|
AU2003270439B2
(en)
|
2002-09-11 |
2009-09-24 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
|
CA2905334A1
(en)
|
2008-04-09 |
2009-10-15 |
Genentech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
EP2853269B1
(en)
|
2008-05-19 |
2019-05-01 |
Advaxis, Inc. |
Dual delivery system for heterologous antigens comprising a recombinant Listeria strain attenuated by mutation of dal/dat and deletion of ActA comprising a nucleic acid molecule encoding an listeriolysin O - prostate specific anigen fusion protein
|
|
US9650639B2
(en)
|
2008-05-19 |
2017-05-16 |
Advaxis, Inc. |
Dual delivery system for heterologous antigens
|
|
US9017660B2
(en)
|
2009-11-11 |
2015-04-28 |
Advaxis, Inc. |
Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
|
|
PT2376535T
(pt)
|
2008-12-09 |
2017-06-23 |
Hoffmann La Roche |
Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t
|
|
PL2415470T3
(pl)
|
2009-03-30 |
2016-12-30 |
|
Kompozycja liposomowa
|
|
US20120077842A1
(en)
|
2009-08-19 |
2012-03-29 |
Eisai R&D Management Co., Ltd. |
Quinoline derivative-containing pharmaceutical composition
|
|
US10016617B2
(en)
|
2009-11-11 |
2018-07-10 |
The Trustees Of The University Of Pennsylvania |
Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
|
|
EP2621527A4
(en)
|
2010-10-01 |
2015-12-09 |
Univ Pennsylvania |
USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE IMMUNITY IN PATIENTS WITH PARASITIC INFECTIONS
|
|
AU2012229218B2
(en)
|
2011-03-11 |
2017-03-02 |
Advaxis, Inc. |
Listeria-based adjuvants
|
|
CN103582483B
(zh)
|
2011-04-01 |
2016-02-17 |
柯瑞斯公司 |
具有锌结合位的磷脂酰肌醇3-激酶抑制剂
|
|
US9945862B2
(en)
|
2011-06-03 |
2018-04-17 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック， インコーポレイテッド |
Ｐｄ−１軸結合アンタゴニストとｍｅｋ阻害剤を使用する癌の治療方法
|
|
BR112014018331A8
(pt)
|
2012-01-25 |
2017-07-11 |
Univ Texas |
Biomarcadores e terapias combinadas usando vírus oncolítico e imunomodulação
|
|
WO2013138337A1
(en)
|
2012-03-12 |
2013-09-19 |
Advaxis |
Suppressor cell function inhibition following listeria vaccine treatment
|
|
CN112587671A
(zh)
*
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
US9682143B2
(en)
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
US20150231241A1
(en)
|
2012-08-14 |
2015-08-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
US9302005B2
(en)
|
2013-03-14 |
2016-04-05 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
|
AU2014239903A1
(en)
*
|
2013-03-14 |
2015-09-17 |
Genentech, Inc. |
Combinations of a MEK inhibitor compound with an HER3/EGFR inhibitor compound and methods of use
|
|
KR20230070054A
(ko)
*
|
2013-03-15 |
2023-05-19 |
제넨테크, 인크. |
Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
|
|
CN107252485A
(zh)
*
|
2013-04-03 |
2017-10-17 |
Ibc药品公司 |
用于诱导对疾病的免疫应答的组合疗法
|
|
EP3003316B1
(en)
*
|
2013-05-31 |
2020-07-22 |
Merck Sharp & Dohme Corp. |
Combination therapies for cancer
|
|
SG11201509742QA
(en)
|
2013-06-03 |
2015-12-30 |
Novartis Ag |
Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor
|
|
WO2014204856A1
(en)
*
|
2013-06-17 |
2014-12-24 |
Catabasis Pharmaceuticals, Inc. |
Fatty acid anticancer derivatives and their uses
|
|
BR112016000853A2
(pt)
*
|
2013-07-16 |
2017-12-12 |
Genentech Inc |
métodos para tratar ou retardar, reduzir ou inibir a recidiva ou a progressão do câncer e a progressão de uma doença imune-relacionada em um indivíduo, para aumentar, melhorar ou estimular uma resposta ou função imune em um indivíduo e kit
|
|
AR097279A1
(es)
|
2013-08-09 |
2016-03-02 |
Actelion Pharmaceuticals Ltd |
Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
|
|
AR097306A1
(es)
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
|
KR102232153B1
(ko)
|
2013-08-20 |
2021-03-24 |
머크 샤프 앤드 돔 코포레이션 |
Pd-1 길항제와 디나시클립의 조합을 사용한 암의 치료
|
|
AR097584A1
(es)
|
2013-09-12 |
2016-03-23 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
|
|
CA3078121A1
(en)
|
2013-09-13 |
2015-03-19 |
Beigene Switzerland Gmbh |
Anti-pd1 antibodies and their use as therapeutics and diagnostics
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
EP3626742A1
(en)
*
|
2013-09-27 |
2020-03-25 |
F. Hoffmann-La Roche AG |
Anti-pdl1 antibody formulations
|
|
WO2015050663A1
(en)
|
2013-10-01 |
2015-04-09 |
Mayo Foundation For Medical Education And Research |
Methods for treating cancer in patients with elevated levels of bim
|
|
EP3079772B1
(en)
|
2013-12-10 |
2020-02-05 |
Merck Sharp & Dohme Corp. |
Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue
|
|
AU2014361473B2
(en)
|
2013-12-12 |
2019-09-26 |
Jiangsu Hengrui Medicine Co., Ltd. |
PD-1 antibody, antigen-binding fragment thereof, and medical application thereof
|
|
CN105899535A
(zh)
*
|
2013-12-17 |
2016-08-24 |
豪夫迈·罗氏有限公司 |
用pd-1轴结合拮抗剂和抗cd20抗体治疗癌症的方法
|
|
LT3083686T
(lt)
*
|
2013-12-17 |
2020-01-10 |
F. Hoffmann-La Roche Ag |
Vėžinių ligų gydymo būdai naudojant pd-1 ašies rišimosi antagonistus ir taksanus
|
|
EP3083687A2
(en)
*
|
2013-12-17 |
2016-10-26 |
F. Hoffmann-La Roche AG |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
EP3084003A4
(en)
|
2013-12-17 |
2017-07-19 |
Merck Sharp & Dohme Corp. |
Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
|
|
CA2936375A1
(en)
|
2014-01-10 |
2015-07-16 |
Shanghai Birdie Biotech, Inc. |
Compounds and compositions for treating her2 positive tumors
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗ｐｄ-ｌ１之人類抗體
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對ｐｄ-１的人類抗體
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
SG11201605824XA
(en)
|
2014-02-04 |
2016-08-30 |
Pfizer |
Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer
|
|
AU2015214404B2
(en)
|
2014-02-04 |
2020-10-01 |
Incyte Corporation |
Combination of a PD-1 antagonist and an IDO1 inhibitor for treating cancer
|
|
ES2783026T3
(es)
|
2014-02-04 |
2020-09-16 |
Pfizer |
Combinación de un antagonista de PD-1 y un agonista de 4-1BB para el tratamiento de cáncer
|
|
DK3889172T3
(da)
*
|
2014-02-10 |
2024-06-17 |
Merck Patent Gmbh |
Målrettet TGF-Beta-inhibering
|
|
US20150259420A1
(en)
|
2014-03-14 |
2015-09-17 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
US11230719B2
(en)
|
2014-03-26 |
2022-01-25 |
Denovo Biopharma Llc |
Retroviral vector having immune-stimulating activity
|
|
MX2016012779A
(es)
|
2014-03-31 |
2017-04-27 |
Genentech Inc |
Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40.
