|
US3798209A
(en)
|
1971-06-01 |
1974-03-19 |
Icn Pharmaceuticals |
1,2,4-triazole nucleosides
|
|
USRE29835E
(en)
|
1971-06-01 |
1978-11-14 |
Icn Pharmaceuticals |
1,2,4-Triazole nucleosides
|
|
US3994974A
(en)
|
1972-02-05 |
1976-11-30 |
Yamanouchi Pharmaceutical Co., Ltd. |
α-Aminomethylbenzyl alcohol derivatives
|
|
US3852267A
(en)
|
1972-08-04 |
1974-12-03 |
Icn Pharmaceuticals |
Phosphoramidates of 3{40 ,5{40 -cyclic purine nucleotides
|
|
US4138547A
(en)
|
1977-12-22 |
1979-02-06 |
Icn Pharmaceuticals, Inc. |
Process for preparing 1,2,4-triazole nucleosides
|
|
JPS57146593A
(en)
|
1981-03-09 |
1982-09-10 |
Ajinomoto Co Inc |
Preparation of ribofuranosyltriazole derivative
|
|
US4816570A
(en)
|
1982-11-30 |
1989-03-28 |
The Board Of Regents Of The University Of Texas System |
Biologically reversible phosphate and phosphonate protective groups
|
|
US4526988A
(en)
|
1983-03-10 |
1985-07-02 |
Eli Lilly And Company |
Difluoro antivirals and intermediate therefor
|
|
US5077056A
(en)
|
1984-08-08 |
1991-12-31 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
US5736155A
(en)
|
1984-08-08 |
1998-04-07 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
NL8403224A
(nl)
|
1984-10-24 |
1986-05-16 |
Oce Andeno Bv |
Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
|
|
US5223263A
(en)
|
1988-07-07 |
1993-06-29 |
Vical, Inc. |
Liponucleotide-containing liposomes
|
|
US5246937A
(en)
|
1985-09-18 |
1993-09-21 |
Beecham Group P.L.C. |
Purine derivatives
|
|
US4797285A
(en)
|
1985-12-06 |
1989-01-10 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
Lipsome/anthraquinone drug composition and method
|
|
US5154930A
(en)
|
1987-03-05 |
1992-10-13 |
The Liposome Company, Inc. |
Pharmacological agent-lipid solution preparation
|
|
GB8719367D0
(en)
|
1987-08-15 |
1987-09-23 |
Wellcome Found |
Therapeutic compounds
|
|
JPH03501253A
(ja)
|
1987-09-22 |
1991-03-22 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
エイズ（ａｉｄｓ）治療を目的とするリポソームによるヌクレオシド類似物質
|
|
IL91664A
(en)
|
1988-09-28 |
1993-05-13 |
Yissum Res Dev Co |
Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
|
|
US6132763A
(en)
|
1988-10-20 |
2000-10-17 |
Polymasc Pharmaceuticals Plc |
Liposomes
|
|
US5705363A
(en)
|
1989-03-02 |
1998-01-06 |
The Women's Research Institute |
Recombinant production of human interferon τ polypeptides and nucleic acids
|
|
US5077057A
(en)
|
1989-04-05 |
1991-12-31 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5549910A
(en)
|
1989-03-31 |
1996-08-27 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5277914A
(en)
|
1989-03-31 |
1994-01-11 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5411947A
(en)
|
1989-06-28 |
1995-05-02 |
Vestar, Inc. |
Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
|
|
US5194654A
(en)
|
1989-11-22 |
1993-03-16 |
Vical, Inc. |
Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5463092A
(en)
|
1989-11-22 |
1995-10-31 |
Vestar, Inc. |
Lipid derivatives of phosphonacids for liposomal incorporation and method of use
|
|
US5026687A
(en)
|
1990-01-03 |
1991-06-25 |
The United States Of America As Represented By The Department Of Health And Human Services |
Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
|
|
AU660925B2
(en)
|
1990-04-06 |
1995-07-13 |
Genelabs Technologies, Inc. |
Hepatitis C virus epitopes
|
|
US5091188A
(en)
|
1990-04-26 |
1992-02-25 |
Haynes Duncan H |
Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
|
|
AU7872491A
(en)
|
1990-05-07 |
1991-11-27 |
Vical, Inc. |
Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs
|
|
EP0531452A4
(en)
|
1990-05-29 |
1993-06-09 |
Vical, Inc. |
Synthesis of glycerol di- and triphosphate derivatives
|
|
ES2083580T3
(es)
|
1990-06-13 |
1996-04-16 |
Arnold Glazier |
Profarmacos de fosforo.
