JP2021501801A5 - - Google Patents
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- JP2021501801A5 JP2021501801A5 JP2020543734A JP2020543734A JP2021501801A5 JP 2021501801 A5 JP2021501801 A5 JP 2021501801A5 JP 2020543734 A JP2020543734 A JP 2020543734A JP 2020543734 A JP2020543734 A JP 2020543734A JP 2021501801 A5 JP2021501801 A5 JP 2021501801A5
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- Prior art keywords
- cancer
- administration
- antibody
- pharmaceutical composition
- receptor occupancy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000556 agonist Substances 0.000 claims 30
- 102000005962 receptors Human genes 0.000 claims 25
- 108020003175 receptors Proteins 0.000 claims 25
- 206010028980 Neoplasm Diseases 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 8
- 230000001270 agonistic effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 238000010171 animal model Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100024263 CD160 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038111 Recurrent cancer Diseases 0.000 claims 1
- 206010070308 Refractory cancer Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 102100029198 SLAM family member 7 Human genes 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 210000005132 reproductive cell Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580346P | 2017-11-01 | 2017-11-01 | |
| US62/580,346 | 2017-11-01 | ||
| US201762581441P | 2017-11-03 | 2017-11-03 | |
| US62/581,441 | 2017-11-03 | ||
| US201762581905P | 2017-11-06 | 2017-11-06 | |
| US62/581,905 | 2017-11-06 | ||
| US201762583808P | 2017-11-09 | 2017-11-09 | |
| US62/583,808 | 2017-11-09 | ||
| US201862628207P | 2018-02-08 | 2018-02-08 | |
| US62/628,207 | 2018-02-08 | ||
| US201862657616P | 2018-04-13 | 2018-04-13 | |
| US62/657,616 | 2018-04-13 | ||
| PCT/US2018/058704 WO2019089921A1 (en) | 2017-11-01 | 2018-11-01 | Immunostimulatory agonistic antibodies for use in treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021501801A JP2021501801A (ja) | 2021-01-21 |
| JP2021501801A5 true JP2021501801A5 (enExample) | 2021-12-09 |
Family
ID=64607296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543734A Pending JP2021501801A (ja) | 2017-11-01 | 2018-11-01 | 癌の処置に用いるための免疫刺激アゴニスト抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11603410B2 (enExample) |
| EP (1) | EP3704159A1 (enExample) |
| JP (1) | JP2021501801A (enExample) |
| KR (1) | KR20200074214A (enExample) |
| CN (1) | CN111542544A (enExample) |
| WO (1) | WO2019089921A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111542544A (zh) | 2017-11-01 | 2020-08-14 | 百时美施贵宝公司 | 用于治疗癌症的免疫刺激性激动性抗体 |
| US20210277135A1 (en) * | 2018-07-13 | 2021-09-09 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a method of treating a cancer or a solid tumor |
| CN118320076A (zh) * | 2019-11-21 | 2024-07-12 | 百济神州有限公司 | 使用抗ox40抗体与抗tim3抗体的组合治疗癌症的方法 |
| CN114728063B (zh) * | 2019-11-21 | 2024-06-14 | 百济神州有限公司 | 用抗ox40抗体和多重激酶抑制剂治疗癌症 |
| MX2022006147A (es) * | 2019-11-21 | 2022-06-17 | Beigene Ltd | Metodos de tratamiento del cancer utilizando anticuerpos anti-ox40 en combinacion con anticuerpos anti-pd1 o anti-pdl1. |
| EP4061846A4 (en) * | 2019-11-21 | 2023-12-20 | BeiGene, Ltd. | Methods of cancer treatment using anti-ox40 antibodies in combination with anti-tigit antibodies |
| CN114729051A (zh) * | 2019-11-21 | 2022-07-08 | 百济神州(北京)生物科技有限公司 | 使用抗ox40抗体与放射组合治疗癌症的方法 |
| BR112022020741A2 (pt) | 2020-04-17 | 2022-12-20 | Hutchison Medipharma Ltd | Anticorpo anti-ox40 e usos do mesmo |
| WO2025195496A1 (en) * | 2024-03-21 | 2025-09-25 | Hanx Biopharmaceuticals, (Wuhan) Ltd. | Immunotherapy for ox40 expressing cancer |
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| EP3383914A4 (en) | 2015-12-02 | 2019-10-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES AND METHOD OF USE THEREOF |
| SG10201912984WA (en) | 2015-12-02 | 2020-03-30 | Agenus Inc | Antibodies and methods of use thereof |
| CA3006963A1 (en) | 2015-12-03 | 2017-06-08 | Ludwig Institute For Cancer Research Ltd. | Anti-ox40 antibodies and methods of use thereof |
| WO2017134292A1 (en) | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
| CN111542544A (zh) | 2017-11-01 | 2020-08-14 | 百时美施贵宝公司 | 用于治疗癌症的免疫刺激性激动性抗体 |
-
2018
- 2018-11-01 CN CN201880085048.3A patent/CN111542544A/zh active Pending
- 2018-11-01 WO PCT/US2018/058704 patent/WO2019089921A1/en not_active Ceased
- 2018-11-01 JP JP2020543734A patent/JP2021501801A/ja active Pending
- 2018-11-01 EP EP18815061.9A patent/EP3704159A1/en not_active Withdrawn
- 2018-11-01 US US16/760,776 patent/US11603410B2/en active Active
- 2018-11-01 KR KR1020207015641A patent/KR20200074214A/ko not_active Ceased
-
2023
- 2023-03-10 US US18/181,661 patent/US20230357423A1/en not_active Abandoned
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