|
|
US10302653B2
(en)
|
2014-05-22 |
2019-05-28 |
Mayo Foundation For Medical Education And Research |
Distinguishing antagonistic and agonistic anti B7-H1 antibodies
|
|
AU2015265607A1
(en)
|
2014-05-28 |
2016-11-17 |
Idenix Pharmaceuticals Llc |
Nucleoside derivatives for the treatment of cancer
|
|
SMT201900668T1
(it)
|
2014-06-06 |
2020-01-14 |
Bristol Myers Squibb Co |
Anticorpi contro il recettore per il fattore di necrosi tumorale indotto da glucocorticoidi(gitr)e loro usi
|
|
KR102130600B1
(ko)
|
2014-07-03 |
2020-07-08 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
|
FI4001311T3
(fi)
|
2014-07-09 |
2026-01-27 |
Birdie Biopharmaceuticals Inc |
Pd-l1/pd-1-vasta-aineiden yhdistelmiä kasvaimien hoitoon
|
|
CN105440135A
(zh)
*
|
2014-09-01 |
2016-03-30 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-pd-l1结合物
|
|
BR112017000497B1
(pt)
|
2014-07-11 |
2023-12-26 |
Ventana Medical Systems, Inc |
Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1
|
|
ES2742500T3
(es)
*
|
2014-07-15 |
2020-02-14 |
Federal Express Corp |
Composiciones para tratamiento del cáncer usando antagonistas de unión al eje de pd-1 e inhibidores de MEK
|
|
EP3193921A4
(en)
|
2014-07-18 |
2018-04-25 |
Advaxis, Inc. |
Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
|
|
BR112017001385B1
(pt)
|
2014-07-22 |
2023-12-05 |
Cb Therapeutics, Inc. |
Anticorpo isolado ou fragmento do mesmo que liga a pd-1, uso deste, composição, polinucleotídeo isolado e vetor de expressão
|
|
US10517875B2
(en)
|
2014-07-23 |
2019-12-31 |
Mayo Foundation for Medical Engineering and Research |
Targeting DNA-PKcs and B7-H1 to treat cancer
|
|
JP6629321B2
(ja)
|
2014-08-05 |
2020-01-15 |
マブクエスト エスエーＭａｂＱｕｅｓｔ ＳＡ |
免疫学的試薬
|
|
ES2987034T3
(es)
|
2014-08-05 |
2024-11-13 |
Apollomics Inc |
Anticuerpos anti-PD-L1
|
|
US9982052B2
(en)
|
2014-08-05 |
2018-05-29 |
MabQuest, SA |
Immunological reagents
|
|
WO2016022994A2
(en)
|
2014-08-08 |
2016-02-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
High affinity pd-1 agents and methods of use
|
|
CA2957146A1
(en)
|
2014-08-12 |
2016-02-18 |
Alligator Bioscience Ab |
Combination therapies with anti cd40 antibodies
|
|
EP3070102A1
(en)
*
|
2015-03-18 |
2016-09-21 |
F. Hoffmann-La Roche AG |
Combination therapy of antibodies human cd40 activating antibodies and anti human pld-1 antibodies
|
|
EP3626740A1
(en)
*
|
2014-08-14 |
2020-03-25 |
F. Hoffmann-La Roche AG |
Combination therapy of antibodies activating human cd40 and antibodies against human pd-l1
|
|
US10695426B2
(en)
|
2014-08-25 |
2020-06-30 |
Pfizer Inc. |
Combination of a PD-1 antagonist and an ALK inhibitor for treating cancer
|
|
EP3187491A4
(en)
|
2014-08-28 |
2018-08-01 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
WO2016033555A1
(en)
|
2014-08-28 |
2016-03-03 |
Halozyme, Inc. |
Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
|
|
US9535074B2
(en)
|
2014-09-08 |
2017-01-03 |
Merck Sharp & Dohme Corp. |
Immunoassay for soluble PD-L1
|
|
US20170281624A1
(en)
|
2014-09-13 |
2017-10-05 |
Novartis Ag |
Combination therapies of alk inhibitors
|
|
EP3194440A1
(en)
*
|
2014-09-15 |
2017-07-26 |
F. Hoffmann-La Roche AG |
Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists
|
|
PL3193931T3
(pl)
|
2014-09-16 |
2021-03-08 |
Innate Pharma |
Neutralizacja szlaków inhibitorowych w limfocytach
|
|
EP3662903A3
(en)
|
2014-10-03 |
2020-10-14 |
Novartis AG |
Combination therapies
|
|
CN106999574B
(zh)
|
2014-10-10 |
2022-05-24 |
伊黛拉制药有限公司 |
使用tlr9激动剂与检查点抑制剂对癌症的治疗
|
|
KR102536786B1
(ko)
|
2014-10-10 |
2023-05-26 |
이나뜨 파르마 에스.에이. |
Ｃｄ７３ 차단
|
|
CN108064282A
(zh)
|
2014-10-14 |
2018-05-22 |
哈洛齐梅公司 |
腺苷脱氨酶-2(ada2)、其变体的组合物及使用其的方法
|
|
ES2952717T3
(es)
|
2014-10-14 |
2023-11-03 |
Novartis Ag |
Moléculas de anticuerpos contra PD-L1 y usos de las mismas
|
|
CN106999583A
(zh)
*
|
2014-11-17 |
2017-08-01 |
豪夫迈·罗氏有限公司 |
包含ox40结合激动剂和pd‑1轴结合拮抗剂的组合疗法
|
|
MX387463B
(es)
|
2014-11-20 |
2025-03-18 |
Hoffmann La Roche |
Moléculas de unión a antígeno biespecíficas activadoras de células t y antagonistas de unión al eje de pd-1 y usos de los mismos para el tratamiento de cáncer.
|
|
CN105669862A
(zh)
*
|
2014-11-21 |
2016-06-15 |
上海中信国健药业股份有限公司 |
抗人pd-l1/kir双特异性抗体及其制备方法和应用
|
|
BR112017011536A2
(pt)
*
|
2014-12-02 |
2018-02-27 |
Celgene Corp |
terapias de combinação
|
|
EP3226688B1
(en)
|
2014-12-05 |
2020-07-01 |
Merck Sharp & Dohme Corp. |
Tricyclic compounds as inhibitors of mutant idh enzymes
|
|
EP3226689B1
(en)
|
2014-12-05 |
2020-01-15 |
Merck Sharp & Dohme Corp. |
Novel tricyclic compounds as inhibitors of mutant idh enzymes
|
|
US20160158360A1
(en)
*
|
2014-12-05 |
2016-06-09 |
Genentech, Inc. |
Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists
|
|
WO2016089833A1
(en)
|
2014-12-05 |
2016-06-09 |
Merck Sharp & Dohme Corp. |
Novel tricyclic compounds as inhibitors of mutant idh enzymes
|
|
CA2968406A1
(en)
|
2014-12-09 |
2016-06-16 |
Mark D. Ayers |
System and methods for deriving gene signature biomarkers of response to pd-1 antagonists
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
US20170363614A1
(en)
*
|
2014-12-22 |
2017-12-21 |
Enumeral Biomedical Holdings, Inc. |
Methods For Screening Therapeutic Compounds
|
|
JP2018503373A
(ja)
*
|
2014-12-30 |
2018-02-08 |
ジェネンテック， インコーポレイテッド |
がんの予後診断及び治療のための方法及び組成物
|
|
JP2016155776A
(ja)
*
|
2015-02-24 |
2016-09-01 |
学校法人兵庫医科大学 |
抗腫瘍効果増強剤および抗腫瘍剤
|
|
WO2016136745A1
(ja)
|
2015-02-25 |
2016-09-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体の苦味抑制方法
|
|
EP4279087A3
(en)
|
2015-02-26 |
2024-01-31 |
Merck Patent GmbH |
Pd-1 / pd-l1 inhibitors for the treatment of cancer
|
|
MX386547B
(es)
|
2015-03-04 |
2025-03-19 |
Merck Sharp & Dohme |
Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer.
|
|
AU2015384801B2
(en)
|
2015-03-04 |
2022-01-06 |
Eisai R&D Management Co., Ltd. |
Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
|
|
EP3268392A2
(en)
|
2015-03-13 |
2018-01-17 |
CytomX Therapeutics, Inc. |
Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
WO2016168133A1
(en)
|
2015-04-17 |
2016-10-20 |
Merck Sharp & Dohme Corp. |
Blood-based biomarkers of tumor sensitivity to pd-1 antagonists
|
|
DK3285809T3
(da)
*
|
2015-04-20 |
2019-11-18 |
Effector Therapeutics Inc |
Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner.
