|
EP2277532A1
(en)
|
2002-09-11 |
2011-01-26 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
|
EP3683230A1
(en)
|
2005-05-12 |
2020-07-22 |
ZymoGenetics, Inc. |
Compositions and methods for modulating immune responses
|
|
WO2009126688A2
(en)
|
2008-04-09 |
2009-10-15 |
Genentech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
ES2549769T3
(es)
|
2009-03-25 |
2015-11-02 |
Genentech, Inc. |
Anticuerpos anti-FGFR3 y métodos que emplean los mismos
|
|
WO2012088446A1
(en)
|
2010-12-22 |
2012-06-28 |
Board Of Trustees Of The Leland Stanford Junior University |
Superagonists and antagonists of interleukin-2
|
|
TWI583699B
(zh)
|
2011-09-23 |
2017-05-21 |
安可美德藥物股份有限公司 |
Ｖｅｇｆ／ｄｌｌ４結合劑類及彼等之用途
|
|
EP2928474B1
(en)
|
2012-12-07 |
2018-11-14 |
ChemoCentryx, Inc. |
Diazole lactams
|
|
TWI888366B
(zh)
|
2013-07-16 |
2025-07-01 |
美商建南德克公司 |
利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對ｐｄ-１的人類抗體
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗ｐｄ-ｌ１之人類抗體
|
|
UA122479C2
(uk)
|
2014-01-24 |
2020-11-25 |
Дана-Фарбер Кенсер Інстітьют, Інк. |
Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
|
|
PL3099717T3
(pl)
|
2014-01-31 |
2019-10-31 |
Novartis Ag |
Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie
|
|
US10618963B2
(en)
|
2014-03-12 |
2020-04-14 |
Yeda Research And Development Co. Ltd |
Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
|
|
US9394365B1
(en)
|
2014-03-12 |
2016-07-19 |
Yeda Research And Development Co., Ltd |
Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
|
|
KR20200029627A
(ko)
|
2014-03-12 |
2020-03-18 |
예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 |
Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
|
|
US10519237B2
(en)
|
2014-03-12 |
2019-12-31 |
Yeda Research And Development Co. Ltd |
Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
|
|
EA201691765A1
(ru)
|
2014-03-14 |
2016-12-30 |
Новартис Аг |
Молекулы антител против lag-3 и их применения
|
|
WO2015143343A2
(en)
*
|
2014-03-21 |
2015-09-24 |
The Brigham And Women's Hospital, Inc. |
Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring
|
|
JP6592505B2
(ja)
|
2014-04-24 |
2019-10-16 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
インターロイキン−２のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト
|
|
LT3148579T
(lt)
|
2014-05-28 |
2021-05-25 |
Agenus Inc. |
Anti-gitr antikūnai ir jų panaudojimo būdai
|
|
CA2957722C
(en)
|
2014-08-19 |
2022-05-31 |
Merck Sharp & Dohme Corp. |
Anti-tigit antibodies
|
|
EP3191126B1
(en)
|
2014-09-13 |
2020-05-13 |
Novartis AG |
Combination therapies of alk inhibitors
|
|
CA2963974A1
(en)
*
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
AR103268A1
(es)
|
2014-12-23 |
2017-04-26 |
Bristol Myers Squibb Co |
Anticuerpos contra tigit
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
SG11201706727XA
(en)
*
|
2015-02-19 |
2017-09-28 |
Bioclin Therapeutics Inc |
Methods, compositions, and kits for treatment of cancer
|
|
US10550173B2
(en)
|
2015-02-19 |
2020-02-04 |
Compugen, Ltd. |
