JP2010511013A5 - - Google Patents

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Publication number
JP2010511013A5
JP2010511013A5 JP2009538704A JP2009538704A JP2010511013A5 JP 2010511013 A5 JP2010511013 A5 JP 2010511013A5 JP 2009538704 A JP2009538704 A JP 2009538704A JP 2009538704 A JP2009538704 A JP 2009538704A JP 2010511013 A5 JP2010511013 A5 JP 2010511013A5
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Japan
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compound
alkyl
formula
inhibitor
heteroaryl
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JP2009538704A
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Japanese (ja)
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JP2010511013A (ja
JP5523107B2 (ja
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Priority claimed from PCT/EP2007/062953 external-priority patent/WO2008065141A1/en
Publication of JP2010511013A publication Critical patent/JP2010511013A/ja
Publication of JP2010511013A5 publication Critical patent/JP2010511013A5/ja
Application granted granted Critical
Publication of JP5523107B2 publication Critical patent/JP5523107B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009538704A 2006-11-30 2007-11-28 グルタミニルシクラーゼの新規阻害剤 Expired - Fee Related JP5523107B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86784506P 2006-11-30 2006-11-30
US60/867,845 2006-11-30
PCT/EP2007/062953 WO2008065141A1 (en) 2006-11-30 2007-11-28 Novel inhibitors of glutaminyl cyclase

Publications (3)

Publication Number Publication Date
JP2010511013A JP2010511013A (ja) 2010-04-08
JP2010511013A5 true JP2010511013A5 (cg-RX-API-DMAC7.html) 2011-02-17
JP5523107B2 JP5523107B2 (ja) 2014-06-18

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JP2009538704A Expired - Fee Related JP5523107B2 (ja) 2006-11-30 2007-11-28 グルタミニルシクラーゼの新規阻害剤

Country Status (7)

Country Link
US (1) US9126987B2 (cg-RX-API-DMAC7.html)
EP (1) EP2091948B1 (cg-RX-API-DMAC7.html)
JP (1) JP5523107B2 (cg-RX-API-DMAC7.html)
AT (1) ATE554085T1 (cg-RX-API-DMAC7.html)
DK (1) DK2091948T3 (cg-RX-API-DMAC7.html)
SI (1) SI2091948T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008065141A1 (cg-RX-API-DMAC7.html)

Families Citing this family (31)

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WO2008055950A1 (en) * 2006-11-09 2008-05-15 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
DK2118101T3 (da) * 2007-03-09 2013-01-02 Probiodrug Ag IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer
DK2142515T3 (da) * 2007-04-18 2014-06-23 Probiodrug Ag Nitrovinyl-diaminderivater som glutaminyl-cyclase-inhibitorer
US9034907B2 (en) * 2007-04-18 2015-05-19 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2474693T3 (es) * 2007-04-18 2014-07-09 Probiodrug Ag Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa
US9512082B2 (en) * 2007-04-18 2016-12-06 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9656991B2 (en) * 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008128981A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
NZ583799A (en) * 2007-09-12 2011-12-22 Probiodrug Ag Transgenic mice comprising a DNA transgene encoding ABeta peptide
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
EA028427B1 (ru) 2008-07-21 2017-11-30 Пробиодруг Аг АНТИТЕЛО, СВЯЗЫВАЮЩЕЕСЯ С Aβ-ПЕПТИДАМИ ИЛИ ИХ ВАРИАНТАМИ, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО, И ЕГО ПРИМЕНЕНИЕ
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EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
US20110152341A1 (en) 2009-12-22 2011-06-23 Probiodrug Ag Cleavage of b-amyloid precursor protein
JP2013519891A (ja) 2010-02-18 2013-05-30 プロビオドルグ エージー ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法
JP6026284B2 (ja) * 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
CN101914094B (zh) * 2010-07-29 2012-08-22 南京大学 1,3,4-噁二唑衍生物及其制法与在制备抗肿瘤药物中的应用
EP2606129B1 (en) 2010-08-19 2015-03-25 Probiodrug AG Crystal structure of glutaminyl cyclase
AU2012228236B2 (en) 2011-03-16 2016-10-27 Vivoryon Therapeutics N.V. Diagnostic antibody assay
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
WO2016097305A1 (en) 2014-12-19 2016-06-23 Probiodrug Ag Novel method for the detection of pglu-abeta peptides
CN105384692B (zh) * 2015-10-26 2018-06-29 深圳大学 一种谷氨酰胺酰基环化酶抑制剂
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
CN111320617A (zh) * 2018-12-17 2020-06-23 华中科技大学 苯基噁二唑类衍生物及其制备方法与应用
CN111362930B (zh) * 2020-04-15 2023-02-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用

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