|
|
US20180134771A1
(en)
*
|
2015-05-07 |
2018-05-17 |
Bioxcel Corporation |
Novel immunomodulatory therapeutic strategies targeting tumors in cancer
|
|
EP4209228A1
(en)
*
|
2015-05-22 |
2023-07-12 |
Translational Drug Development, LLC |
Benzamide and active compound compositions and methods of use
|
|
EP3303361A1
(en)
|
2015-05-27 |
2018-04-11 |
Idenix Pharmaceuticals LLC |
Nucleotides for the treatment of cancer
|
|
JP6884111B2
(ja)
*
|
2015-05-29 |
2021-06-09 |
ジェネンテック， インコーポレイテッド |
癌におけるｐｄ−ｌ１プロモーターのメチル化
|
|
US10751412B2
(en)
|
2015-05-29 |
2020-08-25 |
Merck Sharp & Dohme Corp. |
Combination of a PD-1 antagonist and CPG-C type oligonucleotide for treating cancer
|
|
EP3636660A1
(en)
|
2015-05-30 |
2020-04-15 |
Molecular Templates, Inc. |
De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
|
|
US20180153884A1
(en)
*
|
2015-05-31 |
2018-06-07 |
Curegenix Corporation |
Combination compositions for immunotherapy
|
|
MX373231B
(es)
|
2015-06-16 |
2020-05-08 |
Eisai R&D Man Co Ltd |
Agente anticancerigeno.
|
|
WO2016205200A1
(en)
*
|
2015-06-16 |
2016-12-22 |
Genentech, Inc. |
Anti-cll-1 antibodies and methods of use
|
|
PH12017501857B1
(en)
|
2015-06-16 |
2024-01-17 |
Merck Patent Gmbh |
Pd-l1 antagonist combination treatments
|
|
KR102689256B1
(ko)
|
2015-06-17 |
2024-07-30 |
제넨테크, 인크. |
Pd-1 축 결합 길항제 및 탁산을 사용하여 국소적 진행성 또는 전이성 유방암을 치료하는 방법
|
|
GB201511790D0
(en)
|
2015-07-06 |
2015-08-19 |
Iomet Pharma Ltd |
Pharmaceutical compound
|
|
JP7014706B2
(ja)
|
2015-07-13 |
2022-02-01 |
サイトメックス セラピューティクス インコーポレイテッド |
抗ｐｄ－１抗体、活性化可能抗ｐｄ－１抗体、およびその使用方法
|
|
EP3779998A1
(en)
*
|
2015-07-13 |
2021-02-17 |
Biodesix, Inc. |
Predictive test for melanoma patient benefit from pd-1 antibody drug and classifier development methods
|
|
AU2016293674B2
(en)
|
2015-07-16 |
2019-11-21 |
Bioxcel Therapeutics, Inc. |
A novel approach for treatment of cancer using immunomodulation
|
|
EP3744340A3
(en)
|
2015-07-16 |
2021-03-03 |
Biokine Therapeutics Ltd. |
Compositions and methods for treating cancer
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
PT3317301T
(pt)
|
2015-07-29 |
2021-07-09 |
Novartis Ag |
Terapias de associação compreendendo moléculas de anticorpo contra lag-3
|
|
JP6878405B2
(ja)
|
2015-07-29 |
2021-05-26 |
ノバルティス アーゲー |
Ｐｄ−１に対する抗体分子を含む組み合わせ治療
|
|
WO2017024465A1
(en)
*
|
2015-08-10 |
2017-02-16 |
Innovent Biologics (Suzhou) Co., Ltd. |
Pd-1 antibodies
|
|
JP6596146B2
(ja)
|
2015-08-13 |
2019-10-23 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド化合物
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3338779B1
(en)
|
2015-08-20 |
2021-06-30 |
Eisai R&D Management Co., Ltd. |
Lenvatinib in combination with etoposide and ifosfamide for use in treating a tumor
|
|
EP3344275B8
(en)
|
2015-09-03 |
2023-04-12 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles and uses thereof
|
|
SI3353210T1
(sl)
|
2015-09-25 |
2025-03-31 |
F. Hoffmann-La Roche Ag |
Protitelesa proti TIGIT in postopki uporabe
|
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
|
PE20240096A1
(es)
|
2015-10-02 |
2024-01-18 |
Hoffmann La Roche |
Anticuerpos biespecificos especificos para un receptor de tnf coestimulador
|
|
HK1251475A1
(zh)
|
2015-10-08 |
2019-02-01 |
Macrogenics, Inc. |
用於癌症治疗的联合疗法
|
|
WO2017064043A1
(en)
|
2015-10-12 |
2017-04-20 |
Innate Pharma |
Cd73 blocking agents
|
|
WO2017075045A2
(en)
|
2015-10-30 |
2017-05-04 |
Mayo Foundation For Medical Education And Research |
Antibodies to b7-h1
|
|
JP6936221B2
(ja)
|
2015-11-02 |
2021-09-15 |
ファイブ プライム セラピューティクス， インコーポレイテッド |
Ｃｄ８０細胞外ドメインポリペプチドと、がん治療でのそれらの使用
|
|
EP4046655A1
(en)
|
2015-11-03 |
2022-08-24 |
Janssen Biotech, Inc. |
Antibodies specifically binding pd-1 and their uses
|
|
KR101949108B1
(ko)
|
2015-12-03 |
2019-02-15 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
Sting의 조정제로서의 시클릭 푸린 디뉴클레오티드
|
|
WO2017098421A1
(en)
|
2015-12-08 |
2017-06-15 |
Glaxosmithkline Intellectual Property Development Limited |
Benzothiadiazine compounds
|
|
WO2017106062A1
(en)
|
2015-12-15 |
2017-06-22 |
Merck Sharp & Dohme Corp. |
Novel compounds as indoleamine 2,3-dioxygenase inhibitors
|
|
JP2019503349A
(ja)
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Ｐｄ−１に対する抗体分子およびその使用
|
|
GB201522311D0
(en)
|
2015-12-17 |
2016-02-03 |
Photocure Asa |
Use
|
|
GB201522309D0
(en)
|
2015-12-17 |
2016-02-03 |
Photocure Asa |
Use
|
|
RS64588B1
(sr)
|
2015-12-22 |
2023-10-31 |
Regeneron Pharma |
Kombinacija anti-pd-1 antitela i bispecifičnih anti-cd20/anti-cd3 antitela za lečenje kancera
|
|
CN115252792A
(zh)
|
2016-01-07 |
2022-11-01 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-egfr组合
|
|
CN106943596A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-cd20组合
|
|
CN106943598A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技（北京）有限公司 |
用于治疗肿瘤的抗-her2组合
|
|
BR112018011029A2
(pt)
|
2016-01-08 |
2018-11-21 |
Hoffmann La Roche |
métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits
|
|
SG11201805831RA
(en)
|
2016-01-21 |
2018-08-30 |
Innate Pharma |
Neutralization of inhibitory pathways in lymphocytes
|
|
US11214617B2
(en)
|
2016-01-22 |
2022-01-04 |
MabQuest SA |
Immunological reagents
|
|
ES3034233T3
(en)
|
2016-01-22 |
2025-08-14 |
MabQuest SA |
Non-blocking pd1 specific antibodies
|
|
WO2017136139A1
(en)
|
2016-02-01 |
2017-08-10 |
Biodesix, Inc. |
Predictive test for melanoma patient benefit from interleukin-2 (il2) therapy
|
|
US11078274B2
(en)
|
2016-03-08 |
2021-08-03 |
Innate Pharma |
Siglec neutralizing antibodies
|
|
WO2017153952A1
(en)
|
2016-03-10 |
2017-09-14 |
Glaxosmithkline Intellectual Property Development Limited |
5-sulfamoyl-2-hydroxybenzamide derivatives
|
|
WO2017160599A1
(en)
|
2016-03-14 |
2017-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Use of cd300b antagonists to treat sepsis and septic shock
|
|
BR112018068461A2
(pt)
|
2016-03-15 |
2019-01-22 |
Mersana Therapeutics Inc |
conjugado, composição farmacêutica, métodos para preparação de um conjugado e para alívio de um sintoma de um câncer.