PVRIG polypeptides and methods of treatment
|
|
IL254039B2
(en)
|
2015-02-19 |
2023-12-01 |
Compugen Ltd |
Anti-pvrig antibodies and methods of use
|
|
SMT202100467T1
(it)
|
2015-04-17 |
2021-09-14 |
Alpine Immune Sciences Inc |
Proteine immunomodulatorie con affinità regolabili
|
|
RU2726206C2
(ru)
|
2015-05-21 |
2020-07-09 |
Кемосентрикс, Инк. |
Модуляторы ccr2
|
|
TWI715587B
(zh)
*
|
2015-05-28 |
2021-01-11 |
美商安可美德藥物股份有限公司 |
Ｔｉｇｉｔ結合劑和彼之用途
|
|
AU2016271111B2
(en)
|
2015-05-29 |
2022-04-28 |
Bristol-Myers Squibb Company |
Antibodies against OX40 and uses thereof
|
|
DK3303394T3
(da)
|
2015-05-29 |
2020-07-06 |
Agenus Inc |
Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf
|
|
US20180340025A1
(en)
|
2015-07-29 |
2018-11-29 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
|
JO3620B1
(ar)
*
|
2015-08-05 |
2020-08-27 |
Amgen Res Munich Gmbh |
مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
|
|
CN115925931A
(zh)
|
2015-08-14 |
2023-04-07 |
默沙东公司 |
抗tigit抗体
|
|
EP3344772B1
(en)
*
|
2015-09-01 |
2020-08-26 |
Academia Sinica |
Antagonistic pdl1 aptamers and their applications in cancer therapy
|
|
JP6869987B2
(ja)
|
2015-09-01 |
2021-05-12 |
アジェナス インコーポレイテッド |
抗ｐｄ−１抗体及びその使用方法
|
|
US10946095B2
(en)
|
2015-09-02 |
2021-03-16 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT)
|
|
US11339213B2
(en)
|
2015-09-23 |
2022-05-24 |
Mereo Biopharma 5, Inc. |
Methods and compositions for treatment of cancer
|
|
SG10202007764TA
(en)
|
2015-09-25 |
2020-09-29 |
Genentech Inc |
Anti-tigit antibodies and methods of use
|
|
PT3356413T
(pt)
|
2015-10-01 |
2022-04-04 |
Potenza Therapeutics Inc |
Proteínas de ligação a antigénio anti-tigit e métodos de utilização das mesmas
|
|
MA43028B1
(fr)
|
2015-10-02 |
2021-09-30 |
Hoffmann La Roche |
Anticorps bispécifiques pour pd1 et tim3
|
|
PT3370768T
(pt)
|
2015-11-03 |
2022-04-21 |
Janssen Biotech Inc |
Anticorpos que se ligam especificamente ao pd-1 e seus usos
|
|
WO2017096179A1
(en)
|
2015-12-02 |
2017-06-08 |
Agenus Inc. |
Antibodies and methods of use thereof
|
|
CN108495651A
(zh)
|
2015-12-17 |
2018-09-04 |
诺华股份有限公司 |
抗pd-1的抗体分子及其用途
|
|
ES2954153T3
(es)
|
2015-12-22 |
2023-11-20 |
Regeneron Pharma |
Combinación de anticuerpos anti-PD-1 y anticuerpos biespecíficos anti-CD20/anti-CD3 para tratar el cáncer
|
|
EP3693019A1
(en)
|
2016-01-08 |
2020-08-12 |
Taiho Pharmaceutical Co., Ltd. |
Anti-tumor agent containing immunomodulator
|
|
BR112018011029A2
(pt)
|
2016-01-08 |
2018-11-21 |
Hoffmann La Roche |
métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits
|
|
WO2017130060A1
(en)
|
2016-01-26 |
2017-08-03 |
Ciriello Christopher John |
Automated dental treatment system
|
|
RU2756275C2
(ru)
*
|
2016-03-01 |
2021-09-29 |
Юссум Рисёрч Девелопмент Компани Оф Зэ Хибру Юниверсити Оф Иерусалим Лтд. |
Антитела, специфические к рецептору полиовируса (pvr) человека
|
|
MX2018010485A
(es)
|
2016-03-04 |
2019-01-10 |
Jn Biosciences Llc |
Anticuerpos para inmunoreceptor de celulas t con dominios de ig e itim (tigit).