|
|
US6060080A
(en)
|
1990-07-16 |
2000-05-09 |
Daiichi Pharmaceutical Co., Ltd. |
Liposomal products
|
|
JP2599492B2
(ja)
|
1990-08-21 |
1997-04-09 |
第一製薬株式会社 |
リポソーム製剤の製造法
|
|
DK0481214T3
(da)
|
1990-09-14 |
1999-02-22 |
Acad Of Science Czech Republic |
Prolægemidler af phosphonater
|
|
US5372808A
(en)
|
1990-10-17 |
1994-12-13 |
Amgen Inc. |
Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
|
|
US5256641A
(en)
|
1990-11-01 |
1993-10-26 |
State Of Oregon |
Covalent polar lipid-peptide conjugates for immunological targeting
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5543389A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization |
Covalent polar lipid-peptide conjugates for use in salves
|
|
US5149794A
(en)
|
1990-11-01 |
1992-09-22 |
State Of Oregon |
Covalent lipid-drug conjugates for drug targeting
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5157027A
(en)
|
1991-05-13 |
1992-10-20 |
E. R. Squibb & Sons, Inc. |
Bisphosphonate squalene synthetase inhibitors and method
|
|
CA2112803A1
(en)
|
1991-07-12 |
1993-01-21 |
Karl Y. Hostetler |
Antiviral liponucleosides: treatment of hepatitis b
|
|
NZ243567A
(en)
|
1991-07-22 |
1995-04-27 |
Bristol Myers Squibb Co |
Pharmaceutical oral formulation of a dideoxy purine nucleoside comprising the nucleoside together with a water-insoluble antacid buffering composition
|
|
US5554728A
(en)
|
1991-07-23 |
1996-09-10 |
Nexstar Pharmaceuticals, Inc. |
Lipid conjugates of therapeutic peptides and protease inhibitors
|
|
TW224053B
(enExample)
|
1991-09-13 |
1994-05-21 |
Paul B Chretien |
|
|
DE4200821A1
(de)
|
1992-01-15 |
1993-07-22 |
Bayer Ag |
Geschmacksmaskierte pharmazeutische mittel
|
|
US5676942A
(en)
|
1992-02-10 |
1997-10-14 |
Interferon Sciences, Inc. |
Composition containing human alpha interferon species proteins and method for use thereof
|
|
US5405598A
(en)
|
1992-02-24 |
1995-04-11 |
Schinazi; Raymond F. |
Sensitizing agents for use in boron neutron capture therapy
|
|
US5610054A
(en)
|
1992-05-14 |
1997-03-11 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecule targeted against Hepatitis C virus
|
|
US5770725A
(en)
|
1992-05-25 |
1998-06-23 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
US5849905A
(en)
|
1994-11-23 |
1998-12-15 |
Centre National De La Recherche Scientifique |
Biologically active phosphotriester-type nucleosides and methods for preparing same
|
|
US6020482A
(en)
|
1992-05-25 |
2000-02-01 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
EP0576231B1
(en)
|
1992-06-22 |
1997-05-28 |
Eli Lilly And Company |
Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2, 2-difluoro-D-ribofuranosyl derivatives
|
|
US5256798A
(en)
|
1992-06-22 |
1993-10-26 |
Eli Lilly And Company |
Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
|
|
US5426183A
(en)
|
1992-06-22 |
1995-06-20 |
Eli Lilly And Company |
Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
|
|
CA2105112C
(en)
|
1992-09-01 |
2005-08-02 |
Thomas C. Britton |
A process for anomerizing nucleosides
|
|
GB9226729D0
(en)
|
1992-12-22 |
1993-02-17 |
Wellcome Found |
Therapeutic combination
|
|
US6096331A
(en)
|
1993-02-22 |
2000-08-01 |
Vivorx Pharmaceuticals, Inc. |
Methods and compositions useful for administration of chemotherapeutic agents
|
|
US6749868B1
(en)
|
1993-02-22 |
2004-06-15 |
American Bioscience, Inc. |
Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
|
|
US6753006B1
(en)
|
1993-02-22 |
2004-06-22 |
American Bioscience, Inc. |
Paclitaxel-containing formulations
|
|
CA2155947C
(en)
|
1993-02-22 |
2007-08-21 |
Mark W. Grinstaff |
Methods for in vivo delivery of biologics and compositions useful therefor
|
|
US6537579B1
(en)
|
1993-02-22 |
2003-03-25 |
American Bioscience, Inc. |
Compositions and methods for administration of pharmacologically active compounds
|
|
US5439686A
(en)
|
1993-02-22 |
1995-08-08 |
Vivorx Pharmaceuticals, Inc. |
Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
|
|
AU6247594A
(en)
|
1993-02-24 |
1994-09-14 |
Jui H. Wang |
Compositions and methods of application of reactive antiviral polymers
|
|
US6180134B1
(en)
|
1993-03-23 |
2001-01-30 |
Sequus Pharmaceuticals, Inc. |
Enhanced ciruclation effector composition and method
|
|
JPH08510236A
(ja)
|
1993-05-12 |
1996-10-29 |
カール ワイ． ホステトラー |
局所使用のためのアシクロビル誘導体
|
|
EP0773029A4
(en)
|
1993-07-19 |
1997-09-03 |
Tokyo Tanabe Co |
HEPATITIS C VIRUS PROLIFERATION INHIBITOR
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
US7375198B2
(en)
|
1993-10-26 |
2008-05-20 |
Affymetrix, Inc. |
Modified nucleic acid probes
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
HUT75533A
(en)
|
1993-11-10 |
1997-05-28 |
Schering Corp |
Improved interferon polymer conjugates
|
|
AU6550394A
(en)
|
1994-03-11 |
1995-09-25 |
Isis Pharmaceuticals, Inc. |
Novel pyrimidine nucleosides
|
|
DE4447588C2
(de)
|
1994-05-03 |
1997-11-20 |
Omer Osama Dr Dr Med |
Pflanzliches Arzneimittel zur Behandlung von chronischen und allergischen Rhino-Sino-Bronchitiden
|
|
JPH10501809A
(ja)
|
1994-06-22 |
1998-02-17 |
ネクスター ファーマスーティカルズ，インコーポレイテッド |
分子内求核置換による公知および新規２′−ヌクレオシドの新規製造方法
|
|
US6083953A
(en)
|
1994-07-28 |
2000-07-04 |
Syntex (U.S.A.) Inc. |
2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
|
|
DE4432623A1
(de)
|
1994-09-14 |
1996-03-21 |
Huels Chemische Werke Ag |
Verfahren zur Bleichung von wäßrigen Tensidlösungen
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5696277A
(en)
|
1994-11-15 |
1997-12-09 |
Karl Y. Hostetler |
Antiviral prodrugs
|
|
US5703058A
(en)
|
1995-01-27 |
1997-12-30 |
Emory University |
Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
|
|
US6391859B1
(en)
|
1995-01-27 |
2002-05-21 |
Emory University |
[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
|
|
GB9505025D0
(en)
|
1995-03-13 |
1995-05-03 |
Medical Res Council |
Chemical compounds
|
|
DE19514523A1
(de)
|
1995-04-12 |
1996-10-17 |
Schering Ag |
Neue Cytosin- und Cytidinderivate
|
|
CA2233309A1
(en)
|
1995-09-27 |
1997-04-03 |
Emory University |
Recombinant hepatitis c virus rna replicase
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5767097A
(en)
|
1996-01-23 |
1998-06-16 |
Icn Pharmaceuticals, Inc. |
Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
|
|
GB9602028D0
(en)
|
1996-02-01 |
1996-04-03 |
Amersham Int Plc |
Nucleoside analogues
|
|
US5980884A
(en)
|
1996-02-05 |
1999-11-09 |
Amgen, Inc. |
Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
|
|
AU2064297A
(en)
|
1996-02-29 |
1997-09-16 |
Immusol, Inc |
Hepatitis c virus ribozymes
|
|
US5633388A
(en)
|
1996-03-29 |
1997-05-27 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5830905A
(en)
|
1996-03-29 |
1998-11-03 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5990276A
(en)
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
|
GB9609932D0
(en)
|
1996-05-13 |
1996-07-17 |
Hoffmann La Roche |
Use of IL-12 and IFN alpha for the treatment of infectious diseases
|
|
US5891874A
(en)
|
1996-06-05 |
1999-04-06 |
Eli Lilly And Company |
Anti-viral compound
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US5837257A
(en)
|
1996-07-09 |
1998-11-17 |
Sage R&D |
Use of plant extracts for treatment of HIV, HCV and HBV infections
|
|
US6214375B1
(en)
|
1996-07-16 |
2001-04-10 |
Generex Pharmaceuticals, Inc. |
Phospholipid formulations
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
US5922757A
(en)
|
1996-09-30 |
1999-07-13 |
The Regents Of The University Of California |
Treatment and prevention of hepatic disorders
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
US6224903B1
(en)
|
1996-10-11 |
2001-05-01 |
Sequus Pharmaceuticals, Inc. |
Polymer-lipid conjugate for fusion of target membranes
|
|
US6455690B1
(en)
|
1996-10-16 |
2002-09-24 |
Robert Tam |
L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine
|
|
SK284054B6
(sk)
|
1996-10-16 |
2004-08-03 |
Icn Pharmaceuticals, Inc. |
Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
AU727177B2
(en)
|
1996-10-16 |
2000-12-07 |
Icn Pharmaceuticals, Inc. |
Purine L-nucleosides, analogs and uses thereof
|
|
US6509320B1
(en)
|
1996-10-16 |
2003-01-21 |
Icn Pharmaceuticals, Inc. |
Purine L-nucleosides, analogs and uses thereof
|
|
NZ335276A
(en)
|
1996-10-18 |
2000-09-29 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
IL119833A
(en)
|
1996-12-15 |
2001-01-11 |
Lavie David |
Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
|
|
US5827533A
(en)
|
1997-02-06 |
1998-10-27 |
Duke University |
Liposomes containing active agents aggregated with lipid surfactants
|
|
US6004933A
(en)
|
1997-04-25 |
1999-12-21 |
Cortech Inc. |
Cysteine protease inhibitors
|
|
UA61962C2
(uk)
|
1997-06-30 |
2003-12-15 |
Мерц Фарма Гмбх Унд Ко. Кгаа |
Сполука 1-аміноалкілциклогексану, фармацевтична композиція на її основі та спосіб лікування
|
|
PT1012180E
(pt)
|
1997-08-11 |
2005-04-29 |
Boehringer Ingelheim Ca Ltd |
Analogos de peptidos inibidores da hepatite c
|
|
PT903148E
(pt)
|
1997-09-21 |
2002-02-28 |
Schering Corp |
Terapia de combinacao para a erradicacao de rna de hcv detectavel em doentes tendo infeccao cronica pelo virus da hepatite c
|
|
US6703374B1
(en)
|
1997-10-30 |
2004-03-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Nucleosides for imaging and treatment applications
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
ES2172303T3
(es)
|
1998-01-23 |
2002-09-16 |
Newbiotics Inc |
Agentes terapeuticos obtenidos por catalisis enzimatica.
|
|
EA200700564A1
(ru)
|
1998-02-25 |
2007-08-31 |
Эмори Юниверсити |
2`-фторнуклеозиды
|
|
US6312662B1
(en)
|
1998-03-06 |
2001-11-06 |
Metabasis Therapeutics, Inc. |
Prodrugs phosphorus-containing compounds
|
|
US6787305B1
(en)
|
1998-03-13 |
2004-09-07 |
Invitrogen Corporation |
Compositions and methods for enhanced synthesis of nucleic acid molecules
|
|
US6475985B1
(en)
|
1998-03-27 |
2002-11-05 |
Regents Of The University Of Minnesota |
Nucleosides with antiviral and anticancer activity
|
|
GB9806815D0
(en)
|
1998-03-30 |
1998-05-27 |
Hoffmann La Roche |
Amino acid derivatives
|
|
DE69901321T2
(de)
|
1998-05-15 |
2002-12-12 |
Schering Corp., Kenilworth |
Kombinationstherapie enthaltend Ribavirin und Interferon alpha bei Patienten mit chronischer Hepatitis C Infektion, die nicht antiviral vorbehandelt sind
|
|
US20010014352A1
(en)
|
1998-05-27 |
2001-08-16 |
Udit Batra |
Compressed tablet formulation
|
|
JP3839667B2
(ja)
|
1998-06-08 |
2006-11-01 |
エフ．ホフマン−ラ ロシュ アーゲー |
慢性Ｃ型肝炎の処置のためのＰｅｇ−ＩＮＦ−アルファ及びリバビリンの使用
|
|
US6200598B1
(en)
|
1998-06-18 |
2001-03-13 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
US6726925B1
(en)
|
1998-06-18 |
2004-04-27 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
GB9816358D0
(en)
|
1998-07-27 |
1998-09-23 |
Angeletti P Ist Richerche Bio |
Enzyme inhibitors
|
|
CA2338490A1
(en)
|
1998-07-27 |
2000-02-10 |
Sergio Altamura |
Diketoacid-derivatives as inhibitors of polymerases
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
US6395716B1
(en)
|
1998-08-10 |
2002-05-28 |
Novirio Pharmaceuticals Limited |
β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
|
|
ES2235518T3
(es)
|
1998-10-16 |
2005-07-01 |
Mercian Corporation |
Cristalizacion de hidrocloruro de doxorubicina.