|
|
TW202248213A
(zh)
*
|
2016-03-15 |
2022-12-16 |
日商中外製藥股份有限公司 |
使用pd-1軸結合拮抗劑和抗gpc3抗體治療癌症的方法
|
|
WO2017165778A1
(en)
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments
|
|
WO2017165742A1
(en)
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments
|
|
EP3436829A1
(en)
|
2016-03-30 |
2019-02-06 |
Centre Léon-Bérard |
Lymphocytes expressing cd73 in cancerous patient dictates therapy
|
|
PE20181884A1
(es)
|
2016-04-07 |
2018-12-07 |
Glaxosmithkline Ip Dev Ltd |
Amidas heterociclicas utiles como moduladores de proteinas
|
|
CN109563081A
(zh)
|
2016-04-07 |
2019-04-02 |
葛兰素史克知识产权开发有限公司 |
可用作蛋白调节剂的杂环酰胺类
|
|
RU2754452C2
(ru)
|
2016-04-12 |
2021-09-02 |
Эли Лилли Энд Компани |
Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака
|
|
WO2017181079A2
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Methods for monitoring and treating cancer
|
|
CN109790581A
(zh)
*
|
2016-04-27 |
2019-05-21 |
米拉迪克斯有限公司 |
Kras-变体癌症患者的基于免疫的治疗
|
|
ES2952680T3
(es)
|
2016-04-28 |
2023-11-03 |
Eisai R&D Man Co Ltd |
Eribulina para inhibir el crecimiento tumoral
|
|
US20190298824A1
(en)
|
2016-05-04 |
2019-10-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv |
Albumin-binding immunomodulatory compositions and methods of use thereof
|
|
BR112018072740A2
(pt)
|
2016-05-05 |
2019-02-19 |
Glaxosmithkline Intellectual Property (No. |
realçador de inibidores de homólogo 2 de zeste
|
|
TWI755395B
(zh)
|
2016-05-13 |
2022-02-21 |
美商再生元醫藥公司 |
抗-pd-1抗體與輻射治療癌症之組合
|
|
JP7194022B2
(ja)
|
2016-05-20 |
2022-12-21 |
イーライ リリー アンド カンパニー |
Ｎｏｔｃｈ阻害剤とＰＤ－１またはＰＤ－Ｌ１阻害剤との併用療法
|
|
EP3468960B1
(en)
|
2016-06-08 |
2022-03-23 |
GlaxoSmithKline Intellectual Property Development Limited |
Chemical compounds as atf4 pathway inhibitors
|
|
AU2017279027A1
(en)
|
2016-06-08 |
2018-12-20 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical Compounds
|
|
CN109475536B
(zh)
|
2016-07-05 |
2022-05-27 |
百济神州有限公司 |
用于治疗癌症的PD-l拮抗剂和RAF抑制剂的组合
|
|
WO2018014260A1
(en)
|
2016-07-20 |
2018-01-25 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific antigen binding proteins and methods of use thereof
|
|
BR112019001136A2
(pt)
|
2016-07-20 |
2019-04-30 |
Glaxosmithkline Ip Dev Ltd |
compostos químicos
|
|
CN109476748B
(zh)
*
|
2016-08-08 |
2023-05-23 |
豪夫迈·罗氏有限公司 |
用于癌症的治疗和诊断方法
|
|
ES2971881T3
(es)
|
2016-08-19 |
2024-06-10 |
Beigene Switzerland Gmbh |
Combinación de zanubrutinib con un anticuerpo anti-cd20 o anti-pd-1 para su uso en el tratamiento del cáncer
|
|
JP7138094B2
(ja)
|
2016-08-25 |
2022-09-15 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
マクロファージ活性化剤と組み合わせた抗ｃｓｆ－１ｒ抗体の間欠投与
|
|
EP3518970A1
(en)
*
|
2016-09-29 |
2019-08-07 |
Genentech, Inc. |
Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a taxane
|
|
UA125223C2
(uk)
|
2016-10-04 |
2022-02-02 |
Мерк Шарп І Доум Корп. |
СПОЛУКИ БЕНЗО[b]ТІОФЕНУ ЯК АГОНІСТИ STING
|
|
CA3039451A1
(en)
|
2016-10-06 |
2018-04-12 |
Pfizer Inc. |
Dosing regimen of avelumab for the treatment of cancer
|
|
WO2018068201A1
(en)
|
2016-10-11 |
2018-04-19 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against ctla-4
|
|
SG11201902974PA
(en)
|
2016-10-14 |
2019-05-30 |
Merck Sharp & Dohme |
Combination of a pd-1 antagonist and eribulin for treating urothelial cancer
|
|
MA49863A
(fr)
*
|
2016-11-01 |
2020-06-17 |
Anaptysbio Inc |
Anticorps dirigés contre la mort programmée 1 (pd -1)
|
|
EP4295918A3
(en)
|
2016-11-02 |
2024-03-20 |
Bristol-Myers Squibb Company |
Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma
|
|
CN110312523B
(zh)
|
2016-11-08 |
2024-04-26 |
齐鲁皮吉特湾生物治疗有限公司 |
抗pd1和抗ctla4抗体
|
|
WO2018091542A1
(en)
|
2016-11-21 |
2018-05-24 |
Idenix Pharmaceuticals Llc |
Cyclic phosphate substituted nucleoside derivatives for the treatment of liver diseases
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
US11230596B2
(en)
|
2016-11-30 |
2022-01-25 |
Mereo Biopharma 5, Inc. |
Methods for treatment of cancer comprising TIGIT-binding agents
|
|
JP2020500878A
(ja)
|
2016-12-01 |
2020-01-16 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
併用療法
|
|
CN110234342A
(zh)
|
2016-12-01 |
2019-09-13 |
葛兰素史密斯克莱知识产权发展有限公司 |
组合疗法
|
|
CN110366562A
(zh)
*
|
2016-12-12 |
2019-10-22 |
豪夫迈·罗氏有限公司 |
使用抗pd-l1抗体和抗雄激素治疗癌症的方法
|
|
JP7304287B2
(ja)
|
2016-12-22 |
2023-07-06 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
抗ｐｄ－ｌ１／ｐｄ１治療の不成功後の、抗ｐｄ－ｌ１抗体との組み合わせでの抗ｃｓｆ－１ｒ抗体を用いた腫瘍の治療
|
|
CN108239149B
(zh)
*
|
2016-12-25 |
2021-03-05 |
南京传奇生物科技有限公司 |
高亲和力、高特异性、多抗原识别表位的具有更高功能性的抗人pd-l1抗体
|
|
WO2018129301A1
(en)
|
2017-01-05 |
2018-07-12 |
Biodesix, Inc. |
Method for identification of cancer patients with durable benefit from immunotherapy in overall poor prognosis subgroups
|
|
WO2018127570A1
(en)
|
2017-01-05 |
2018-07-12 |
Netris Pharma |
Combined treatment with netrin-1 interfering drug and immune checkpoint inhibitors drugs
|
|
SG11201906192SA
(en)
|
2017-01-09 |
2019-08-27 |
Tesaro Inc |
Methods of treating cancer with anti-pd-1 antibodies
|
|
US11555038B2
(en)
|
2017-01-25 |
2023-01-17 |
Beigene, Ltd. |
Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
|
|
AU2018212788A1
(en)
|
2017-01-27 |
2019-07-25 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as STING agonists
|
|
JP7213188B2
(ja)
|
2017-01-27 |
2023-01-26 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド
|
|
WO2018141959A1
(en)
|
2017-02-06 |
2018-08-09 |
Innate Pharma |
Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
|
|
AU2018219637B2
(en)
|
2017-02-08 |
2023-07-13 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
IL321717A
(en)
|
2017-02-21 |
2025-08-01 |
Regeneron Pharma |
Anti-PD-1 antibodies for the treatment of lung cancer
|
|
CN108503691B
(zh)
*
|
2017-02-25 |
2021-07-23 |
复旦大学 |
一种人pd-l1蛋白高亲和性肽及其应用
|
|
CA3052767A1
(en)
|
2017-02-27 |
2018-08-30 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides as kinase inhibitors
|
|
WO2018160538A1
(en)
|
2017-02-28 |
2018-09-07 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
EP3596469A1
(en)
|
2017-03-12 |
2020-01-22 |
Yeda Research and Development Co., Ltd. |
Methods of diagnosing and prognosing cancer
|
|
WO2018167780A1
(en)
|
2017-03-12 |
2018-09-20 |
Yeda Research And Development Co. Ltd. |
Methods of prognosing and treating cancer
|
|
AU2018235092B2
(en)
|
2017-03-16 |
2024-09-19 |
Innate Pharma |
Compositions and methods for treating cancer
|
|
MX2019011657A
(es)
|
2017-03-30 |
2019-11-18 |
Merck Patent Gmbh |
Combinacion de un anticuerpo anti ligando 1 de muerte programada (pd-l1) e inhibidor de proteina cinasa dependiente de acido desoxirribonucleico (dna-pk) para tratamiento de cancer.
