|
USRE29835E
(en)
|
1971-06-01 |
1978-11-14 |
Icn Pharmaceuticals |
1,2,4-Triazole nucleosides
|
|
US3798209A
(en)
|
1971-06-01 |
1974-03-19 |
Icn Pharmaceuticals |
1,2,4-triazole nucleosides
|
|
US3994974A
(en)
|
1972-02-05 |
1976-11-30 |
Yamanouchi Pharmaceutical Co., Ltd. |
α-Aminomethylbenzyl alcohol derivatives
|
|
US3852267A
(en)
|
1972-08-04 |
1974-12-03 |
Icn Pharmaceuticals |
Phosphoramidates of 3{40 ,5{40 -cyclic purine nucleotides
|
|
US4138547A
(en)
|
1977-12-22 |
1979-02-06 |
Icn Pharmaceuticals, Inc. |
Process for preparing 1,2,4-triazole nucleosides
|
|
JPS57146593A
(en)
|
1981-03-09 |
1982-09-10 |
Ajinomoto Co Inc |
Preparation of ribofuranosyltriazole derivative
|
|
US4816570A
(en)
|
1982-11-30 |
1989-03-28 |
The Board Of Regents Of The University Of Texas System |
Biologically reversible phosphate and phosphonate protective groups
|
|
US4526988A
(en)
|
1983-03-10 |
1985-07-02 |
Eli Lilly And Company |
Difluoro antivirals and intermediate therefor
|
|
US5736155A
(en)
|
1984-08-08 |
1998-04-07 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
US5077056A
(en)
|
1984-08-08 |
1991-12-31 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
NL8403224A
(nl)
|
1984-10-24 |
1986-05-16 |
Oce Andeno Bv |
Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
|
|
US5223263A
(en)
|
1988-07-07 |
1993-06-29 |
Vical, Inc. |
Liponucleotide-containing liposomes
|
|
US5246937A
(en)
|
1985-09-18 |
1993-09-21 |
Beecham Group P.L.C. |
Purine derivatives
|
|
US4797285A
(en)
|
1985-12-06 |
1989-01-10 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
Lipsome/anthraquinone drug composition and method
|
|
US5154930A
(en)
|
1987-03-05 |
1992-10-13 |
The Liposome Company, Inc. |
Pharmacological agent-lipid solution preparation
|
|
GB8719367D0
(en)
|
1987-08-15 |
1987-09-23 |
Wellcome Found |
Therapeutic compounds
|
|
WO1989002733A1
(en)
|
1987-09-22 |
1989-04-06 |
The Regents Of The University Of California |
Liposomal nucleoside analogues for treating aids
|
|
IL91664A
(en)
|
1988-09-28 |
1993-05-13 |
Yissum Res Dev Co |
Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
|
|
US6132763A
(en)
|
1988-10-20 |
2000-10-17 |
Polymasc Pharmaceuticals Plc |
Liposomes
|
|
US5705363A
(en)
|
1989-03-02 |
1998-01-06 |
The Women's Research Institute |
Recombinant production of human interferon τ polypeptides and nucleic acids
|
|
US5549910A
(en)
|
1989-03-31 |
1996-08-27 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5077057A
(en)
|
1989-04-05 |
1991-12-31 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5277914A
(en)
|
1989-03-31 |
1994-01-11 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5194654A
(en)
|
1989-11-22 |
1993-03-16 |
Vical, Inc. |
Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
|
|
US5411947A
(en)
|
1989-06-28 |
1995-05-02 |
Vestar, Inc. |
Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5463092A
(en)
|
1989-11-22 |
1995-10-31 |
Vestar, Inc. |
Lipid derivatives of phosphonacids for liposomal incorporation and method of use
|
|
US5026687A
(en)
|
1990-01-03 |
1991-06-25 |
The United States Of America As Represented By The Department Of Health And Human Services |
Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
|
|
ATE194844T1
(de)
|
1990-04-06 |
2000-08-15 |
Genelabs Tech Inc |
Hepatitis c-virus-epitope
|
|
US5091188A
(en)
|
1990-04-26 |
1992-02-25 |
Haynes Duncan H |
Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
|
|
WO1991016920A1
(en)
|
1990-05-07 |
1991-11-14 |
Vical, Inc. |
Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs
|
|
WO1991018914A1
(en)
|
1990-05-29 |
1991-12-12 |
Vical, Inc. |
Synthesis of glycerol di- and triphosphate derivatives
|
|
WO1991019721A1
(en)
|
1990-06-13 |
1991-12-26 |
Arnold Glazier |
Phosphorous produgs
|
|
US6060080A
(en)
|
1990-07-16 |
2000-05-09 |
Daiichi Pharmaceutical Co., Ltd. |
Liposomal products
|
|
JP2599492B2
(ja)
|
1990-08-21 |
1997-04-09 |
第一製薬株式会社 |
リポソーム製剤の製造法
|
|
ES2118069T3
(es)
|
1990-09-14 |
1998-09-16 |
Acad Of Science Czech Republic |
Profarmacos de fosfonatos.
