JP2020503273A5 - - Google Patents
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- JP2020503273A5 JP2020503273A5 JP2019529206A JP2019529206A JP2020503273A5 JP 2020503273 A5 JP2020503273 A5 JP 2020503273A5 JP 2019529206 A JP2019529206 A JP 2019529206A JP 2019529206 A JP2019529206 A JP 2019529206A JP 2020503273 A5 JP2020503273 A5 JP 2020503273A5
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- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 78
- 102000049823 human TIGIT Human genes 0.000 claims description 78
- 238000000034 method Methods 0.000 claims description 76
- 206010028980 Neoplasm Diseases 0.000 claims description 41
- 239000003814 drug Substances 0.000 claims description 37
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 28
- 239000000126 substance Substances 0.000 claims description 22
- 230000001225 therapeutic effect Effects 0.000 claims description 22
- 230000002401 inhibitory effect Effects 0.000 claims description 17
- 230000004614 tumor growth Effects 0.000 claims description 17
- 229940124060 PD-1 antagonist Drugs 0.000 claims description 14
- 229940123751 PD-L1 antagonist Drugs 0.000 claims description 14
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 12
- 206010038038 rectal cancer Diseases 0.000 claims description 12
- 201000001275 rectum cancer Diseases 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 10
- 230000000112 colonic effect Effects 0.000 claims description 10
- 102100029740 Poliovirus receptor Human genes 0.000 claims description 9
- 108010048507 poliovirus receptor Proteins 0.000 claims description 9
- 108091092878 Microsatellite Proteins 0.000 claims description 8
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 6
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims description 6
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 6
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 6
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims description 6
- 201000004101 esophageal cancer Diseases 0.000 claims description 6
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 5
- 208000014018 liver neoplasm Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims description 5
- 206010061424 Anal cancer Diseases 0.000 claims description 4
- 208000007860 Anus Neoplasms Diseases 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 206010062878 Gastrooesophageal cancer Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
- 201000011165 anus cancer Diseases 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 201000006974 gastroesophageal cancer Diseases 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 239000013612 plasmid Substances 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 6
- 230000009827 complement-dependent cellular cytotoxicity Effects 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 229960005386 ipilimumab Drugs 0.000 claims 6
- 229960002621 pembrolizumab Drugs 0.000 claims 6
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 4
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 4
- 102000048776 human CD274 Human genes 0.000 claims 4
- 102000048362 human PDCD1 Human genes 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 229960003852 atezolizumab Drugs 0.000 claims 3
- 229950002916 avelumab Drugs 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 229960005395 cetuximab Drugs 0.000 claims 3
- 229950009791 durvalumab Drugs 0.000 claims 3
- 230000002357 endometrial effect Effects 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 229960003301 nivolumab Drugs 0.000 claims 3
- 229960001972 panitumumab Drugs 0.000 claims 3
- 229960002087 pertuzumab Drugs 0.000 claims 3
- 229950010968 romosozumab Drugs 0.000 claims 3
- 229960000575 trastuzumab Drugs 0.000 claims 3
- 230000005751 tumor progression Effects 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 description 4
- 206010014733 Endometrial cancer Diseases 0.000 description 3
- 206010014759 Endometrial neoplasm Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 3
- 108010074708 B7-H1 Antigen Proteins 0.000 description 2
- 208000032818 Microsatellite Instability Diseases 0.000 description 2
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 108010029697 CD40 Ligand Proteins 0.000 description 1
- 102100032937 CD40 ligand Human genes 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 description 1
- 206010061968 Gastric neoplasm Diseases 0.000 description 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000003812 Interleukin-15 Human genes 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 102000000646 Interleukin-3 Human genes 0.000 description 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 description 1
- 108010042215 OX40 Ligand Proteins 0.000 description 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 description 1
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 201000000053 blastoma Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 201000008184 embryoma Diseases 0.000 description 1
- 208000023965 endometrium neoplasm Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 208000025402 neoplasm of esophagus Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022103151A JP2022130561A (ja) | 2016-11-30 | 2022-06-28 | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427903P | 2016-11-30 | 2016-11-30 | |
| US62/427,903 | 2016-11-30 | ||
| US201762479609P | 2017-03-31 | 2017-03-31 | |
| US62/479,609 | 2017-03-31 | ||
| PCT/US2017/063918 WO2018102536A1 (en) | 2016-11-30 | 2017-11-30 | Methods for treatment of cancer comprising tigit-binding agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103151A Division JP2022130561A (ja) | 2016-11-30 | 2022-06-28 | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503273A JP2020503273A (ja) | 2020-01-30 |
| JP2020503273A5 true JP2020503273A5 (enExample) | 2021-10-14 |
| JP7126269B2 JP7126269B2 (ja) | 2022-08-26 |
