JP5852005B2 - 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト - Google Patents

高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト Download PDF

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JP5852005B2
JP5852005B2 JP2012542215A JP2012542215A JP5852005B2 JP 5852005 B2 JP5852005 B2 JP 5852005B2 JP 2012542215 A JP2012542215 A JP 2012542215A JP 2012542215 A JP2012542215 A JP 2012542215A JP 5852005 B2 JP5852005 B2 JP 5852005B2
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acid
amino acid
disorders
inhibitors
peptide
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JP2013512923A5 (https=
JP2013512923A (ja
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クンバール シャイルバイ，
クンバール シャイルバイ，
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シナジー ファーマシューティカルズ インコーポレイテッド
シナジー ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012542215A 2009-12-03 2010-12-03 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト Active JP5852005B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/630,654 US8969514B2 (en) 2007-06-04 2009-12-03 Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US12/630,654 2009-12-03
PCT/US2010/058848 WO2011069038A2 (en) 2009-12-03 2010-12-03 Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases

Related Child Applications (1)

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JP2015126368A Division JP5942023B2 (ja) 2009-12-03 2015-06-24 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト

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JP2013512923A JP2013512923A (ja) 2013-04-18
JP2013512923A5 JP2013512923A5 (https=) 2014-01-30
JP5852005B2 true JP5852005B2 (ja) 2016-02-03

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JP2012542215A Active JP5852005B2 (ja) 2009-12-03 2010-12-03 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2015126368A Expired - Fee Related JP5942023B2 (ja) 2009-12-03 2015-06-24 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2016102368A Expired - Fee Related JP6106313B2 (ja) 2009-12-03 2016-05-23 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2017040593A Active JP6251432B2 (ja) 2009-12-03 2017-03-03 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2017226132A Withdrawn JP2018065834A (ja) 2009-12-03 2017-11-24 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2019191828A Withdrawn JP2020023551A (ja) 2009-12-03 2019-10-21 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト

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JP2015126368A Expired - Fee Related JP5942023B2 (ja) 2009-12-03 2015-06-24 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2016102368A Expired - Fee Related JP6106313B2 (ja) 2009-12-03 2016-05-23 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2017040593A Active JP6251432B2 (ja) 2009-12-03 2017-03-03 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2017226132A Withdrawn JP2018065834A (ja) 2009-12-03 2017-11-24 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト
JP2019191828A Withdrawn JP2020023551A (ja) 2009-12-03 2019-10-21 高コレステロール血症、アテローム性動脈硬化症、冠動脈性心疾患、胆石、肥満症、および他の心血管疾患の処置のために有用なグアニル酸シクラーゼのアゴニスト

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US (3) US8969514B2 (https=)
EP (3) EP2923706A1 (https=)
JP (6) JP5852005B2 (https=)
CN (2) CN105963676B (https=)
AU (2) AU2010325900B2 (https=)
CA (2) CA2782691C (https=)
ES (1) ES2540326T3 (https=)
HK (1) HK1215387A1 (https=)
IL (2) IL220090B (https=)
MX (2) MX346972B (https=)
WO (1) WO2011069038A2 (https=)

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