|
|
US5372808A
(en)
|
1990-10-17 |
1994-12-13 |
Amgen Inc. |
Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
|
|
US5256641A
(en)
|
1990-11-01 |
1993-10-26 |
State Of Oregon |
Covalent polar lipid-peptide conjugates for immunological targeting
|
|
US5149794A
(en)
|
1990-11-01 |
1992-09-22 |
State Of Oregon |
Covalent lipid-drug conjugates for drug targeting
|
|
US5543389A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization |
Covalent polar lipid-peptide conjugates for use in salves
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5157027A
(en)
|
1991-05-13 |
1992-10-20 |
E. R. Squibb & Sons, Inc. |
Bisphosphonate squalene synthetase inhibitors and method
|
|
WO1993000910A1
(en)
|
1991-07-12 |
1993-01-21 |
Vical, Inc. |
Antiviral liponucleosides: treatment of hepatitis b
|
|
HU9202318D0
(en)
|
1991-07-22 |
1992-10-28 |
Bristol Myers Squibb Co |
Method for preparing medical preparatives containing didesoxi-purine nucleoside
|
|
US5554728A
(en)
|
1991-07-23 |
1996-09-10 |
Nexstar Pharmaceuticals, Inc. |
Lipid conjugates of therapeutic peptides and protease inhibitors
|
|
TW224053B
(enExample)
|
1991-09-13 |
1994-05-21 |
Paul B Chretien |
|
|
DE4200821A1
(de)
|
1992-01-15 |
1993-07-22 |
Bayer Ag |
Geschmacksmaskierte pharmazeutische mittel
|
|
US5676942A
(en)
|
1992-02-10 |
1997-10-14 |
Interferon Sciences, Inc. |
Composition containing human alpha interferon species proteins and method for use thereof
|
|
US5405598A
(en)
|
1992-02-24 |
1995-04-11 |
Schinazi; Raymond F. |
Sensitizing agents for use in boron neutron capture therapy
|
|
US5610054A
(en)
|
1992-05-14 |
1997-03-11 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecule targeted against Hepatitis C virus
|
|
US5849905A
(en)
|
1994-11-23 |
1998-12-15 |
Centre National De La Recherche Scientifique |
Biologically active phosphotriester-type nucleosides and methods for preparing same
|
|
US6020482A
(en)
|
1992-05-25 |
2000-02-01 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
US5770725A
(en)
|
1992-05-25 |
1998-06-23 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
ATE153669T1
(de)
|
1992-06-22 |
1997-06-15 |
Lilly Co Eli |
Verfahren zur herstellung von mit alpha-anomeren angereicherten 1-halogen-2-deoxy-2,2-difluor-d- ribofuranosyl-derivaten
|
|
US5256798A
(en)
|
1992-06-22 |
1993-10-26 |
Eli Lilly And Company |
Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
|
|
US5426183A
(en)
|
1992-06-22 |
1995-06-20 |
Eli Lilly And Company |
Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
|
|
CA2105112C
(en)
|
1992-09-01 |
2005-08-02 |
Thomas C. Britton |
A process for anomerizing nucleosides
|
|
GB9226729D0
(en)
|
1992-12-22 |
1993-02-17 |
Wellcome Found |
Therapeutic combination
|
|
CN1245156C
(zh)
|
1993-02-22 |
2006-03-15 |
美国生物科学有限公司 |
用于体内传送生物制品的方法及用于该方法的组合物
|
|
US6749868B1
(en)
|
1993-02-22 |
2004-06-15 |
American Bioscience, Inc. |
Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
|
|
US6753006B1
(en)
|
1993-02-22 |
2004-06-22 |
American Bioscience, Inc. |
Paclitaxel-containing formulations
|
|
US6096331A
(en)
|
1993-02-22 |
2000-08-01 |
Vivorx Pharmaceuticals, Inc. |
Methods and compositions useful for administration of chemotherapeutic agents
|
|
US5439686A
(en)
|
1993-02-22 |
1995-08-08 |
Vivorx Pharmaceuticals, Inc. |
Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
|
|
US6537579B1
(en)
|
1993-02-22 |
2003-03-25 |
American Bioscience, Inc. |
Compositions and methods for administration of pharmacologically active compounds
|
|
ATE181557T1
(de)
|
1993-02-24 |
1999-07-15 |
Jui H Wang |
Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren
|
|
US6180134B1
(en)
|
1993-03-23 |
2001-01-30 |
Sequus Pharmaceuticals, Inc. |
Enhanced ciruclation effector composition and method
|
|
CA2162574A1
(en)
|
1993-05-12 |
1994-11-24 |
Karl Y. Hostetler |
Acyclovir derivatives for topical use
|
|
AU688344B2
(en)
|
1993-07-19 |
1998-03-12 |
Mitsubishi-Tokyo Pharmaceuticals, Inc. |
Hepatitis C virus proliferation inhibitor
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
US7375198B2
(en)
|
1993-10-26 |
2008-05-20 |
Affymetrix, Inc. |
Modified nucleic acid probes
|
|
AU691225B2
(en)
|
1993-11-10 |
1998-05-14 |
Schering Corporation |
Improved interferon polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
AU6550394A
(en)
|
1994-03-11 |
1995-09-25 |
Isis Pharmaceuticals, Inc. |
Novel pyrimidine nucleosides
|
|
DE4415539C2
(de)
|
1994-05-03 |
1996-08-01 |
Osama Dr Dr Med Omer |
Pflanzen mit virustatischer und antiviraler Wirkung
|
|
CA2192950A1
(en)
|
1994-06-22 |
1995-12-28 |
Danny P.C. Mcgee |
Novel method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
|
|
US6083953A
(en)
|
1994-07-28 |
2000-07-04 |
Syntex (U.S.A.) Inc. |
2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
|
|
DE4432623A1
(de)
|
1994-09-14 |
1996-03-21 |
Huels Chemische Werke Ag |
Verfahren zur Bleichung von wäßrigen Tensidlösungen
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5696277A
(en)
|
1994-11-15 |
1997-12-09 |
Karl Y. Hostetler |
Antiviral prodrugs
|
|
US6391859B1
(en)
|
1995-01-27 |
2002-05-21 |
Emory University |
[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
|
|
US5703058A
(en)
|
1995-01-27 |
1997-12-30 |
Emory University |
Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
|
|
GB9505025D0
(en)
|
1995-03-13 |
1995-05-03 |
Medical Res Council |
Chemical compounds
|
|
DE19514523A1
(de)
|
1995-04-12 |
1996-10-17 |
Schering Ag |
Neue Cytosin- und Cytidinderivate
|
|
JP4191797B2
(ja)
|
1995-09-27 |
2008-12-03 |
エモリー ユニバーシティー |
組み換えc型肝炎ウイルスrnaレプリカーゼ
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5767097A
(en)
|
1996-01-23 |
1998-06-16 |
Icn Pharmaceuticals, Inc. |
Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
|
|
GB9602028D0
(en)
|
1996-02-01 |
1996-04-03 |
Amersham Int Plc |
Nucleoside analogues
|
|
US5980884A
(en)
|
1996-02-05 |
1999-11-09 |
Amgen, Inc. |
Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
|
|
JP2000506010A
(ja)
|
1996-02-29 |
2000-05-23 |
イミューソル インコーポレイテッド |
C型肝炎ウイルスリボザイム
|
|
US5830905A
(en)
|
1996-03-29 |
1998-11-03 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5633388A
(en)
|
1996-03-29 |
1997-05-27 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5990276A
(en)
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
|
GB9609932D0
(en)
|
1996-05-13 |
1996-07-17 |
Hoffmann La Roche |
Use of IL-12 and IFN alpha for the treatment of infectious diseases
|
|
US5891874A
(en)
|
1996-06-05 |
1999-04-06 |
Eli Lilly And Company |
Anti-viral compound
|
|
WO2005121370A2
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that facilitate risc loading
|
|
US5837257A
(en)
|
1996-07-09 |
1998-11-17 |
Sage R&D |
Use of plant extracts for treatment of HIV, HCV and HBV infections
|
|
US6214375B1
(en)
|
1996-07-16 |
2001-04-10 |
Generex Pharmaceuticals, Inc. |
Phospholipid formulations
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
US5922757A
(en)
|
1996-09-30 |
1999-07-13 |
The Regents Of The University Of California |
Treatment and prevention of hepatic disorders
|
|
US6224903B1
(en)
|
1996-10-11 |
2001-05-01 |
Sequus Pharmaceuticals, Inc. |
Polymer-lipid conjugate for fusion of target membranes
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
SI20024A
(sl)
|
1996-10-16 |
2000-02-29 |
Icn Pharmaceuticals, Inc. |
Purinovi L-nukleozidi, analogi in uporaba od teh
|
|
US6455690B1
(en)
|
1996-10-16 |
2002-09-24 |
Robert Tam |
L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine
|
|
US6509320B1
(en)
|
1996-10-16 |
2003-01-21 |
Icn Pharmaceuticals, Inc. |
Purine L-nucleosides, analogs and uses thereof
|
|
CA2267279A1
(en)
|
1996-10-16 |
1998-04-23 |
Devron Averett |
Monocyclic l-nucleosides, analogs and uses thereof
|
|
CN1133649C
(zh)
|
1996-10-18 |
2004-01-07 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
IL119833A
(en)
|
1996-12-15 |
2001-01-11 |
Lavie David |
Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
|
|
US5827533A
(en)
|
1997-02-06 |
1998-10-27 |
Duke University |
Liposomes containing active agents aggregated with lipid surfactants
|
|
US6004933A
(en)
|
1997-04-25 |
1999-12-21 |
Cortech Inc. |
Cysteine protease inhibitors
|
|
JP3963488B2
(ja)
|
1997-06-30 |
2007-08-22 |
メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツンク ウント コンパニー コマンディゲゼルシャフト アウフ アクチェン |
1−アミノ−アルキルシクロヘキサンnmda受容体拮抗薬
|
|
US6143715A
(en)
|
1997-08-11 |
2000-11-07 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptide analogues
|
|
ES2186660T3
(es)
|
1997-09-21 |
2003-05-16 |
Schering Corp |
Terapia de combinacion para erradicar hcv-rna detectable en pacientes con infeccion por hepatitis c cronica.
|
|
US6703374B1
(en)
|
1997-10-30 |
2004-03-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Nucleosides for imaging and treatment applications
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
CN1192102C
(zh)
|
1998-01-23 |
2005-03-09 |
新生物生物公司 |
酶催化的治疗剂
|
|
KR100954390B1
(ko)
|
1998-02-25 |
2010-04-26 |
에모리 유니버시티 |
2'-플루오로뉴클레오사이드
|
|
US6312662B1
(en)
|
1998-03-06 |
2001-11-06 |
Metabasis Therapeutics, Inc. |
Prodrugs phosphorus-containing compounds
|
|
US6787305B1
(en)
|
1998-03-13 |
2004-09-07 |
Invitrogen Corporation |
Compositions and methods for enhanced synthesis of nucleic acid molecules
|
|
WO1999049873A1
(en)
|
1998-03-27 |
1999-10-07 |
Regents Of The University Of Minnesota |
Nucleosides with antiviral and anticancer activity
|
|
GB9806815D0
(en)
|
1998-03-30 |
1998-05-27 |
Hoffmann La Roche |
Amino acid derivatives
|
|
CN1230198C
(zh)
|
1998-05-15 |
2005-12-07 |
先灵公司 |
给首次接受抗病毒疗法的G慢性丙型肝炎感染患者施用包括利巴韦林和α干扰素的联合疗法
|
|
US20010014352A1
(en)
|
1998-05-27 |
2001-08-16 |
Udit Batra |
Compressed tablet formulation
|
|
TR200003635T2
(tr)
|
1998-06-08 |
2001-04-20 |
F.Hoffmann-La Roche Ag |
Peg-IFN-ALFA ve ribavirinin kronik hepatit C tedavisinde kullanılması.
|
|
US6200598B1
(en)
|
1998-06-18 |
2001-03-13 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
US6726925B1
(en)
|
1998-06-18 |
2004-04-27 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
AU756627B2
(en)
|
1998-07-27 |
2003-01-16 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Diketoacid-derivatives as inhibitors of polymerases
|
|
GB9816358D0
(en)
|
1998-07-27 |
1998-09-23 |
Angeletti P Ist Richerche Bio |
Enzyme inhibitors
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
KR100634342B1
(ko)
|
1998-08-10 |
2006-10-16 |
이데닉스(케이만)리미티드 |
B형 간염의 치료용 β-L-2'-데옥시-뉴클레오시드
|
|
ES2235518T3
(es)
|
1998-10-16 |
2005-07-01 |
Mercian Corporation |
Cristalizacion de hidrocloruro de doxorubicina.