Family
ID=62241934
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529206A Active JP7126269B2 (ja) | 2016-11-30 | 2017-11-30 | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
| JP2022103151A Pending JP2022130561A (ja) | 2016-11-30 | 2022-06-28 | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103151A Pending JP2022130561A (ja) | 2016-11-30 | 2022-06-28 | Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11230596B2 (enExample) |
| EP (1) | EP3548071A4 (enExample) |
| JP (2) | JP7126269B2 (enExample) |
| KR (1) | KR102461228B1 (enExample) |
| CN (1) | CN110662552A (enExample) |
| AU (1) | AU2017368155B2 (enExample) |
| BR (1) | BR112019010943A8 (enExample) |
| CA (1) | CA3044664C (enExample) |
| IL (1) | IL266847B2 (enExample) |
| MX (1) | MX2019006072A (enExample) |
| NZ (1) | NZ753515A (enExample) |
| RU (1) | RU2765410C2 (enExample) |
| WO (1) | WO2018102536A1 (enExample) |
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| CA2905334A1 (en) | 2008-04-09 | 2009-10-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| US11230596B2 (en) | 2016-11-30 | 2022-01-25 | Mereo Biopharma 5, Inc. | Methods for treatment of cancer comprising TIGIT-binding agents |
| DK3618863T3 (da) | 2017-05-01 | 2023-08-21 | Agenus Inc | Anti-tigit-antistoffer og fremgangsmåder til anvendelse deraf |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| CN108948182A (zh) * | 2018-07-25 | 2018-12-07 | 中国人民解放军第四军医大学 | Tigit-ecd重组蛋白抗同种异体免疫排斥反应的应用 |
| TWI728400B (zh) | 2018-07-26 | 2021-05-21 | 美商美國禮來大藥廠 | Cd226促效劑抗體 |
| EP3898677A1 (en) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| MX2021014189A (es) | 2019-05-20 | 2022-01-06 | Cytune Pharma | Regimenes de dosificacion de agonistas de la il-2/il-15r?y para el tratamiento del cancer o enfermedades infecciosas. |
| BR112021022171A2 (pt) * | 2019-06-13 | 2021-12-21 | Green Cross Corp | Anticorpo para tigit, seu uso e método para produzir o mesmo |
| US11667709B2 (en) | 2019-09-24 | 2023-06-06 | Industrial Technology Research Institute | Anti-TIGIT antibodies and methods of use |
| US20220340660A1 (en) * | 2019-10-01 | 2022-10-27 | Merck Sharp & Dohme Corp. | Biomarkers for anti-tigit antibody treatment |
| TW202136287A (zh) | 2019-12-17 | 2021-10-01 | 法商Ｏｓｅ免疫治療公司 | 包含il-7變體之雙官能分子 |
| CN115943312A (zh) | 2020-05-07 | 2023-04-07 | 法国居里学院 | 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途 |
| CN115916348A (zh) | 2020-06-18 | 2023-04-04 | 基因泰克公司 | 使用抗tigit抗体和pd-1轴结合拮抗剂的治疗 |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| AU2021367887A1 (en) | 2020-10-26 | 2023-06-01 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
| KR20230096047A (ko) | 2020-10-26 | 2023-06-29 | 싸이튠 파마 | 비흑색종 피부암 치료용 IL-2/IL-15Rβγ 작용제 |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| AU2021390545A1 (en) * | 2020-12-03 | 2023-07-06 | Shattuck Labs, Inc. | Methods of treating cancer using tigit-and light-based chimeric proteins |
| WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
| MX2023011964A (es) | 2021-04-09 | 2024-01-08 | Ose Immunotherapeutics | Nuevo andamio para moléculas bifuncionales con propiedades mejoradas. |
| WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
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| CN118871463A (zh) | 2021-07-28 | 2024-10-29 | 基因泰克公司 | 用于治疗癌症的方法和组合物 |
| WO2023017191A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
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| WO2023215719A1 (en) | 2022-05-02 | 2023-11-09 | Arcus Biosciences, Inc. | Anti-tigit antibodies and uses of the same |
| KR20230168273A (ko) * | 2022-06-03 | 2023-12-13 | (주)지아이이노베이션 | 항-tigit 항체를 포함하는 이중 특이적 항체 및 이의 용도 |
| EP4537107A2 (en) | 2022-06-07 | 2025-04-16 | Genentech, Inc. | Method for determining the efficacy of a lung cancer treatment comprising an anti-pd-l1 antagonist and an anti-tigit antagonist antibody |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
| WO2024200823A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
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| WO2025132831A1 (en) | 2023-12-19 | 2025-06-26 | Universite D'aix-Marseille | N-heteroaryl derivatives and uses thereof for treating cancer |
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| WO2025242836A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2025262250A1 (en) | 2024-06-20 | 2025-12-26 | Negio Therapeutics | Guanfacine derivatives and their uses |
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2017
- 2017-11-30 US US16/464,820 patent/US11230596B2/en active Active
- 2017-11-30 KR KR1020197017345A patent/KR102461228B1/ko active Active
- 2017-11-30 BR BR112019010943A patent/BR112019010943A8/pt unknown
- 2017-11-30 CN CN201780074119.5A patent/CN110662552A/zh active Pending
- 2017-11-30 EP EP17876358.7A patent/EP3548071A4/en not_active Withdrawn
- 2017-11-30 WO PCT/US2017/063918 patent/WO2018102536A1/en not_active Ceased
- 2017-11-30 RU RU2019115428A patent/RU2765410C2/ru active
- 2017-11-30 JP JP2019529206A patent/JP7126269B2/ja active Active
- 2017-11-30 AU AU2017368155A patent/AU2017368155B2/en active Active
- 2017-11-30 MX MX2019006072A patent/MX2019006072A/es unknown
- 2017-11-30 CA CA3044664A patent/CA3044664C/en active Active
- 2017-11-30 NZ NZ753515A patent/NZ753515A/en not_active IP Right Cessation
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2019
- 2019-05-23 IL IL266847A patent/IL266847B2/en unknown
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2020
- 2020-12-11 US US17/119,883 patent/US11136384B2/en active Active
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2021
- 2021-12-09 US US17/547,178 patent/US20220340653A1/en not_active Abandoned
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2022
- 2022-06-28 JP JP2022103151A patent/JP2022130561A/ja active Pending
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