EA030839B1 - Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей - Google Patents

Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей Download PDF

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Publication number
EA030839B1
EA030839B1 EA201490876A EA201490876A EA030839B1 EA 030839 B1 EA030839 B1 EA 030839B1 EA 201490876 A EA201490876 A EA 201490876A EA 201490876 A EA201490876 A EA 201490876A EA 030839 B1 EA030839 B1 EA 030839B1
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Prior art keywords
asbti
bile
bile acid
administered
dose
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EA201490876A
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English (en)
Russian (ru)
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EA201490876A1 (ru
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Бронислава Гедулин
Майкл Грей
Нейл О'Доннел
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ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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EA201490876A 2011-10-28 2012-10-26 Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей EA030839B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607487P 2012-03-06 2012-03-06
US201261607503P 2012-03-06 2012-03-06
PCT/US2012/062284 WO2013063512A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

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