|
|
US11603407B2
(en)
|
2017-04-06 |
2023-03-14 |
Regeneron Pharmaceuticals, Inc. |
Stable antibody formulation
|
|
CN108794467A
(zh)
|
2017-04-27 |
2018-11-13 |
博笛生物科技有限公司 |
2-氨基-喹啉衍生物
|
|
WO2018201014A1
(en)
|
2017-04-28 |
2018-11-01 |
Five Prime Therapeutics, Inc. |
Methods of treatment with cd80 extracellular domain polypeptides
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN110831597A
(zh)
|
2017-05-16 |
2020-02-21 |
卫材R&D管理有限公司 |
肝细胞癌的治疗
|
|
CN110869392A
(zh)
|
2017-05-16 |
2020-03-06 |
百时美施贵宝公司 |
用抗gitr激动性抗体治疗癌症
|
|
US11168144B2
(en)
|
2017-06-01 |
2021-11-09 |
Cytomx Therapeutics, Inc. |
Activatable anti-PDL1 antibodies, and methods of use thereof
|
|
WO2018225093A1
(en)
|
2017-06-07 |
2018-12-13 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds as atf4 pathway inhibitors
|
|
CA3066048A1
(en)
|
2017-06-09 |
2018-12-13 |
Glaxosmithkline Intellectual Property Development Limited |
Combination therapy
|
|
CA3061959A1
(en)
|
2017-06-09 |
2018-12-13 |
Providence Health & Services - Oregon |
Utilization of cd39 and cd103 for identification of human tumor reactive t cells for treatment of cancer
|
|
CN110769827A
(zh)
|
2017-06-23 |
2020-02-07 |
博笛生物科技有限公司 |
药物组合物
|
|
US11597768B2
(en)
|
2017-06-26 |
2023-03-07 |
Beigene, Ltd. |
Immunotherapy for hepatocellular carcinoma
|
|
WO2019008506A1
(en)
|
2017-07-03 |
2019-01-10 |
Glaxosmithkline Intellectual Property Development Limited |
N- (3- (2- (4-CHLOROPHENOXY) ACETAMIDO) BICYCLO [1.1.1] PENTAN-1-YL) -2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES
|
|
EP3649108A1
(en)
|
2017-07-03 |
2020-05-13 |
GlaxoSmithKline Intellectual Property Development Limited |
2-(4-chlorophenoxy)-n-((1 -(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases
|
|
AU2018298676A1
(en)
|
2017-07-10 |
2019-12-19 |
Innate Pharma |
Siglec-9-neutralizing antibodies
|
|
US11293066B2
(en)
|
2017-07-18 |
2022-04-05 |
Institut Gustave Roussy |
Method for assessing the response to PD-1/PDL-1 targeting drugs
|
|
WO2019021208A1
(en)
|
2017-07-27 |
2019-01-31 |
Glaxosmithkline Intellectual Property Development Limited |
USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS
|
|
US11312772B2
(en)
|
2017-08-04 |
2022-04-26 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment
|
|
AU2018311966A1
(en)
|
2017-08-04 |
2020-02-13 |
Merck Sharp & Dohme Llc |
Benzo[b]thiophene sting agonists for cancer treatment
|
|
UY37866A
(es)
|
2017-09-07 |
2019-03-29 |
Glaxosmithkline Ip Dev Ltd |
Nuevos compuestos derivados de benzoimidazol sustituidos que reducen la proteína myc (c-myc) en las células e inhiben la histona acetiltransferasa de p300/cbp.
|
|
WO2019053617A1
(en)
|
2017-09-12 |
2019-03-21 |
Glaxosmithkline Intellectual Property Development Limited |
CHEMICAL COMPOUNDS
|
|
TW201927771A
(zh)
|
2017-10-05 |
2019-07-16 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
可作為蛋白質調節劑之雜環醯胺及其使用方法
|
|
BR112020006780A2
(pt)
|
2017-10-05 |
2020-10-06 |
Glaxosmithkline Intellectual Property Development Limited |
moduladores do estimulador de genes do interferon (sting)
|
|
WO2019068907A1
(en)
|
2017-10-06 |
2019-04-11 |
Innate Pharma |
RESTORATION OF T CELL ACTIVITY BY AXIS CD39 / CD73
|
|
CN109663130B
(zh)
*
|
2017-10-13 |
2021-06-29 |
江苏恒瑞医药股份有限公司 |
Pd-1抗体和mek抑制剂联合在制备治疗肿瘤的药物中的用途
|
|
MX2020004074A
(es)
|
2017-10-19 |
2020-10-16 |
Debiopharm Int Sa |
Producto de combinacion para el tratamiento de cancer.
|
|
EP3703692B1
(en)
|
2017-11-01 |
2025-07-23 |
Merck Sharp & Dohme LLC |
Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
|
|
CN111886012A
(zh)
|
2017-11-06 |
2020-11-03 |
朱诺治疗学股份有限公司 |
细胞疗法与γ分泌酶抑制剂的组合
|
|
BR112020008258B8
(pt)
|
2017-11-14 |
2023-01-31 |
Merck Sharp & Dohme |
Compostos de biarila substituída ou seus sais farmaceuticamente aceitáveis, sua composição e seu uso como inibidores de indoleamina 2,3-dioxigenase (ido)
|
|
EP3709986B1
(en)
|
2017-11-14 |
2023-11-01 |
Merck Sharp & Dohme LLC |
Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
|
|
MX2020004756A
(es)
|
2017-11-16 |
2020-08-20 |
Novartis Ag |
Terapias de combinacion.
|
|
US11638760B2
(en)
|
2017-11-27 |
2023-05-02 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
WO2019108795A1
(en)
|
2017-11-29 |
2019-06-06 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
|
|
CN108165536A
(zh)
*
|
2017-12-11 |
2018-06-15 |
浙江大学 |
一种重组溶瘤痘苗病毒及其制备方法与应用
|
|
ES2927194T3
(es)
|
2017-12-15 |
2022-11-03 |
Janssen Biotech Inc |
Dinucleótidos cíclicos como agonistas de STING
|
|
WO2019125974A1
(en)
|
2017-12-20 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3727463A1
(en)
|
2017-12-21 |
2020-10-28 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
AU2018396970B2
(en)
|
2017-12-28 |
2025-09-25 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against TIGIT
|
|
SG11202006254QA
(en)
*
|
2018-01-10 |
2020-07-29 |
Array Biopharma Inc |
Methods and combination therapy to treat cancer
|
|
CA3264983A1
(en)
|
2018-01-15 |
2025-10-31 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against pd-1
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
WO2019152743A1
(en)
|
2018-01-31 |
2019-08-08 |
Celgene Corporation |
Combination therapy using adoptive cell therapy and checkpoint inhibitor
|
|
WO2019177873A1
(en)
|
2018-03-13 |
2019-09-19 |
Merck Sharp & Dohme Corp. |
Arginase inhibitors and methods of use
|
|
MX2020009478A
(es)
|
2018-03-14 |
2020-10-22 |
Merck Patent Gmbh |
Compuestos y sus usos para tratar tumores en un paciente.