|
|
WO2017160599A1
(en)
|
2016-03-14 |
2017-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Use of cd300b antagonists to treat sepsis and septic shock
|
|
CN109153719B
(zh)
*
|
2016-03-15 |
2022-12-30 |
中外制药株式会社 |
使用pd-1轴结合拮抗剂和抗gpc3抗体治疗癌症的方法
|
|
CN109069638B
(zh)
|
2016-03-24 |
2022-03-29 |
璟尚生物制药公司 |
用于癌症治疗的三特异性抑制剂
|
|
IL261998B2
(en)
*
|
2016-04-07 |
2023-03-01 |
Chemocentryx Inc |
Reducing your burden by giving ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
|
|
AU2017248830B2
(en)
|
2016-04-15 |
2023-03-09 |
Alpine Immune Sciences, Inc. |
CD80 variant immunomodulatory proteins and uses thereof
|
|
PL3443350T3
(pl)
*
|
2016-04-15 |
2021-05-31 |
F. Hoffmann-La Roche Ag |
Sposoby monitorowania i leczenia nowotworu
|
|
IL262227B
(en)
*
|
2016-04-20 |
2022-07-01 |
Univ Tsukuba |
Regulatory t cell activator, and use thereof
|
|
TWI822521B
(zh)
|
2016-05-13 |
2023-11-11 |
美商再生元醫藥公司 |
藉由投予pd-1抑制劑治療皮膚癌之方法
|
|
EP3491013A1
(en)
|
2016-07-28 |
2019-06-05 |
Alpine Immune Sciences, Inc. |
Cd155 variant immunomodulatory proteins and uses thereof
|
|
US11471488B2
(en)
|
2016-07-28 |
2022-10-18 |
Alpine Immune Sciences, Inc. |
CD155 variant immunomodulatory proteins and uses thereof
|
|
WO2018022945A1
(en)
|
2016-07-28 |
2018-02-01 |
Alpine Immune Sciences, Inc. |
Cd112 variant immunomodulatory proteins and uses thereof
|
|
US20220354888A1
(en)
*
|
2016-08-03 |
2022-11-10 |
Aalborg Universitet |
ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS
|
|
KR102585976B1
(ko)
|
2016-08-17 |
2023-10-05 |
컴퓨젠 엘티디. |
항-tigit 항체, 항-pvrig 항체 및 이들의 조합
|
|
WO2018041120A1
(en)
*
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric tigit
|
|
CN107815467B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
CA3041340A1
(en)
|
2016-11-09 |
2018-05-17 |
Agenus Inc. |
Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
|
|
MX2019006072A
(es)
|
2016-11-30 |
2019-08-14 |
Oncomed Pharm Inc |
Metodos para tratamiento de cancer que comprenden agentes de enlace al inmunoreceptor de celulas t con dominios ige itim (tigit).
|
|
WO2018102746A1
(en)
*
|
2016-12-02 |
2018-06-07 |
Rigel Pharmaceuticals, Inc. |
Antigen binding molecules to tigit
|
|
CN110300599B
(zh)
|
2016-12-07 |
2024-07-02 |
艾吉纳斯公司 |
抗体和其使用方法
|
|
IL307242B1
(en)
|
2016-12-07 |
2026-07-01 |
Agenus Inc |
Anti-CTLA-4 antibodies and methods of using them
|
|
WO2018111890A1
(en)
*
|
2016-12-12 |
2018-06-21 |
Genentech, Inc. |
Methods of treating cancer using anti-pd-l1 antibodies and antiandrogens
|
|
US10232053B2
(en)
|
2016-12-30 |
2019-03-19 |
Trieza Therapeutics, Inc. |
Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
|
|
EP3565839A4
(en)
|
2017-01-05 |
2021-04-21 |
Gensun Biopharma Inc. |
CHECKPOINT REGULATOR ANTAGONISTS
|
|
MX2019008348A
(es)
*
|
2017-01-18 |
2019-10-21 |
Genentech Inc |
Anticuerpos idiotipo contra anticuerpos anti-pd-l1 y usos de estos solicitudes relacionadas.
