | 2004-02-12 | 2005-08-17 | Pepscan Systems B.V. | Method for the detection of early B cell populations in vaccine development |
| WO2005082874A1 (ja) * | 2004-02-27 | 2005-09-09 | Asahi Kasei Pharma Corporation | 新規なベンゾチアゼピン及びベンゾチエピン化合物 |
| DE102004016845A1 (de) | 2004-04-07 | 2005-10-27 | Bayer Healthcare Ag | Phenylthioessigsäure-Derivate und ihre Verwendung |
| WO2006017257A2 (en) | 2004-07-12 | 2006-02-16 | Phenomix Corporation | Azetidinone derivatives |
| US7501955B2 (en) | 2004-09-13 | 2009-03-10 | Avery Dennison Corporation | RFID device with content insensitivity and position insensitivity |
| JP2008513465A (ja) | 2004-09-15 | 2008-05-01 | ザ プレジデント アンド フェロウズ オブ ハーバード カレッジ | 肥満及び糖尿病の治療におけるerストレス低減 |
| DE102004046623A1 (de) | 2004-09-25 | 2006-03-30 | Bayer Healthcare Ag | Neue Pyrimidin-Derivate und ihre Verwendung |
| EP1807070A1 (en) | 2004-09-29 | 2007-07-18 | Schering Corporation | Combinations of substituted azetidinones and cb1 antagonists |
| EP1799889B1 (de) | 2004-10-13 | 2008-08-27 | Maschinenfabrik Rieter Ag | Verfahren zum befestigen eines garniturstreifens an einem deckelstab, garniturclip sowie presswerkzeug zum bearbeiten eines garniturclips. |
| JPWO2006041150A1 (ja) | 2004-10-15 | 2008-05-22 | 田辺三菱製薬株式会社 | 糖尿病の予防および/または治療薬 |
| KR20070068407A (ko) | 2004-10-25 | 2007-06-29 | 노파르티스 아게 | Dpp―iv 억제제, ppar 항당뇨병제 및메트포르민의 조합물 |
| WO2006057637A1 (en) | 2004-11-24 | 2006-06-01 | Seo Hong Yoo | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
| DE102004058062A1 (de) | 2004-12-02 | 2006-06-08 | Bayer Healthcare Ag | Cyclische Iminocarbamate und ihre Verwendung |
| EP1819684B1 (en) | 2004-12-03 | 2013-08-07 | Intervet International B.V. | Substituted piperazines as cb1 antagonists |
| US20070032420A1 (en) | 2005-02-09 | 2007-02-08 | Entelos, Inc. | Treating diabetes with glucagon-like peptide-1 secretagogues |
| US7441178B2 (en) | 2005-02-24 | 2008-10-21 | Keyeye Communications | Low complexity decoding of low density parity check codes |
| US20060193895A1 (en) | 2005-02-25 | 2006-08-31 | Use-Techno Corporation | Additive for food and beverage, pharmaceutical composition, GLUT4 translocator, and method for translocating GLUT4 |
| DE102005027150A1 (de) | 2005-03-12 | 2006-09-28 | Bayer Healthcare Ag | Pyrimidincarbonsäure-Derivate und ihre Verwendung |
| FR2883284A1 (fr) | 2005-03-15 | 2006-09-22 | Commissariat Energie Atomique | Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux |
| UY29445A1 (es) | 2005-03-30 | 2006-10-02 | Generex Pharm Inc | Composiciones para la transmisión transmucosa oral de la metformina |
| US20080031968A1 (en) | 2005-04-01 | 2008-02-07 | The Brigham And Women's Hospital, Inc. | Methods for increasing cellular energy expenditure |
| WO2006105913A1 (en) | 2005-04-04 | 2006-10-12 | Julius-Maximillians-Universität Würzburg | Tripeptides that down regulate the activity of plasma membrane transporters including sodium-d-glucose cotransporter sglt1 |
| WO2006105912A2 (en) | 2005-04-04 | 2006-10-12 | Julius-Maximilians-Universität Würzburg | Peptides that down regulate the activity of plasma membrane transporters including sodium-d-glucose cotransporter sglt1 |
| EP1877067A1 (en) | 2005-04-26 | 2008-01-16 | Microbia, Inc. | 4-biarylyl-1-phenylazetidin-2-one glucuronide derivatives for hypercholesterolemia |
| DE102005020229A1 (de) | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
| WO2006116814A1 (en) | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition and uses thereof |
| WO2006121861A2 (en) | 2005-05-05 | 2006-11-16 | Microbia, Inc. | Biphenylazetidinone cholesterol absorption inhibitors |
| WO2006122186A2 (en) | 2005-05-10 | 2006-11-16 | Microbia, Inc. | 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia |
| JP2008540573A (ja) | 2005-05-13 | 2008-11-20 | マイクロビア インコーポレーテッド | 4−ビアリーリル−1−フェニラゼチジン−2−オン類 |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
| US20070025953A1 (en) | 2005-07-27 | 2007-02-01 | Jones Michael R | Co-therapy for diabetic conditions |