|
|
TWI841554B
(zh)
|
2018-03-21 |
2024-05-11 |
丹麥商珍美寶股份有限公司 |
以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
|
|
US12094587B2
(en)
|
2018-03-29 |
2024-09-17 |
Biodesix, Inc. |
Apparatus and method for identification of primary immune resistance in cancer patients
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Ｓｔｉｎｇアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
WO2019193541A1
(en)
|
2018-04-06 |
2019-10-10 |
Glaxosmithkline Intellectual Property Development Limited |
Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
|
|
WO2019193540A1
(en)
|
2018-04-06 |
2019-10-10 |
Glaxosmithkline Intellectual Property Development Limited |
Heteroaryl derivatives of formula (i) as atf4 inhibitors
|
|
EP3781687A4
(en)
|
2018-04-20 |
2022-02-09 |
Merck Sharp & Dohme Corp. |
NEW RIG-I SUBSTITUTED AGONISTS: COMPOSITIONS AND METHODS THEREOF
|
|
CN112352052A
(zh)
|
2018-05-04 |
2021-02-09 |
托利斯有限公司 |
激活上皮细胞和髓样细胞的tlr3配体
|
|
TW202014201A
(zh)
|
2018-05-04 |
2020-04-16 |
德商馬克專利公司 |
用於治療癌症之ＰＤ-１／ＰＤ-Ｌ１，ＴＧＦβ及ＤＮＡ-ＰＫ之組合抑制
|
|
JP7460608B2
(ja)
|
2018-05-07 |
2024-04-02 |
ジェンマブ エー／エス |
抗ｐｄ－１抗体と抗組織因子抗体－薬物コンジュゲートとの組み合わせを用いるがんの治療方法
|
|
EA202092136A1
(ru)
*
|
2018-05-07 |
2021-03-22 |
Генмаб А/С |
Способы лечения рака с помощью комбинации антитела к pd-1 и конъюгата антитела к тканевому фактору и лекарственного средства
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
BR112020023872A2
(pt)
|
2018-05-24 |
2021-02-17 |
Janssen Biotech, Inc. |
agentes de ligação de psma e seus usos
|
|
WO2019232319A1
(en)
|
2018-05-31 |
2019-12-05 |
Peloton Therapeutics, Inc. |
Compositions and methods for inhibiting cd73
|
|
WO2019231870A1
(en)
|
2018-05-31 |
2019-12-05 |
Merck Sharp & Dohme Corp. |
Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
|
|
US11555071B2
(en)
|
2018-06-03 |
2023-01-17 |
Lamkap Bio Beta Ltd. |
Bispecific antibodies against CEACAM5 and CD47
|
|
EP3808376A4
(en)
|
2018-06-17 |
2021-09-01 |
L&L Biopharma Co., Ltd. |
TARGET ANTIBODIES CLDN18.2, BISPECIFIC ANTIBODIES, ADC AND CAR, AND THEIR APPLICATIONS
|
|
DK3807316T3
(da)
|
2018-06-18 |
2024-07-29 |
Innate Pharma |
Sammensætninger og fremgangsmåder til behandling af cancer
|
|
WO2019245890A1
(en)
|
2018-06-20 |
2019-12-26 |
Merck Sharp & Dohme Corp. |
Arginase inhibitors and methods of use
|
|
CN111902428B
(zh)
|
2018-07-03 |
2023-11-10 |
上海健信生物医药科技有限公司 |
一种双特异性抗体及其用途
|
|
EP3818082A1
(en)
*
|
2018-07-04 |
2021-05-12 |
F. Hoffmann-La Roche AG |
Novel bispecific agonistic 4-1bb antigen binding molecules
|
|
EP3820843A1
(en)
|
2018-07-09 |
2021-05-19 |
GlaxoSmithKline Intellectual Property Development Limited |
Chemical compounds
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
MX2021000165A
(es)
|
2018-07-11 |
2021-05-28 |
Actym Therapeutics Inc |
Cepas bacterianas inmunoestimuladoras modificadas y usos de las mismas.
|
|
MA53381A
(fr)
|
2018-07-24 |
2021-06-02 |
Amgen Inc |
Association d'inhibiteurs de la voie lilrb1/2 et d'inhibiteurs de la voie pd-1
|
|
WO2020031107A1
(en)
|
2018-08-08 |
2020-02-13 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds
|
|
WO2020044206A1
(en)
|
2018-08-29 |
2020-03-05 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides as kinase inhibitors for use in the treatment cancer
|
|
WO2020052551A1
(en)
*
|
2018-09-10 |
2020-03-19 |
Genesail Biotech (Shanghai) Co. Ltd. |
A modified oncolytic virus, composition and use thereof
|
|
BR112021004371A2
(pt)
|
2018-09-11 |
2021-05-25 |
Curis Inc. |
terapia em combinação com um inibidor de fosfoinositídeo 3-quinase com uma porção de ligação a zinco
|
|
KR20250035608A
(ko)
*
|
2018-09-11 |
2025-03-12 |
아이테오스 벨지움 에스에이 |
A2a 억제제로서 싸이오카바메이트 유도체, 이의 약학 조성물 및 항암제와의 조합물
|
|
EP3849606A4
(en)
|
2018-09-13 |
2022-06-29 |
Merck Sharp & Dohme Corp. |
Combination of pd-1 antagonist and lag3 antagonist for treating non-microsatellite instablity-high/proficient mismatch repair colorectal cancer
|
|
CA3114024A1
(en)
|
2018-09-26 |
2020-04-02 |
Merck Patent Gmbh |
Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer
|
|
CA3115802A1
(en)
|
2018-10-17 |
2020-04-23 |
Biolinerx Ltd. |
Treatment of metastatic pancreatic adenocarcinoma
|
|
EP3867232B1
(en)
|
2018-10-17 |
2024-12-18 |
Merck Sharp & Dohme LLC |
Novel arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
|
|
CN113226369A
(zh)
|
2018-10-22 |
2021-08-06 |
葛兰素史克知识产权开发有限公司 |
给药
|
|
EA202191175A1
(ru)
|
2018-10-29 |
2021-09-08 |
Мерсана Терапьютикс, Инк. |
Сконструированные с цистеином конъюгаты антитело-лекарственное средство, содержащие пептидсодержащие линкеры
|
|
TWI844571B
(zh)
|
2018-10-30 |
2024-06-11 |
丹麥商珍美寶股份有限公司 |
使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
|
|
US12264189B2
(en)
|
2018-10-31 |
2025-04-01 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
|
US12257286B2
(en)
|
2018-10-31 |
2025-03-25 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
|
WO2020092183A1
(en)
|
2018-11-01 |
2020-05-07 |
Merck Sharp & Dohme Corp. |
Novel substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
|
|
EP3877366B1
(en)
|
2018-11-06 |
2026-01-28 |
Merck Sharp & Dohme LLC |
Novel substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors
|
|
CA3119563A1
(en)
*
|
2018-11-14 |
2020-05-22 |
Bayer Aktiengesellschaft |
Pharmaceutical combination of anti-ceacam6 and either anti-pd-1 or anti-pd-l1 antibodies for the treatment of cancer
|
|
CN113301899A
(zh)
|
2018-11-16 |
2021-08-24 |
艾科尔公司 |
用于治疗癌症的药物组合
|
|
EP3883576B1
(en)
|
2018-11-20 |
2025-12-17 |
Merck Sharp & Dohme LLC |
Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
|
|
WO2020106558A1
(en)
|
2018-11-20 |
2020-05-28 |
Merck Sharp & Dohme Corp. |
Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
|
|
CN113453678A
(zh)
|
2018-11-26 |
2021-09-28 |