|
|
US6635278B1
(en)
|
1998-12-15 |
2003-10-21 |
Gilead Sciences, Inc. |
Pharmaceutical formulations
|
|
CA2354536A1
(en)
|
1998-12-18 |
2000-06-29 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction hcv combination therapy
|
|
US6267985B1
(en)
|
1999-06-30 |
2001-07-31 |
Lipocine Inc. |
Clear oil-containing pharmaceutical compositions
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6294192B1
(en)
|
1999-02-26 |
2001-09-25 |
Lipocine, Inc. |
Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
|
|
US6383471B1
(en)
|
1999-04-06 |
2002-05-07 |
Lipocine, Inc. |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
|
|
US7919119B2
(en)
|
1999-05-27 |
2011-04-05 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
US6395300B1
(en)
|
1999-05-27 |
2002-05-28 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
CN1079473C
(zh)
|
1999-05-31 |
2002-02-20 |
李岭群 |
预制梁连接筋
|
|
WO2001005433A2
(en)
|
1999-07-14 |
2001-01-25 |
Board Of Regents, The University Of Texas System |
Delivery and retention of activity agents to lymph nodes
|
|
BR0012896A
(pt)
|
1999-07-30 |
2002-06-18 |
Abbott Gmbh & Co Kg |
2-pirazolin-5-onas
|
|
JP4979866B2
(ja)
|
1999-09-08 |
2012-07-18 |
リガンド・ファーマシューティカルズ・インコーポレイテッド |
肝臓に特異的なドラッグデリバリーのためのプロドラッグ
|
|
CA2389745C
(en)
|
1999-11-04 |
2010-03-23 |
Shire Biochem Inc. |
Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
|
|
TR200601782T2
(tr)
|
1999-11-12 |
2006-09-21 |
Pharmasset Ltd. |
2'-Deoksi-L-Nükleositlerin sentezi.
|
|
US20060034937A1
(en)
|
1999-11-23 |
2006-02-16 |
Mahesh Patel |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
SK11922002A3
(sk)
|
2000-02-18 |
2003-06-03 |
Shire Biochem Inc. |
Použitie analógov nukleozidov na liečenie alebo prevenciu infekcií spôsobených flavivírusom
|
|
JP2003532643A
(ja)
|
2000-04-13 |
2003-11-05 |
フアーマセツト・リミテツド |
肝炎ウイルス感染症を治療するための３’−または２’−ヒドロキシメチル置換ヌクレオシド誘導体
|
|
US6924270B2
(en)
|
2000-04-20 |
2005-08-02 |
Schering Corporation |
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
DE60105424T2
(de)
|
2000-05-26 |
2005-09-22 |
Idenix (Cayman) Ltd. |
Methoden zur behandlung von delta hepatitis virus infektionen mit beta-l-2' deoxy-nucleosiden
|
|
US6787526B1
(en)
|
2000-05-26 |
2004-09-07 |
Idenix Pharmaceuticals, Inc. |
Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
|
|
PL359169A1
(en)
|
2000-05-26 |
2004-08-23 |
Idenix (Cayman) Limited |
Methods and compositions for treating flaviviruses and pestiviruses
|
|
FR2810322B1
(fr)
|
2000-06-14 |
2006-11-10 |
Pasteur Institut |
PRODUCTION COMBINATOIRE D'ANALOGUES DE NUCLEOTIDES ET NUCLEOTIDES (XiTP)
|
|
MY141594A
(en)
|
2000-06-15 |
2010-05-14 |
Novirio Pharmaceuticals Ltd |
3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
UA72612C2
(en)
|
2000-07-06 |
2005-03-15 |
|
Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
|
|
US6680068B2
(en)
|
2000-07-06 |
2004-01-20 |
The General Hospital Corporation |
Drug delivery formulations and targeting
|
|
HRP20030047B1
(hr)
|
2000-07-21 |
2016-02-26 |
Gilead Sciences, Inc. |
Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava
|
|
AR034127A1
(es)
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
|
AR029851A1
(es)
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
|
SK742003A3
(en)
|
2000-07-21 |
2003-06-03 |
Schering Corp |
Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
US20020068702A1
(en)
|
2000-07-21 |
2002-06-06 |
Marguerita Lim-Wilby |
Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
US6897201B2
(en)
|
2000-08-21 |
2005-05-24 |
Inspire Pharmaceuticals, Inc. |
Compositions and methods for the treatment of glaucoma or ocular hypertension
|
|
AR039558A1
(es)
|
2000-08-21 |
2005-02-23 |
Inspire Pharmaceuticals Inc |
Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
|
|
US7018985B1
(en)
|
2000-08-21 |
2006-03-28 |
Inspire Pharmaceuticals, Inc. |
Composition and method for inhibiting platelet aggregation
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
KR20090089922A
(ko)
|
2000-10-18 |
2009-08-24 |
파마셋 인코포레이티드 |
바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
|
|
AU2002213343A1
(en)
|
2000-10-18 |
2002-04-29 |
Schering Corporation |
Ribavirin-pegylated interferon alfa HCV combination therapy
|
|
US6555677B2
(en)
|
2000-10-31 |
2003-04-29 |
Merck & Co., Inc. |
Phase transfer catalyzed glycosidation of an indolocarbazole
|
|
MXPA03004299A
(es)
|
2000-11-20 |
2004-02-12 |
Bristol Myers Squibb Co |
Inhibidores de tripeptido de hepatitis c.
|
|
AU3659102A
(en)
|
2000-12-12 |
2002-06-24 |
Schering Corp |
Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus
|
|
WO2002048116A2
(en)
|
2000-12-13 |
2002-06-20 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
WO2002048157A2
(en)
|
2000-12-13 |
2002-06-20 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
|
|
JP2005502580A
(ja)
|
2000-12-15 |
2005-01-27 |
フアーマセツト・リミテツド |
フラビウィルス感染治療用抗ウィルス薬
|
|
US7105499B2
(en)
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
MXPA03006514A
(es)
|
2001-01-22 |
2004-12-02 |
Merck & Co Inc |
Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico.