| WO2007035703A1 (en) | 2005-09-20 | 2007-03-29 | Schering Corporation | 1- [ [1- [ (2-amin0-6-methyl-4-pyridinyl) methyl] -4-flu0r0-4-piperidinyl,] carbonyl] -4- [2- (2-pyridinyl) -3h-imidaz0 [4 , 5-b] pyridin-3-yl] piperidine useful as histamine h3 antagonist |
| US7459584B2 (en) | 2005-09-22 | 2008-12-02 | Board Of Trustees Of Michigan State University | Process for the preparation of lactic acid and glyceric acid |
| AU2006297130B2 (en) | 2005-09-30 | 2009-12-24 | Novartis Ag | DPP IV inhibitor for use in the treatment of autoimmune diseases and graft rejection |
| US8366650B2 (en) | 2005-10-24 | 2013-02-05 | Satiogen Pharmaceuticals, Inc. | Biliary/pancreatic shunt device and method for treatment of metabolic and other diseases |
| ES2374165T3 (es) | 2005-12-19 | 2012-02-14 | Glaxosmithkline Llc | Agonistas del receptor x farnesoide. |
| BRPI0620255A2 (pt) | 2005-12-21 | 2011-11-08 | Schering Corp | uso de agentes redutores de colesterol e/ou antagonista/agonista inverso do receptor de h3 |
| AR058985A1 (es) | 2006-01-13 | 2008-03-05 | Schering Corp | Diaril piperidinas como moduladores de cb1. |
| WO2007084450A2 (en) | 2006-01-18 | 2007-07-26 | Schering Corporation | Cannibinoid receptor modulators |
| AU2007243131A1 (en) | 2006-01-20 | 2007-11-08 | Smithkline Beecham Corporation | Use of sulfonamide derivatives in the treatment of disorders of the metabolism and the nervous system |
| CA2642220A1 (en) | 2006-02-14 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions |
| DE102006009813A1 (de) | 2006-03-01 | 2007-09-06 | Bayer Healthcare Ag | Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel |
| WO2007123949A2 (en) | 2006-04-21 | 2007-11-01 | Schering Corporation | Cannabinoid receptor modulators |
| DE102006024024A1 (de) | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| DE102006026585A1 (de) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung |
| DE102006026583A1 (de) | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung |
| EP2040713B1 (en) | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| WO2008028037A2 (en) | 2006-08-30 | 2008-03-06 | Andrew Young | Distender device and method for treatment of obesity and metabolic and other diseases |
| DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006043519A1 (de) | 2006-09-12 | 2008-03-27 | Bayer Healthcare Ag | 4-Phenoxynikotinsäure-Derivate und ihre Verwendung |
| DE102006043520A1 (de) | 2006-09-12 | 2008-03-27 | Bayer Healthcare Ag | 2-Phenoxynikotinsäure-Derivate und ihre Verwendung |
| US7884080B2 (en) | 2006-09-15 | 2011-02-08 | Schering Plough Corporation | Azetidinone derivatives and methods of use thereof |
| CN101541795A (zh) | 2006-09-15 | 2009-09-23 | 先灵公司 | 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物 |
| WO2008033447A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
| WO2008033468A2 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism |
| JP2010503672A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 脂質代謝障害、疼痛、糖尿病、および他の障害を治療するためのスピロ環アゼチジノン誘導体 |
| WO2008033465A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
| WO2008034087A2 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Treating schizophrenia with combinations of levodopa and an antipsychotic agent |
| MX2009002920A (es) | 2006-09-15 | 2009-04-01 | Schering Corp | Tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos. |
| DE102006044696A1 (de) | 2006-09-22 | 2008-03-27 | Bayer Healthcare Ag | 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung |
| WO2008039829A2 (en) | 2006-09-26 | 2008-04-03 | Ironwood Pharmaceuticals, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
| CL2007003035A1 (es) | 2006-10-24 | 2008-05-16 | Smithkline Beechman Corp | Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos, |
| US20080161400A1 (en) | 2006-10-26 | 2008-07-03 | Xenoport, Inc. | Use of forms of propofol for treating diseases associated with oxidative stress |