|
|
US6635278B1
(en)
|
1998-12-15 |
2003-10-21 |
Gilead Sciences, Inc. |
Pharmaceutical formulations
|
|
AR021876A1
(es)
|
1998-12-18 |
2002-08-07 |
Schering Corp |
Terapia de combinacion para vhc por induccion de ribavirina - interferon alfa pegilado
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6294192B1
(en)
|
1999-02-26 |
2001-09-25 |
Lipocine, Inc. |
Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
|
|
US6267985B1
(en)
|
1999-06-30 |
2001-07-31 |
Lipocine Inc. |
Clear oil-containing pharmaceutical compositions
|
|
US6383471B1
(en)
|
1999-04-06 |
2002-05-07 |
Lipocine, Inc. |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
|
|
US7919119B2
(en)
|
1999-05-27 |
2011-04-05 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
US6395300B1
(en)
|
1999-05-27 |
2002-05-28 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
CN1079473C
(zh)
|
1999-05-31 |
2002-02-20 |
李岭群 |
预制梁连接筋
|
|
AU5905400A
(en)
|
1999-07-14 |
2001-02-05 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivery and retention of active agents to lymph nodes
|
|
HK1049154A1
(zh)
|
1999-07-30 |
2003-05-02 |
Abbott Gmbh & Co. Kg |
作为酪氨酸激酶抑制剂的2-吡唑啉-5-酮
|
|
US6752981B1
(en)
|
1999-09-08 |
2004-06-22 |
Metabasis Therapeutics, Inc. |
Prodrugs for liver specific drug delivery
|
|
WO2001032153A2
(en)
|
1999-11-04 |
2001-05-10 |
Shire Biochem Inc. |
Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
|
|
JP2003513984A
(ja)
|
1999-11-12 |
2003-04-15 |
フアーマセツト・リミテツド |
2’−デオキシ−l−ヌクレオシドの合成
|
|
US20060034937A1
(en)
|
1999-11-23 |
2006-02-16 |
Mahesh Patel |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
SK11922002A3
(sk)
|
2000-02-18 |
2003-06-03 |
Shire Biochem Inc. |
Použitie analógov nukleozidov na liečenie alebo prevenciu infekcií spôsobených flavivírusom
|
|
JP2003532643A
(ja)
|
2000-04-13 |
2003-11-05 |
フアーマセツト・リミテツド |
肝炎ウイルス感染症を治療するための3’−または2’−ヒドロキシメチル置換ヌクレオシド誘導体
|
|
WO2001081359A1
(en)
|
2000-04-20 |
2001-11-01 |
Schering Corporation |
Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
US6596700B2
(en)
|
2000-05-26 |
2003-07-22 |
Idenix Pharmaceuticals Inc. |
Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
|
|
CZ301182B6
(cs)
|
2000-05-26 |
2009-12-02 |
Idenix (Cayman) Limited |
Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
|
|
US6787526B1
(en)
|
2000-05-26 |
2004-09-07 |
Idenix Pharmaceuticals, Inc. |
Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
|
|
FR2810322B1
(fr)
|
2000-06-14 |
2006-11-10 |
Pasteur Institut |
PRODUCTION COMBINATOIRE D'ANALOGUES DE NUCLEOTIDES ET NUCLEOTIDES (XiTP)
|
|
MY141594A
(en)
|
2000-06-15 |
2010-05-14 |
Novirio Pharmaceuticals Ltd |
3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
UA72612C2
(en)
|
2000-07-06 |
2005-03-15 |
|
Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
|
|
US6680068B2
(en)
|
2000-07-06 |
2004-01-20 |
The General Hospital Corporation |
Drug delivery formulations and targeting
|
|
AR029851A1
(es)
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
|
DK1301519T4
(da)
|
2000-07-21 |
2021-12-20 |
Gilead Sciences Inc |
Prodrugs af phosphonatnukleotidanaloger og fremgangsmåder til udvælgelse og fremstilling heraf
|
|
AR034127A1
(es)
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
|
EP1301527A2
(en)
|
2000-07-21 |
2003-04-16 |
Corvas International, Inc. |
Peptides as ns3-serine protease inhibitors of hepatitis c virus
|
|
CZ2003195A3
(cs)
|
2000-07-21 |
2003-04-16 |
Schering Corporation |
Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek
|
|
AR039558A1
(es)
|
2000-08-21 |
2005-02-23 |
Inspire Pharmaceuticals Inc |
Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
|
|
US7018985B1
(en)
|
2000-08-21 |
2006-03-28 |
Inspire Pharmaceuticals, Inc. |
Composition and method for inhibiting platelet aggregation
|
|
US6897201B2
(en)
|
2000-08-21 |
2005-05-24 |
Inspire Pharmaceuticals, Inc. |
Compositions and methods for the treatment of glaucoma or ocular hypertension
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
HK1052878A1
(zh)
|
2000-10-18 |
2003-10-03 |
Schering Corporation |
利巴传林-聚乙二醇化干扰素α:丙型肝炎病毒的联合治疗
|
|
DK2251015T3
(da)
|
2000-10-18 |
2013-05-13 |
Gilead Pharmasset Llc |
Modificerede nukleotider til behandling af virusinfektioner og abnorm celleproliferation
|
|
US6555677B2
(en)
|
2000-10-31 |
2003-04-29 |
Merck & Co., Inc. |
Phase transfer catalyzed glycosidation of an indolocarbazole
|
|
WO2002060926A2
(en)
|
2000-11-20 |
2002-08-08 |
Bristol-Myers Squibb Company |
Hepatitis c tripeptide inhibitors
|
|
IL155842A0
(en)
|
2000-12-12 |
2003-12-23 |
Schering Corp |
Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus
|
|
AU2002230763A1
(en)
|
2000-12-13 |
2008-01-03 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
US6727366B2
(en)
|
2000-12-13 |
2004-04-27 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis C virus NS3 protease inhibitors
|
|
BR0116221A
(pt)
|
2000-12-15 |
2005-09-13 |
Pharmasset Ltd |
Agentes antivirais para tratamento de infecções por flaviviridae
|
|
SK286630B6
(sk)
*
|
2001-01-22 |
2009-02-05 |
Merck & Co., Inc. |
Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
US7105499B2
(en)
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
MY129350A
(en)
|
2001-04-25 |
2007-03-30 |
Bristol Myers Squibb Co |
Aripiprazole oral solution
|
|
GB0112617D0
(en)
|
2001-05-23 |
2001-07-18 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
GB0114286D0
(en)
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
WO2003000713A1
(en)
|
2001-06-21 |
2003-01-03 |
Glaxo Group Limited |
Nucleoside compounds in hcv
|
|
DE60217114T2
(de)
|