|
|
MY129350A
(en)
|
2001-04-25 |
2007-03-30 |
Bristol Myers Squibb Co |
Aripiprazole oral solution
|
|
GB0112617D0
(en)
|
2001-05-23 |
2001-07-18 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
GB0114286D0
(en)
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
EP1404694A1
(en)
|
2001-06-21 |
2004-04-07 |
Glaxo Group Limited |
Nucleoside compounds in hcv
|
|
KR100926244B1
(ko)
|
2001-07-11 |
2009-11-12 |
버텍스 파마슈티칼스 인코포레이티드 |
브릿지된 바이사이클릭 세린 프로테아제 억제제
|
|
EP2335700A1
(en)
|
2001-07-25 |
2011-06-22 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C virus polymerase inhibitors with a heterobicylic structure
|
|
ATE252594T1
(de)
|
2001-07-30 |
2003-11-15 |
Clariant Lsm Italia Spa |
Verfahren zur herstellung von ribavirin
|
|
ATE394409T1
(de)
|
2001-08-02 |
2008-05-15 |
Ilex Oncology Inc |
Verfahren zur herstellung von purinnukleosiden
|
|
US6962991B2
(en)
|
2001-09-12 |
2005-11-08 |
Epoch Biosciences, Inc. |
Process for the synthesis of pyrazolopyrimidines
|
|
WO2003022861A1
(en)
|
2001-09-13 |
2003-03-20 |
Bristol-Myers Squibb Company |
Process for the preparation of rebeccamycin and analogs thereof
|
|
WO2003024461A1
(en)
|
2001-09-20 |
2003-03-27 |
Schering Corporation |
Hcv combination therapy
|
|
AU2002330154A1
(en)
|
2001-09-28 |
2003-04-07 |
Centre National De La Recherche Scientifique |
Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
|
|
DE60221875T2
(de)
|
2001-11-02 |
2007-12-20 |
Glaxo Group Ltd., Greenford |
4-(6-gliedrige)-heteroaryl-acyl-pyrrolidinderivate als hcv-inhibitoren
|
|
AU2002359518A1
(en)
|
2001-11-27 |
2003-06-10 |
Bristol-Myers Squibb Company |
Efavirenz tablet formulation having unique biopharmaceutical characteristics
|
|
GB0129945D0
(en)
|
2001-12-13 |
2002-02-06 |
Mrc Technology Ltd |
Chemical compounds
|
|
BR0214944A
(pt)
|
2001-12-14 |
2005-06-07 |
Pharmasset Ltd |
Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais
|
|
WO2003051899A1
(en)
|
2001-12-17 |
2003-06-26 |
Ribapharm Inc. |
Deazapurine nucleoside libraries and compounds
|
|
AU2002364216A1
(en)
|
2001-12-21 |
2003-07-15 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza l-nucleosides
|
|
WO2003062256A1
(en)
|
2002-01-17 |
2003-07-31 |
Ribapharm Inc. |
2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
|
|
US7070801B2
(en)
|
2002-01-30 |
2006-07-04 |
National Institute Of Advanced Industrial Science And Technology |
Sugar-modified liposome and products comprising the liposome
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US7323453B2
(en)
|
2002-02-13 |
2008-01-29 |
Merck & Co., Inc. |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds
|
|
WO2003073989A2
(en)
|
2002-02-28 |
2003-09-12 |
Biota, Inc. |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
|
RU2004128943A
(ru)
|
2002-02-28 |
2005-04-20 |
Байота, Инк. (Us) |
Средства, имитирующие нуклеотиды, и их пролекарственные формы
|
|
TW200408645A
(en)
|
2002-04-26 |
2004-06-01 |
Gilead Sciences Inc |
Non nucleoside reverse transcriptase inhibitors
|
|
US20040014108A1
(en)
|
2002-05-24 |
2004-01-22 |
Eldrup Anne B. |
Oligonucleotides having modified nucleoside units
|
|
WO2003106477A1
(en)
|
2002-06-01 |
2003-12-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
WO2003101993A1
(en)
|
2002-06-04 |
2003-12-11 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
|
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
AU2003242672B2
(en)
|
2002-06-07 |
2009-12-17 |
Universitair Medisch Centrum Utrecht |
New compounds for modulating the activity of exhange proteins directly activated by camp (EPACS)
|
|
WO2003105770A2
(en)
|
2002-06-17 |
2003-12-24 |
Merck & Co., Inc. |
Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
AU2003269890A1
(en)
|
2002-06-21 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
US20060234962A1
(en)
|
2002-06-27 |
2006-10-19 |
Olsen David B |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
KR20050035194A
(ko)
|
2002-06-28 |
2005-04-15 |
이데닉스 (케이만) 리미티드 |
플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
|
|
KR20050055630A
(ko)
|
2002-06-28 |
2005-06-13 |
이데닉스 (케이만) 리미티드 |
플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체
|
|
AU2003247084B9
(en)
|
2002-06-28 |
2018-07-26 |
Centre National De La Recherche Scientifique |
Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections
|
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
|
BR0305259A
(pt)
|
2002-07-01 |
2004-10-05 |
Upjohn Co |
Inibidores de hcv ns5b polimerase
|
|
US6973905B2
(en)
|
2002-07-01 |
2005-12-13 |
Cinetic Automation Corporation |
Valve lash adjustment apparatus and method
|
|
US7041690B2
(en)
|
2002-07-01 |
2006-05-09 |
Pharmacia & Upjohn Company, Llc |
Inhibitors of HCV NS5B polymerase
|
|
EP1556399A4
(en)
|
2002-07-16 |
2007-09-26 |
Merck & Co Inc |
Nucleoside derivatives as inhibitors of RNA-dependent viral RNA polymerase
|
|
WO2004009610A2
(en)
|
2002-07-24 |
2004-01-29 |
Ptc Therapeutics, Inc. |
Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
|
|
WO2004009020A2
(en)
|
2002-07-24 |
2004-01-29 |
Merck & Co., Inc. |
Pyrrolopyrimidine thionucleoside analogs as antivirals
|
|
CA2492607A1
(en)
|
2002-07-25 |
2004-02-05 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza d-nucleosides and uses thereof
|
|
AU2003261434A1
(en)
|
2002-08-12 |
2004-02-25 |
Bristol-Myers Squibb Company |
Iminothiazolidinones as inhibitors of hcv replication
|
|
SI1572095T1
(sl)
|
2002-09-13 |
2015-12-31 |
Novartis Ag |
Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv
|
|
JP2006505571A
(ja)
|
2002-10-15 |
2006-02-16 |
リゲル ファーマシューテイカルズ、インコーポレイテッド |
置換されたインドール及びｈｃｖ阻害剤としてのその使用
|
|