| DE102006053637B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP2083832B1 (de) | 2006-11-14 | 2011-01-05 | Sanofi-Aventis Deutschland GmbH | Neue 1,4-benzothiepin-1,1-dioxidderivate mit verbesserten eigenschaften, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| DE102006053635B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| WO2008067219A2 (en) | 2006-11-29 | 2008-06-05 | Kalypsys, Inc. | Quinazolinone modulators of tgr5 |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| CA2674683A1 (en) | 2007-01-16 | 2008-07-24 | The Burnham Institute For Medical Research | Compositions and methods for treatment of colorectal cancer |
| CN101679476B (zh) | 2007-01-19 | 2014-05-07 | 英特塞普特医药品公司 | 23取代的胆汁酸作为tgr5调节剂及其使用方法 |
| WO2008097976A1 (en) | 2007-02-09 | 2008-08-14 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| US20100144864A1 (en) | 2007-04-05 | 2010-06-10 | Ironwood Pharmaceuticals, Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
| WO2008130616A2 (en) | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| WO2009026537A1 (en) | 2007-08-23 | 2009-02-26 | Theracos, Inc. | Benzylbenzene derivatives and methods of use |
| WO2009115398A1 (en) | 2008-03-18 | 2009-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vitamin d compounds for the treatment of biliary diseases |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| WO2009147967A1 (ja) | 2008-06-05 | 2009-12-10 | 株式会社Adeka | アルミニウムフェノキシド化合物及び該化合物を用いた安定化ポリマーの製造方法 |
| AU2009276507B2 (en) | 2008-07-30 | 2015-11-19 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| JP2010072371A (ja) | 2008-09-18 | 2010-04-02 | Mitsubishi Heavy Ind Ltd | 定着装置および定着方法ならびに電子写真印刷機 |
| CN102325784B (zh) | 2008-11-19 | 2014-11-19 | 英特塞普特医药品公司 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
| JP2012509891A (ja) * | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ,インク. | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| CN102316889B (zh) | 2008-11-26 | 2014-11-26 | 萨蒂奥根制药公司 | 组合物及使用方法 |
| US20110065676A1 (en) | 2009-06-24 | 2011-03-17 | Schering Corporation | Combination therapies comprising par1 antagonists with nar agonists |
| JP5909774B2 (ja) * | 2009-08-25 | 2016-04-27 | クィン ビル セラピューティクス インコーポレイテッド | 胆道疾患を治療するためのポリヒドロキシル化胆汁酸 |
| WO2011075539A2 (en) | 2009-12-18 | 2011-06-23 | Satiogen Pharmaceuticals, Inc. | Treatment of obesity or diabetes with bile acid sequestrants |
| EP2995317A1 (en) | 2010-05-26 | 2016-03-16 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| SMT201800453T1 (it) | 2010-11-04 | 2018-11-09 | Albireo Ab | Inibitori di ibat per il trattamento delle epatopatie |
| US20120114588A1 (en) | 2010-11-08 | 2012-05-10 | Albireo Ab | Ibat inhibitors for treatment of metabolic disorders and related conditions |
| ES2586956T3 (es) | 2010-11-08 | 2016-10-19 | Albireo Ab | Combinación farmacéutica que comprende un inhibidor de IBAT y un aglutinante de ácidos biliares |
| AU2011326873B2 (en) | 2010-11-08 | 2015-02-19 | Albireo Ab | IBAT inhibitors for treatment of metabolic disorders and related conditions |
| US20130022551A1 (en) * | 2011-07-22 | 2013-01-24 | Trustees Of Boston University | DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS |
| MX363161B (es) * | 2011-10-28 | 2019-03-13 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
| US8987482B2 (en) | 2011-10-28 | 2015-03-24 | Basf Se | Process for producing a supported silver catalyst |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| US9007272B2 (en) | 2012-07-19 | 2015-04-14 | Tensorcom, Inc. | Method and apparatus for the alignment of a 60 GHz endfire antenna |
| EP2968230A2 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| PT3435996T (pt) | 2016-03-31 | 2025-05-13 | Genfit | Elafibranor para utilização no tratamento de colangite biliar primária |
| EP3612175B1 (en) | 2017-04-18 | 2025-09-10 | Genfit | Combination of elafibranor with an anti-nash, anti-fibrotic or anti-cholestatic agent |
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