|
|
CN110944651A
(zh)
|
2017-02-08 |
2020-03-31 |
蜻蜓疗法股份有限公司 |
用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途
|
|
EP4273258A3
(en)
|
2017-02-20 |
2024-01-17 |
Dragonfly Therapeutics, Inc. |
Proteins binding her2, nkg2d and cd16
|
|
CN111050788A
(zh)
*
|
2017-02-28 |
2020-04-21 |
西雅图基因公司 |
抗tigit抗体
|
|
MX2019010295A
(es)
|
2017-03-01 |
2019-11-21 |
Genentech Inc |
Métodos de diagnóstico y terapéuticos para el cáncer.
|
|
JOP20190203A1
(ar)
*
|
2017-03-30 |
2019-09-03 |
Potenza Therapeutics Inc |
بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها
|
|
CA3052532A1
(en)
|
2017-04-05 |
2018-10-11 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies specifically binding to pd1 and lag3
|
|
US11603407B2
(en)
|
2017-04-06 |
2023-03-14 |
Regeneron Pharmaceuticals, Inc. |
Stable antibody formulation
|
|
LT3618863T
(lt)
|
2017-05-01 |
2023-10-10 |
Agenus Inc. |
Anti-tigit antikūnai ir jų panaudojimo būdai
|
|
JOP20190260A1
(ar)
|
2017-05-02 |
2019-10-31 |
Merck Sharp & Dohme |
صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
|
|
SG11201909941QA
(en)
*
|
2017-05-02 |
2019-11-28 |
Merck Sharp & Dohme |
Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof
|
|
JP7348072B2
(ja)
|
2017-06-01 |
2023-09-20 |
コンピュジェン リミテッド |
三重併用抗体療法
|
|
ES3000510T3
(en)
|
2017-06-09 |
2025-02-28 |
Providence Health & Services Oregon |
Tumor-infiltrating t-cells for use in the treatment of cancer
|
|
WO2018229163A1
(en)
|
2017-06-14 |
2018-12-20 |
King's College London |
Methods of activating v delta 2 negative gamma delta t cells
|
|
AU2018287317B2
(en)
|
2017-06-19 |
2024-06-20 |
Medicenna Therapeutics Inc. |
Uses and methods for IL-2 superagonists, agonists, and fusions thereof
|
|
JP7383605B2
(ja)
*
|
2017-06-25 |
2023-11-20 |
システィミューン， インク． |
抗ｐｄ－ｌ１抗体とその作製及び使用方法
|
|
IL272227B2
(en)
|
2017-07-27 |
2025-09-01 |
iTeos Belgium SA |
Anti-tigit antibodies
|
|
MX2020001637A
(es)
*
|
2017-08-11 |
2020-08-20 |
Blink Biomedical Sas |
Agentes de union a cd96 como inmunomoduladores.
|
|
RU2021110369A
(ru)
*
|
2017-09-07 |
2021-06-01 |
Драгонфлай Терапьютикс, Инк. |
Белки, связывающие nkg2d, cd16 и опухолеассоциированный антиген
|
|
EP3687525B1
(en)
|
2017-09-25 |
2025-10-29 |
ChemoCentryx, Inc. |
Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
|
|
CN109575140B
(zh)
*
|
2017-09-29 |
2021-02-23 |
北京比洋生物技术有限公司 |
靶向pd-1或pd-l1且靶向vegf家族的双靶向融合蛋白及其用途
|
|
CN111051347B
(zh)
|
2017-09-29 |
2021-12-21 |
江苏恒瑞医药股份有限公司 |
Tigit抗体、其抗原结合片段及医药用途
|
|
EP3694870A1
(en)
|
2017-10-10 |
2020-08-19 |
Alpine Immune Sciences, Inc. |
Ctla-4 variant immunomodulatory proteins and uses thereof
|
|
AU2018348350B2
(en)
|
2017-10-11 |
2024-05-02 |
Aurigene Oncology Limited |
Crystalline forms of 3-substituted 1,2,4-oxadiazole
|
|
MX2020004531A
(es)
|
2017-11-03 |
2020-08-03 |
Aurigene Discovery Tech Ltd |
Inhibidores dobles de tim-3 y las vias de pd-1.