US20040229840A1
(en)
|
2002-10-29 |
2004-11-18 |
Balkrishen Bhat |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
US7265152B2
(en)
|
2002-11-01 |
2007-09-04 |
Viropharma Incorporated |
Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
AU2003298658A1
(en)
|
2002-11-15 |
2004-06-15 |
Idenix (Cayman) Limited |
2'-branched nucleosides and flaviviridae mutation
|
|
TWI332507B
(en)
|
2002-11-19 |
2010-11-01 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
DK1585548T3
(en)
|
2002-12-09 |
2018-09-03 |
Abraxis Bioscience Llc |
COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS
|
|
US7598373B2
(en)
|
2002-12-12 |
2009-10-06 |
Idenix Pharmaceuticals, Inc. |
Process for the production of 2-C-methyl-D-ribonolactone
|
|
PT1583542E
(pt)
|
2003-01-14 |
2008-09-17 |
Gilead Sciences Inc |
Composições e métodos para terapia de combinação antiviral
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
WO2004080466A1
(en)
|
2003-03-07 |
2004-09-23 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
US7582748B2
(en)
|
2003-03-20 |
2009-09-01 |
Microbiologica Quimica E Farmaceutical Ltd. |
Methods of manufacture of 2′-deoxy-β-L-nucleosides
|
|
ATE422895T1
(de)
|
2003-04-16 |
2009-03-15 |
Bristol Myers Squibb Co |
Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus
|
|
SG182849A1
(en)
|
2003-04-25 |
2012-08-30 |
Gilead Sciences Inc |
Antiviral phosphonate analogs
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
EP1620109A2
(en)
|
2003-04-25 |
2006-02-01 |
Gilead Sciences, Inc. |
Kinase inhibitor phosphonate conjugates
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
EP1617848A2
(en)
|
2003-04-25 |
2006-01-25 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate conjugates
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
US20040259934A1
(en)
|
2003-05-01 |
2004-12-23 |
Olsen David B. |
Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
|
|
WO2004096210A1
(en)
|
2003-05-01 |
2004-11-11 |
Glaxo Group Limited |
Acylated indoline and tetrahydroquinoline derivatives as hcv inhibitors
|
|
US20040229839A1
(en)
|
2003-05-14 |
2004-11-18 |
Biocryst Pharmaceuticals, Inc. |
Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
WO2005020884A2
(en)
|
2003-05-14 |
2005-03-10 |
Idenix (Cayman) Limited |
Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
RU2358979C2
(ru)
|
2003-05-30 |
2009-06-20 |
Фармассет, Инк. |
Модифицированные фторированные аналоги нуклеозида
|
|
EP1644479A4
(en)
|
2003-06-16 |
2008-04-23 |
Mark W Grinstaff |
FUNCTIONAL SYNTHETIC MOLECULES AND MACROMOLECULES FOR GENERAL FEEDING
|
|
GB0317009D0
(en)
|
2003-07-21 |
2003-08-27 |
Univ Cardiff |
Chemical compounds
|
|
ATE478886T1
(de)
|
2003-07-25 |
2010-09-15 |
Idenix Pharmaceuticals Inc |
Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
|
|
WO2005021568A2
(en)
|
2003-08-27 |
2005-03-10 |
Biota, Inc. |
Novel tricyclic nucleosides or nucleotides as therapeutic agents
|
|
WO2005027962A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
EP1664091A1
(en)
|
2003-09-18 |
2006-06-07 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
US20050148534A1
(en)
|
2003-09-22 |
2005-07-07 |
Castellino Angelo J. |
Small molecule compositions and methods for increasing drug efficiency using compositions thereof
|
|
WO2005037214A2
(en)
|
2003-10-14 |
2005-04-28 |
Intermune, Inc. |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
|
|
US7491794B2
(en)
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
|
CN1893978A
(zh)
|
2003-10-27 |
2007-01-10 |
沃泰克斯药物股份有限公司 |
用于hcv治疗的组合
|
|
US7026339B2
(en)
|
2003-11-07 |
2006-04-11 |
Fan Yang |
Inhibitors of HCV NS5B polymerase
|
|
TW200528459A
(en)
|
2004-01-06 |
2005-09-01 |
Achillion Pharmaceuticals Inc |
Azabenzofuran substituted thioureas; inhibitors of viral replication
|
|
CN1913778A
(zh)
|
2004-01-28 |
2007-02-14 |
默克公司 |
趋化因子受体活性的氨基环戊基吡啶并吡嗪酮调节剂
|
|
EP1718150A1
(en)
|
2004-02-25 |
2006-11-08 |
The Government of the United States of America, represented by the Secretary, Department of Health and Human Services |
Methylation inhibitor compounds
|
|
WO2005087788A2
(en)
|
2004-03-04 |
2005-09-22 |
The Regents Of The University Of California |
Methods for preparation of nucleoside phosphonate esters
|
|
EP1749007A2
(en)
|
2004-03-30 |
2007-02-07 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
|
GB0408995D0
(en)
|
2004-04-22 |
2004-05-26 |
Glaxo Group Ltd |
Compounds
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
WO2005123087A2
(en)
|
2004-06-15 |
2005-12-29 |
Merck & Co., Inc. |
C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase
|
|
US20060040944A1
(en)
|
2004-06-23 |
2006-02-23 |
Gilles Gosselin |
5-Aza-7-deazapurine derivatives for treating Flaviviridae
|
|
US20070265222A1
(en)
|
2004-06-24 |
2007-11-15 |
Maccoss Malcolm |
Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
|
|
US7217523B2
(en)
|
2004-07-02 |
2007-05-15 |
Regents Of The University Of Minnesota |
Nucleoside phosphoramidates and nucleoside phosphoramidases
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
ES2386005T3
(es)
|
2004-07-21 |
2012-08-07 |
Gilead Pharmasset Llc |
Preparación de 2-desoxi-2-fluoro-d-ribofuranosil pirimidinas y purinas sustituidas con alquilo y sus derivados
|
|
PT2258376T
(pt)
|
2004-07-27 |
2019-05-31 |
Gilead Sciences Inc |
Análogos fosfonatados de compostos inibidores do vih
|
|
US7348425B2
(en)
|
2004-08-09 |
2008-03-25 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7153848B2
(en)
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
ES2327252T3
(es)
|
2004-08-23 |
2009-10-27 |
F. Hoffmann-La Roche Ag |
4'-azido nucleosidos antivirales.
