JP2018518454A5 - - Google Patents
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- JP2018518454A5 JP2018518454A5 JP2017552082A JP2017552082A JP2018518454A5 JP 2018518454 A5 JP2018518454 A5 JP 2018518454A5 JP 2017552082 A JP2017552082 A JP 2017552082A JP 2017552082 A JP2017552082 A JP 2017552082A JP 2018518454 A5 JP2018518454 A5 JP 2018518454A5
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
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- 101100087591 Mus musculus Rictor gene Proteins 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021100601A JP7242760B2 (ja) | 2015-04-03 | 2021-06-17 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
| JP2023035685A JP2023063377A (ja) | 2015-04-03 | 2023-03-08 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143016P | 2015-04-03 | 2015-04-03 | |
| US62/143,016 | 2015-04-03 | ||
| US201562191797P | 2015-07-13 | 2015-07-13 | |
| US62/191,797 | 2015-07-13 | ||
| PCT/US2016/025802 WO2016161410A2 (en) | 2015-04-03 | 2016-04-03 | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100601A Division JP7242760B2 (ja) | 2015-04-03 | 2021-06-17 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518454A JP2018518454A (ja) | 2018-07-12 |
| JP2018518454A5 true JP2018518454A5 (enExample) | 2019-05-16 |
| JP6901400B2 JP6901400B2 (ja) | 2021-07-14 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552082A Active JP6901400B2 (ja) | 2015-04-03 | 2016-04-03 | ＴＧＦ−β及びＰＤ−１の阻害物質を使用する癌の治療法 |
| JP2021100601A Active JP7242760B2 (ja) | 2015-04-03 | 2021-06-17 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
| JP2023035685A Pending JP2023063377A (ja) | 2015-04-03 | 2023-03-08 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021100601A Active JP7242760B2 (ja) | 2015-04-03 | 2021-06-17 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
| JP2023035685A Pending JP2023063377A (ja) | 2015-04-03 | 2023-03-08 | ＴＧＦ－β及びＰＤ－１の阻害物質を使用する癌の治療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10167334B2 (enExample) |
| EP (2) | EP3770171A1 (enExample) |
| JP (3) | JP6901400B2 (enExample) |
| CN (2) | CN108136001B (enExample) |
| ES (1) | ES2820768T3 (enExample) |
| WO (1) | WO2016161410A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108136001B (zh) * | 2015-04-03 | 2022-07-29 | 佐马技术有限公司 | 使用TGF-β抑制剂和PD-1抑制剂治疗癌症 |
| US10513558B2 (en) | 2015-07-13 | 2019-12-24 | Cytomx Therapeutics, Inc. | Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof |
| MY197664A (en) * | 2015-09-03 | 2023-06-30 | Ono Pharmaceutical Co | Immunity enhancing agent for cancer by allergin-1 antagonist |
| WO2017158043A1 (en) | 2016-03-15 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Early and non invasive method for assessing a subject's risk of having pancreatic ductal adenocarcinoma and methods of treatement of such disease |
| AU2018205233A1 (en) * | 2017-01-07 | 2019-07-11 | Merck Patent Gmbh | Dosing regimens and dosage forms for targeted TGFβ inhibition |
| TW202421659A (zh) | 2017-01-20 | 2024-06-01 | 美商健臻公司 | 骨靶向抗體 |
| TWI787230B (zh) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗ＴＧＦ-β抗體及其用途 |
| EA201991729A1 (ru) * | 2017-01-20 | 2019-12-30 | Санофи | Антитела к tgf-бета и их применение |
| AR110904A1 (es) * | 2017-01-20 | 2019-05-15 | Sanofi Sa | ANTICUERPOS ANTI-TGF-b Y SU USO |
| JOP20190260A1 (ar) * | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| EP3634437A4 (en) * | 2017-05-19 | 2020-11-18 | Case Western Reserve University | COMPOSITIONS AND METHODS FOR EX VIVO EXPANSION OF NATURAL KILLER CELLS AND THEIR THERAPEUTIC USES |
| WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | ANTI-LAP ANTIBODIES AND USES THEREOF |
| EP3717475B1 (en) | 2017-11-20 | 2023-06-07 | Icahn School of Medicine at Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| CN111819193A (zh) | 2018-01-05 | 2020-10-23 | 西奈山伊坎医学院 | 增加胰腺β细胞增殖的方法、治疗方法以及组合物 |
| CA3093340A1 (en) * | 2018-03-20 | 2019-09-26 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| CN111821434A (zh) * | 2019-04-17 | 2020-10-27 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
| KR20210006405A (ko) * | 2018-05-04 | 2021-01-18 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1/PD-L1, TGFβ 및 DNA-PK의 조합 억제 |
| WO2020009938A1 (en) * | 2018-07-03 | 2020-01-09 | Catalent Pharma Solutions, Llc | Multifunctional protein molecules comprising decorin and use thereof |
| AU2019336197A1 (en) | 2018-09-07 | 2021-02-18 | Pfizer Inc. | Anti-avb8 antibodies and compositions and uses thereof |
| JP2022504839A (ja) | 2018-10-10 | 2022-01-13 | ティロス・セラピューティクス・インコーポレイテッド | 抗ｌａｐ抗体変異体及びその使用 |
| CN112955462B (zh) * | 2018-10-18 | 2024-05-07 | 国家医疗保健研究所 | 用于治疗实体瘤的βIG-H3拮抗剂和免疫检查点抑制剂的组合 |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| CN113164386A (zh) * | 2018-11-21 | 2021-07-23 | 亮点医疗有限责任公司 | 纳米复合聚(i:c)制剂及其用途 |
| WO2020146345A1 (en) * | 2019-01-07 | 2020-07-16 | Children's Medical Center Corporation | Methods of treating cancer using lsd1 inhibitors and/or tgf-beta inhibitors in combination with immunotherapy |
| TW202043267A (zh) | 2019-01-30 | 2020-12-01 | 美商供石公司 | TGFβ之LTBP複合物專一性抑制劑及其用途 |
| WO2020248908A1 (zh) * | 2019-06-10 | 2020-12-17 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
| CN110464841B (zh) * | 2019-08-19 | 2020-05-22 | 启辰生生物科技(珠海)有限公司 | 免疫增强的药物组合物及其应用 |
| CN110734498A (zh) * | 2019-10-15 | 2020-01-31 | 上海科棋药业科技有限公司 | 一种用于解除免疫抑制的融合蛋白及其应用 |
| EP4048704A4 (en) * | 2019-10-21 | 2023-11-22 | Nanjing Leads Biolabs Co., Ltd. | RECOMBINANT PROTEIN TARGETING PD-1 AND TGFß |
| AU2020375161A1 (en) * | 2019-11-01 | 2022-05-19 | Ares Trading S.A. | Combined inhibition of PD-1, TGFβ and ATM together with radiotherapy for the treatment of cancer |
| JP2023506958A (ja) * | 2019-12-20 | 2023-02-20 | ノバルティス アーゲー | 骨髄線維症および骨髄異形成症候群を処置するための、デシタビンまたは抗ｐｄ－１抗体スパルタリズマブを伴うかまたは伴わない抗ｔｉｍ－３抗体ｍｂｇ４５３および抗ｔｇｆ－ベータ抗体ｎｉｓ７９３の組合せ |
| JP2023511255A (ja) | 2020-01-11 | 2023-03-17 | スカラー ロック インコーポレイテッド | ＴＧＦ－β阻害剤及びその使用 |
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- 2016-04-03 CN CN201680025721.5A patent/CN108136001B/zh active Active
- 2016-04-03 US US15/089,579 patent/US10167334B2/en active Active
- 2016-04-03 CN CN202210813731.2A patent/CN116327915A/zh active Pending
- 2016-04-03 EP EP20181469.6A patent/EP3770171A1/en not_active Withdrawn
- 2016-04-03 EP EP16763992.1A patent/EP3277716B1/en active Active
- 2016-04-03 WO PCT/US2016/025802 patent/WO2016161410A2/en not_active Ceased
- 2016-04-03 ES ES16763992T patent/ES2820768T3/es active Active
- 2016-04-03 JP JP2017552082A patent/JP6901400B2/ja active Active
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- 2018-12-17 US US16/222,725 patent/US10683347B2/en active Active
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- 2023-03-08 JP JP2023035685A patent/JP2023063377A/ja active Pending
- 2023-05-11 US US18/316,210 patent/US20230416354A1/en not_active Abandoned
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