|
|
EP3706798A1
(en)
|
2017-11-06 |
2020-09-16 |
Aurigene Discovery Technologies Limited |
Conjoint therapies for immunomodulation
|
|
CN108254557B
(zh)
*
|
2017-12-26 |
2019-05-31 |
首都医科大学附属北京地坛医院 |
用cd8阳性的t细胞上pd-1和tigit确定hbv相关原发性肝癌预后的系统
|
|
SG11202004158QA
(en)
|
2017-12-28 |
2020-06-29 |
Nanjing Legend Biotech Co Ltd |
Single-domain antibodies and variants thereof against tigit
|
|
TWI877769B
(zh)
*
|
2017-12-30 |
2025-03-21 |
英屬開曼群島商百濟神州有限公司 |
抗tigit抗體及其作為治療和診斷的用途
|
|
SG11202006148UA
(en)
|
2018-01-03 |
2020-07-29 |
Alpine Immune Sciences Inc |
Multi-domain immunomodulatory proteins and methods of use thereof
|
|
US20190269664A1
(en)
|
2018-01-08 |
2019-09-05 |
Chemocentryx, Inc. |
Methods of treating solid tumors with ccr2 antagonists
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
US20210363243A1
(en)
*
|
2018-02-01 |
2021-11-25 |
Merck Sharp & Dohme Corp. |
Methods for treating cancer or infection using a combination of an anti-pd-1 antibody, an anti-lag3 antibody, and an anti-tigit antibody
|
|
SG11202004521QA
(en)
*
|
2018-02-06 |
2020-06-29 |
I Mab Biopharma Us Ltd |
Antibodies to t cell immunoreceptor with ig and itim domains (tigit) and uses thereof
|
|
CA3090244A1
(en)
|
2018-02-08 |
2019-08-15 |
Dragonfly Therapeutics, Inc. |
Antibody variable domains targeting the nkg2d receptor
|
|
MX2020008333A
(es)
|
2018-02-08 |
2020-09-21 |
Dragonfly Therapeutics Inc |
Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales.
|
|
CN112119093A
(zh)
|
2018-02-20 |
2020-12-22 |
蜻蜓治疗公司 |
结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法
|
|
US20200399376A1
(en)
*
|
2018-02-26 |
2020-12-24 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
MX428543B
(es)
|
2018-02-28 |
2025-11-13 |
Yuhan Corp |
Anti cuerpos anti tigit y usos de los mismos.
|
|
EP3768259A4
(en)
*
|
2018-03-14 |
2022-04-06 |
Aurigene Discovery Technologies Limited |
METHODS OF MODULATION OF TIGIT AND PD-1 SIGNALING PATHWAYS USING 1,2,4-OXADIAZOLE COMPOUNDS
|
|
CN108546298B
(zh)
*
|
2018-03-29 |
2021-05-14 |
中国人民解放军军事科学院军事医学研究院 |
一种特异性结合pd-1的单克隆抗体
|
|
CN108546299B
(zh)
*
|
2018-03-29 |
2019-09-24 |
中国人民解放军军事科学院军事医学研究院 |
解除pd-1对机体免疫抑制的靶向分子
|
|
AU2019266407A1
(en)
|
2018-05-10 |
2021-01-07 |
Cyberdontics (Usa), Inc. |
Automated dental drill
|
|
SG11202011461TA
(en)
|
2018-06-01 |
2020-12-30 |
Compugen Ltd |
Anti-pvrig/anti-tigit bispecific antibodies and methods of use
|
|
JP2021529557A
(ja)
|
2018-06-29 |
2021-11-04 |
ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． |
抗腫瘍免疫チェックポイント調節因子アンタゴニスト
|
|
TWI754157B
(zh)
|
2018-07-25 |
2022-02-01 |
大陸商信達生物製藥（蘇州）有限公司 |
抗ｔｉｇｉｔ抗體及其用途
|
|
EA202091888A1
(ru)
|
2018-08-08 |
2020-10-23 |
Драгонфлай Терапьютикс, Инк. |
Вариабельные домены антител, нацеленные на рецептор nkg2d
|
|
CA3108427A1
(en)
|
2018-08-08 |