2001-07-11 |
2007-10-25 |
Vertex Pharmaceuticals Inc., Cambridge |
Verbrückte bizyklische serinproteaseinhibitoren
|
|
EP2335700A1
(en)
|
2001-07-25 |
2011-06-22 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C virus polymerase inhibitors with a heterobicylic structure
|
|
ATE252594T1
(de)
|
2001-07-30 |
2003-11-15 |
Clariant Lsm Italia Spa |
Verfahren zur herstellung von ribavirin
|
|
WO2003011877A2
(en)
|
2001-08-02 |
2003-02-13 |
Ilex Oncology Inc. |
Process for preparing purine nucleosides
|
|
US6962991B2
(en)
|
2001-09-12 |
2005-11-08 |
Epoch Biosciences, Inc. |
Process for the synthesis of pyrazolopyrimidines
|
|
US7227019B2
(en)
|
2001-09-13 |
2007-06-05 |
Bristol-Myers Squibb Company |
Process for the preparation of rebeccamycin and analogs thereof
|
|
WO2003024461A1
(en)
|
2001-09-20 |
2003-03-27 |
Schering Corporation |
Hcv combination therapy
|
|
EP1435974A4
(en)
|
2001-09-28 |
2006-09-06 |
Idenix Cayman Ltd |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES
|
|
JP2005515172A
(ja)
|
2001-11-02 |
2005-05-26 |
グラクソ グループ リミテッド |
Hcv阻害剤としての4−(6−員)−ヘテロアリールアシルピロリジン誘導体
|
|
EP1448170A4
(en)
|
2001-11-27 |
2010-05-12 |
Bristol Myers Squibb Co |
EFAVIRENZ STAMP PREPARATIONS HAVING UNIQUE BIOPHARMACEUTICAL CHARACTERISTICS
|
|
GB0129945D0
(en)
|
2001-12-13 |
2002-02-06 |
Mrc Technology Ltd |
Chemical compounds
|
|
BR0214944A
(pt)
|
2001-12-14 |
2005-06-07 |
Pharmasset Ltd |
Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais
|
|
WO2003051899A1
(en)
|
2001-12-17 |
2003-06-26 |
Ribapharm Inc. |
Deazapurine nucleoside libraries and compounds
|
|
AU2002364216A1
(en)
|
2001-12-21 |
2003-07-15 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza l-nucleosides
|
|
WO2003062256A1
(en)
|
2002-01-17 |
2003-07-31 |
Ribapharm Inc. |
2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
|
|
US7070801B2
(en)
|
2002-01-30 |
2006-07-04 |
National Institute Of Advanced Industrial Science And Technology |
Sugar-modified liposome and products comprising the liposome
|
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
WO2003068244A1
(en)
|
2002-02-13 |
2003-08-21 |
Merck & Co., Inc. |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds
|
|
RU2004128943A
(ru)
|
2002-02-28 |
2005-04-20 |
Байота, Инк. (Us) |
Средства, имитирующие нуклеотиды, и их пролекарственные формы
|
|
EP1485396A2
(en)
|
2002-02-28 |
2004-12-15 |
Biota, Inc. |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
|
JP4942915B2
(ja)
|
2002-04-26 |
2012-05-30 |
ギリアード サイエンシーズ, インコーポレイテッド |
Hivプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積
|
|
WO2003100017A2
(en)
|
2002-05-24 |
2003-12-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
JP4602076B2
(ja)
|
2002-06-04 |
2010-12-22 |
ネオジェネシス ファーマシューティカルズ インコーポレイテッド |
抗ウイルス剤としてのピラゾロ[1,5a]ピリミジン化合物
|
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
CA2488611C
(en)
|
2002-06-07 |
2011-11-15 |
Kylix, B.V. |
Compounds for modulating the activity of exchange proteins directly activated by camp (epacs)
|
|
AU2003248708A1
(en)
|
2002-06-17 |
2003-12-31 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
WO2003105770A2
(en)
|
2002-06-17 |
2003-12-24 |
Merck & Co., Inc. |
Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
JP2005530843A
(ja)
|
2002-06-21 |
2005-10-13 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウィルスポリメラーゼ阻害剤としてのヌクレオシド誘導体
|
|
JP2006512288A
(ja)
|
2002-06-27 |
2006-04-13 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
|
|
MXPA04012802A
(es)
|
2002-06-28 |
2005-04-19 |
Idenix Cayman Ltd |
Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
|
|
CN104193791A
(zh)
|
2002-06-28 |
2014-12-10 |
埃迪尼克斯医药公司 |
用于治疗黄病毒感染的修饰的2’和3’-核苷前药
|
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
|
AU2003263412A1
(en)
|
2002-06-28 |
2004-01-19 |
Centre National De La Recherche Scientifique (Cnrs) |
1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
|
|
US6973905B2
(en)
|
2002-07-01 |
2005-12-13 |
Cinetic Automation Corporation |
Valve lash adjustment apparatus and method
|
|
BR0305426A
(pt)
|
2002-07-01 |
2004-08-24 |
Upjohn Co |
Compostos inibidores de ns5b polimerase de hcv, bem como composição farmacêutica compreendendo os mesmos
|
|
US6930106B2
(en)
|
2002-07-01 |
2005-08-16 |
Pharmacia & Upjohn Company |
Inhibitors of HCV NS5B polymerase
|
|
JP2005533108A
(ja)
|
2002-07-16 |
2005-11-04 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウイルスポリメラーゼの阻害剤としてのヌクレオシド誘導体
|
|
CA2493816A1
(en)
|
2002-07-24 |
2004-01-29 |
Ptc Therapeutics, Inc. |
Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
|
|
WO2004009020A2
(en)
|
2002-07-24 |
2004-01-29 |
Merck & Co., Inc. |
Pyrrolopyrimidine thionucleoside analogs as antivirals
|
|
CA2492607A1
(en)
|
2002-07-25 |
2004-02-05 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza d-nucleosides and uses thereof
|
|
US20050069522A1
(en)
|
2002-08-12 |
2005-03-31 |
Richard Colonno |
Combination pharmaceutical agents as inhibitors of HCV replication
|
|
BR0314259A
(pt)
|
2002-09-13 |
2005-07-26 |
Idenix Cayman Ltd |
ß-l-2'-desoxinucleosìdeos para o tratamento de cepas de hbv resistentes e terapias combinadas
|
|
WO2004035571A1
(en)
|
2002-10-15 |
2004-04-29 |
Rigel Pharmaceuticals, Inc. |
Substituted indoles and their use as hcv inhibitors
|
|
US20040229840A1
(en)
|
2002-10-29 |
2004-11-18 |
Balkrishen Bhat |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
HN2003000348A
(es)
|
2002-11-01 |
2008-10-14 |
Viropharma Inc |
Compuestos de benzofurano, composiciones y metodos para tratamiento y profilaxis de infeccion virales de hepatitis c y enfermedades asociadas.