|
|
WO2006021340A1
(en)
|
2004-08-23 |
2006-03-02 |
F.Hoffmann-La Roche Ag |
Heterocyclic antiviral compounds
|
|
WO2006029081A2
(en)
|
2004-09-02 |
2006-03-16 |
Neopharm, Inc. |
Nucleoside-lipid conjugates, their method of preparation and uses thereof
|
|
ES2725457T3
(es)
|
2004-09-14 |
2019-09-24 |
Gilead Pharmasset Llc |
Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
|
|
AU2005289517A1
(en)
|
2004-09-24 |
2006-04-06 |
Centre National De La Recherche Scientifique |
Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus
|
|
KR20070058602A
(ko)
|
2004-09-30 |
2007-06-08 |
티보텍 파마슈티칼즈 리미티드 |
Ｈｃｖ 저해 바이-사이클릭 피리미딘
|
|
AU2005317081A1
(en)
|
2004-10-21 |
2006-06-22 |
Merck & Co., Inc. |
Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection
|
|
EP1827460A4
(en)
|
2004-12-09 |
2012-03-14 |
Univ Minnesota |
NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT
|
|
WO2006065590A2
(en)
|
2004-12-16 |
2006-06-22 |
Xtl Biopharmaceuticals Inc. |
Pyridine and pyrimidine antiviral compositions
|
|
WO2006063717A2
(en)
|
2004-12-16 |
2006-06-22 |
Febit Biotech Gmbh |
Polymerase-independent analysis of the sequence of polynucleotides
|
|
WO2006093801A1
(en)
|
2005-02-25 |
2006-09-08 |
Abbott Laboratories |
Thiadiazine derivatives useful as anti-infective agents
|
|
HRP20070435A9
(en)
|
2005-02-28 |
2008-09-30 |
Genelabs Technologies |
Tricyclic-nucleoside compounds for treating viral infections
|
|
AU2006222563A1
(en)
|
2005-03-08 |
2006-09-14 |
Biota Scientific Management Pty Ltd. |
Bicyclic nucleosides and nucleotides as therapeutic agents
|
|
BRPI0609650A2
(pt)
|
2005-03-25 |
2010-04-20 |
Tibotec Pharm Ltd |
inibidores heterobicìlicos de hvc
|
|
WO2006116557A1
(en)
|
2005-04-25 |
2006-11-02 |
Genelabs Technologies, Inc. |
Nucleoside compounds for treating viral infections
|
|
WO2006119347A1
(en)
|
2005-05-02 |
2006-11-09 |
Pharmaessentia Corp. |
STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
AR054122A1
(es)
|
2005-05-12 |
2007-06-06 |
Tibotec Pharm Ltd |
Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas
|
|
AR056347A1
(es)
|
2005-05-12 |
2007-10-03 |
Tibotec Pharm Ltd |
Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
US20060276405A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods for treating hepatitis C
|
|
US8143288B2
(en)
|
2005-06-06 |
2012-03-27 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
|
US20060293752A1
(en)
|
2005-06-27 |
2006-12-28 |
Missoum Moumene |
Intervertebral disc prosthesis and associated methods
|
|
EP2305696A3
(en)
|
2005-07-25 |
2011-10-12 |
Intermune, Inc. |
Macrocyclic inhibitors of Hepatitis C virus replication
|
|
EP1912730A2
(en)
|
2005-07-28 |
2008-04-23 |
Isp Investments Inc. |
Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced
|
|
AR055105A1
(es)
|
2005-07-29 |
2007-08-08 |
Tibotec Pharm Ltd |
Inhibidores macrociclicos del virus de la hepatitis c
|
|
WO2007016300A2
(en)
|
2005-07-29 |
2007-02-08 |
Automotive Systems Laboratory, Inc. |
Magnetic crash sensor
|
|
BRPI0614637A2
(pt)
|
2005-07-29 |
2011-04-12 |
Tibotec Pharm Ltd |
inibidores macrocìclicos do vìrus da hepatite c
|
|
WO2007014922A1
(en)
|
2005-07-29 |
2007-02-08 |
Tibotec Pharmaceuticals Ltd. |
Macrocyclic inhibitors of hepatitis c virus
|
|
US20070059360A1
(en)
|
2005-07-29 |
2007-03-15 |
Ashish Jaiswal |
Water-dispersible anti-retroviral pharmaceutical compositions
|
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
|
EP1919904B1
(en)
|
2005-07-29 |
2014-01-08 |
Janssen R&D Ireland |
Macrocyclic inhibitors of hepatitis c virus
|
|
CN101287472B
(zh)
|
2005-08-15 |
2011-10-12 |
弗·哈夫曼-拉罗切有限公司 |
抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
|
|
GB0519488D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
GB0519478D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
BRPI0619563A2
(pt)
|
2005-12-09 |
2011-10-04 |
Pharmasset Inc |
nucleosìdeos antivirais
|
|
BRPI0619733A2
(pt)
|
2005-12-12 |
2011-10-11 |
Genelabs Tech Inc |
compostos antivirais de n-(anel aromático de 6 membros)-amido
|
|
WO2007076035A2
(en)
|
2005-12-21 |
2007-07-05 |
Abbott Laboratories |
Anti-viral compounds
|
|
ATE541844T1
(de)
|
2005-12-21 |
2012-02-15 |
Abbott Lab |
Antivirale verbindungen
|
|
GB0602046D0
(en)
|
2006-02-01 |
2006-03-15 |
Smithkline Beecham Corp |
Compounds
|
|
WO2007092000A1
(en)
|
2006-02-06 |
2007-08-16 |
Bristol-Myers Squibb Company |
Inhibitors of hcv replication
|
|
EP1987050A2
(en)
|
2006-02-14 |
2008-11-05 |
Merck & Co., Inc. |
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
AU2007216247A1
(en)
|
2006-02-17 |
2007-08-23 |
Pfizer Limited |
