JP2017501155A5 - - Google Patents
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- JP2017501155A5 JP2017501155A5 JP2016539319A JP2016539319A JP2017501155A5 JP 2017501155 A5 JP2017501155 A5 JP 2017501155A5 JP 2016539319 A JP2016539319 A JP 2016539319A JP 2016539319 A JP2016539319 A JP 2016539319A JP 2017501155 A5 JP2017501155 A5 JP 2017501155A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- binding antagonist
- cancer
- medicament according
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003814 drug Substances 0.000 claims 80
- 239000005557 antagonist Substances 0.000 claims 57
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 44
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 44
- 201000011510 cancer Diseases 0.000 claims 25
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 24
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 23
- 229940123237 Taxane Drugs 0.000 claims 19
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 19
- 239000003937 drug carrier Substances 0.000 claims 13
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 12
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 12
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 12
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical group O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 9
- 229960001592 paclitaxel Drugs 0.000 claims 8
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 102000048362 human PDCD1 Human genes 0.000 claims 5
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 229940028652 abraxane Drugs 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 230000004044 response Effects 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 150000003278 haem Chemical class 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 190000008236 carboplatin Chemical group 0.000 claims 1
- 230000001461 cytolytic effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361917264P | 2013-12-17 | 2013-12-17 | |
| US61/917,264 | 2013-12-17 | ||
| PCT/US2014/070974 WO2015095404A2 (en) | 2013-12-17 | 2014-12-17 | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020034955A Division JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501155A JP2017501155A (ja) | 2017-01-12 |
| JP2017501155A5 true JP2017501155A5 (enExample) | 2018-02-01 |
| JP6841656B2 JP6841656B2 (ja) | 2021-03-10 |
Family
ID=52293262
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539949A Withdrawn JP2017507900A (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2016539319A Active JP6841656B2 (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2019074325A Pending JP2019142900A (ja) | 2013-12-17 | 2019-04-09 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2020034955A Withdrawn JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2022000201A Active JP7645204B2 (ja) | 2013-12-17 | 2022-01-04 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2024179266A Pending JP2025020147A (ja) | 2013-12-17 | 2024-10-11 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539949A Withdrawn JP2017507900A (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019074325A Pending JP2019142900A (ja) | 2013-12-17 | 2019-04-09 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2020034955A Withdrawn JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2022000201A Active JP7645204B2 (ja) | 2013-12-17 | 2022-01-04 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2024179266A Pending JP2025020147A (ja) | 2013-12-17 | 2024-10-11 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (12) | US10570213B2 (enExample) |
| EP (4) | EP3647324A1 (enExample) |
| JP (6) | JP2017507900A (enExample) |
| KR (5) | KR20160089531A (enExample) |
| CN (3) | CN112353943A (enExample) |
| AU (3) | AU2014364587C1 (enExample) |
| BR (1) | BR112016013896A2 (enExample) |
| CA (2) | CA2933883A1 (enExample) |
| DK (1) | DK3083686T4 (enExample) |
| ES (1) | ES2763429T5 (enExample) |
| FI (1) | FI3083686T4 (enExample) |
| HK (1) | HK1225634A1 (enExample) |
| HR (1) | HRP20192288T4 (enExample) |
| HU (1) | HUE047699T2 (enExample) |
| IL (3) | IL296657A (enExample) |
| LT (1) | LT3083686T (enExample) |
| MX (3) | MX2016007887A (enExample) |
| MY (1) | MY189089A (enExample) |
| NZ (2) | NZ760065A (enExample) |
| PL (1) | PL3083686T5 (enExample) |
| PT (1) | PT3083686T (enExample) |
| RS (1) | RS59659B2 (enExample) |
| RU (1) | RU2719487C2 (enExample) |
| SG (4) | SG10202002334PA (enExample) |
| SI (1) | SI3083686T2 (enExample) |
| WO (2) | WO2015095418A1 (enExample) |
| ZA (1) | ZA201603753B (enExample) |
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| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| KR20250091300A (ko) | 2008-12-09 | 2025-06-20 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| RU2605390C2 (ru) | 2011-08-23 | 2016-12-20 | Рош Гликарт Аг | Биспецифические антитела, специфичные к антигенам, активирующим т-клетки, и опухолевому антигену, и способы их применения |
| MX2015003616A (es) | 2012-10-08 | 2015-06-05 | Roche Glycart Ag | Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso. |
| MX375359B (es) | 2013-02-26 | 2025-03-06 | Roche Glycart Ag | Moléculas biespecíficas de unión a antígeno activadoras de células t. |
| BR112015017800A2 (pt) | 2013-02-26 | 2017-11-21 | Roche Glycart Ag | moléculas de ligação ao antígeno biespecífica ativadora de célula t, polinucleotídeo, polipeptídeo, vetor, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica ativadora de célula t, composição farmacêutica e uso da molécula de ligação ao antígeno biespecífica ativadora de célula t |
| RU2737727C2 (ru) | 2013-04-16 | 2020-12-02 | Дженентек, Инк. | Варианты пертузумаба и их аналитическая характеристика |
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- 2014-12-17 KR KR1020227032906A patent/KR102630750B1/ko active Active
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2016
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2019
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2020
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2021
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2023
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2024
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