|
|
AU2003291753B2
(en)
|
2002-11-05 |
2010-07-08 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
WO2004044136A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2’-modified nucleosides for use in gene modulation
|
|
WO2004046331A2
(en)
|
2002-11-15 |
2004-06-03 |
Idenix (Cayman) Limited |
2’-branched nucleosides and flaviviridae mutation
|
|
TWI332507B
(en)
|
2002-11-19 |
2010-11-01 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
SI1585548T1
(sl)
|
2002-12-09 |
2018-11-30 |
Abraxis Bioscience, Llc |
Sestave in metode odmerjanja farmakoloških sredstev
|
|
US7598373B2
(en)
|
2002-12-12 |
2009-10-06 |
Idenix Pharmaceuticals, Inc. |
Process for the production of 2-C-methyl-D-ribonolactone
|
|
NZ540728A
(en)
|
2003-01-14 |
2008-08-29 |
Gilead Sciences Inc |
Compositions and methods for combination antiviral therapy
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
KR20060008297A
(ko)
|
2003-03-20 |
2006-01-26 |
마이크로 바이올로지카 퀴미카 이 파마슈티카 리미티드 |
2'-데옥시-β-L-뉴클레오시드의 제조방법
|
|
EP2033654B1
(en)
|
2003-04-16 |
2012-05-16 |
Bristol-Myers Squibb Company |
Process for resolving a mixture of alkyl ester enantiomers using an enzyme
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
EP1628685B1
(en)
|
2003-04-25 |
2010-12-08 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
KR20060061930A
(ko)
|
2003-04-25 |
2006-06-08 |
길리애드 사이언시즈, 인코포레이티드 |
항암성 포스포네이트 유사체
|
|
MXPA05011296A
(es)
|
2003-04-25 |
2006-01-24 |
Gilead Sciences Inc |
Conjugados de fosfonato inhibidores de la cinasa.
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
WO2004096210A1
(en)
|
2003-05-01 |
2004-11-11 |
Glaxo Group Limited |
Acylated indoline and tetrahydroquinoline derivatives as hcv inhibitors
|
|
US20040259934A1
(en)
|
2003-05-01 |
2004-12-23 |
Olsen David B. |
Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
|
|
US20040229839A1
(en)
|
2003-05-14 |
2004-11-18 |
Biocryst Pharmaceuticals, Inc. |
Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
WO2005020884A2
(en)
|
2003-05-14 |
2005-03-10 |
Idenix (Cayman) Limited |
Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
EP2345659A1
(en)
|
2003-05-30 |
2011-07-20 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
|
WO2005007810A2
(en)
|
2003-06-16 |
2005-01-27 |
Grinstaff Mark W |
Functional synthetic molecules and macromolecules for gene delivery
|
|
GB0317009D0
(en)
|
2003-07-21 |
2003-08-27 |
Univ Cardiff |
Chemical compounds
|
|
DE602004028841D1
(de)
|
2003-07-25 |
2010-10-07 |
Centre Nat Rech Scient |
Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
|
|
CA2537114C
(en)
|
2003-08-27 |
2012-10-02 |
Biota, Inc. |
Tricyclic nucleosides or nucleotides as therapeutic agents
|
|
JP5379347B2
(ja)
|
2003-09-18 |
2013-12-25 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
4’−チオヌクレオシドおよびオリゴマー化合物
|
|
EP1664091A1
(en)
|
2003-09-18 |
2006-06-07 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
US20050148534A1
(en)
|
2003-09-22 |
2005-07-07 |
Castellino Angelo J. |
Small molecule compositions and methods for increasing drug efficiency using compositions thereof
|
|
OA13315A
(en)
|
2003-10-14 |
2007-04-13 |
Intermune Inc |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication.
|
|
US7491794B2
(en)
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
|
EP1677827B1
(en)
|
2003-10-27 |
2008-12-10 |
Vertex Pharmaceuticals Incorporated |
Combinations for hcv treatment
|
|
US7026339B2
(en)
|
2003-11-07 |
2006-04-11 |
Fan Yang |
Inhibitors of HCV NS5B polymerase
|
|
TW200528459A
(en)
|
2004-01-06 |
2005-09-01 |
Achillion Pharmaceuticals Inc |
Azabenzofuran substituted thioureas; inhibitors of viral replication
|
|
US20070155731A1
(en)
|
2004-01-28 |
2007-07-05 |
Gabor Butora |
Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
|
|
AU2005216971A1
(en)
|
2004-02-25 |
2005-09-09 |
Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Office Of Technology Transfer |
Methylation inhibitor compounds
|
|
WO2005087788A2
(en)
|
2004-03-04 |
2005-09-22 |
The Regents Of The University Of California |
Methods for preparation of nucleoside phosphonate esters
|
|
EA012389B1
(ru)
|
2004-03-30 |
2009-10-30 |
Интермун, Инк. |
Макроциклические соединения в качестве ингибиторов вирусной репликации
|
|
GB0408995D0
(en)
|
2004-04-22 |
2004-05-26 |
Glaxo Group Ltd |
Compounds
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
EP1758453B1
(en)
|
2004-06-15 |
2014-07-16 |
Merck Sharp & Dohme Corp. |
C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase
|
|
BRPI0512360A
(pt)
|
2004-06-23 |
2008-03-11 |
Idenix Cayman Ltd |
derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
|
|
AU2005267421B2
(en)
|
2004-06-24 |
2010-06-03 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
US7217523B2
(en)
|
2004-07-02 |
2007-05-15 |
Regents Of The University Of Minnesota |
Nucleoside phosphoramidates and nucleoside phosphoramidases
|
|
ES2386005T3
(es)
|
2004-07-21 |
2012-08-07 |
Gilead Pharmasset Llc |
Preparación de 2-desoxi-2-fluoro-d-ribofuranosil pirimidinas y purinas sustituidas con alquilo y sus derivados
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
WO2006110157A2
(en)
|
2004-07-27 |
2006-10-19 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates as anti hiv agents
|
|
US7153848B2
(en)
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7348425B2
(en)
|
2004-08-09 |
2008-03-25 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
ES2327252T3
(es)
|
2004-08-23 |
2009-10-27 |
F. Hoffmann-La Roche Ag |
4'-azido nucleosidos antivirales.