2020-02-13 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
|
|
CN113164570B
(zh)
|
2018-08-08 |
2024-05-14 |
蜻蜓疗法股份有限公司 |
结合nkg2d、cd16和肿瘤相关抗原的蛋白质
|
|
EP3841123A2
(en)
|
2018-08-23 |
2021-06-30 |
Seagen Inc. |
Anti-tigit antibodies
|
|
CN112840026B
(zh)
*
|
2018-10-18 |
2025-01-14 |
施能康公司 |
抑制tigit基因表达的组合物和方法
|
|
JP7497351B2
(ja)
|
2018-11-13 |
2024-06-10 |
コンパス セラピューティクス リミテッド ライアビリティ カンパニー |
チェックポイント分子に対する多重特異性結合性構築物およびその使用
|
|
CN109448790B
(zh)
*
|
2018-11-19 |
2021-11-09 |
上海科技大学 |
一种确定肿瘤免疫治疗标志物的存储介质、设备及装置
|
|
AR117327A1
(es)
|
2018-12-20 |
2021-07-28 |
23Andme Inc |
Anticuerpos anti-cd96 y métodos de uso de estos
|
|
CN113811549A
(zh)
|
2019-02-21 |
2021-12-17 |
Xencor股份有限公司 |
非靶向和靶向性il-10 fc融合蛋白
|
|
WO2020206033A1
(en)
*
|
2019-04-02 |
2020-10-08 |
Kenjockety Biotechnology, Inc. |
Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
|
|
EP3725370A1
(en)
|
2019-04-19 |
2020-10-21 |
ImmunoBrain Checkpoint, Inc. |
Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
|
|
TWI760751B
(zh)
*
|
2019-05-29 |
2022-04-11 |
美商美國禮來大藥廠 |
Tigit及pd-1/tigit-結合分子
|
|
CN110128550B
(zh)
*
|
2019-05-30 |
2023-01-13 |
南京惟亚德生物医药有限公司 |
一种新型的同时阻断免疫检查点pd-l1和tigit的复制型溶瘤腺病毒和应用
|
|
EP3990116A1
(en)
|
2019-06-28 |
2022-05-04 |
Gensun Biopharma Inc. |
ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
|
|
CA3146986A1
(en)
|
2019-07-15 |
2021-01-21 |
Shanghai Junshi Biosciences Co., Ltd. |
Anti-tigit antibodies and application thereof
|
|
WO2021021767A1
(en)
*
|
2019-07-30 |
2021-02-04 |
Merck Sharp & Dohme Corp. |
Anti-pd-1/lag3/tigit trispecific antibodies and anti-pd-1/lag3 bispecific antibodies
|
|
WO2021024020A1
(en)
|
2019-08-06 |
2021-02-11 |
Astellas Pharma Inc. |
Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
|
|
TWI764291B
(zh)
|
2019-09-24 |
2022-05-11 |
財團法人工業技術研究院 |
抗tigit抗體及使用方法
|
|
AU2020351734A1
(en)
*
|
2019-09-27 |
2022-04-14 |
Genentech, Inc. |
Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies
|
|
AU2020355614B2
(en)
|
2019-09-27 |
2024-12-05 |
Glaxosmithkline Intellectual Property Development Limited |
Antigen binding proteins
|
|
KR20220082007A
(ko)
|
2019-10-08 |
2022-06-16 |
넥틴 테라퓨틱스 리미티드 |
폴리오바이러스 수용체(pvr)에 대한 항체 및 이의 용도
|
|
WO2021086889A1
(en)
*
|
2019-10-29 |
2021-05-06 |
Chinook Therapeutics, Inc. |
Methods and compositions for treatment of cancer and infectious diseases
|
|
WO2021113831A1
(en)
|
2019-12-05 |
2021-06-10 |
Compugen Ltd. |
Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
|
|
US12692311B2
(en)
|
2020-01-29 |
2026-07-28 |
William Robert Arathoon Living Trust Dated August 29, 2016 |
Anti-MDR1 antibodies and uses thereof
|
|
JP7745556B2
(ja)
|
2020-02-21 |
2025-09-29 |
マクロジェニクス，インコーポレーテッド |
Ｃｄ１３７結合分子及びその使用
|
|
EP4119162A4
(en)
|
2020-03-13 |
2023-08-23 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