3 -deazapurine derivatives as TLR7 modulators
|
|
US8895531B2
(en)
|
2006-03-23 |
2014-11-25 |
Rfs Pharma Llc |
2′-fluoronucleoside phosphonates as antiviral agents
|
|
DE602007006796D1
(de)
|
2006-05-25 |
2010-07-08 |
Bristol Myers Squibb Co |
Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b-hemmer
|
|
WO2007140200A2
(en)
|
2006-05-25 |
2007-12-06 |
Bristol-Myers Squibb Company |
Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
|
|
KR101477822B1
(ko)
|
2006-07-07 |
2015-01-02 |
길리애드 사이언시즈, 인코포레이티드 |
치료제의 약동학 특성의 모듈레이터
|
|
EP2043613A1
(en)
|
2006-07-14 |
2009-04-08 |
Fmc Corporation |
Solid form
|
|
EP1881001A1
(en)
|
2006-07-20 |
2008-01-23 |
Tibotec Pharmaceuticals Ltd. |
HCV NS-3 serine protease inhibitors
|
|
US8329159B2
(en)
|
2006-08-11 |
2012-12-11 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
WO2008045419A1
(en)
|
2006-10-10 |
2008-04-17 |
Pharmasset, Inc. |
Preparation of nucleosides ribofuranosyl pyrimidines
|
|
PL216525B1
(pl)
|
2006-10-17 |
2014-04-30 |
Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk |
5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
|
|
GB0623493D0
(en)
|
2006-11-24 |
2007-01-03 |
Univ Cardiff |
Chemical compounds
|
|
JP2010513484A
(ja)
|
2006-12-20 |
2010-04-30 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Ｒｎａ依存性ｒｎａウイルス感染治療用ヌクレオシド環状ホスホロアミデート
|
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
AU2007342367B2
(en)
|
2007-01-05 |
2012-12-06 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
GB0709791D0
(en)
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
CN101108870A
(zh)
|
2007-08-03 |
2008-01-23 |
冷一欣 |
核苷磷酸酯类化合物及制备方法和应用
|
|
US8629171B2
(en)
|
2007-08-08 |
2014-01-14 |
Bristol-Myers Squibb Company |
Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
|
|
CA2699280A1
(en)
|
2007-09-14 |
2009-03-26 |
Schering Corporation |
Method of treating hepatitis c patients
|
|
JO2778B1
(en)
|
2007-10-16 |
2014-03-15 |
ايساي انك |
Certain Compounds, Compositions and Methods
|
|
JP5238939B2
(ja)
|
2007-11-07 |
2013-07-17 |
三菱化学株式会社 |
長繊維強化複合樹脂組成物および成形品
|
|
US20090318380A1
(en)
|
2007-11-20 |
2009-12-24 |
Pharmasset, Inc. |
2',4'-substituted nucleosides as antiviral agents
|
|
TW200936146A
(en)
|
2007-11-29 |
2009-09-01 |
Metabasis Therapeutics Inc |
Antiviral nucleoside compounds
|
|
WO2009086192A1
(en)
|
2007-12-21 |
2009-07-09 |
Alios Biopharma, Inc. |
Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
|
|
US8227431B2
(en)
|
2008-03-17 |
2012-07-24 |
Hetero Drugs Limited |
Nucleoside derivatives
|
|
WO2009120878A2
(en)
|
2008-03-26 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Non-natural ribonucleotides, and methods of use thereof
|
|
WO2009142842A2
(en)
|
2008-04-15 |
2009-11-26 |
Intermune, Inc. |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
|
EP3042660A3
(en)
|
2008-04-15 |
2016-10-26 |
RFS Pharma, LLC. |
Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
|
|
PL2280973T3
(pl)
|
2008-04-23 |
2013-05-31 |
Gilead Sciences Inc |
Analogi karba-nukleozydowe do leczenia przeciwwirusowego
|
|
WO2010036407A2
(en)
|
2008-05-15 |
2010-04-01 |
Biocryst Pharmaceuticals, Inc. |
Antiviral nucleoside analogs
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
EP2313102A2
(en)
|
2008-07-03 |
2011-04-27 |
Biota Scientific Management |
Bycyclic nucleosides and nucleotides as therapeutic agents
|
|
WO2010042834A1
(en)
|
2008-10-09 |
2010-04-15 |
Anadys Pharmaceuticals, Inc. |
A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
|
|
MX2011006890A
(es)
|
2008-12-23 |
2011-07-20 |
Pharmasset Inc |
Analogos de nucleosidos.
|
|
CL2009002206A1
(es)
|
2008-12-23 |
2011-08-26 |
Gilead Pharmasset Llc |
Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
|
|
AR074897A1
(es)
|
2008-12-23 |
2011-02-23 |
Pharmasset Inc |
Fosforamidatos de nucleosidos
|
|
CN102271688A
(zh)
|
2009-01-07 |
2011-12-07 |
西尼克斯公司 |
用于治疗hcv的环孢菌素衍生物和核苷的组合
|
|
BRPI1013643A2
(pt)
|
2009-02-10 |
2016-04-19 |
Gilead Sciences Inc |
análogos de carba-nucleosídeo para tratamento antiviral
|
|
JO3027B1
(ar)
*
|
2009-05-14 |
2016-09-05 |
Janssen Products Lp |
نيوكليوسيدات يوراسيل سبيرواوكسيتان
|
|
TWI576352B
(zh)
*
|
2009-05-20 |
2017-04-01 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
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AP2012006535A0
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2010-03-31 |
2012-10-31 |
Gilead Pharmasset Llc |
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ES2716158T3
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2010-11-30 |
2019-06-10 |
Gilead Pharmasset Llc |
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