|
|
ATE437875T1
(de)
|
2004-08-23 |
2009-08-15 |
Hoffmann La Roche |
Heterozyklische antivirale verbindungen
|
|
WO2006029081A2
(en)
|
2004-09-02 |
2006-03-16 |
Neopharm, Inc. |
Nucleoside-lipid conjugates, their method of preparation and uses thereof
|
|
ES2769377T3
(es)
|
2004-09-14 |
2020-06-25 |
Gilead Pharmasset Llc |
Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo
|
|
US20080280850A1
(en)
|
2004-09-24 |
2008-11-13 |
Jean-Pierre Sommadossi |
Methods and Compositions for Treating Flaviviruses, Pestiviruses and Hepacivirus
|
|
AP2007003923A0
(en)
|
2004-09-30 |
2007-02-28 |
Tibotec Pharm Ltd |
Hcv inhibiting bi-cyclic pyrimidines
|
|
US20080280842A1
(en)
|
2004-10-21 |
2008-11-13 |
Merck & Co., Inc. |
Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
|
|
JP2008523082A
(ja)
|
2004-12-09 |
2008-07-03 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
抗菌活性および抗癌活性を有するヌクレオチド
|
|
EP1828217A2
(en)
|
2004-12-16 |
2007-09-05 |
Febit Biotech GmbH |
Polymerase-independent analysis of the sequence of polynucleotides
|
|
WO2006065590A2
(en)
|
2004-12-16 |
2006-06-22 |
Xtl Biopharmaceuticals Inc. |
Pyridine and pyrimidine antiviral compositions
|
|
WO2006093801A1
(en)
|
2005-02-25 |
2006-09-08 |
Abbott Laboratories |
Thiadiazine derivatives useful as anti-infective agents
|
|
CA2597685A1
(en)
|
2005-02-28 |
2006-09-08 |
Genelabs Technologies, Inc. |
Tricyclic-nucleoside compounds for treating viral infections
|
|
AU2006222563A1
(en)
|
2005-03-08 |
2006-09-14 |
Biota Scientific Management Pty Ltd. |
Bicyclic nucleosides and nucleotides as therapeutic agents
|
|
BRPI0609650A2
(pt)
|
2005-03-25 |
2010-04-20 |
Tibotec Pharm Ltd |
inibidores heterobicìlicos de hvc
|
|
TW200720285A
(en)
|
2005-04-25 |
2007-06-01 |
Genelabs Tech Inc |
Nucleoside compounds for treating viral infections
|
|
US7485716B2
(en)
|
2005-05-02 |
2009-02-03 |
Pharmaessentia Corp. |
Stereoselective synthesis of β-nucleosides
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
AR054122A1
(es)
|
2005-05-12 |
2007-06-06 |
Tibotec Pharm Ltd |
Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas
|
|
AR056347A1
(es)
|
2005-05-12 |
2007-10-03 |
Tibotec Pharm Ltd |
Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
US20060276405A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods for treating hepatitis C
|
|
US8143288B2
(en)
|
2005-06-06 |
2012-03-27 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
|
US20060293752A1
(en)
|
2005-06-27 |
2006-12-28 |
Missoum Moumene |
Intervertebral disc prosthesis and associated methods
|
|
GEP20105124B
(en)
|
2005-07-25 |
2010-11-25 |
Array Biopharma Inc |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
|
JP2009502969A
(ja)
|
2005-07-28 |
2009-01-29 |
アイエスピー インヴェストメンツ インコーポレイテッド |
非晶質エファビレンツ及びその製造
|
|
EP1915585A2
(en)
|
2005-07-29 |
2008-04-30 |
Automotive Systems Laboratory Inc. |
Magnetic crash sensor
|
|
RU2441870C2
(ru)
|
2005-07-29 |
2012-02-10 |
Тиботек Фармасьютикалз Лтд. |
Макроциклические ингибиторы вируса гепатита с
|
|
WO2007013047A2
(en)
|
2005-07-29 |
2007-02-01 |
Ranbaxy Laboratories Limited |
Water-dispersible anti-retroviral pharmaceutical compositions
|
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
|
DE602006019883D1
(de)
|
2005-07-29 |
2011-03-10 |
Medivir Ab |
Makrocyclische inhibitoren des hepatitis-c-virus
|
|
RS52058B
(sr)
|
2005-07-29 |
2012-04-30 |
Tibotec Pharmaceuticals |
Makrociklički inhibitori virusa hepatitisa c
|
|
TWI393723B
(zh)
|
2005-07-29 |
2013-04-21 |
Tibotec Pharm Ltd |
C型肝炎病毒之大環抑制劑(九)
|
|
JP2009504704A
(ja)
|
2005-08-15 |
2009-02-05 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗ウイルス4′−置換プロヌクレオチドホスホルアミダート
|
|
GB0519478D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
GB0519488D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
BRPI0619563A2
(pt)
|
2005-12-09 |
2011-10-04 |
Pharmasset Inc |
nucleosìdeos antivirais
|
|
AU2006326494A1
(en)
|
2005-12-12 |
2007-06-21 |
Genelabs Technologies, Inc. |
N-(6-membered aromatic ring)-amido anti-viral compounds
|
|
US7910595B2
(en)
|
2005-12-21 |
2011-03-22 |
Abbott Laboratories |
Anti-viral compounds
|
|
ATE475660T1
(de)
|
2005-12-21 |
2010-08-15 |
Abbott Lab |
Antivirale verbindungen
|
|
GB0602046D0
(en)
|
2006-02-01 |
2006-03-15 |
Smithkline Beecham Corp |
Compounds
|
|
WO2007092000A1
(en)
|
2006-02-06 |
2007-08-16 |
Bristol-Myers Squibb Company |
Inhibitors of hcv replication
|
|
EP1987050A2
(en)
|
2006-02-14 |
2008-11-05 |
Merck & Co., Inc. |
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
KR20080085232A
(ko)
|
2006-02-17 |
