HUP0401108A2 - Spirovegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Spirovegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401108A2
HUP0401108A2 HU0401108A HUP0401108A HUP0401108A2 HU P0401108 A2 HUP0401108 A2 HU P0401108A2 HU 0401108 A HU0401108 A HU 0401108A HU P0401108 A HUP0401108 A HU P0401108A HU P0401108 A2 HUP0401108 A2 HU P0401108A2
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HU
Hungary
Prior art keywords
optionally substituted
nitrogen atom
methine group
chain
disorders
Prior art date
Application number
HU0401108A
Other languages
English (en)
Inventor
Takehiro Fukami
Katsumasa Nonoshita
Takeshi Sagara
Hiroyuki Kishino
Original Assignee
Banyu Pharmaceutical Co., Ltd.
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Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Publication of HUP0401108A2 publication Critical patent/HUP0401108A2/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát az (I) általános képletű vegyületek, sóik vagyésztereik képezik - a képletben A jelentése egyenes láncú 1 - 6szénatomos, adott esetben helyettesített szénhidrogéncsoport, ahol afenti szénhidrogén- lánc adott esetben oxigénvagy nitrogénatommalmegszakított lehet; Ar1 jelentése aril- vagy heteroarilcsoport,amelyek mindegyike adott esetben helyettesített lehet; n értéke 0 vagy1; R0 jelentése hidrogénatom vagy rövid szénláncú alkiléncsoport,amely A bármely kapcsolódásra képes helyzetében kötődhet; T, U, V és Wjelentése egymástól függetlenül nitrogénatom vagy adott esetbenhelyettesített metincsoport, és T, U, V és W közül legalább kettőnek ajelentése metincsoport; X jelentése -N-(SO2R1)-, -N-(COR2)- vagy -CO-;Y jelentése -C(R3)(R4)-, -O- vagy -N-(R5)- és Z jelentése metincsoportvagy nitrogénatom. A találmány szerinti vegyületek NPY antagonistaaktivitással bírnak, és kardiovaszkuláris megbetegedések, mint magasvérnyomás, vesebaj (nepropátia), szívbetegség, érgörcs,arterioszklerózis, stb.; központi idegrendszeri megbetegedések,például bulímia, depresszió, szorongás, roham, epilepszia, demencia,fájdalom, alkoholizmus, kábítószer megvonása, napiritmusrendellenességek, skizofrénia stb.; metabolizmussal kapcsolatosmegbetegedések, például elhízás, diabétesz, hormonzavarok,hiperkoleszterinémia, hiperlipidémia stb.; szexuális és reproduktívdiszfunkciók, gasztrointesztinális rendellenességek, példáulgasztrointesztinális motilitási rendellenesség, kezelésére szolgálnak. Ó
HU0401108A 2001-08-07 2002-08-02 Spirovegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0401108A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001239567 2001-08-07
PCT/JP2002/007922 WO2003014083A1 (fr) 2001-08-07 2002-08-02 Composes spiro

Publications (1)

Publication Number Publication Date
HUP0401108A2 true HUP0401108A2 (hu) 2004-09-28

Family

ID=19070298

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401108A HUP0401108A2 (hu) 2001-08-07 2002-08-02 Spirovegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Country Status (18)

Country Link
US (1) US7205417B2 (hu)
EP (1) EP1415986B1 (hu)
JP (1) JP4341404B2 (hu)
KR (1) KR20040023731A (hu)
CN (1) CN1538956A (hu)
AT (1) ATE427935T1 (hu)
AU (1) AU2002323787B2 (hu)
BR (1) BR0211740A (hu)
CA (1) CA2456599A1 (hu)
DE (1) DE60231880D1 (hu)
EA (1) EA006964B1 (hu)
HU (1) HUP0401108A2 (hu)
IL (1) IL160139A0 (hu)
MX (1) MXPA04001144A (hu)
NO (1) NO20040534L (hu)
PL (1) PL367983A1 (hu)
WO (1) WO2003014083A1 (hu)
ZA (1) ZA200400091B (hu)

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