PVRIG-BINDING PROTEIN AND ITS MEDICAL USES
|
|
CN113563470B
(zh)
*
|
2020-04-29 |
2023-02-10 |
广州昂科免疫生物技术有限公司 |
结合tigit抗原的抗体及其制备方法与应用
|
|
AU2021268340A1
(en)
|
2020-05-06 |
2022-12-08 |
Dragonfly Therapeutics, Inc. |
Proteins binding NKG2D, CD16 and CLEC12A
|
|
US12202882B2
(en)
|
2020-05-08 |
2025-01-21 |
Alpine Immune Sciences, Inc. |
APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
|
|
CN111995681B
(zh)
|
2020-05-09 |
2022-03-08 |
华博生物医药技术（上海）有限公司 |
抗tigit的抗体、其制备方法和应用
|
|
TW202210514A
(zh)
|
2020-06-02 |
2022-03-16 |
美商阿克思生物科學有限公司 |
針對tigit的抗體
|
|
WO2021257124A1
(en)
|
2020-06-18 |
2021-12-23 |
Genentech, Inc. |
Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
|
|
CN116234568A
(zh)
|
2020-07-07 |
2023-06-06 |
生物技术公司 |
用于hpv阳性癌症的治疗性rna
|
|
TW202216778A
(zh)
|
2020-07-15 |
2022-05-01 |
美商安進公司 |
Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷
|
|
CN115708865A
(zh)
*
|
2020-08-25 |
2023-02-24 |
沣潮医药科技（上海）有限公司 |
Tigit免疫粘附素在制备调节血管生成产品中的应用
|
|
WO2022044010A1
(en)
|
2020-08-26 |
2022-03-03 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Anti-t-cell immunoglobulin and itim domain (tigit) antibodies for the treatment of fungal infections
|
|
CN116801810A
(zh)
|
2020-09-03 |
2023-09-22 |
网络牙科(美国)公司 |
用于牙齿解剖结构的cna分析的方法和装置
|
|
KR102647295B1
(ko)
*
|
2020-09-03 |
2024-03-14 |
한국과학기술연구원 |
암 면역 치료의 효능 예측을 위한 바이오마커 및 이의 용도
|
|
CN114539418A
(zh)
|
2020-11-26 |
2022-05-27 |
上海华奥泰生物药业股份有限公司 |
双特异性抗体及其用途
|
|
JP2024508207A
(ja)
|
2020-12-02 |
2024-02-26 |
ブイアイビー ブイゼットダブリュ |
がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト
|
|
WO2022135667A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Therapeutic rna for treating cancer
|
|
TW202245808A
(zh)
|
2020-12-21 |
2022-12-01 |
德商拜恩迪克公司 |
用於治療癌症之治療性ｒｎａ
|
|
WO2022135666A1
(en)
|
2020-12-21 |
2022-06-30 |
BioNTech SE |
Treatment schedule for cytokine proteins
|
|
EP4293045A4
(en)
|
2021-01-14 |
2024-12-11 |
Shanghai Junshi Biosciences Co., Ltd. |
PHARMACEUTICAL COMPOSITION OF ANTI-TIGIT ANTIBODY AND ITS APPLICATION
|
|
EP4281189A4
(en)
*
|
2021-01-21 |
2025-01-08 |
BeiGene Switzerland GmbH |
METHODS OF TREATING CANCER USING ANTI-TIGIT ANTIBODIES IN COMBINATION WITH ANTI-PD1 ANTIBODIES
|
|
EP4301774A4
(en)
|
2021-03-03 |
2025-08-13 |
Dragonfly Therapeutics Inc |
METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
|
|
JP2024514816A
(ja)
*
|
2021-04-09 |
2024-04-03 |
シージェン インコーポレイテッド |
抗ｔｉｇｉｔ抗体を用いるがんの治療方法
|
|
AR125753A1
(es)
|
2021-05-04 |
2023-08-09 |
Agenus Inc |
Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos
|
|
CA3217279A1
(en)
|
2021-05-04 |
2022-11-10 |
Olga Ignatovich |
Anti-tigit antibodies and methods of use thereof
|
|
US20240277842A1
(en)
|
2021-06-07 |
2024-08-22 |
Providence Health & Services - Oregon |
Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
|
|
WO2023285552A1
(en)
|