德彪药业国际股份公司 |
Hiv感染的联合治疗
|
|
WO2020112581A1
(en)
|
2018-11-28 |
2020-06-04 |
Merck Sharp & Dohme Corp. |
Novel substituted piperazine amide compounds as indoleamine 2, 3-dioxygenase (ido) inhibitors
|
|
BR112021010353A2
(pt)
|
2018-11-30 |
2021-08-31 |
Glaxosmithkline Intellectual Property Development Limited |
Compostos úteis em terapia hiv
|
|
JOP20210117A1
(ar)
|
2018-11-30 |
2023-01-30 |
Merck Sharp & Dohme |
مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها
|
|
EP3894401A2
(en)
|
2018-12-11 |
2021-10-20 |
Theravance Biopharma R&D IP, LLC |
Naphthyridine and quinoline derivatives useful as alk5 inhibitors
|
|
WO2020131598A1
(en)
|
2018-12-18 |
2020-06-25 |
Merck Sharp & Dohme Corp. |
Arginase inhibitors and methods of use
|
|
WO2020128972A1
(en)
|
2018-12-20 |
2020-06-25 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
WO2020128893A1
(en)
|
2018-12-21 |
2020-06-25 |
Pfizer Inc. |
Combination treatments of cancer comprising a tlr agonist
|
|
AU2020222346B2
(en)
|
2019-02-15 |
2021-12-09 |
Novartis Ag |
Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
ES3032659T3
(en)
|
2019-02-15 |
2025-07-23 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
CN109879855B
(zh)
*
|
2019-03-26 |
2021-01-05 |
中国医学科学院医药生物技术研究所 |
靶向肿瘤细胞表面pd-l1分子的抑制剂及其应用
|
|
WO2020205688A1
(en)
|
2019-04-04 |
2020-10-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
KR20220002899A
(ko)
|
2019-04-19 |
2022-01-07 |
얀센 바이오테크 인코포레이티드 |
항-psma/cd3 항체로 전립선암을 치료하는 방법
|
|
WO2020216697A1
(en)
|
2019-04-23 |
2020-10-29 |
Innate Pharma |
Cd73 blocking antibodies
|
|
BR112021022659A2
(pt)
|
2019-05-15 |
2022-03-29 |
Chemocentryx Inc |
Compostos triarílicos para o tratamento de doenças pd-l1
|
|
JP2022533390A
(ja)
|
2019-05-16 |
2022-07-22 |
スティングセラ インコーポレイテッド |
オキソアクリジニル酢酸誘導体および使用方法
|
|
US20220251079A1
(en)
|
2019-05-16 |
2022-08-11 |
Stingthera, Inc. |
Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use
|
|
CN113874036A
(zh)
|
2019-05-24 |
2021-12-31 |
辉瑞公司 |
使用cdk抑制剂的联合治疗
|
|
WO2020260547A1
(en)
|
2019-06-27 |
2020-12-30 |
Rigontec Gmbh |
Design method for optimized rig-i ligands
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
CN114269780B
(zh)
*
|
2019-07-19 |
2024-01-19 |
北京先通生物医药技术有限公司 |
一种新型抗pd-l1抗体及其用途
|
|
US11083705B2
(en)
|
2019-07-26 |
2021-08-10 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition for treating tumor
|
|
US12036204B2
(en)
|
2019-07-26 |
2024-07-16 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition for treating tumor
|
|
KR20220056176A
(ko)
|
2019-08-02 |
2022-05-04 |
메르사나 테라퓨틱스, 인코포레이티드 |
암 치료를 위한 sting(인터페론 유전자의 자극인자) 작용제로서의 비스-[n-((5-카바모일)-1h-벤조[d]이미다졸-2-일)-피라졸-5-카복사미드] 유도체 및 관련 화합물
|
|
WO2021024020A1
(en)
|
2019-08-06 |
2021-02-11 |
Astellas Pharma Inc. |
Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
|
|
PL4013512T3
(pl)
|
2019-09-18 |
2024-06-10 |
Lamkap Bio Alpha AG |
Przeciwciała dwuswoiste przeciwko CEACAM5 i CD3
|
|
CA3155090A1
(en)
|
2019-09-20 |
2021-03-25 |
Transgene |
Combination of a poxvirus encoding hpv polypeptides and il-2 with an anti-pd-l1 antibody
|
|
MX2022003523A
(es)
|
2019-09-27 |
2022-04-25 |
Glaxosmithkline Ip Dev Ltd |
Proteinas de union a antigenos.
|
|
MX2022005187A
(es)
|
2019-10-28 |
2022-07-27 |
Shanghai Inst Materia Medica Cas |
Compuesto de ácido oxocarboxílico heterocíclico de cinco miembros y el uso médico del mismo.
|
|
AU2020374883A1
(en)
|
2019-10-29 |
2022-05-26 |
Eisai R&D Management Co., Ltd. |
Combination of a PD-1 antagonist, a VEGFR/FGFR/RET tyrosine kinase inhibitor and a CBP/beta-catenin inhibitor for treating cancer
|
|
CN114728941A
(zh)
|
2019-11-22 |
2022-07-08 |
施万生物制药研发Ip有限责任公司 |
作为alk5抑制剂的经取代的1,5-萘啶或喹啉
|
|
EP3831849A1
(en)
|
2019-12-02 |
2021-06-09 |
LamKap Bio beta AG |
Bispecific antibodies against ceacam5 and cd47
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
US20220396577A1
(en)
|
2019-12-17 |
2022-12-15 |
Merck Sharp & Dohme Llc |
Novel substituted 1,3-8-triazaspiro[4,5] decane-2,4-dione compounds as indoleamine 2,3-dioxygenase (ido) and/or tryptophan 2,3-dioxygenase (tdo) inhibitors
|
|
US12415785B2
(en)
|
2019-12-18 |
2025-09-16 |
Ctxt Pty Ltd |
Compound modulators of sting
|
|
BR112022011902A2
(pt)
|
2019-12-20 |
2022-09-06 |
Novartis Ag |
Terapias de combinação
|
|
US20230140132A1
(en)
|
2020-01-07 |
2023-05-04 |
Merck Sharp & Dohme Llc |
Arginase inhibitors and methods of use
|
|
JP2023519673A
(ja)
|
2020-03-31 |
2023-05-12 |
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー |
置換ピリミジンおよび使用方法
|
|
CA3174297A1
(en)
|
2020-04-02 |
2021-10-07 |
Jeremy R. Duvall |
Antibody drug conjugates comprising sting agonists
|
|
CN115461362A
(zh)
|
2020-04-14 |
2022-12-09 |
葛兰素史密斯克莱知识产权发展有限公司 |
基于ICOS抗体和PD-L1抗体TGF-β受体融合蛋白的癌症组合疗法
|
|
TW202206100A
(zh)
|
2020-04-27 |
2022-02-16 |
美商西健公司 |
癌症之治療
|
|
JP7311720B2
(ja)
|
2020-05-06 |
2023-07-19 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Ｉｌ４ｉ１阻害剤及び使用方法
|
|
WO2021249969A1
(en)
|
2020-06-10 |
2021-12-16 |
Merck Patent Gmbh |
Combination product for the treatment of cancer diseases
|
|
CN116323607A
(zh)
|
2020-06-10 |
2023-06-23 |
施万生物制药研发Ip有限责任公司 |
用作alk5抑制剂的萘啶衍生物
|
|
US11780920B2
(en)
|
2020-06-19 |
2023-10-10 |
Hoffmann-La Roche Inc. |
Antibodies binding to CD3 and CD19
|
|
CN115916199A
(zh)
|
2020-06-23 |
2023-04-04 |
诺华股份有限公司 |
包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案
|
|
US20230293530A1
(en)
|
2020-06-24 |
2023-09-21 |
Yeda Research And Development Co. Ltd. |
Agents for sensitizing solid tumors to treatment
|
|
WO2022003554A1
(en)
|
2020-07-01 |
2022-01-06 |
Pfizer Inc. |
Biomarkers for pd-1 axis binding antagonist therapy
|
|
MX2023000197A
(es)
|
2020-07-07 |
2023-02-22 |
BioNTech SE |
Arn terapeutico para el cancer positivo para vph.