2008-09-23 |
화이자 리미티드 |
Tlr7 조절제로서 3-데아자퓨린 유도체
|
|
US8895531B2
(en)
|
2006-03-23 |
2014-11-25 |
Rfs Pharma Llc |
2′-fluoronucleoside phosphonates as antiviral agents
|
|
ATE469155T1
(de)
|
2006-05-25 |
2010-06-15 |
Bristol Myers Squibb Co |
Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b- hemmer
|
|
WO2007140200A2
(en)
|
2006-05-25 |
2007-12-06 |
Bristol-Myers Squibb Company |
Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
|
|
AP2985A
(en)
|
2006-07-07 |
2014-09-30 |
Gilead Sciences Inc |
Modulators of pharmacokinetic properties of therapeutics
|
|
US20080014228A1
(en)
|
2006-07-14 |
2008-01-17 |
Olivia Darmuzey |
Solid form
|
|
EP1881001A1
(en)
|
2006-07-20 |
2008-01-23 |
Tibotec Pharmaceuticals Ltd. |
HCV NS-3 serine protease inhibitors
|
|
US8329159B2
(en)
|
2006-08-11 |
2012-12-11 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CN101600725B
(zh)
|
2006-10-10 |
2014-11-26 |
吉利德制药有限责任公司 |
制备呋喃核糖基嘧啶核苷
|
|
PL216525B1
(pl)
|
2006-10-17 |
2014-04-30 |
Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk |
5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
|
|
GB0623493D0
(en)
|
2006-11-24 |
2007-01-03 |
Univ Cardiff |
Chemical compounds
|
|
WO2008079206A1
(en)
|
2006-12-20 |
2008-07-03 |
Merck & Co., Inc. |
Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
JP2010515680A
(ja)
|
2007-01-05 |
2010-05-13 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Rna依存性rnaウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
GB0709791D0
(en)
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
CN101108870A
(zh)
|
2007-08-03 |
2008-01-23 |
冷一欣 |
核苷磷酸酯类化合物及制备方法和应用
|
|
US8629171B2
(en)
|
2007-08-08 |
2014-01-14 |
Bristol-Myers Squibb Company |
Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
|
|
DK2061513T3
(da)
|
2007-09-14 |
2011-11-21 |
Schering Corp |
Fremgangsmåde til behandling af patienter med hepatitis C
|
|
JO2778B1
(en)
|
2007-10-16 |
2014-03-15 |
ايساي انك |
Certain Compounds, Compositions and Methods
|
|
JP5238939B2
(ja)
|
2007-11-07 |
2013-07-17 |
三菱化学株式会社 |
長繊維強化複合樹脂組成物および成形品
|
|
US20090318380A1
(en)
|
2007-11-20 |
2009-12-24 |
Pharmasset, Inc. |
2',4'-substituted nucleosides as antiviral agents
|
|
TW200936146A
(en)
|
2007-11-29 |
2009-09-01 |
Metabasis Therapeutics Inc |
Antiviral nucleoside compounds
|
|
WO2009086192A1
(en)
|
2007-12-21 |
2009-07-09 |
Alios Biopharma, Inc. |
Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
|
|
US8227431B2
(en)
|
2008-03-17 |
2012-07-24 |
Hetero Drugs Limited |
Nucleoside derivatives
|
|
WO2009142822A2
(en)
|
2008-03-26 |
2009-11-26 |
Alnylam Pharmaceuticals, Inc. |
2-f modified rna interference agents
|
|
CN102046622A
(zh)
|
2008-04-15 |
2011-05-04 |
因特蒙公司 |
丙型肝炎病毒复制的新颖大环抑制剂
|
|
CA2722308C
(en)
|
2008-04-15 |
2024-02-27 |
Rfs Pharma, Llc. |
Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
|
|
HUE038946T2
(hu)
|
2008-04-23 |
2018-12-28 |
Gilead Sciences Inc |
1'-szubsztituált carba-nukleozid analógok antivirális kezelésre
|
|
WO2010036407A2
(en)
|
2008-05-15 |
2010-04-01 |
Biocryst Pharmaceuticals, Inc. |
Antiviral nucleoside analogs
|
|
US8173621B2
(en)
*
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
WO2010002877A2
(en)
|
2008-07-03 |
2010-01-07 |
Biota Scientific Management |
Bycyclic nucleosides and nucleotides as therapeutic agents
|
|
US20110229438A1
(en)
|
2008-10-09 |
2011-09-22 |
Anadys Pharmaceuticals, Inc. |
Method of inhibiting hepatitus c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
|
|
BRPI0923815A2
(pt)
|
2008-12-23 |
2015-07-14 |
Pharmasset Inc |
Síntese de nucleosídeos de purina
|
|
AU2009329917B2
(en)
|
2008-12-23 |
2016-03-31 |
Gilead Pharmasset Llc |
Nucleoside analogs
|
|
CN102695513A
(zh)
|
2008-12-23 |
2012-09-26 |
吉利德制药有限责任公司 |
核苷氨基磷酸酯
|
|
MX2011007194A
(es)
|
2009-01-07 |
2013-07-12 |
Scynexis Inc |
Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc).
|
|
KR101834707B1
(ko)
|
2009-02-10 |
2018-03-05 |
길리애드 사이언시즈, 인코포레이티드 |
항바이러스 치료를 위한 카르바-뉴클레오시드 유사체
|
|
JO3027B1
(ar)
*
|
2009-05-14 |
2016-09-05 |
Janssen Products Lp |
نيوكليوسيدات يوراسيل سبيرواوكسيتان
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
TWI583692B
(zh)
*
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
SMT201700412T1
(it)
|
2010-03-31 |
2017-11-15 |
Gilead Pharmasset Llc |
Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato
|
|
US8563530B2
(en)
|
2010-03-31 |
2013-10-22 |
Gilead Pharmassel LLC |
Purine nucleoside phosphoramidate
|
|
PT3042910T
(pt)
|
2010-11-30 |
2019-04-16 |
Gilead Pharmasset Llc |
2'-espiro-nucleósidos para utilização na terapia da hepatite c
|