2021-07-13 |
2023-01-19 |
BioNTech SE |
Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
|
|
CN118871463A
(zh)
|
2021-07-28 |
2024-10-29 |
基因泰克公司 |
用于治疗癌症的方法和组合物
|
|
US20250064794A1
(en)
*
|
2021-08-10 |
2025-02-27 |
Eisai R&D Management Co., Ltd. |
A therapeutic combination comprising a tigit antagonist, a pd-1 antagonist, and lenvatinib
|
|
JP2024535793A
(ja)
|
2021-09-15 |
2024-10-02 |
江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 |
Ｐｄ－１に特異的に結合するタンパク質及びその医薬的使用
|
|
US20240376207A1
(en)
|
2021-09-15 |
2024-11-14 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody
|
|
WO2023056403A1
(en)
|
2021-09-30 |
2023-04-06 |
Genentech, Inc. |
Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
|
|
TW202333802A
(zh)
|
2021-10-11 |
2023-09-01 |
德商拜恩迪克公司 |
用於肺癌之治療性rna(二)
|
|
AU2021478400A1
(en)
|
2021-12-17 |
2024-06-06 |
Tnax Biopharma Corporation |
Humanized anti-dnam-1 antibody
|
|
CA3259975A1
(en)
|
2022-03-15 |
2023-09-21 |
Compugen Ltd. |
Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
|
|
JP2025523387A
(ja)
|
2022-06-07 |
2025-07-23 |
ジェネンテック， インコーポレイテッド |
抗ｐｄ－ｌ１アンタゴニストおよび抗ｔｉｇｉｔアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法
|
|
JP2026501506A
(ja)
|
2022-12-14 |
2026-01-16 |
アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ |
Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法
|
|
KR20250163916A
(ko)
|
2023-03-06 |
2025-11-21 |
제넨테크, 인크. |
비소세포 폐암의 예후 및 치료 방법
|
|
EP4681729A4
(en)
|
2023-03-15 |
2026-07-15 |
Shanghai Mabgen Biotech Ltd |
PHARMACEUTICAL COMPOSITION CONTAINING A PD-1/PVRIG/TIGIT BINDING PROTEIN AND ITS MEDICAL USE
|
|
US20240366319A1
(en)
|
2023-05-04 |
2024-11-07 |
Perceptive Technologies, Inc. |
Robotic Dental System and Method of Preparing for a Robotic Dental Procedure
|
|
CN116444675B
(zh)
*
|
2023-05-11 |
2023-12-22 |
亲和(武汉)生命科技有限责任公司 |
一种Pfu DNA聚合酶纳米抗体及其制备方法和应用
|
|
TW202515608A
(zh)
|
2023-06-26 |
2025-04-16 |
以色列商坎布根有限公司 |
Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途
|
|
WO2025016012A1
(en)
*
|
2023-07-14 |
2025-01-23 |
Genor Biopharma Co., Ltd. |
Anti-PD-1/CTLA-4/TIGIT TRISPECIFIC ANTIBODIES AND USE THEREOF
|
|
WO2026033885A1
(en)
|
2024-08-08 |
2026-02-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
|
|
AR134560A1
(es)
|
2023-12-08 |
2026-01-28 |
Astellas Pharma Inc |
Terapia de combinación que implica agentes de unión biespecíficos que se unen a cldn18.2 y cd3 y agentes que estabilizan o aumentan la expresión de cldn18.2
|
|
WO2025120867A1
(en)
|
2023-12-08 |
2025-06-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
|
|
WO2025120866A1
(en)
|
2023-12-08 |
2025-06-12 |
Astellas Pharma Inc. |
Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
|
|
WO2025174933A1
(en)
|
2024-02-14 |
2025-08-21 |
Genentech, Inc. |
Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel
|