|
|
CA3189383A1
(en)
*
|
2020-07-13 |
2022-01-20 |
Verastem, Inc. |
Combination therapy for treating abnormal cell growth
|
|
CN116194480A
(zh)
*
|
2020-08-13 |
2023-05-30 |
百时美施贵宝公司 |
将il-2重定向到目的靶细胞的方法
|
|
CA3189987A1
(en)
|
2020-09-02 |
2022-03-10 |
Pharmabcine Inc. |
Combination therapy of a pd-1 antagonist and an antagonist for vegfr-2 for treating patients with cancer
|
|
HRP20240213T1
(hr)
|
2020-12-18 |
2024-04-26 |
Lamkap Bio Beta Ag |
Bispecifična antitijela protiv ceacam5 i cd47
|
|
WO2022135666A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Treatment schedule for cytokine proteins
|
|
WO2022135667A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Therapeutic rna for treating cancer
|
|
TW202245808A
(zh)
|
2020-12-21 |
2022-12-01 |
德商拜恩迪克公司 |
用於治療癌症之治療性ｒｎａ
|
|
JP2024504758A
(ja)
|
2021-01-28 |
2024-02-01 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｐｓｍａ結合タンパク質及びその使用
|
|
CN117794929A
(zh)
|
2021-02-02 |
2024-03-29 |
法国施维雅药厂 |
选择性bcl-xl protac化合物及使用方法
|
|
WO2022185160A1
(en)
|
2021-03-02 |
2022-09-09 |
Glaxosmithkline Intellectual Property Development Limited |
Substituted pyridines as dnmt1 inhibitors
|
|
CN117321418A
(zh)
|
2021-03-18 |
2023-12-29 |
诺华股份有限公司 |
癌症生物标志物及其使用方法
|
|
TW202304506A
(zh)
|
2021-03-25 |
2023-02-01 |
日商安斯泰來製藥公司 |
涉及抗claudin 18.2抗體的組合治療以治療癌症
|
|
EP4314060A1
(en)
|
2021-03-31 |
2024-02-07 |
GlaxoSmithKline Intellectual Property Development Limited |
Antigen binding proteins and combinations thereof
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
AU2022254104A1
(en)
|
2021-04-08 |
2023-10-26 |
Nurix Therapeutics, Inc. |
Combination therapies with cbl-b inhibitor compounds
|
|
MX2023011964A
(es)
|
2021-04-09 |
2024-01-08 |
Ose Immunotherapeutics |
Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
|
|
WO2022214652A1
(en)
|
2021-04-09 |
2022-10-13 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
WO2022227015A1
(en)
|
2021-04-30 |
2022-11-03 |
Merck Sharp & Dohme Corp. |
Il4i1 inhibitors and methods of use
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
WO2022251359A1
(en)
|
2021-05-26 |
2022-12-01 |
Theravance Biopharma R&D Ip, Llc |
Bicyclic inhibitors of alk5 and methods of use
|
|
WO2022261018A1
(en)
|
2021-06-07 |
2022-12-15 |
Providence Health & Services - Oregon |
Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
|
|
JP2024525758A
(ja)
|
2021-07-13 |
2024-07-12 |
ビオンテック・ソシエタス・エウロパエア |
がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤
|
|
EP4376870A4
(en)
*
|
2021-07-28 |
2025-07-23 |
Anwita Biosciences Inc |
INTERLEUKIN-2 MUTEINS, FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS
|
|
EP4377348A1
(en)
|
2021-07-30 |
2024-06-05 |
Seagen Inc. |
Treatment for cancer
|
|
WO2023039583A1
(en)
*
|
2021-09-10 |
2023-03-16 |
Trustees Of Tufts College |
Anti-pd-1 immunoglobulin polypeptides and uses thereof
|
|
WO2023051926A1
(en)
|
2021-09-30 |
2023-04-06 |
BioNTech SE |
Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
|
|
TW202333802A
(zh)
|
2021-10-11 |
2023-09-01 |
德商拜恩迪克公司 |
用於肺癌之治療性rna(二)
|
|
WO2023079428A1
(en)
|
2021-11-03 |
2023-05-11 |
Pfizer Inc. |
Combination therapies using tlr7/8 agonist
|
|
WO2023083439A1
(en)
|
2021-11-09 |
2023-05-19 |
BioNTech SE |
Tlr7 agonist and combinations for cancer treatment
|
|
IL315262A
(en)
|
2022-03-03 |
2024-10-01 |
Pfizer |
Multiple specific antibodies related to IL-4, IL-13 and/or TSLP and their uses
|
|
WO2023172643A1
(en)
*
|
2022-03-08 |
2023-09-14 |
Whitehead Institute For Biomedical Research |
The combination of macrophage-directed immunotherapy and targeted agents for treatment of cancer
|
|
AU2023273734A1
(en)
|
2022-05-20 |
2024-12-12 |
Les Laboratoires Servier |
Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
WO2023225320A1
(en)
|
2022-05-20 |
2023-11-23 |
Novartis Ag |
Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
AR129423A1
(es)
|
2022-05-27 |
2024-08-21 |
Viiv Healthcare Co |
Compuestos útiles en la terapia contra el hiv
|
|
US11873296B2
(en)
|
2022-06-07 |
2024-01-16 |
Verastem, Inc. |
Solid forms of a dual RAF/MEK inhibitor
|
|
JP2025523424A
(ja)
|
2022-06-16 |
2025-07-23 |
ランカプ バイオ ベータ リミテッド |
Ｃｅａｃａｍ５およびｃｄ４７に対する二重特異性抗体ならびにｃｅａｃａｍ５およびｃｄ３に対する二重特異性抗体の併用療法
|
|
AU2023401158A1
(en)
|
2022-12-01 |
2025-05-29 |
BioNTech SE |
Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy
|
|
AU2023393653A1
(en)
|
2022-12-14 |
2025-05-22 |
Astellas Pharma Europe Bv |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
|
|
WO2024140919A1
(zh)
*
|
2022-12-29 |
2024-07-04 |
南京圣和药业股份有限公司 |
抗crtam/抗pd-l1抗体及其应用
|
|
EP4676462A1
(en)
|
2023-03-07 |
2026-01-14 |
Photocure ASA |
Therapy for bladder cancer
|
|
CN120752058A
(zh)
|
2023-03-10 |
2025-10-03 |
诺华股份有限公司 |
panRAS抑制剂抗体-药物缀合物及其使用方法
|
|
WO2024206357A1
(en)
|
2023-03-29 |
2024-10-03 |
Merck Sharp & Dohme Llc |
Il4i1 inhibitors and methods of use
|
|
WO2024229406A1
(en)
|
2023-05-04 |
2024-11-07 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
WO2025034702A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Rmc-6291 for use in the treatment of ras protein-related disease or disorder
|
|
WO2025042742A1
(en)
|
2023-08-18 |
2025-02-27 |
Bristol-Myers Squibb Company |
Compositions comprising antibodies that bind bcma and cd3 and methods of treatment
|
|
WO2025056180A1
(en)
|
2023-09-15 |
2025-03-20 |
BioNTech SE |
Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists
|
|
TW202530228A
(zh)
|
2023-10-12 |
2025-08-01 |
美商銳新醫藥公司 |
Ｒａｓ抑制劑
|
|
WO2025096843A1
(en)
|
2023-11-03 |
2025-05-08 |
Amgen Inc. |
Bispecific molecules
|
|
TW202540185A
(zh)
|
2023-11-22 |
2025-10-16 |
法商施維雅藥廠 |
抗cd74抗體藥物結合物及其使用方法
|
|
WO2025120867A1
(en)
|
2023-12-08 |
2025-06-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
|
|
WO2025120866A1
(en)
|
2023-12-08 |
2025-06-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
|
|
WO2025121445A1
(en)
|
2023-12-08 |
2025-06-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025213154A1
(en)
|
2024-04-05 |
2025-10-09 |
Amgen Inc. |
Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors
|
|
TW202539634A
(zh)
|
2024-04-10 |
2025-10-16 |
瑞士商諾華公司 |
Ｐａｎｒａｓ抑制劑及其使用方法
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20250375445A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025259515A2
(en)
|
2024-06-11 |
2025-12-18 |
Amgen Inc. |
Combination treatment
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|